Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos
Phenotype	class.cls#double_gel_8d_versus_double_gel_72h_repos
Upregulated in class	double_gel_8d
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	0.5603625
Normalized Enrichment Score (NES)	2.0792
Nominal p-value	0.0
FDR q-value	0.0026945102
FWER p-Value	0.054

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	IGFBP7	IGFBP7 Entrez, Source	insulin-like growth factor binding protein 7	5	0.972	0.0695	Yes
2	CCND2	CCND2 Entrez, Source	cyclin D2	11	0.815	0.1277	Yes
3	RAMP1	RAMP1 Entrez, Source	receptor (calcitonin) activity modifying protein 1	37	0.635	0.1715	Yes
4	EMP1	EMP1 Entrez, Source	epithelial membrane protein 1	44	0.606	0.2146	Yes
5	SERPINE2	SERPINE2 Entrez, Source	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	104	0.424	0.2406	Yes
6	RGS1	RGS1 Entrez, Source	regulator of G-protein signalling 1	140	0.372	0.2647	Yes
7	GJA1	GJA1 Entrez, Source	gap junction protein, alpha 1, 43kDa (connexin 43)	196	0.324	0.2838	Yes
8	FOXO1A	FOXO1A Entrez, Source	forkhead box O1A (rhabdomyosarcoma)	213	0.311	0.3050	Yes
9	LAMC1	LAMC1 Entrez, Source	laminin, gamma 1 (formerly LAMB2)	224	0.303	0.3260	Yes
10	SPARC	SPARC Entrez, Source	secreted protein, acidic, cysteine-rich (osteonectin)	234	0.297	0.3466	Yes
11	CD48	CD48 Entrez, Source	CD48 molecule	239	0.291	0.3673	Yes
12	TRPM4	TRPM4 Entrez, Source	transient receptor potential cation channel, subfamily M, member 4	250	0.282	0.3868	Yes
13	PTGER4	PTGER4 Entrez, Source	prostaglandin E receptor 4 (subtype EP4)	361	0.225	0.3946	Yes
14	DPYSL2	DPYSL2 Entrez, Source	dihydropyrimidinase-like 2	366	0.223	0.4104	Yes
15	TMOD1	TMOD1 Entrez, Source	tropomodulin 1	370	0.220	0.4259	Yes
16	CYP2E1	CYP2E1 Entrez, Source	cytochrome P450, family 2, subfamily E, polypeptide 1	412	0.206	0.4377	Yes
17	GSN	GSN Entrez, Source	gelsolin (amyloidosis, Finnish type)	417	0.205	0.4521	Yes
18	P2RX5	P2RX5 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 5	423	0.203	0.4663	Yes
19	PROM1	PROM1 Entrez, Source	prominin 1	448	0.196	0.4786	Yes
20	F2RL1	F2RL1 Entrez, Source	coagulation factor II (thrombin) receptor-like 1	508	0.181	0.4871	Yes
21	EHD3	EHD3 Entrez, Source	EH-domain containing 3	518	0.179	0.4994	Yes
22	SCRN1	SCRN1 Entrez, Source	secernin 1	568	0.170	0.5079	Yes
23	ITM2C	ITM2C Entrez, Source	integral membrane protein 2C	696	0.150	0.5091	Yes
24	MLLT3	MLLT3 Entrez, Source	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	808	0.139	0.5107	Yes
25	TFPI	TFPI Entrez, Source	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	825	0.137	0.5193	Yes
26	LMO4	LMO4 Entrez, Source	LIM domain only 4	827	0.136	0.5290	Yes
27	FCER1A	FCER1A Entrez, Source	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	844	0.135	0.5375	Yes
28	CD69	CD69 Entrez, Source	CD69 molecule	898	0.129	0.5428	Yes
29	TGFB1I1	TGFB1I1 Entrez, Source	transforming growth factor beta 1 induced transcript 1	919	0.127	0.5504	Yes
30	HSPB1	HSPB1 Entrez, Source	heat shock 27kDa protein 1	1084	0.116	0.5463	Yes
31	NBL1	NBL1 Entrez, Source	neuroblastoma, suppression of tumorigenicity 1	1115	0.114	0.5523	Yes
32	B4GALT6	B4GALT6 Entrez, Source	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6	1117	0.114	0.5604	Yes
33	VIL2	VIL2 Entrez, Source	villin 2 (ezrin)	1333	0.102	0.5514	No
34	ELA2	ELA2 Entrez, Source	elastase 2, neutrophil	1522	0.093	0.5439	No
35	IL5RA	IL5RA Entrez, Source	interleukin 5 receptor, alpha	1677	0.086	0.5384	No
36	SLC38A1	SLC38A1 Entrez, Source	solute carrier family 38, member 1	1690	0.085	0.5437	No
37	SERINC5	SERINC5 Entrez, Source	serine incorporator 5	1858	0.078	0.5366	No
38	WASF1	WASF1 Entrez, Source	WAS protein family, member 1	1914	0.076	0.5379	No
39	FZD2	FZD2 Entrez, Source	frizzled homolog 2 (Drosophila)	2019	0.073	0.5353	No
40	ALAS2	ALAS2 Entrez, Source	aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)	2100	0.070	0.5342	No
41	TACSTD2	TACSTD2 Entrez, Source	tumor-associated calcium signal transducer 2	2200	0.067	0.5316	No
42	FZD6	FZD6 Entrez, Source	frizzled homolog 6 (Drosophila)	2258	0.066	0.5320	No
43	GNAI1	GNAI1 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	2424	0.061	0.5239	No
44	GMPR	GMPR Entrez, Source	guanosine monophosphate reductase	2611	0.057	0.5140	No
45	ASS1	ASS1 Entrez, Source	argininosuccinate synthetase 1	2650	0.056	0.5152	No
46	BZRAP1	BZRAP1 Entrez, Source	benzodiazapine receptor (peripheral) associated protein 1	2978	0.049	0.4939	No
47	APP	APP Entrez, Source	amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)	3298	0.043	0.4729	No
48	TMEM158	TMEM158 Entrez, Source	transmembrane protein 158	4032	0.030	0.4196	No
49	TRH	TRH Entrez, Source	thyrotropin-releasing hormone	4036	0.030	0.4215	No
50	SNCA	SNCA Entrez, Source	synuclein, alpha (non A4 component of amyloid precursor)	4052	0.029	0.4225	No
51	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	4207	0.027	0.4127	No
52	SH3BP4	SH3BP4 Entrez, Source	SH3-domain binding protein 4	4238	0.026	0.4124	No
53	KIT	KIT Entrez, Source	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	4345	0.025	0.4061	No
54	GNG7	GNG7 Entrez, Source	guanine nucleotide binding protein (G protein), gamma 7	4525	0.022	0.3942	No
55	BLNK	BLNK Entrez, Source	B-cell linker	4539	0.022	0.3948	No
56	SERPING1	SERPING1 Entrez, Source	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)	4547	0.022	0.3958	No
57	MX1	MX1 Entrez, Source	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	4566	0.022	0.3960	No
58	RPS6KA2	RPS6KA2 Entrez, Source	ribosomal protein S6 kinase, 90kDa, polypeptide 2	4610	0.021	0.3942	No
59	CD2	CD2 Entrez, Source	CD2 molecule	4735	0.019	0.3862	No
60	MYH11	MYH11 Entrez, Source	myosin, heavy chain 11, smooth muscle	4899	0.017	0.3751	No
61	LCN2	LCN2 Entrez, Source	lipocalin 2 (oncogene 24p3)	4934	0.016	0.3737	No
62	NCAM1	NCAM1 Entrez, Source	neural cell adhesion molecule 1	5249	0.012	0.3508	No
63	FHL1	FHL1 Entrez, Source	four and a half LIM domains 1	5266	0.012	0.3504	No
64	OPTN	OPTN Entrez, Source	optineurin	5299	0.011	0.3488	No
65	RUNX3	RUNX3 Entrez, Source	runt-related transcription factor 3	5356	0.010	0.3453	No
66	PAM	PAM Entrez, Source	peptidylglycine alpha-amidating monooxygenase	5501	0.008	0.3350	No
67	BPGM	BPGM Entrez, Source	2,3-bisphosphoglycerate mutase	5600	0.007	0.3281	No
68	NRXN2	NRXN2 Entrez, Source	neurexin 2	6107	0.001	0.2899	No
69	MSLN	MSLN Entrez, Source	mesothelin	6309	-0.002	0.2748	No
70	CD3D	CD3D Entrez, Source	CD3d molecule, delta (CD3-TCR complex)	6312	-0.002	0.2748	No
71	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	6337	-0.002	0.2732	No
72	EVL	EVL Entrez, Source	Enah/Vasp-like	6399	-0.003	0.2688	No
73	TGFBI	TGFBI Entrez, Source	transforming growth factor, beta-induced, 68kDa	6410	-0.003	0.2683	No
74	MST1	MST1 Entrez, Source	macrophage stimulating 1 (hepatocyte growth factor-like)	6456	-0.004	0.2651	No
75	RAP2A	RAP2A Entrez, Source	RAP2A, member of RAS oncogene family	6516	-0.005	0.2610	No
76	BAALC	BAALC Entrez, Source	brain and acute leukemia, cytoplasmic	6612	-0.006	0.2542	No
77	ALDH2	ALDH2 Entrez, Source	aldehyde dehydrogenase 2 family (mitochondrial)	6734	-0.007	0.2456	No
78	EGFL7	EGFL7 Entrez, Source	EGF-like-domain, multiple 7	6762	-0.008	0.2441	No
79	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	6866	-0.009	0.2370	No
80	ERG	ERG Entrez, Source	v-ets erythroblastosis virus E26 oncogene homolog (avian)	6929	-0.010	0.2330	No
81	ITGA6	ITGA6 Entrez, Source	integrin, alpha 6	6967	-0.010	0.2309	No
82	CD38	CD38 Entrez, Source	CD38 molecule	7086	-0.012	0.2229	No
83	UGCG	UGCG Entrez, Source	UDP-glucose ceramide glucosyltransferase	7435	-0.016	0.1977	No
84	GATA3	GATA3 Entrez, Source	GATA binding protein 3	7809	-0.021	0.1710	No
85	CIITA	CIITA Entrez, Source	class II, major histocompatibility complex, transactivator	7855	-0.021	0.1691	No
86	ADCY3	ADCY3 Entrez, Source	adenylate cyclase 3	8531	-0.031	0.1203	No
87	FLNB	FLNB Entrez, Source	filamin B, beta (actin binding protein 278)	8603	-0.032	0.1172	No
88	DLK1	DLK1 Entrez, Source	delta-like 1 homolog (Drosophila)	8739	-0.034	0.1095	No
89	SERPINF1	SERPINF1 Entrez, Source	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	8926	-0.036	0.0980	No
90	SCCPDH	SCCPDH Entrez, Source	saccharopine dehydrogenase (putative)	8949	-0.037	0.0990	No
91	CCR2	CCR2 Entrez, Source	chemokine (C-C motif) receptor 2	8978	-0.037	0.0996	No
92	TPSAB1	TPSAB1 Entrez, Source	tryptase alpha/beta 1	8986	-0.037	0.1017	No
93	ROBO1	ROBO1 Entrez, Source	roundabout, axon guidance receptor, homolog 1 (Drosophila)	9015	-0.038	0.1023	No
94	NARFL	NARFL Entrez, Source	nuclear prelamin A recognition factor-like	9164	-0.040	0.0940	No
95	ST18	ST18 Entrez, Source	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	9371	-0.043	0.0815	No
96	PDE4B	PDE4B Entrez, Source	phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)	9537	-0.046	0.0723	No
97	PRODH	PRODH Entrez, Source	proline dehydrogenase (oxidase) 1	9764	-0.050	0.0587	No
98	CD200	CD200 Entrez, Source	CD200 molecule	9804	-0.050	0.0594	No
99	CHI3L1	CHI3L1 Entrez, Source	chitinase 3-like 1 (cartilage glycoprotein-39)	9869	-0.051	0.0583	No
100	PALM	PALM Entrez, Source	paralemmin	10122	-0.056	0.0432	No
101	JUP	JUP Entrez, Source	junction plakoglobin	10241	-0.057	0.0384	No
102	HGF	HGF Entrez, Source	hepatocyte growth factor (hepapoietin A; scatter factor)	10486	-0.062	0.0244	No
103	LRP3	LRP3 Entrez, Source	low density lipoprotein receptor-related protein 3	10545	-0.063	0.0245	No
104	VEGF	VEGF Entrez, Source	vascular endothelial growth factor	10686	-0.066	0.0187	No
105	FGFR1	FGFR1 Entrez, Source	fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)	10807	-0.069	0.0145	No
106	PTPRM	PTPRM Entrez, Source	protein tyrosine phosphatase, receptor type, M	10978	-0.073	0.0069	No
107	SPON1	SPON1 Entrez, Source	spondin 1, extracellular matrix protein	11183	-0.078	-0.0030	No
108	SYNGR1	SYNGR1 Entrez, Source	synaptogyrin 1	11243	-0.080	-0.0017	No
109	NT5E	NT5E Entrez, Source	5'-nucleotidase, ecto (CD73)	11299	-0.081	0.0000	No
110	PDE3B	PDE3B Entrez, Source	phosphodiesterase 3B, cGMP-inhibited	11375	-0.083	0.0003	No
111	GPM6B	GPM6B Entrez, Source	glycoprotein M6B	11468	-0.085	-0.0005	No
112	NPR3	NPR3 Entrez, Source	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	11674	-0.091	-0.0095	No
113	ISG20	ISG20 Entrez, Source	interferon stimulated exonuclease gene 20kDa	12100	-0.107	-0.0339	No
114	FGF13	FGF13 Entrez, Source	fibroblast growth factor 13	12314	-0.117	-0.0416	No
115	C1ORF24	C1ORF24 Entrez, Source	chromosome 1 open reading frame 24	12389	-0.121	-0.0385	No
116	SNRPN /// SNURF			12618	-0.136	-0.0460	No
117	MMP9	MMP9 Entrez, Source	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	12642	-0.137	-0.0379	No
118	POU4F1	POU4F1 Entrez, Source	POU domain, class 4, transcription factor 1	12659	-0.138	-0.0292	No
119	IFI44	IFI44 Entrez, Source	interferon-induced protein 44	12681	-0.140	-0.0207	No
120	ARHGEF12	ARHGEF12 Entrez, Source	Rho guanine nucleotide exchange factor (GEF) 12	12697	-0.141	-0.0117	No
121	AK3L1	AK3L1 Entrez, Source	adenylate kinase 3-like 1	12819	-0.155	-0.0098	No
122	DHRS3	DHRS3 Entrez, Source	dehydrogenase/reductase (SDR family) member 3	12962	-0.175	-0.0079	No
123	H1F0	H1F0 Entrez, Source	H1 histone family, member 0	13032	-0.193	0.0007	No
124	VLDLR	VLDLR Entrez, Source	very low density lipoprotein receptor	13265	-0.315	0.0058	No