Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_double_gel_72h.class.cls #double_gel_8d_versus_double_gel_72h_repos |
| Phenotype | class.cls#double_gel_8d_versus_double_gel_72h_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | VERHAAK_AML_NPM1_MUT_VS_WT_UP |
| Enrichment Score (ES) | 0.48035976 |
| Normalized Enrichment Score (NES) | 1.7871399 |
| Nominal p-value | 0.001618123 |
| FDR q-value | 0.033363145 |
| FWER p-Value | 0.979 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GDF15 | GDF15 Entrez, Source | growth differentiation factor 15 | 58 | 0.559 | 0.0454 | Yes |
| 2 | PRKAR2B | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 69 | 0.494 | 0.0887 | Yes |
| 3 | VNN1 | VNN1 Entrez, Source | vanin 1 | 96 | 0.443 | 0.1261 | Yes |
| 4 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 118 | 0.402 | 0.1603 | Yes |
| 5 | DEFB1 | DEFB1 Entrez, Source | defensin, beta 1 | 158 | 0.356 | 0.1891 | Yes |
| 6 | CCL20 | CCL20 Entrez, Source | chemokine (C-C motif) ligand 20 | 160 | 0.355 | 0.2206 | Yes |
| 7 | LGALS2 | LGALS2 Entrez, Source | lectin, galactoside-binding, soluble, 2 (galectin 2) | 176 | 0.340 | 0.2497 | Yes |
| 8 | GGT1 | GGT1 Entrez, Source | gamma-glutamyltransferase 1 | 240 | 0.289 | 0.2707 | Yes |
| 9 | SCHIP1 | SCHIP1 Entrez, Source | schwannomin interacting protein 1 | 280 | 0.261 | 0.2910 | Yes |
| 10 | JAG1 | JAG1 Entrez, Source | jagged 1 (Alagille syndrome) | 323 | 0.239 | 0.3091 | Yes |
| 11 | LTBP1 | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 372 | 0.219 | 0.3250 | Yes |
| 12 | S100A6 | S100A6 Entrez, Source | S100 calcium binding protein A6 | 402 | 0.209 | 0.3415 | Yes |
| 13 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 436 | 0.199 | 0.3567 | Yes |
| 14 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 535 | 0.175 | 0.3649 | Yes |
| 15 | IER3 | IER3 Entrez, Source | immediate early response 3 | 598 | 0.165 | 0.3749 | Yes |
| 16 | FGR | FGR Entrez, Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 655 | 0.157 | 0.3847 | Yes |
| 17 | PHLDA1 | PHLDA1 Entrez, Source | pleckstrin homology-like domain, family A, member 1 | 772 | 0.143 | 0.3886 | Yes |
| 18 | PF4 | PF4 Entrez, Source | platelet factor 4 (chemokine (C-X-C motif) ligand 4) | 798 | 0.140 | 0.3992 | Yes |
| 19 | PLA2G4A | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 812 | 0.139 | 0.4106 | Yes |
| 20 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 888 | 0.130 | 0.4165 | Yes |
| 21 | CCR1 | CCR1 Entrez, Source | chemokine (C-C motif) receptor 1 | 979 | 0.123 | 0.4207 | Yes |
| 22 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 1014 | 0.121 | 0.4288 | Yes |
| 23 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 1050 | 0.118 | 0.4367 | Yes |
| 24 | TRIB1 | TRIB1 Entrez, Source | tribbles homolog 1 (Drosophila) | 1067 | 0.116 | 0.4458 | Yes |
| 25 | TMEM176B | TMEM176B Entrez, Source | transmembrane protein 176B | 1087 | 0.116 | 0.4547 | Yes |
| 26 | SLC16A3 | SLC16A3 Entrez, Source | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) | 1110 | 0.114 | 0.4632 | Yes |
| 27 | BCL2A1 | BCL2A1 Entrez, Source | BCL2-related protein A1 | 1231 | 0.108 | 0.4637 | Yes |
| 28 | CAST | CAST Entrez, Source | calpastatin | 1258 | 0.107 | 0.4713 | Yes |
| 29 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 1327 | 0.103 | 0.4753 | Yes |
| 30 | HNMT | HNMT Entrez, Source | histamine N-methyltransferase | 1378 | 0.100 | 0.4804 | Yes |
| 31 | MARCKS | MARCKS Entrez, Source | myristoylated alanine-rich protein kinase C substrate | 1688 | 0.085 | 0.4646 | No |
| 32 | TBXAS1 | TBXAS1 Entrez, Source | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) | 2143 | 0.069 | 0.4364 | No |
| 33 | CD14 | CD14 Entrez, Source | CD14 molecule | 2182 | 0.068 | 0.4396 | No |
| 34 | SORT1 | SORT1 Entrez, Source | sortilin 1 | 2504 | 0.060 | 0.4207 | No |
| 35 | PELI1 | PELI1 Entrez, Source | pellino homolog 1 (Drosophila) | 2551 | 0.058 | 0.4224 | No |
| 36 | SMPDL3A | SMPDL3A Entrez, Source | sphingomyelin phosphodiesterase, acid-like 3A | 2687 | 0.055 | 0.4171 | No |
| 37 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 2770 | 0.053 | 0.4157 | No |
| 38 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 2794 | 0.053 | 0.4187 | No |
| 39 | TLR4 | TLR4 Entrez, Source | toll-like receptor 4 | 2800 | 0.053 | 0.4230 | No |
| 40 | SCPEP1 | SCPEP1 Entrez, Source | serine carboxypeptidase 1 | 2876 | 0.051 | 0.4219 | No |
| 41 | EREG | EREG Entrez, Source | epiregulin | 2999 | 0.049 | 0.4170 | No |
| 42 | HOXA4 | HOXA4 Entrez, Source | homeobox A4 | 3020 | 0.048 | 0.4197 | No |
| 43 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 3216 | 0.044 | 0.4090 | No |
| 44 | CARD9 | CARD9 Entrez, Source | caspase recruitment domain family, member 9 | 3230 | 0.044 | 0.4119 | No |
| 45 | CLU | CLU Entrez, Source | clusterin | 3299 | 0.043 | 0.4106 | No |
| 46 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 3396 | 0.041 | 0.4069 | No |
| 47 | CCL4 | CCL4 Entrez, Source | chemokine (C-C motif) ligand 4 | 3468 | 0.039 | 0.4051 | No |
| 48 | CTSL | CTSL Entrez, Source | cathepsin L | 3892 | 0.032 | 0.3759 | No |
| 49 | SNX10 | SNX10 Entrez, Source | sorting nexin 10 | 3945 | 0.031 | 0.3748 | No |
| 50 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 3978 | 0.031 | 0.3751 | No |
| 51 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 4037 | 0.030 | 0.3734 | No |
| 52 | CAMK1 | CAMK1 Entrez, Source | calcium/calmodulin-dependent protein kinase I | 4104 | 0.029 | 0.3709 | No |
| 53 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 4298 | 0.025 | 0.3586 | No |
| 54 | PLEK | PLEK Entrez, Source | pleckstrin | 4826 | 0.018 | 0.3204 | No |
| 55 | ADCY2 | ADCY2 Entrez, Source | adenylate cyclase 2 (brain) | 4922 | 0.016 | 0.3147 | No |
| 56 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 4953 | 0.016 | 0.3138 | No |
| 57 | PPBP | PPBP Entrez, Source | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | 5643 | 0.006 | 0.2623 | No |
| 58 | LMNA | LMNA Entrez, Source | lamin A/C | 5805 | 0.004 | 0.2505 | No |
| 59 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 6191 | -0.000 | 0.2215 | No |
| 60 | HOXA5 | HOXA5 Entrez, Source | homeobox A5 | 6663 | -0.007 | 0.1865 | No |
| 61 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 6827 | -0.008 | 0.1750 | No |
| 62 | SEPP1 | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 6950 | -0.010 | 0.1666 | No |
| 63 | NGFRAP1 | NGFRAP1 Entrez, Source | nerve growth factor receptor (TNFRSF16) associated protein 1 | 7029 | -0.011 | 0.1617 | No |
| 64 | CX3CR1 | CX3CR1 Entrez, Source | chemokine (C-X3-C motif) receptor 1 | 7144 | -0.012 | 0.1542 | No |
| 65 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 7177 | -0.013 | 0.1529 | No |
| 66 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 7433 | -0.016 | 0.1351 | No |
| 67 | FGL2 | FGL2 Entrez, Source | fibrinogen-like 2 | 7684 | -0.019 | 0.1179 | No |
| 68 | PTAFR | PTAFR Entrez, Source | platelet-activating factor receptor | 8055 | -0.024 | 0.0921 | No |
| 69 | SLC15A3 | SLC15A3 Entrez, Source | solute carrier family 15, member 3 | 8234 | -0.027 | 0.0811 | No |
| 70 | SERPINB2 | SERPINB2 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 8340 | -0.028 | 0.0757 | No |
| 71 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 8582 | -0.032 | 0.0603 | No |
| 72 | EMR1 | EMR1 Entrez, Source | egf-like module containing, mucin-like, hormone receptor-like 1 | 8587 | -0.032 | 0.0629 | No |
| 73 | DPEP2 | DPEP2 Entrez, Source | dipeptidase 2 | 8823 | -0.035 | 0.0483 | No |
| 74 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 8852 | -0.035 | 0.0493 | No |
| 75 | LAPTM4B | LAPTM4B Entrez, Source | lysosomal associated protein transmembrane 4 beta | 8874 | -0.036 | 0.0509 | No |
| 76 | HIP1 | HIP1 Entrez, Source | huntingtin interacting protein 1 | 8980 | -0.037 | 0.0463 | No |
| 77 | TCIRG1 | TCIRG1 Entrez, Source | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 9056 | -0.038 | 0.0440 | No |
| 78 | KCNJ2 | KCNJ2 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 2 | 9082 | -0.039 | 0.0456 | No |
| 79 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 9179 | -0.040 | 0.0419 | No |
| 80 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 9367 | -0.043 | 0.0316 | No |
| 81 | C2 | C2 Entrez, Source | complement component 2 | 9498 | -0.045 | 0.0258 | No |
| 82 | CAT | CAT Entrez, Source | catalase | 9526 | -0.046 | 0.0278 | No |
| 83 | RHAG | RHAG Entrez, Source | Rh-associated glycoprotein | 9587 | -0.047 | 0.0274 | No |
| 84 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 9594 | -0.047 | 0.0311 | No |
| 85 | MAFB | MAFB Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) | 9601 | -0.047 | 0.0349 | No |
| 86 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 10417 | -0.061 | -0.0213 | No |
| 87 | CD86 | CD86 Entrez, Source | CD86 molecule | 10637 | -0.065 | -0.0321 | No |
| 88 | LGALS3BP | LGALS3BP Entrez, Source | lectin, galactoside-binding, soluble, 3 binding protein | 10919 | -0.071 | -0.0469 | No |
| 89 | MVP | MVP Entrez, Source | major vault protein | 10938 | -0.072 | -0.0419 | No |
| 90 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 10939 | -0.072 | -0.0355 | No |
| 91 | PDGFD | PDGFD Entrez, Source | platelet derived growth factor D | 10958 | -0.072 | -0.0304 | No |
| 92 | CYP1B1 | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 10964 | -0.073 | -0.0243 | No |
| 93 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 11134 | -0.077 | -0.0303 | No |
| 94 | QPRT | QPRT Entrez, Source | quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) | 11677 | -0.091 | -0.0631 | No |
| 95 | HMOX1 | HMOX1 Entrez, Source | heme oxygenase (decycling) 1 | 12319 | -0.117 | -0.1011 | No |
| 96 | HCK | HCK Entrez, Source | hemopoietic cell kinase | 12385 | -0.120 | -0.0953 | No |
| 97 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 12570 | -0.133 | -0.0974 | No |
| 98 | NINJ1 | NINJ1 Entrez, Source | ninjurin 1 | 12581 | -0.133 | -0.0863 | No |
| 99 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12596 | -0.134 | -0.0754 | No |
| 100 | SECTM1 | SECTM1 Entrez, Source | secreted and transmembrane 1 | 12728 | -0.144 | -0.0724 | No |
| 101 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 12736 | -0.145 | -0.0601 | No |
| 102 | ABCC4 | ABCC4 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | 12968 | -0.176 | -0.0618 | No |
| 103 | G0S2 | G0S2 Entrez, Source | G0/G1switch 2 | 13227 | -0.274 | -0.0569 | No |
| 104 | AQP9 | AQP9 Entrez, Source | aquaporin 9 | 13248 | -0.296 | -0.0321 | No |
| 105 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 13311 | -0.439 | 0.0023 | No |
