Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | ACTIN_CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS |
| Enrichment Score (ES) | -0.5119507 |
| Normalized Enrichment Score (NES) | -1.6960132 |
| Nominal p-value | 0.0019493178 |
| FDR q-value | 0.077586085 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 309 | 0.392 | 0.0264 | No |
| 2 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 407 | 0.337 | 0.0618 | No |
| 3 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 1326 | 0.162 | 0.0133 | No |
| 4 | TESK2 | TESK2 Entrez, Source | testis-specific kinase 2 | 2143 | 0.116 | -0.0334 | No |
| 5 | LIMK1 | LIMK1 Entrez, Source | LIM domain kinase 1 | 3076 | 0.083 | -0.0931 | No |
| 6 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 3317 | 0.076 | -0.1016 | No |
| 7 | GHSR | GHSR Entrez, Source | growth hormone secretagogue receptor | 3367 | 0.074 | -0.0958 | No |
| 8 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 3512 | 0.071 | -0.0977 | No |
| 9 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 3860 | 0.063 | -0.1159 | No |
| 10 | SCIN | SCIN Entrez, Source | scinderin | 3942 | 0.061 | -0.1142 | No |
| 11 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 4003 | 0.059 | -0.1112 | No |
| 12 | TTN | TTN Entrez, Source | titin | 4401 | 0.050 | -0.1347 | No |
| 13 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 4419 | 0.050 | -0.1296 | No |
| 14 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 4606 | 0.046 | -0.1378 | No |
| 15 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 5315 | 0.032 | -0.1870 | No |
| 16 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5460 | 0.029 | -0.1942 | No |
| 17 | TSC1 | TSC1 Entrez, Source | tuberous sclerosis 1 | 5506 | 0.028 | -0.1941 | No |
| 18 | PLA2G1B | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 6057 | 0.017 | -0.2333 | No |
| 19 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 6436 | 0.009 | -0.2606 | No |
| 20 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 6561 | 0.007 | -0.2691 | No |
| 21 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 6928 | -0.000 | -0.2966 | No |
| 22 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 6944 | -0.001 | -0.2976 | No |
| 23 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 7115 | -0.004 | -0.3099 | No |
| 24 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 7224 | -0.007 | -0.3172 | No |
| 25 | TAOK2 | TAOK2 Entrez, Source | TAO kinase 2 | 7244 | -0.007 | -0.3177 | No |
| 26 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 7261 | -0.008 | -0.3179 | No |
| 27 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 7397 | -0.010 | -0.3268 | No |
| 28 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7461 | -0.012 | -0.3301 | No |
| 29 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 8008 | -0.024 | -0.3682 | No |
| 30 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 8458 | -0.033 | -0.3977 | No |
| 31 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 8499 | -0.034 | -0.3964 | No |
| 32 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 8634 | -0.037 | -0.4017 | No |
| 33 | GHRL | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 8739 | -0.040 | -0.4045 | No |
| 34 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 8997 | -0.046 | -0.4181 | No |
| 35 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 9002 | -0.046 | -0.4126 | No |
| 36 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9176 | -0.051 | -0.4192 | No |
| 37 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 9496 | -0.060 | -0.4356 | No |
| 38 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9885 | -0.071 | -0.4558 | No |
| 39 | PACSIN2 | PACSIN2 Entrez, Source | protein kinase C and casein kinase substrate in neurons 2 | 10159 | -0.080 | -0.4662 | No |
| 40 | CDC42EP2 | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 10646 | -0.097 | -0.4905 | No |
| 41 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 10778 | -0.102 | -0.4874 | No |
| 42 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 11105 | -0.117 | -0.4971 | Yes |
| 43 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 11123 | -0.118 | -0.4834 | Yes |
| 44 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11190 | -0.121 | -0.4731 | Yes |
| 45 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 11232 | -0.123 | -0.4605 | Yes |
| 46 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 11321 | -0.127 | -0.4510 | Yes |
| 47 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 11702 | -0.150 | -0.4606 | Yes |
| 48 | NUAK2 | NUAK2 Entrez, Source | NUAK family, SNF1-like kinase, 2 | 11901 | -0.166 | -0.4545 | Yes |
| 49 | PSCD2 | PSCD2 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) | 12104 | -0.182 | -0.4467 | Yes |
| 50 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 12106 | -0.182 | -0.4237 | Yes |
| 51 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 12111 | -0.182 | -0.4008 | Yes |
| 52 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12275 | -0.202 | -0.3875 | Yes |
| 53 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12307 | -0.205 | -0.3639 | Yes |
| 54 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12500 | -0.229 | -0.3493 | Yes |
| 55 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12585 | -0.241 | -0.3250 | Yes |
| 56 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 13018 | -0.375 | -0.3099 | Yes |
| 57 | DBN1 | DBN1 Entrez, Source | drebrin 1 | 13319 | -1.054 | -0.1988 | Yes |
| 58 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.581 | 0.0002 | Yes |
