Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | AGEING_KIDNEY_SPECIFIC_UP |
| Enrichment Score (ES) | -0.51592094 |
| Normalized Enrichment Score (NES) | -1.8913605 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.023143094 |
| FWER p-Value | 0.508 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 104 | 0.612 | 0.0210 | No |
| 2 | CFB | CFB Entrez, Source | complement factor B | 112 | 0.599 | 0.0487 | No |
| 3 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 241 | 0.443 | 0.0600 | No |
| 4 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 267 | 0.421 | 0.0780 | No |
| 5 | RARRES1 | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 325 | 0.381 | 0.0916 | No |
| 6 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 362 | 0.357 | 0.1057 | No |
| 7 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 500 | 0.300 | 0.1095 | No |
| 8 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 510 | 0.296 | 0.1228 | No |
| 9 | C3 | C3 Entrez, Source | complement component 3 | 636 | 0.257 | 0.1255 | No |
| 10 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 1016 | 0.190 | 0.1058 | No |
| 11 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 1034 | 0.189 | 0.1135 | No |
| 12 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 1554 | 0.145 | 0.0811 | No |
| 13 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 1598 | 0.143 | 0.0846 | No |
| 14 | EBF1 | EBF1 Entrez, Source | early B-cell factor 1 | 1627 | 0.141 | 0.0892 | No |
| 15 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 1743 | 0.134 | 0.0868 | No |
| 16 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 1870 | 0.128 | 0.0833 | No |
| 17 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 2073 | 0.118 | 0.0736 | No |
| 18 | CXCL14 | CXCL14 Entrez, Source | chemokine (C-X-C motif) ligand 14 | 2190 | 0.115 | 0.0703 | No |
| 19 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 2309 | 0.110 | 0.0666 | No |
| 20 | CTHRC1 | CTHRC1 Entrez, Source | collagen triple helix repeat containing 1 | 2319 | 0.109 | 0.0710 | No |
| 21 | VTCN1 | VTCN1 Entrez, Source | V-set domain containing T cell activation inhibitor 1 | 2355 | 0.108 | 0.0735 | No |
| 22 | ASNS | ASNS Entrez, Source | asparagine synthetase | 2424 | 0.106 | 0.0734 | No |
| 23 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 2588 | 0.100 | 0.0657 | No |
| 24 | UBD | UBD Entrez, Source | ubiquitin D | 3213 | 0.078 | 0.0223 | No |
| 25 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3378 | 0.074 | 0.0134 | No |
| 26 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 3459 | 0.072 | 0.0107 | No |
| 27 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 3574 | 0.069 | 0.0054 | No |
| 28 | FEZ2 | FEZ2 Entrez, Source | fasciculation and elongation protein zeta 2 (zygin II) | 3801 | 0.064 | -0.0087 | No |
| 29 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 3931 | 0.061 | -0.0155 | No |
| 30 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 4002 | 0.059 | -0.0180 | No |
| 31 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 4100 | 0.057 | -0.0226 | No |
| 32 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 4122 | 0.057 | -0.0216 | No |
| 33 | MOXD1 | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 4131 | 0.056 | -0.0195 | No |
| 34 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 4372 | 0.051 | -0.0352 | No |
| 35 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 4526 | 0.048 | -0.0445 | No |
| 36 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 4745 | 0.043 | -0.0590 | No |
| 37 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 4881 | 0.040 | -0.0673 | No |
| 38 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 4933 | 0.039 | -0.0693 | No |
| 39 | SPARCL1 | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 5171 | 0.035 | -0.0856 | No |
| 40 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 5282 | 0.032 | -0.0924 | No |
| 41 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 5294 | 0.032 | -0.0917 | No |
| 42 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 5362 | 0.031 | -0.0953 | No |
| 43 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 5577 | 0.026 | -0.1102 | No |
| 44 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 5609 | 0.025 | -0.1114 | No |
| 45 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 5666 | 0.024 | -0.1145 | No |
| 46 | RPN2 | RPN2 Entrez, Source | ribophorin II | 5801 | 0.022 | -0.1235 | No |
| 47 | CRELD2 | CRELD2 Entrez, Source | cysteine-rich with EGF-like domains 2 | 5826 | 0.022 | -0.1243 | No |
| 48 | RPN1 | RPN1 Entrez, Source | ribophorin I | 5839 | 0.021 | -0.1242 | No |
| 49 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 5843 | 0.021 | -0.1235 | No |
| 50 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 5893 | 0.020 | -0.1262 | No |
| 51 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 6416 | 0.009 | -0.1652 | No |
| 52 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 6436 | 0.009 | -0.1662 | No |
| 53 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 6727 | 0.004 | -0.1880 | No |
| 54 | DPP3 | DPP3 Entrez, Source | dipeptidyl-peptidase 3 | 6990 | -0.002 | -0.2077 | No |
| 55 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 7183 | -0.006 | -0.2219 | No |
| 56 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 7279 | -0.008 | -0.2287 | No |
| 57 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 7328 | -0.009 | -0.2319 | No |
| 58 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 7447 | -0.011 | -0.2403 | No |
| 59 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 7512 | -0.013 | -0.2445 | No |
| 60 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 7739 | -0.017 | -0.2608 | No |
| 61 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 8011 | -0.024 | -0.2802 | No |
| 62 | TMED3 | TMED3 Entrez, Source | transmembrane emp24 protein transport domain containing 3 | 8092 | -0.025 | -0.2850 | No |
| 63 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 8458 | -0.033 | -0.3110 | No |
| 64 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 8592 | -0.037 | -0.3193 | No |
| 65 | LUM | LUM Entrez, Source | lumican | 8618 | -0.037 | -0.3195 | No |
| 66 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 8946 | -0.045 | -0.3421 | No |
| 67 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 8974 | -0.045 | -0.3420 | No |
| 68 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 9265 | -0.053 | -0.3614 | No |
| 69 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 9279 | -0.054 | -0.3598 | No |
| 70 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 9289 | -0.054 | -0.3579 | No |
| 71 | SYMPK | SYMPK Entrez, Source | symplekin | 9466 | -0.059 | -0.3685 | No |
| 72 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 9563 | -0.061 | -0.3728 | No |
| 73 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 9902 | -0.072 | -0.3950 | No |
| 74 | FN1 | FN1 Entrez, Source | fibronectin 1 | 9917 | -0.072 | -0.3927 | No |
| 75 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 10024 | -0.075 | -0.3971 | No |
| 76 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 10083 | -0.078 | -0.3978 | No |
| 77 | PLOD3 | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 10940 | -0.109 | -0.4574 | No |
| 78 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 10972 | -0.110 | -0.4545 | No |
| 79 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 10987 | -0.111 | -0.4504 | No |
| 80 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 11009 | -0.112 | -0.4466 | No |
| 81 | WFDC2 | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 11128 | -0.118 | -0.4500 | No |
| 82 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 11168 | -0.120 | -0.4473 | No |
| 83 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 11298 | -0.126 | -0.4511 | No |
| 84 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11372 | -0.130 | -0.4505 | No |
| 85 | HEXB | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 11439 | -0.133 | -0.4492 | No |
| 86 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 11479 | -0.136 | -0.4457 | No |
| 87 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 11573 | -0.142 | -0.4460 | No |
| 88 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 12499 | -0.229 | -0.5051 | Yes |
| 89 | GGA2 | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 12571 | -0.239 | -0.4992 | Yes |
| 90 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 12678 | -0.260 | -0.4949 | Yes |
| 91 | PROM1 | PROM1 Entrez, Source | prominin 1 | 12722 | -0.269 | -0.4855 | Yes |
| 92 | RAB34 | RAB34 Entrez, Source | RAB34, member RAS oncogene family | 12771 | -0.279 | -0.4760 | Yes |
| 93 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 12800 | -0.286 | -0.4646 | Yes |
| 94 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 12818 | -0.293 | -0.4520 | Yes |
| 95 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 12864 | -0.308 | -0.4409 | Yes |
| 96 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12902 | -0.323 | -0.4285 | Yes |
| 97 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 12937 | -0.335 | -0.4152 | Yes |
| 98 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 12998 | -0.364 | -0.4026 | Yes |
| 99 | COL27A1 | COL27A1 Entrez, Source | collagen, type XXVII, alpha 1 | 13079 | -0.412 | -0.3892 | Yes |
| 100 | TPBG | TPBG Entrez, Source | trophoblast glycoprotein | 13155 | -0.487 | -0.3719 | Yes |
| 101 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13197 | -0.560 | -0.3485 | Yes |
| 102 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 13207 | -0.576 | -0.3221 | Yes |
| 103 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13208 | -0.576 | -0.2949 | Yes |
| 104 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 13213 | -0.582 | -0.2677 | Yes |
| 105 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 13219 | -0.601 | -0.2398 | Yes |
| 106 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13273 | -0.768 | -0.2076 | Yes |
| 107 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 13305 | -0.964 | -0.1644 | Yes |
| 108 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 13311 | -1.014 | -0.1169 | Yes |
| 109 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13327 | -1.146 | -0.0640 | Yes |
| 110 | PKIB | PKIB Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 13334 | -1.378 | 0.0006 | Yes |
