Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | BRCA1_OVEREXP_UP |
| Enrichment Score (ES) | -0.45555273 |
| Normalized Enrichment Score (NES) | -1.6974415 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.07726264 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ID4 | ID4 Entrez, Source | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 169 | 0.502 | 0.0175 | No |
| 2 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 356 | 0.360 | 0.0251 | No |
| 3 | CD9 | CD9 Entrez, Source | CD9 molecule | 512 | 0.295 | 0.0312 | No |
| 4 | SEPHS2 | SEPHS2 Entrez, Source | selenophosphate synthetase 2 | 836 | 0.216 | 0.0198 | No |
| 5 | ATP6V0A1 | ATP6V0A1 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a1 | 869 | 0.212 | 0.0302 | No |
| 6 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 874 | 0.211 | 0.0426 | No |
| 7 | PCBD1 | PCBD1 Entrez, Source | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) | 936 | 0.202 | 0.0501 | No |
| 8 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 938 | 0.201 | 0.0622 | No |
| 9 | ABCD3 | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 1076 | 0.184 | 0.0630 | No |
| 10 | IDH1 | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 1183 | 0.172 | 0.0654 | No |
| 11 | WWP1 | WWP1 Entrez, Source | WW domain containing E3 ubiquitin protein ligase 1 | 1206 | 0.170 | 0.0740 | No |
| 12 | ENPP2 | ENPP2 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) | 1416 | 0.156 | 0.0675 | No |
| 13 | NFYC | NFYC Entrez, Source | nuclear transcription factor Y, gamma | 1659 | 0.139 | 0.0576 | No |
| 14 | PPP1R1A | PPP1R1A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 1788 | 0.132 | 0.0559 | No |
| 15 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 1875 | 0.127 | 0.0571 | No |
| 16 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 2281 | 0.111 | 0.0332 | No |
| 17 | ZFP36L1 | ZFP36L1 Entrez, Source | zinc finger protein 36, C3H type-like 1 | 2292 | 0.111 | 0.0391 | No |
| 18 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 2738 | 0.094 | 0.0112 | No |
| 19 | NEU1 | NEU1 Entrez, Source | sialidase 1 (lysosomal sialidase) | 2830 | 0.090 | 0.0097 | No |
| 20 | RABGGTB | RABGGTB Entrez, Source | Rab geranylgeranyltransferase, beta subunit | 3002 | 0.085 | 0.0019 | No |
| 21 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3109 | 0.081 | -0.0012 | No |
| 22 | KDELR2 | KDELR2 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 3147 | 0.080 | 0.0008 | No |
| 23 | FGF9 | FGF9 Entrez, Source | fibroblast growth factor 9 (glia-activating factor) | 3279 | 0.077 | -0.0044 | No |
| 24 | TEGT | TEGT Entrez, Source | testis enhanced gene transcript (BAX inhibitor 1) | 3765 | 0.065 | -0.0372 | No |
| 25 | SDHC | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 3898 | 0.062 | -0.0434 | No |
| 26 | CREB1 | CREB1 Entrez, Source | cAMP responsive element binding protein 1 | 3915 | 0.062 | -0.0409 | No |
| 27 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 4419 | 0.050 | -0.0759 | No |
| 28 | TAF11 | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 4448 | 0.049 | -0.0751 | No |
| 29 | SSR1 | SSR1 Entrez, Source | signal sequence receptor, alpha (translocon-associated protein alpha) | 4574 | 0.047 | -0.0817 | No |
| 30 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 4819 | 0.041 | -0.0977 | No |
| 31 | ACTR1B | ACTR1B Entrez, Source | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | 5068 | 0.037 | -0.1142 | No |
| 32 | SUCLG1 | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 5260 | 0.033 | -0.1267 | No |
| 33 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 5317 | 0.032 | -0.1290 | No |
| 34 | NDUFS1 | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 5395 | 0.030 | -0.1330 | No |
| 35 | TSNAX | TSNAX Entrez, Source | translin-associated factor X | 5703 | 0.024 | -0.1548 | No |
| 36 | TRAM1 | TRAM1 Entrez, Source | translocation associated membrane protein 1 | 5707 | 0.024 | -0.1536 | No |
| 37 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 6042 | 0.017 | -0.1778 | No |
| 38 | VAMP3 | VAMP3 Entrez, Source | vesicle-associated membrane protein 3 (cellubrevin) | 6158 | 0.015 | -0.1856 | No |
| 39 | HMGN3 | HMGN3 Entrez, Source | high mobility group nucleosomal binding domain 3 | 6294 | 0.012 | -0.1951 | No |
| 40 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 6561 | 0.007 | -0.2148 | No |
| 41 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 6709 | 0.004 | -0.2257 | No |
| 42 | NID1 | NID1 Entrez, Source | nidogen 1 | 6775 | 0.003 | -0.2304 | No |
| 43 | TM9SF2 | TM9SF2 Entrez, Source | transmembrane 9 superfamily member 2 | 6813 | 0.002 | -0.2331 | No |
| 44 | GALNT3 | GALNT3 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | 6950 | -0.001 | -0.2433 | No |
| 45 | SFRS5 | SFRS5 Entrez, Source | splicing factor, arginine/serine-rich 5 | 7071 | -0.004 | -0.2522 | No |
| 46 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 7239 | -0.007 | -0.2644 | No |
| 47 | TITF1 | TITF1 Entrez, Source | thyroid transcription factor 1 | 7264 | -0.008 | -0.2657 | No |
| 48 | SEPP1 | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 7281 | -0.008 | -0.2664 | No |
| 49 | CSDA | CSDA Entrez, Source | cold shock domain protein A | 7299 | -0.008 | -0.2672 | No |
| 50 | TM9SF1 | TM9SF1 Entrez, Source | transmembrane 9 superfamily member 1 | 7468 | -0.012 | -0.2792 | No |
| 51 | TMED10 | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 7641 | -0.015 | -0.2913 | No |
| 52 | SCAMP1 | SCAMP1 Entrez, Source | secretory carrier membrane protein 1 | 7837 | -0.019 | -0.3049 | No |
| 53 | FCGRT | FCGRT Entrez, Source | Fc fragment of IgG, receptor, transporter, alpha | 8110 | -0.026 | -0.3239 | No |
| 54 | TSG101 | TSG101 Entrez, Source | tumor susceptibility gene 101 | 8160 | -0.027 | -0.3260 | No |
| 55 | COPS2 | COPS2 Entrez, Source | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 8185 | -0.027 | -0.3262 | No |
| 56 | PGRMC1 | PGRMC1 Entrez, Source | progesterone receptor membrane component 1 | 8187 | -0.027 | -0.3246 | No |
| 57 | TIMM17A | TIMM17A Entrez, Source | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 8212 | -0.028 | -0.3247 | No |
| 58 | ADCYAP1 | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 8517 | -0.035 | -0.3456 | No |
| 59 | GUCY1B3 | GUCY1B3 Entrez, Source | guanylate cyclase 1, soluble, beta 3 | 8595 | -0.037 | -0.3492 | No |
| 60 | LUM | LUM Entrez, Source | lumican | 8618 | -0.037 | -0.3486 | No |
| 61 | TMED2 | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 8660 | -0.038 | -0.3495 | No |
| 62 | PPP6C | PPP6C Entrez, Source | protein phosphatase 6, catalytic subunit | 8915 | -0.044 | -0.3660 | No |
| 63 | PPP4C | PPP4C Entrez, Source | protein phosphatase 4 (formerly X), catalytic subunit | 8977 | -0.045 | -0.3679 | No |
| 64 | HIST2H2AA3 | HIST2H2AA3 Entrez, Source | histone cluster 2, H2aa3 | 9131 | -0.050 | -0.3765 | No |
| 65 | SERINC3 | SERINC3 Entrez, Source | serine incorporator 3 | 9151 | -0.050 | -0.3749 | No |
| 66 | COPS8 | COPS8 Entrez, Source | COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) | 9327 | -0.055 | -0.3848 | No |
| 67 | RAB2 | RAB2 Entrez, Source | RAB2, member RAS oncogene family | 9370 | -0.056 | -0.3846 | No |
| 68 | EXOC5 | EXOC5 Entrez, Source | exocyst complex component 5 | 9426 | -0.058 | -0.3852 | No |
| 69 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 9441 | -0.058 | -0.3828 | No |
| 70 | AGPS | AGPS Entrez, Source | alkylglycerone phosphate synthase | 9442 | -0.058 | -0.3793 | No |
| 71 | DR1 | DR1 Entrez, Source | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 9489 | -0.059 | -0.3791 | No |
| 72 | RAB6A | RAB6A Entrez, Source | RAB6A, member RAS oncogene family | 9798 | -0.068 | -0.3983 | No |
| 73 | PRKAR1A | PRKAR1A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 9898 | -0.071 | -0.4015 | No |
| 74 | FSTL1 | FSTL1 Entrez, Source | follistatin-like 1 | 10104 | -0.078 | -0.4123 | No |
| 75 | ADD3 | ADD3 Entrez, Source | adducin 3 (gamma) | 10162 | -0.080 | -0.4117 | No |
| 76 | HTATIP | HTATIP Entrez, Source | HIV-1 Tat interacting protein, 60kDa | 10248 | -0.083 | -0.4132 | No |
| 77 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 10267 | -0.084 | -0.4095 | No |
| 78 | CXADR | CXADR Entrez, Source | coxsackie virus and adenovirus receptor | 10484 | -0.091 | -0.4203 | No |
| 79 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 10550 | -0.093 | -0.4196 | No |
| 80 | ANXA4 | ANXA4 Entrez, Source | annexin A4 | 11026 | -0.113 | -0.4487 | Yes |
| 81 | TUBB3 | TUBB3 Entrez, Source | tubulin, beta 3 | 11053 | -0.114 | -0.4438 | Yes |
| 82 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 11069 | -0.115 | -0.4380 | Yes |
| 83 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 11087 | -0.116 | -0.4323 | Yes |
| 84 | DDX3X | DDX3X Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | 11094 | -0.116 | -0.4257 | Yes |
| 85 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 11110 | -0.117 | -0.4198 | Yes |
| 86 | LTB4DH | LTB4DH Entrez, Source | leukotriene B4 12-hydroxydehydrogenase | 11276 | -0.125 | -0.4247 | Yes |
| 87 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 11298 | -0.126 | -0.4187 | Yes |
| 88 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 11301 | -0.126 | -0.4112 | Yes |
| 89 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 11315 | -0.127 | -0.4045 | Yes |
| 90 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11372 | -0.130 | -0.4009 | Yes |
| 91 | RDX | RDX Entrez, Source | radixin | 11397 | -0.131 | -0.3948 | Yes |
| 92 | CD47 | CD47 Entrez, Source | CD47 molecule | 11473 | -0.136 | -0.3923 | Yes |
| 93 | CALM2 | CALM2 Entrez, Source | calmodulin 2 (phosphorylase kinase, delta) | 11648 | -0.147 | -0.3966 | Yes |
| 94 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 11762 | -0.153 | -0.3959 | Yes |
| 95 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 11775 | -0.155 | -0.3875 | Yes |
| 96 | EXTL2 | EXTL2 Entrez, Source | exostoses (multiple)-like 2 | 11815 | -0.158 | -0.3809 | Yes |
| 97 | PICALM | PICALM Entrez, Source | phosphatidylinositol binding clathrin assembly protein | 11850 | -0.160 | -0.3738 | Yes |
| 98 | NPC2 | NPC2 Entrez, Source | Niemann-Pick disease, type C2 | 11880 | -0.163 | -0.3661 | Yes |
| 99 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 11889 | -0.164 | -0.3569 | Yes |
| 100 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 11891 | -0.164 | -0.3471 | Yes |
| 101 | DEK | DEK Entrez, Source | DEK oncogene (DNA binding) | 11962 | -0.170 | -0.3421 | Yes |
| 102 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 12070 | -0.179 | -0.3394 | Yes |
| 103 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.3350 | Yes |
| 104 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12216 | -0.193 | -0.3273 | Yes |
| 105 | WRB | WRB Entrez, Source | tryptophan rich basic protein | 12266 | -0.200 | -0.3189 | Yes |
| 106 | PLD3 | PLD3 Entrez, Source | phospholipase D family, member 3 | 12403 | -0.215 | -0.3162 | Yes |
| 107 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 12405 | -0.215 | -0.3033 | Yes |
| 108 | ITGB3BP | ITGB3BP Entrez, Source | integrin beta 3 binding protein (beta3-endonexin) | 12465 | -0.223 | -0.2943 | Yes |
| 109 | ALCAM | ALCAM Entrez, Source | activated leukocyte cell adhesion molecule | 12557 | -0.237 | -0.2869 | Yes |
| 110 | HMMR | HMMR Entrez, Source | hyaluronan-mediated motility receptor (RHAMM) | 12560 | -0.237 | -0.2728 | Yes |
| 111 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 12626 | -0.249 | -0.2626 | Yes |
| 112 | ADD1 | ADD1 Entrez, Source | adducin 1 (alpha) | 12900 | -0.322 | -0.2639 | Yes |
| 113 | CYBA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 12989 | -0.359 | -0.2489 | Yes |
| 114 | CIRBP | CIRBP Entrez, Source | cold inducible RNA binding protein | 13049 | -0.397 | -0.2294 | Yes |
| 115 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13055 | -0.401 | -0.2055 | Yes |
| 116 | PPIC | PPIC Entrez, Source | peptidylprolyl isomerase C (cyclophilin C) | 13206 | -0.575 | -0.1822 | Yes |
| 117 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13208 | -0.576 | -0.1475 | Yes |
| 118 | MAT2A | MAT2A Entrez, Source | methionine adenosyltransferase II, alpha | 13252 | -0.684 | -0.1094 | Yes |
| 119 | TCEAL1 | TCEAL1 Entrez, Source | transcription elongation factor A (SII)-like 1 | 13276 | -0.778 | -0.0642 | Yes |
| 120 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13327 | -1.146 | 0.0011 | Yes |
