Details for gene set CARBOXYLIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos
Phenotype	class.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in class	double_gel_8d
GeneSet	CARBOXYLIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.6789023
Normalized Enrichment Score (NES)	2.6026647
Nominal p-value	0.0
FDR q-value	0.0
FWER p-Value	0.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	9	1.171	0.0363	Yes
2	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	10	1.121	0.0718	Yes
3	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	16	0.933	0.1009	Yes
4	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	17	0.930	0.1303	Yes
5	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	35	0.815	0.1548	Yes
6	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	56	0.731	0.1763	Yes
7	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	60	0.721	0.1989	Yes
8	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	95	0.621	0.2160	Yes
9	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	98	0.617	0.2353	Yes
10	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	104	0.612	0.2543	Yes
11	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	108	0.606	0.2732	Yes
12	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	113	0.597	0.2917	Yes
13	ASL	ASL Entrez, Source	argininosuccinate lyase	122	0.586	0.3097	Yes
14	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	135	0.556	0.3263	Yes
15	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	177	0.496	0.3389	Yes
16	ACLY	ACLY Entrez, Source	ATP citrate lyase	186	0.487	0.3537	Yes
17	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	201	0.472	0.3676	Yes
18	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	212	0.461	0.3814	Yes
19	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	223	0.456	0.3950	Yes
20	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	231	0.450	0.4087	Yes
21	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	236	0.445	0.4225	Yes
22	ARG1	ARG1 Entrez, Source	arginase, liver	246	0.438	0.4357	Yes
23	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	247	0.438	0.4495	Yes
24	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	259	0.427	0.4622	Yes
25	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	260	0.427	0.4757	Yes
26	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	271	0.419	0.4882	Yes
27	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	277	0.416	0.5010	Yes
28	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	284	0.409	0.5134	Yes
29	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	291	0.403	0.5257	Yes
30	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	389	0.344	0.5293	Yes
31	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	392	0.341	0.5399	Yes
32	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	401	0.338	0.5500	Yes
33	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	403	0.337	0.5606	Yes
34	PAH	PAH Entrez, Source	phenylalanine hydroxylase	411	0.336	0.5706	Yes
35	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	501	0.299	0.5734	Yes
36	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	524	0.292	0.5809	Yes
37	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	537	0.288	0.5891	Yes
38	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	543	0.285	0.5978	Yes
39	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	580	0.273	0.6037	Yes
40	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	584	0.271	0.6120	Yes
41	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	623	0.260	0.6174	Yes
42	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	642	0.255	0.6241	Yes
43	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	656	0.251	0.6310	Yes
44	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	732	0.231	0.6327	Yes
45	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	750	0.228	0.6386	Yes
46	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	753	0.227	0.6456	Yes
47	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	870	0.211	0.6435	Yes
48	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	950	0.200	0.6438	Yes
49	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	1027	0.189	0.6441	Yes
50	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	1046	0.187	0.6486	Yes
51	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	1158	0.175	0.6458	Yes
52	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	1180	0.172	0.6496	Yes
53	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	1183	0.172	0.6549	Yes
54	SDS	SDS Entrez, Source	serine dehydratase	1222	0.169	0.6574	Yes
55	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	1252	0.167	0.6605	Yes
56	HDC	HDC Entrez, Source	histidine decarboxylase	1256	0.167	0.6655	Yes
57	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	1278	0.165	0.6691	Yes
58	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	1296	0.164	0.6731	Yes
59	SCLY	SCLY Entrez, Source	selenocysteine lyase	1345	0.161	0.6745	Yes
60	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	1355	0.160	0.6789	Yes
61	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	1535	0.147	0.6700	No
62	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	1598	0.143	0.6698	No
63	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	1617	0.142	0.6730	No
64	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	1680	0.138	0.6726	No
65	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	1747	0.134	0.6719	No
66	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	1770	0.133	0.6744	No
67	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	1785	0.132	0.6775	No
68	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	1864	0.128	0.6757	No
69	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	1920	0.125	0.6755	No
70	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	2183	0.115	0.6593	No
71	PTGES	PTGES Entrez, Source	prostaglandin E synthase	2249	0.113	0.6579	No
72	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	2294	0.111	0.6581	No
73	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	2352	0.108	0.6572	No
74	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	2527	0.102	0.6472	No
75	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	2832	0.090	0.6271	No
76	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	2968	0.086	0.6196	No
77	ARPP-19	ARPP-19 Entrez, Source	-	3013	0.084	0.6189	No
78	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	3082	0.082	0.6164	No
79	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	3114	0.081	0.6166	No
80	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	3231	0.078	0.6103	No
81	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	3429	0.073	0.5977	No
82	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	3436	0.073	0.5995	No
83	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	3545	0.070	0.5935	No
84	GSS	GSS Entrez, Source	glutathione synthetase	3596	0.069	0.5919	No
85	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	3691	0.067	0.5869	No
86	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	3774	0.065	0.5828	No
87	AMT	AMT Entrez, Source	aminomethyltransferase	3875	0.063	0.5772	No
88	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	4291	0.053	0.5474	No
89	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	4310	0.053	0.5477	No
90	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	4353	0.052	0.5462	No
91	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	4613	0.046	0.5280	No
92	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	4665	0.045	0.5256	No
93	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	4874	0.040	0.5111	No
94	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	5183	0.034	0.4889	No
95	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	5784	0.022	0.4442	No
96	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	6103	0.016	0.4206	No
97	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	6381	0.010	0.4000	No
98	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	6397	0.010	0.3991	No
99	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	6420	0.009	0.3978	No
100	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	6525	0.007	0.3901	No
101	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	7015	-0.002	0.3532	No
102	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	7234	-0.007	0.3369	No
103	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	7432	-0.011	0.3224	No
104	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	7451	-0.011	0.3214	No
105	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	7757	-0.018	0.2988	No
106	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	7996	-0.023	0.2816	No
107	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	8124	-0.026	0.2728	No
108	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	8177	-0.027	0.2697	No
109	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8334	-0.031	0.2589	No
110	SLC3A1	SLC3A1 Entrez, Source	1	8542	-0.036	0.2443	No
111	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	8548	-0.036	0.2451	No
112	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	8939	-0.045	0.2170	No
113	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	9206	-0.051	0.1984	No
114	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	9551	-0.061	0.1743	No
115	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	9642	-0.064	0.1695	No
116	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	10024	-0.075	0.1431	No
117	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	10142	-0.079	0.1367	No
118	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	10462	-0.090	0.1155	No
119	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	10638	-0.097	0.1053	No
120	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	10791	-0.102	0.0970	No
121	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	10907	-0.107	0.0917	No
122	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	10944	-0.109	0.0924	No
123	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	10959	-0.110	0.0948	No
124	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	11033	-0.113	0.0929	No
125	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	11523	-0.139	0.0602	No
126	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	12246	-0.198	0.0119	No
127	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	12469	-0.223	0.0021	No
128	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	12983	-0.354	-0.0255	No
129	SMS	SMS Entrez, Source	spermine synthase	13083	-0.414	-0.0199	No
130	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	13167	-0.505	-0.0102	No
131	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	13266	-0.741	0.0058	No