Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_single_gel_8d.class.cls
#double_gel_8d_versus_single_gel_8d_repos
Phenotypeclass.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in classdouble_gel_8d
GeneSetCELLULAR_LIPID_METABOLIC_PROCESS
Enrichment Score (ES)0.5120244
Normalized Enrichment Score (NES)2.022989
Nominal p-value0.0
FDR q-value0.0011995017
FWER p-Value0.095
Table: GSEA Results Summary



Fig 1: Enrichment plot: CELLULAR_LIPID_METABOLIC_PROCESS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GLYATGLYAT
Entrez,  Source
glycine-N-acyltransferase101.1210.0392Yes
2PEMTPEMT
Entrez,  Source
phosphatidylethanolamine N-methyltransferase260.8610.0687Yes
3ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain600.7210.0918Yes
4LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase760.6770.1148Yes
5FADS2FADS2
Entrez,  Source
fatty acid desaturase 2980.6170.1352Yes
6IDI1IDI1
Entrez,  Source
isopentenyl-diphosphate delta isomerase 11100.6030.1558Yes
7APOMAPOM
Entrez,  Source
apolipoprotein M1560.5270.1711Yes
8HACL1HACL1
Entrez,  Source
2-hydroxyacyl-CoA lyase 11770.4960.1873Yes
9NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 21870.4860.2039Yes
10ACOT12ACOT12
Entrez,  Source
acyl-CoA thioesterase 122120.4610.2185Yes
11LPLLPL
Entrez,  Source
lipoprotein lipase2300.4510.2333Yes
12ACOT2ACOT2
Entrez,  Source
acyl-CoA thioesterase 22310.4500.2493Yes
13ECHS1ECHS1
Entrez,  Source
enoyl Coenzyme A hydratase, short chain, 1, mitochondrial2600.4270.2624Yes
14DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase2820.4120.2755Yes
15SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like2840.4090.2900Yes
16HSD3B1HSD3B1
Entrez,  Source
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 12930.4020.3037Yes
17CHPT1CHPT1
Entrez,  Source
choline phosphotransferase 13020.3960.3172Yes
18FDPSFDPS
Entrez,  Source
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)3150.3860.3300Yes
19DHCR7DHCR7
Entrez,  Source
7-dehydrocholesterol reductase3330.3750.3421Yes
20SLC27A5SLC27A5
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 53920.3410.3498Yes
21FADS1FADS1
Entrez,  Source
fatty acid desaturase 14010.3380.3612Yes
22CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 24030.3370.3732Yes
23MVKMVK
Entrez,  Source
mevalonate kinase (mevalonic aciduria)4820.3090.3783Yes
24FAAHFAAH
Entrez,  Source
fatty acid amide hydrolase5010.2990.3876Yes
25ACADVLACADVL
Entrez,  Source
acyl-Coenzyme A dehydrogenase, very long chain5370.2880.3952Yes
26NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 45430.2850.4049Yes
27BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)5800.2730.4119Yes
28MLYCDMLYCD
Entrez,  Source
malonyl-CoA decarboxylase5840.2710.4214Yes
29NR1I2NR1I2
Entrez,  Source
nuclear receptor subfamily 1, group I, member 26130.2620.4286Yes
30SCP2SCP2
Entrez,  Source
sterol carrier protein 26240.2600.4371Yes
31PCYT2PCYT2
Entrez,  Source
phosphate cytidylyltransferase 2, ethanolamine6250.2600.4463Yes
32DGAT2DGAT2
Entrez,  Source
diacylglycerol O-acyltransferase homolog 2 (mouse)6270.2590.4555Yes
33AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)6560.2510.4623Yes
34PPARAPPARA
Entrez,  Source
peroxisome proliferative activated receptor, alpha7320.2310.4648Yes
35PEX7PEX7
Entrez,  Source
peroxisomal biogenesis factor 77380.2300.4727Yes
36APOA5APOA5
Entrez,  Source
apolipoprotein A-V8270.2170.4737Yes
37NSDHLNSDHL
Entrez,  Source
NAD(P) dependent steroid dehydrogenase-like8290.2160.4813Yes
38ALDH5A1ALDH5A1
Entrez,  Source
aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)8700.2110.4858Yes
39B4GALNT1B4GALNT1
Entrez,  Source
beta-1,4-N-acetyl-galactosaminyl transferase 19290.2020.4886Yes
40CPT1ACPT1A
Entrez,  Source
carnitine palmitoyltransferase 1A (liver)9500.2000.4942Yes
41APOA1APOA1
Entrez,  Source
apolipoprotein A-I10520.1870.4932Yes
42RARRES2RARRES2
Entrez,  Source
retinoic acid receptor responder (tazarotene induced) 210790.1840.4978Yes
43ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain11580.1750.4981Yes
44CLN8CLN8
Entrez,  Source
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)11780.1730.5029Yes
45HAO2HAO2
Entrez,  Source
hydroxyacid oxidase 2 (long chain)11800.1720.5089Yes
46CPT1BCPT1B
Entrez,  Source
carnitine palmitoyltransferase 1B (muscle)12780.1650.5075Yes
47ACADSACADS
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain12960.1640.5120Yes
48APOC3APOC3
Entrez,  Source
apolipoprotein C-III14780.1510.5037No
49BMP6BMP6
Entrez,  Source
bone morphogenetic protein 616530.1400.4955No
50PECIPECI
Entrez,  Source
peroxisomal D3,D2-enoyl-CoA isomerase16800.1380.4984No
51IHPK2IHPK2
Entrez,  Source
inositol hexaphosphate kinase 216980.1370.5020No
52STSSTS
Entrez,  Source
steroid sulfatase (microsomal), arylsulfatase C, isozyme S17430.1340.5034No
53HADHBHADHB
Entrez,  Source
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit17470.1340.5080No
54PPARGC1APPARGC1A
Entrez,  Source
peroxisome proliferative activated receptor, gamma, coactivator 1, alpha17700.1330.5111No
55DGAT1DGAT1
Entrez,  Source
diacylglycerol O-acyltransferase homolog 1 (mouse)18220.1300.5118No
56TNFRSF1ATNFRSF1A
Entrez,  Source
tumor necrosis factor receptor superfamily, member 1A19200.1250.5089No
57DHRS9DHRS9
Entrez,  Source
dehydrogenase/reductase (SDR family) member 919980.1220.5074No
58RDH11RDH11
Entrez,  Source
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)20180.1210.5103No
59PTGESPTGES
Entrez,  Source
prostaglandin E synthase22490.1130.4969No
60SCARB1SCARB1
Entrez,  Source
scavenger receptor class B, member 122520.1120.5007No
61ECH1ECH1
Entrez,  Source
enoyl Coenzyme A hydratase 1, peroxisomal22940.1110.5015No
62MIFMIF
Entrez,  Source
macrophage migration inhibitory factor (glycosylation-inhibiting factor)23520.1080.5011No
63CELCEL
Entrez,  Source
carboxyl ester lipase (bile salt-stimulated lipase)26780.0960.4799No
64SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 127310.0940.4793No
65HPGDHPGD
Entrez,  Source
hydroxyprostaglandin dehydrogenase 15-(NAD)28320.0900.4749No
66CYP19A1CYP19A1
Entrez,  Source
cytochrome P450, family 19, subfamily A, polypeptide 129090.0880.4723No
67PLA2G5PLA2G5
Entrez,  Source
phospholipase A2, group V29250.0870.4743No
68NEU3NEU3
Entrez,  Source
sialidase 3 (membrane sialidase)29370.0870.4765No
69PIGCPIGC
Entrez,  Source
phosphatidylinositol glycan anchor biosynthesis, class C30120.0840.4739No
70ADIPOR2ADIPOR2
Entrez,  Source
adiponectin receptor 231140.0810.4692No
71PIGKPIGK
Entrez,  Source
phosphatidylinositol glycan anchor biosynthesis, class K31420.0800.4700No
72PPARDPPARD
Entrez,  Source
peroxisome proliferative activated receptor, delta32310.0780.4661No
73PI4K2A33500.0750.4598No
74ST6GALNAC6ST6GALNAC6
Entrez,  Source
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 634210.0730.4571No
75PLA2G2DPLA2G2D
Entrez,  Source
phospholipase A2, group IID35840.0690.4472No
76PIK3R1PIK3R1
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)38760.0620.4274No
77AKR1B10AKR1B10
Entrez,  Source
aldo-keto reductase family 1, member B10 (aldose reductase)40970.0570.4128No
78ACOX3ACOX3
Entrez,  Source
acyl-Coenzyme A oxidase 3, pristanoyl42910.0530.4000No
79ACADMACADM
Entrez,  Source
acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain43100.0530.4005No
80ST8SIA5ST8SIA5
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 544400.0500.3925No
81PLA1APLA1A
Entrez,  Source
phospholipase A1 member A44690.0490.3921No
82IL4IL4
Entrez,  Source
interleukin 445500.0470.3878No
83NR0B1NR0B1
Entrez,  Source
nuclear receptor subfamily 0, group B, member 145570.0470.3890No
84ABCD2ABCD2
Entrez,  Source
ATP-binding cassette, sub-family D (ALD), member 246130.0460.3864No
85PLCB2PLCB2
Entrez,  Source
phospholipase C, beta 249240.0390.3644No
86HDLBPHDLBP
Entrez,  Source
high density lipoprotein binding protein (vigilin)50950.0360.3527No
87SHHSHH
Entrez,  Source
sonic hedgehog homolog (Drosophila)53820.0310.3321No
88TSPOTSPO
Entrez,  Source
translocator protein (18kDa)54750.0280.3262No
89PPAP2APPAP2A
Entrez,  Source
phosphatidic acid phosphatase type 2A57510.0230.3061No
90PTGDSPTGDS
Entrez,  Source
prostaglandin D2 synthase 21kDa (brain)57840.0220.3045No
91PTGS1PTGS1
Entrez,  Source
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)61030.0160.2810No
92HSD11B2HSD11B2
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 261110.0160.2810No
93PLA2G6PLA2G6
Entrez,  Source
phospholipase A2, group VI (cytosolic, calcium-independent)63860.0100.2606No
94CLN3CLN3
Entrez,  Source
ceroid-lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)66860.0040.2381No
95GPX4GPX4
Entrez,  Source
glutathione peroxidase 4 (phospholipid hydroperoxidase)67210.0040.2356No
96PRDX6PRDX6
Entrez,  Source
peroxiredoxin 668500.0010.2260No
97RETSATRETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)68800.0010.2238No
98PLAAPLAA
Entrez,  Source
phospholipase A2-activating protein6968-0.0010.2173No
99PIGSPIGS
Entrez,  Source
phosphatidylinositol glycan anchor biosynthesis, class S7220-0.0070.1985No
100ASAH2ASAH2
Entrez,  Source
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 27305-0.0080.1924No
101CYP7B1CYP7B1
Entrez,  Source
cytochrome P450, family 7, subfamily B, polypeptide 17432-0.0110.1832No
102ADIPOR1ADIPOR1
Entrez,  Source
adiponectin receptor 17451-0.0110.1823No
103SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7856-0.0200.1523No
104FDXRFDXR
Entrez,  Source
ferredoxin reductase7908-0.0210.1492No
105GNPATGNPAT
Entrez,  Source
glyceronephosphate O-acyltransferase7996-0.0230.1435No
106DPM2DPM2
Entrez,  Source
dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit8278-0.0290.1232No
107HSD3B7HSD3B7
Entrez,  Source
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 78334-0.0310.1201No
108ST8SIA1ST8SIA1
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 18578-0.0360.1030No
109PSAPPSAP
Entrez,  Source
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)8783-0.0400.0890No
110ST3GAL6ST3GAL6
Entrez,  Source
ST3 beta-galactoside alpha-2,3-sialyltransferase 68796-0.0410.0895No
111SMPD2SMPD2
Entrez,  Source
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)8946-0.0450.0798No
112IMPA1IMPA1
Entrez,  Source
inositol(myo)-1(or 4)-monophosphatase 19105-0.0490.0696No
113CNBPCNBP
Entrez,  Source
CCHC-type zinc finger, nucleic acid binding protein9302-0.0540.0566No
114PTENPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)9345-0.0560.0554No
115IHPK1IHPK1
Entrez,  Source
inositol hexaphosphate kinase 19424-0.0580.0516No
116AGPSAGPS
Entrez,  Source
alkylglycerone phosphate synthase9442-0.0580.0524No
117PLCD1PLCD1
Entrez,  Source
phospholipase C, delta 19490-0.0590.0509No
118PNLIPRP2PNLIPRP2
Entrez,  Source
pancreatic lipase-related protein 29686-0.0650.0385No
119STUB1STUB1
Entrez,  Source
STIP1 homology and U-box containing protein 19754-0.0670.0357No
120YWHAHYWHAH
Entrez,  Source
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide9794-0.0680.0352No
121SERINC1SERINC1
Entrez,  Source
serine incorporator 19801-0.0680.0372No
122PPT1PPT1
Entrez,  Source
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)9878-0.0710.0339No
123DEGS1DEGS1
Entrez,  Source
degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)10024-0.0750.0256No
124GBA2GBA2
Entrez,  Source
glucosidase, beta (bile acid) 210142-0.0790.0196No
125AGPAT1AGPAT1
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)10638-0.097-0.0145No
126MBTPS2MBTPS2
Entrez,  Source
membrane-bound transcription factor peptidase, site 210788-0.102-0.0222No
127SPTLC1SPTLC1
Entrez,  Source
serine palmitoyltransferase, long chain base subunit 110792-0.102-0.0188No
128B4GALT4B4GALT4
Entrez,  Source
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 410803-0.103-0.0159No
129LYPLA3LYPLA3
Entrez,  Source
lysophospholipase 3 (lysosomal phospholipase A2)10907-0.107-0.0199No
130CD81CD81
Entrez,  Source
CD81 molecule10933-0.108-0.0179No
131CD74CD74
Entrez,  Source
CD74 molecule, major histocompatibility complex, class II invariant chain10944-0.109-0.0148No
132PCYT1BPCYT1B
Entrez,  Source
phosphate cytidylyltransferase 1, choline, beta11101-0.117-0.0224No
133ST6GALNAC4ST6GALNAC4
Entrez,  Source
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 411266-0.125-0.0304No
134AGPAT6AGPAT6
Entrez,  Source
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)11302-0.127-0.0286No
135BRCA1BRCA1
Entrez,  Source
breast cancer 1, early onset11523-0.139-0.0403No
136PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha11601-0.144-0.0410No
137CYP11A1CYP11A1
Entrez,  Source
cytochrome P450, family 11, subfamily A, polypeptide 111705-0.150-0.0435No
138NPC2NPC2
Entrez,  Source
Niemann-Pick disease, type C211880-0.163-0.0509No
139PIGVPIGV
Entrez,  Source
phosphatidylinositol glycan anchor biosynthesis, class V11904-0.166-0.0468No
140ST8SIA3ST8SIA3
Entrez,  Source
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 311933-0.167-0.0429No
141LTA4HLTA4H
Entrez,  Source
leukotriene A4 hydrolase12246-0.198-0.0595No
142DHRS3DHRS3
Entrez,  Source
dehydrogenase/reductase (SDR family) member 312291-0.203-0.0556No
143SMPD3SMPD3
Entrez,  Source
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)12464-0.223-0.0607No
144CROTCROT
Entrez,  Source
carnitine O-octanoyltransferase12469-0.223-0.0531No
145ASAH1ASAH1
Entrez,  Source
N-acylsphingosine amidohydrolase (acid ceramidase) 112503-0.229-0.0474No
146SGPL1SGPL1
Entrez,  Source
sphingosine-1-phosphate lyase 112559-0.237-0.0431No
147PLCE1PLCE1
Entrez,  Source
phospholipase C, epsilon 112575-0.239-0.0358No
148SPHK1SPHK1
Entrez,  Source
sphingosine kinase 112700-0.264-0.0357No
149UGCGUGCG
Entrez,  Source
UDP-glucose ceramide glucosyltransferase12723-0.270-0.0278No
150ADMADM
Entrez,  Source
adrenomedullin12796-0.285-0.0231No
151SOAT1SOAT1
Entrez,  Source
sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 112979-0.351-0.0244No
152SERINC2SERINC2
Entrez,  Source
serine incorporator 213088-0.417-0.0178No
153ABCG1ABCG1
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 113094-0.421-0.0032No
154SERINC5SERINC5
Entrez,  Source
serine incorporator 513224-0.6150.0089No
Table: GSEA details [plain text format]



Fig 2: CELLULAR_LIPID_METABOLIC_PROCESS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CELLULAR_LIPID_METABOLIC_PROCESS: Random ES distribution   
Gene set null distribution of ES for CELLULAR_LIPID_METABOLIC_PROCESS