Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | CELL_CYCLE_KEGG |
| Enrichment Score (ES) | -0.71007574 |
| Normalized Enrichment Score (NES) | -2.2269127 |
| Nominal p-value | 0.0 |
| FDR q-value | 4.3094569E-4 |
| FWER p-Value | 0.0010 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2307 | 0.110 | -0.1604 | No |
| 2 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 3808 | 0.064 | -0.2657 | No |
| 3 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 4056 | 0.058 | -0.2773 | No |
| 4 | HDAC5 | HDAC5 Entrez, Source | histone deacetylase 5 | 4333 | 0.052 | -0.2919 | No |
| 5 | MAD2L2 | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 4562 | 0.047 | -0.3034 | No |
| 6 | CDC25A | CDC25A Entrez, Source | cell division cycle 25A | 4801 | 0.042 | -0.3164 | No |
| 7 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 5273 | 0.032 | -0.3480 | No |
| 8 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 5345 | 0.031 | -0.3496 | No |
| 9 | CDH1 | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 5558 | 0.026 | -0.3624 | No |
| 10 | HDAC3 | HDAC3 Entrez, Source | histone deacetylase 3 | 6040 | 0.017 | -0.3965 | No |
| 11 | ORC4L | ORC4L Entrez, Source | origin recognition complex, subunit 4-like (yeast) | 6443 | 0.009 | -0.4257 | No |
| 12 | CCNH | CCNH Entrez, Source | cyclin H | 7280 | -0.008 | -0.4876 | No |
| 13 | MPEG1 | MPEG1 Entrez, Source | - | 7644 | -0.015 | -0.5131 | No |
| 14 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 7859 | -0.020 | -0.5268 | No |
| 15 | DTX4 | DTX4 Entrez, Source | deltex 4 homolog (Drosophila) | 8671 | -0.038 | -0.5833 | No |
| 16 | ORC1L | ORC1L Entrez, Source | origin recognition complex, subunit 1-like (yeast) | 8707 | -0.039 | -0.5812 | No |
| 17 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 8782 | -0.040 | -0.5820 | No |
| 18 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9083 | -0.048 | -0.5988 | No |
| 19 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 10276 | -0.084 | -0.6785 | No |
| 20 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 10391 | -0.088 | -0.6766 | No |
| 21 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 10651 | -0.097 | -0.6846 | No |
| 22 | BUB3 | BUB3 Entrez, Source | BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) | 10991 | -0.111 | -0.6969 | Yes |
| 23 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 11099 | -0.117 | -0.6910 | Yes |
| 24 | CDC25B | CDC25B Entrez, Source | cell division cycle 25B | 11352 | -0.129 | -0.6947 | Yes |
| 25 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 11463 | -0.135 | -0.6869 | Yes |
| 26 | PTTG1 | PTTG1 Entrez, Source | pituitary tumor-transforming 1 | 11624 | -0.145 | -0.6817 | Yes |
| 27 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11673 | -0.148 | -0.6677 | Yes |
| 28 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.6512 | Yes |
| 29 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 11978 | -0.171 | -0.6524 | Yes |
| 30 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 12031 | -0.176 | -0.6354 | Yes |
| 31 | HDAC7A | HDAC7A Entrez, Source | histone deacetylase 7A | 12032 | -0.176 | -0.6145 | Yes |
| 32 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.6019 | Yes |
| 33 | ORC3L | ORC3L Entrez, Source | origin recognition complex, subunit 3-like (yeast) | 12302 | -0.205 | -0.5880 | Yes |
| 34 | HDAC6 | HDAC6 Entrez, Source | histone deacetylase 6 | 12329 | -0.208 | -0.5652 | Yes |
| 35 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 12496 | -0.228 | -0.5505 | Yes |
| 36 | ORC6L | ORC6L Entrez, Source | origin recognition complex, subunit 6 like (yeast) | 12525 | -0.232 | -0.5250 | Yes |
| 37 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 12630 | -0.250 | -0.5031 | Yes |
| 38 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12794 | -0.284 | -0.4816 | Yes |
| 39 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12821 | -0.294 | -0.4486 | Yes |
| 40 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 12897 | -0.319 | -0.4163 | Yes |
| 41 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12954 | -0.340 | -0.3801 | Yes |
| 42 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 12986 | -0.357 | -0.3400 | Yes |
| 43 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13016 | -0.374 | -0.2976 | Yes |
| 44 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 13028 | -0.381 | -0.2532 | Yes |
| 45 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 13047 | -0.395 | -0.2076 | Yes |
| 46 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 13099 | -0.425 | -0.1609 | Yes |
| 47 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13247 | -0.677 | -0.0915 | Yes |
| 48 | MCM6 | MCM6 Entrez, Source | MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) | 13289 | -0.828 | 0.0040 | Yes |
