Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.93885046 |
| Normalized Enrichment Score (NES) | 2.3676581 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 110 | 0.603 | 0.0902 | Yes |
| 2 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 126 | 0.572 | 0.1825 | Yes |
| 3 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 157 | 0.524 | 0.2658 | Yes |
| 4 | SQLE | SQLE Entrez, Source | squalene epoxidase | 188 | 0.485 | 0.3427 | Yes |
| 5 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 194 | 0.481 | 0.4209 | Yes |
| 6 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 199 | 0.477 | 0.4985 | Yes |
| 7 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 284 | 0.409 | 0.5589 | Yes |
| 8 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 315 | 0.386 | 0.6196 | Yes |
| 9 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 328 | 0.380 | 0.6807 | Yes |
| 10 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 333 | 0.375 | 0.7417 | Yes |
| 11 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 434 | 0.327 | 0.7877 | Yes |
| 12 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 452 | 0.319 | 0.8386 | Yes |
| 13 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 482 | 0.309 | 0.8868 | Yes |
| 14 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 617 | 0.261 | 0.9193 | Yes |
| 15 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 829 | 0.216 | 0.9389 | Yes |
