Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_single_gel_8d.class.cls
#double_gel_8d_versus_single_gel_8d_repos
Phenotypeclass.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in classsingle_gel_8d
GeneSetCYTOSKELETON
Enrichment Score (ES)-0.5522876
Normalized Enrichment Score (NES)-2.1529677
Nominal p-value0.0
FDR q-value7.560644E-4
FWER p-Value0.0060
Table: GSEA Results Summary



Fig 1: Enrichment plot: CYTOSKELETON   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)520.7480.0245No
2CORO1ACORO1A
Entrez,  Source
coronin, actin binding protein, 1A1360.5560.0393No
3ABRAABRA
Entrez,  Source
actin-binding Rho activating protein11900.172-0.0342No
4UXTUXT
Entrez,  Source
ubiquitously-expressed transcript12250.169-0.0304No
5TGM1TGM1
Entrez,  Source
transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)15890.144-0.0525No
6NARFNARF
Entrez,  Source
nuclear prelamin A recognition factor16050.143-0.0482No
7SPTBN4SPTBN4
Entrez,  Source
spectrin, beta, non-erythrocytic 416510.140-0.0463No
8STOML2STOML2
Entrez,  Source
stomatin (EPB72)-like 216520.140-0.0410No
9SNIPSNIP
Entrez,  Source
-17460.134-0.0429No
10TNNC1TNNC1
Entrez,  Source
troponin C type 1 (slow)17520.134-0.0382No
11MYL3MYL3
Entrez,  Source
myosin, light chain 3, alkali; ventricular, skeletal, slow18440.129-0.0402No
12CACNA1CCACNA1C
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1C subunit19560.124-0.0440No
13LRPPRCLRPPRC
Entrez,  Source
leucine-rich PPR-motif containing20300.121-0.0449No
14DMDDMD
Entrez,  Source
dystrophin (muscular dystrophy, Duchenne and Becker types)21460.116-0.0493No
15ABCA2ABCA2
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 227540.094-0.0918No
16HINT1HINT1
Entrez,  Source
histidine triad nucleotide binding protein 128350.090-0.0945No
17FLNBFLNB
Entrez,  Source
filamin B, beta (actin binding protein 278)33170.076-0.1281No
18DNALI1DNALI1
Entrez,  Source
dynein, axonemal, light intermediate chain 133300.075-0.1262No
19DYNLL2DYNLL2
Entrez,  Source
dynein, light chain, LC8-type 234510.072-0.1326No
20MYH6MYH6
Entrez,  Source
myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)36030.069-0.1414No
21DYNC1I1DYNC1I1
Entrez,  Source
dynein, cytoplasmic 1, intermediate chain 137080.066-0.1468No
22NUDT21NUDT21
Entrez,  Source
nudix (nucleoside diphosphate linked moiety X)-type motif 2139270.061-0.1610No
23ARHGDIBARHGDIB
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) beta40030.059-0.1645No
24DRD2DRD2
Entrez,  Source
dopamine receptor D240370.059-0.1648No
25DAG1DAG1
Entrez,  Source
dystroglycan 1 (dystrophin-associated glycoprotein 1)41710.056-0.1727No
26TNNI3TNNI3
Entrez,  Source
troponin I type 3 (cardiac)41960.055-0.1725No
27ARPC1AARPC1A
Entrez,  Source
actin related protein 2/3 complex, subunit 1A, 41kDa44190.050-0.1874No
28TNNT2TNNT2
Entrez,  Source
troponin T type 2 (cardiac)45720.047-0.1972No
29NF2NF2
Entrez,  Source
neurofibromin 2 (bilateral acoustic neuroma)46060.046-0.1979No
30MAPTMAPT
Entrez,  Source
microtubule-associated protein tau48120.042-0.2119No
31DCXDCX
Entrez,  Source
doublecortex; lissencephaly, X-linked (doublecortin)50040.038-0.2250No
32ACTR1BACTR1B
Entrez,  Source
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)50680.037-0.2284No
33APPBP2APPBP2
Entrez,  Source
amyloid beta precursor protein (cytoplasmic tail) binding protein 251410.035-0.2325No
34ACTN3ACTN3
Entrez,  Source
actinin, alpha 351590.035-0.2325No
35GABARAPL2GABARAPL2
Entrez,  Source
GABA(A) receptor-associated protein-like 253070.032-0.2425No
36CCNA1CCNA1
Entrez,  Source
cyclin A153450.031-0.2441No
37TSC1TSC1
Entrez,  Source
tuberous sclerosis 155060.028-0.2552No
38AVILAVIL
Entrez,  Source
advillin55170.027-0.2549No
39AKAP4AKAP4
Entrez,  Source
A kinase (PRKA) anchor protein 455290.027-0.2547No
40CDH1CDH1
Entrez,  Source
cadherin 1, type 1, E-cadherin (epithelial)55580.026-0.2558No
41EML2EML2
Entrez,  Source
echinoderm microtubule associated protein like 257140.023-0.2667No
42FSCN3FSCN3
Entrez,  Source
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)60450.017-0.2911No
43MYL2MYL2
Entrez,  Source
myosin, light chain 2, regulatory, cardiac, slow62930.012-0.3094No
44SLC4A1SLC4A1
Entrez,  Source
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)64790.008-0.3232No
45TOP2ATOP2A
Entrez,  Source
topoisomerase (DNA) II alpha 170kDa67090.004-0.3404No
46ATG4BATG4B
Entrez,  Source
ATG4 autophagy related 4 homolog B (S. cerevisiae)67860.003-0.3461No
47CETN3CETN3
Entrez,  Source
centrin, EF-hand protein, 3 (CDC31 homolog, yeast)68560.001-0.3513No
48TPT1TPT1
Entrez,  Source
tumor protein, translationally-controlled 16974-0.002-0.3601No
49MEFVMEFV
Entrez,  Source
Mediterranean fever7026-0.003-0.3639No
50ALS2ALS2
Entrez,  Source
amyotrophic lateral sclerosis 2 (juvenile)7100-0.004-0.3693No
51TRPC4TRPC4
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 47210-0.006-0.3773No
52WASF2WASF2
Entrez,  Source
WAS protein family, member 27261-0.008-0.3808No
53WASLWASL
Entrez,  Source
Wiskott-Aldrich syndrome-like7397-0.010-0.3907No
54UTRNUTRN
Entrez,  Source
utrophin (homologous to dystrophin)7645-0.015-0.4089No
55MAP1AMAP1A
Entrez,  Source
microtubule-associated protein 1A7727-0.017-0.4144No
56IVLIVL
Entrez,  Source
involucrin7745-0.018-0.4150No
57KATNA1KATNA1
Entrez,  Source
katanin p60 (ATPase-containing) subunit A 17746-0.018-0.4143No
58MYH7MYH7
Entrez,  Source
myosin, heavy chain 7, cardiac muscle, beta7898-0.021-0.4250No
59AMPHAMPH
Entrez,  Source
amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)8098-0.025-0.4391No
60STAU1STAU1
Entrez,  Source
staufen, RNA binding protein, homolog 1 (Drosophila)8162-0.027-0.4429No
61KIF1BKIF1B
Entrez,  Source
kinesin family member 1B8176-0.027-0.4429No
62NPM1NPM1
Entrez,  Source
nucleophosmin (nucleolar phosphoprotein B23, numatrin)8204-0.028-0.4439No
63SYNPOSYNPO
Entrez,  Source
synaptopodin8210-0.028-0.4432No
64KIF4AKIF4A
Entrez,  Source
kinesin family member 4A8274-0.029-0.4469No
65MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 18437-0.033-0.4579No
66ESPNESPN
Entrez,  Source
espin8501-0.034-0.4614No
67MYOM1MYOM1
Entrez,  Source
myomesin 1 (skelemin) 185kDa8685-0.039-0.4738No
68HAP1HAP1
Entrez,  Source
huntingtin-associated protein 1 (neuroan 1)8717-0.039-0.4747No
69MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 118842-0.042-0.4825No
70RAE1RAE1
Entrez,  Source
RAE1 RNA export 1 homolog (S. pombe)8844-0.042-0.4810No
71HIP1HIP1
Entrez,  Source
huntingtin interacting protein 19098-0.049-0.4984No
72TUBB2CTUBB2C
Entrez,  Source
tubulin, beta 2C9110-0.049-0.4974No
73GFAPGFAP
Entrez,  Source
glial fibrillary acidic protein9126-0.049-0.4966No
74STOMSTOM
Entrez,  Source
stomatin9313-0.055-0.5087No
75MARCKSMARCKS
Entrez,  Source
myristoylated alanine-rich protein kinase C substrate9387-0.057-0.5121No
76ACTL7BACTL7B
Entrez,  Source
actin-like 7B9475-0.059-0.5164No
77ARPC5ARPC5
Entrez,  Source
actin related protein 2/3 complex, subunit 5, 16kDa9496-0.060-0.5157No
78ZW10ZW10
Entrez,  Source
ZW10, kinetochore associated, homolog (Drosophila)9627-0.063-0.5231No
79CABP1CABP1
Entrez,  Source
calcium binding protein 1 (calbrain)9694-0.065-0.5257No
80ACTC1ACTC1
Entrez,  Source
actin, alpha, cardiac muscle 19699-0.065-0.5235No
81PTPN21PTPN21
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 219804-0.068-0.5288No
82TUBG1TUBG1
Entrez,  Source
tubulin, gamma 19827-0.069-0.5279No
83CAPZA2CAPZA2
Entrez,  Source
capping protein (actin filament) muscle Z-line, alpha 29837-0.069-0.5259No
84KALRNKALRN
Entrez,  Source
kalirin, RhoGEF kinase9923-0.072-0.5296No
85ARHGDIAARHGDIA
Entrez,  Source
Rho GDP dissociation inhibitor (GDI) alpha9931-0.073-0.5274No
86BRCA2BRCA2
Entrez,  Source
breast cancer 2, early onset10026-0.075-0.5317No
87MYO9BMYO9B
Entrez,  Source
myosin IXB10160-0.080-0.5387No
88ACTR2ACTR2
Entrez,  Source
ARP2 actin-related protein 2 homolog (yeast)10226-0.082-0.5405No
89PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10276-0.084-0.5411No
90SIRT2SIRT2
Entrez,  Source
sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)10295-0.085-0.5392No
91APCAPC
Entrez,  Source
adenomatosis polyposis coli10296-0.085-0.5360No
92DCTN2DCTN2
Entrez,  Source
dynactin 2 (p50)10303-0.085-0.5333No
93ARPC1BARPC1B
Entrez,  Source
actin related protein 2/3 complex, subunit 1B, 41kDa10374-0.087-0.5353No
94CTNNB1CTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa10376-0.087-0.5320No
95ACTBACTB
Entrez,  Source
actin, beta10590-0.095-0.5446No
96CETN1CETN1
Entrez,  Source
centrin, EF-hand protein, 110599-0.095-0.5416No
97KIF5AKIF5A
Entrez,  Source
kinesin family member 5A10741-0.100-0.5485Yes
98KATNB1KATNB1
Entrez,  Source
katanin p80 (WD repeat containing) subunit B 110749-0.101-0.5452Yes
99ABLIM2ABLIM2
Entrez,  Source
actin binding LIM protein family, member 210755-0.101-0.5417Yes
100CCT3CCT3
Entrez,  Source
chaperonin containing TCP1, subunit 3 (gamma)10769-0.102-0.5389Yes
101PAFAH1B1PAFAH1B1
Entrez,  Source
platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa10819-0.104-0.5386Yes
102LYSTLYST
Entrez,  Source
lysosomal trafficking regulator10864-0.105-0.5380Yes
103DDX20DDX20
Entrez,  Source
DEAD (Asp-Glu-Ala-Asp) box polypeptide 2010894-0.106-0.5361Yes
104CTTNCTTN
Entrez,  Source
cortactin10911-0.107-0.5333Yes
105SLC9A3R1SLC9A3R1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 110921-0.108-0.5299Yes
106CAPZBCAPZB
Entrez,  Source
capping protein (actin filament) muscle Z-line, beta10922-0.108-0.5258Yes
107BMFBMF
Entrez,  Source
Bcl2 modifying factor10943-0.109-0.5231Yes
108CDC20CDC20
Entrez,  Source
CDC20 cell division cycle 20 homolog (S. cerevisiae)11099-0.117-0.5305Yes
109ARHGEF2ARHGEF2
Entrez,  Source
rho/rac guanine nucleotide exchange factor (GEF) 211105-0.117-0.5264Yes
110BIRC5BIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)11117-0.118-0.5228Yes
111LSP1LSP1
Entrez,  Source
lymphocyte-specific protein 111156-0.119-0.5211Yes
112CDC42BPBCDC42BPB
Entrez,  Source
CDC42 binding protein kinase beta (DMPK-like)11232-0.123-0.5221Yes
113AKAP9AKAP9
Entrez,  Source
A kinase (PRKA) anchor protein (yotiao) 911273-0.125-0.5204Yes
114POLBPOLB
Entrez,  Source
polymerase (DNA directed), beta11294-0.126-0.5172Yes
115TBCETBCE
Entrez,  Source
tubulin-specific chaperone e11303-0.127-0.5130Yes
116DYNC1LI2DYNC1LI2
Entrez,  Source
dynein, cytoplasmic 1, light intermediate chain 211327-0.128-0.5099Yes
117LMNB1LMNB1
Entrez,  Source
lamin B111329-0.128-0.5051Yes
118DCTN1DCTN1
Entrez,  Source
dynactin 1 (p150, glued homolog, Drosophila)11343-0.128-0.5012Yes
119CASP8CASP8
Entrez,  Source
caspase 8, apoptosis-related cysteine peptidase11401-0.131-0.5005Yes
120CDC16CDC16
Entrez,  Source
CDC16 cell division cycle 16 homolog (S. cerevisiae)11467-0.135-0.5003Yes
121TUBGCP3TUBGCP3
Entrez,  Source
tubulin, gamma complex associated protein 311484-0.136-0.4964Yes
122TPM3TPM3
Entrez,  Source
tropomyosin 311497-0.137-0.4921Yes
123GAS8GAS8
Entrez,  Source
growth arrest-specific 811506-0.138-0.4875Yes
124SMTNSMTN
Entrez,  Source
smoothelin11525-0.139-0.4836Yes
125SEPT7SEPT7
Entrez,  Source
septin 711577-0.142-0.4820Yes
126ACTR3ACTR3
Entrez,  Source
ARP3 actin-related protein 3 homolog (yeast)11578-0.142-0.4766Yes
127NDE1NDE1
Entrez,  Source
nudE nuclear distribution gene E homolog 1 (A. nidulans)11603-0.144-0.4730Yes
128MYH10MYH10
Entrez,  Source
myosin, heavy chain 10, non-muscle11608-0.144-0.4678Yes
129SEPT9SEPT9
Entrez,  Source
septin 911618-0.145-0.4630Yes
130MYO1CMYO1C
Entrez,  Source
myosin IC11628-0.145-0.4582Yes
131CALD1CALD1
Entrez,  Source
caldesmon 111630-0.145-0.4527Yes
132CDC27CDC27
Entrez,  Source
cell division cycle 2711658-0.148-0.4492Yes
133NEDD9NEDD9
Entrez,  Source
neural precursor cell expressed, developmentally down-regulated 911695-0.149-0.4462Yes
134DYNLL1DYNLL1
Entrez,  Source
dynein, light chain, LC8-type 111702-0.150-0.4410Yes
135KIF5BKIF5B
Entrez,  Source
kinesin family member 5B11762-0.153-0.4397Yes
136PXNPXN
Entrez,  Source
paxillin11831-0.159-0.4388Yes
137PCM1PCM1
Entrez,  Source
pericentriolar material 111860-0.161-0.4348Yes
138KIF2CKIF2C
Entrez,  Source
kinesin family member 2C11889-0.164-0.4307Yes
139KIFC3KIFC3
Entrez,  Source
kinesin family member C311973-0.171-0.4305Yes
140CDK5RAP2CDK5RAP2
Entrez,  Source
CDK5 regulatory subunit associated protein 211990-0.172-0.4252Yes
141SMC3SMC3
Entrez,  Source
structural maintenance of chromosomes 312021-0.175-0.4209Yes
142WASF1WASF1
Entrez,  Source
WAS protein family, member 112111-0.182-0.4207Yes
143TSGA14TSGA14
Entrez,  Source
testis specific, 1412175-0.189-0.4183Yes
144MAPRE1MAPRE1
Entrez,  Source
microtubule-associated protein, RP/EB family, member 112234-0.197-0.4152Yes
145SORBS2SORBS2
Entrez,  Source
sorbin and SH3 domain containing 212297-0.204-0.4121Yes
146GSNGSN
Entrez,  Source
gelsolin (amyloidosis, Finnish type)12307-0.205-0.4050Yes
147HDAC6HDAC6
Entrez,  Source
histone deacetylase 612329-0.208-0.3987Yes
148CLIC5CLIC5
Entrez,  Source
chloride intracellular channel 512338-0.209-0.3914Yes
149LASP1LASP1
Entrez,  Source
LIM and SH3 protein 112412-0.216-0.3887Yes
150PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 212413-0.216-0.3805Yes
151BIN1BIN1
Entrez,  Source
bridging integrator 112429-0.219-0.3733Yes
152MID1MID1
Entrez,  Source
midline 1 (Opitz/BBB syndrome)12463-0.223-0.3674Yes
153KIF3CKIF3C
Entrez,  Source
kinesin family member 3C12481-0.225-0.3601Yes
154DCTN4DCTN4
Entrez,  Source
dynactin 4 (p62)12513-0.230-0.3537Yes
155NUMA1NUMA1
Entrez,  Source
nuclear mitotic apparatus protein 112531-0.233-0.3462Yes
156CLASP2CLASP2
Entrez,  Source
cytoplasmic linker associated protein 212533-0.233-0.3374Yes
157AURKAAURKA
Entrez,  Source
aurora kinase A12548-0.235-0.3295Yes
158TPM4TPM4
Entrez,  Source
tropomyosin 412551-0.235-0.3207Yes
159MYH9MYH9
Entrez,  Source
myosin, heavy chain 9, non-muscle12585-0.241-0.3141Yes
160DSPDSP
Entrez,  Source
desmoplakin12592-0.244-0.3053Yes
161BASP1BASP1
Entrez,  Source
brain abundant, membrane attached signal protein 112594-0.244-0.2961Yes
162CKAP5CKAP5
Entrez,  Source
cytoskeleton associated protein 512613-0.247-0.2881Yes
163CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)12614-0.247-0.2787Yes
164CLIC4CLIC4
Entrez,  Source
chloride intracellular channel 412732-0.272-0.2772Yes
165HSPB1HSPB1
Entrez,  Source
heat shock 27kDa protein 112892-0.318-0.2772Yes
166CLASP1CLASP1
Entrez,  Source
cytoplasmic linker associated protein 112909-0.326-0.2661Yes
167MAP1BMAP1B
Entrez,  Source
microtubule-associated protein 1B12944-0.337-0.2559Yes
168CCNB2CCNB2
Entrez,  Source
cyclin B212954-0.340-0.2436Yes
169TUBBTUBB
Entrez,  Source
tubulin, beta12961-0.344-0.2310Yes
170TPM1TPM1
Entrez,  Source
tropomyosin 1 (alpha)12998-0.364-0.2199Yes
171CAPGCAPG
Entrez,  Source
capping protein (actin filament), gelsolin-like13018-0.375-0.2071Yes
172CEP57CEP57
Entrez,  Source
centrosomal protein 57kDa13119-0.442-0.1979Yes
173VIMVIM
Entrez,  Source
vimentin13164-0.501-0.1822Yes
174PDLIM5PDLIM5
Entrez,  Source
PDZ and LIM domain 513173-0.513-0.1633Yes
175MSNMSN
Entrez,  Source
moesin13302-0.941-0.1372Yes
176NEFLNEFL
Entrez,  Source
neurofilament, light polypeptide 68kDa13304-0.959-0.1009Yes
177ANXA1ANXA1
Entrez,  Source
annexin A113327-1.146-0.0590Yes
178ACTA1ACTA1
Entrez,  Source
actin, alpha 1, skeletal muscle13340-1.5810.0002Yes
Table: GSEA details [plain text format]



Fig 2: CYTOSKELETON   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CYTOSKELETON: Random ES distribution   
Gene set null distribution of ES for CYTOSKELETON