Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS |
| Enrichment Score (ES) | -0.485641 |
| Normalized Enrichment Score (NES) | -1.8106822 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.045084037 |
| FWER p-Value | 0.885 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SNAP29 | SNAP29 Entrez, Source | synaptosomal-associated protein, 29kDa | 264 | 0.423 | 0.0040 | No |
| 2 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 309 | 0.392 | 0.0230 | No |
| 3 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 407 | 0.337 | 0.0347 | No |
| 4 | CCL3 | CCL3 Entrez, Source | chemokine (C-C motif) ligand 3 | 447 | 0.321 | 0.0500 | No |
| 5 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 825 | 0.217 | 0.0339 | No |
| 6 | UXT | UXT Entrez, Source | ubiquitously-expressed transcript | 1225 | 0.169 | 0.0133 | No |
| 7 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 1326 | 0.162 | 0.0149 | No |
| 8 | SPTBN4 | SPTBN4 Entrez, Source | spectrin, beta, non-erythrocytic 4 | 1651 | 0.140 | -0.0016 | No |
| 9 | LRPPRC | LRPPRC Entrez, Source | leucine-rich PPR-motif containing | 2030 | 0.121 | -0.0234 | No |
| 10 | TESK2 | TESK2 Entrez, Source | testis-specific kinase 2 | 2143 | 0.116 | -0.0253 | No |
| 11 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 2146 | 0.116 | -0.0188 | No |
| 12 | APBA1 | APBA1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) | 2378 | 0.108 | -0.0302 | No |
| 13 | NUBP1 | NUBP1 Entrez, Source | nucleotide binding protein 1 (MinD homolog, E. coli) | 2842 | 0.090 | -0.0601 | No |
| 14 | LIMK1 | LIMK1 Entrez, Source | LIM domain kinase 1 | 3076 | 0.083 | -0.0730 | No |
| 15 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3109 | 0.081 | -0.0708 | No |
| 16 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 3317 | 0.076 | -0.0822 | No |
| 17 | GHSR | GHSR Entrez, Source | growth hormone secretagogue receptor | 3367 | 0.074 | -0.0817 | No |
| 18 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 3512 | 0.071 | -0.0885 | No |
| 19 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 3603 | 0.069 | -0.0914 | No |
| 20 | DYNC1I1 | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 3708 | 0.066 | -0.0956 | No |
| 21 | KPNA2 | KPNA2 Entrez, Source | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 3717 | 0.066 | -0.0924 | No |
| 22 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 3860 | 0.063 | -0.0996 | No |
| 23 | SCIN | SCIN Entrez, Source | scinderin | 3942 | 0.061 | -0.1022 | No |
| 24 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 4003 | 0.059 | -0.1034 | No |
| 25 | NLGN1 | NLGN1 Entrez, Source | neuroligin 1 | 4064 | 0.058 | -0.1046 | No |
| 26 | ARHGAP4 | ARHGAP4 Entrez, Source | Rho GTPase activating protein 4 | 4241 | 0.054 | -0.1149 | No |
| 27 | TTN | TTN Entrez, Source | titin | 4401 | 0.050 | -0.1240 | No |
| 28 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 4419 | 0.050 | -0.1225 | No |
| 29 | HOOK3 | HOOK3 Entrez, Source | hook homolog 3 (Drosophila) | 4489 | 0.049 | -0.1249 | No |
| 30 | TNNT2 | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 4572 | 0.047 | -0.1285 | No |
| 31 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 4606 | 0.046 | -0.1283 | No |
| 32 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 4812 | 0.042 | -0.1415 | No |
| 33 | YKT6 | YKT6 Entrez, Source | YKT6 v-SNARE homolog (S. cerevisiae) | 4981 | 0.038 | -0.1520 | No |
| 34 | OPA1 | OPA1 Entrez, Source | optic atrophy 1 (autosomal dominant) | 5005 | 0.038 | -0.1516 | No |
| 35 | CENPJ | CENPJ Entrez, Source | centromere protein J | 5047 | 0.037 | -0.1526 | No |
| 36 | APOE | APOE Entrez, Source | apolipoprotein E | 5056 | 0.037 | -0.1511 | No |
| 37 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 5315 | 0.032 | -0.1688 | No |
| 38 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5460 | 0.029 | -0.1781 | No |
| 39 | TSC1 | TSC1 Entrez, Source | tuberous sclerosis 1 | 5506 | 0.028 | -0.1799 | No |
| 40 | PLA2G1B | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 6057 | 0.017 | -0.2205 | No |
| 41 | ANK3 | ANK3 Entrez, Source | ankyrin 3, node of Ranvier (ankyrin G) | 6084 | 0.017 | -0.2216 | No |
| 42 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 6436 | 0.009 | -0.2476 | No |
| 43 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 6561 | 0.007 | -0.2566 | No |
| 44 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 6928 | -0.000 | -0.2842 | No |
| 45 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 6944 | -0.001 | -0.2853 | No |
| 46 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 7115 | -0.004 | -0.2980 | No |
| 47 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 7224 | -0.007 | -0.3057 | No |
| 48 | TAOK2 | TAOK2 Entrez, Source | TAO kinase 2 | 7244 | -0.007 | -0.3068 | No |
| 49 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 7261 | -0.008 | -0.3075 | No |
| 50 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 7397 | -0.010 | -0.3172 | No |
| 51 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7461 | -0.012 | -0.3213 | No |
| 52 | THY1 | THY1 Entrez, Source | Thy-1 cell surface antigen | 7638 | -0.015 | -0.3337 | No |
| 53 | TMED10 | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 7641 | -0.015 | -0.3330 | No |
| 54 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 7664 | -0.016 | -0.3338 | No |
| 55 | DNAJB6 | DNAJB6 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 6 | 7823 | -0.019 | -0.3446 | No |
| 56 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7856 | -0.020 | -0.3459 | No |
| 57 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 7898 | -0.021 | -0.3478 | No |
| 58 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 8008 | -0.024 | -0.3547 | No |
| 59 | KIF1B | KIF1B Entrez, Source | kinesin family member 1B | 8176 | -0.027 | -0.3658 | No |
| 60 | STX5 | STX5 Entrez, Source | syntaxin 5 | 8264 | -0.029 | -0.3708 | No |
| 61 | KIF4A | KIF4A Entrez, Source | kinesin family member 4A | 8274 | -0.029 | -0.3698 | No |
| 62 | MARK1 | MARK1 Entrez, Source | MAP/microtubule affinity-regulating kinase 1 | 8437 | -0.033 | -0.3802 | No |
| 63 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 8458 | -0.033 | -0.3798 | No |
| 64 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 8499 | -0.034 | -0.3809 | No |
| 65 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 8634 | -0.037 | -0.3889 | No |
| 66 | GHRL | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 8739 | -0.040 | -0.3945 | No |
| 67 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 8842 | -0.042 | -0.3998 | No |
| 68 | DES | DES Entrez, Source | desmin | 8928 | -0.044 | -0.4037 | No |
| 69 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 8997 | -0.046 | -0.4063 | No |
| 70 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 9002 | -0.046 | -0.4040 | No |
| 71 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9176 | -0.051 | -0.4142 | No |
| 72 | SEPT5 | SEPT5 Entrez, Source | septin 5 | 9433 | -0.058 | -0.4303 | No |
| 73 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 9496 | -0.060 | -0.4316 | No |
| 74 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 9534 | -0.061 | -0.4309 | No |
| 75 | MAST1 | MAST1 Entrez, Source | microtubule associated serine/threonine kinase 1 | 9577 | -0.062 | -0.4306 | No |
| 76 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 9827 | -0.069 | -0.4455 | No |
| 77 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9885 | -0.071 | -0.4457 | No |
| 78 | PACSIN2 | PACSIN2 Entrez, Source | protein kinase C and casein kinase substrate in neurons 2 | 10159 | -0.080 | -0.4618 | No |
| 79 | MYO9B | MYO9B Entrez, Source | myosin IXB | 10160 | -0.080 | -0.4573 | No |
| 80 | APC | APC Entrez, Source | adenomatosis polyposis coli | 10296 | -0.085 | -0.4627 | No |
| 81 | RHOT2 | RHOT2 Entrez, Source | ras homolog gene family, member T2 | 10381 | -0.088 | -0.4641 | No |
| 82 | CDC42EP2 | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 10646 | -0.097 | -0.4785 | No |
| 83 | KIF5A | KIF5A Entrez, Source | kinesin family member 5A | 10741 | -0.100 | -0.4800 | Yes |
| 84 | KATNB1 | KATNB1 Entrez, Source | katanin p80 (WD repeat containing) subunit B 1 | 10749 | -0.101 | -0.4748 | Yes |
| 85 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 10778 | -0.102 | -0.4711 | Yes |
| 86 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10819 | -0.104 | -0.4682 | Yes |
| 87 | PCLO | PCLO Entrez, Source | piccolo (presynaptic cytomatrix protein) | 10844 | -0.105 | -0.4641 | Yes |
| 88 | PLD2 | PLD2 Entrez, Source | phospholipase D2 | 11071 | -0.115 | -0.4746 | Yes |
| 89 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 11105 | -0.117 | -0.4705 | Yes |
| 90 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 11123 | -0.118 | -0.4651 | Yes |
| 91 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11190 | -0.121 | -0.4632 | Yes |
| 92 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 11232 | -0.123 | -0.4593 | Yes |
| 93 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 11321 | -0.127 | -0.4587 | Yes |
| 94 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 11608 | -0.144 | -0.4722 | Yes |
| 95 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 11702 | -0.150 | -0.4707 | Yes |
| 96 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 11762 | -0.153 | -0.4665 | Yes |
| 97 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 11889 | -0.164 | -0.4667 | Yes |
| 98 | NUAK2 | NUAK2 Entrez, Source | NUAK family, SNF1-like kinase, 2 | 11901 | -0.166 | -0.4581 | Yes |
| 99 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12021 | -0.175 | -0.4572 | Yes |
| 100 | PSCD2 | PSCD2 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) | 12104 | -0.182 | -0.4531 | Yes |
| 101 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 12106 | -0.182 | -0.4428 | Yes |
| 102 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 12111 | -0.182 | -0.4327 | Yes |
| 103 | MYO1E | MYO1E Entrez, Source | myosin IE | 12127 | -0.184 | -0.4234 | Yes |
| 104 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 12234 | -0.197 | -0.4202 | Yes |
| 105 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12275 | -0.202 | -0.4118 | Yes |
| 106 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12307 | -0.205 | -0.4025 | Yes |
| 107 | LASP1 | LASP1 Entrez, Source | LIM and SH3 protein 1 | 12412 | -0.216 | -0.3981 | Yes |
| 108 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 12463 | -0.223 | -0.3892 | Yes |
| 109 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12500 | -0.229 | -0.3789 | Yes |
| 110 | CLASP2 | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 12533 | -0.233 | -0.3681 | Yes |
| 111 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12585 | -0.241 | -0.3583 | Yes |
| 112 | KIF1A | KIF1A Entrez, Source | kinesin family member 1A | 12598 | -0.244 | -0.3453 | Yes |
| 113 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 12613 | -0.247 | -0.3323 | Yes |
| 114 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 12909 | -0.326 | -0.3361 | Yes |
| 115 | KRT20 | KRT20 Entrez, Source | keratin 20 | 13006 | -0.369 | -0.3224 | Yes |
| 116 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 13018 | -0.375 | -0.3019 | Yes |
| 117 | NEXN | NEXN Entrez, Source | nexilin (F actin binding protein) | 13033 | -0.382 | -0.2813 | Yes |
| 118 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 13288 | -0.823 | -0.2537 | Yes |
| 119 | ABI2 | ABI2 Entrez, Source | abl interactor 2 | 13301 | -0.939 | -0.2013 | Yes |
| 120 | NEFL | NEFL Entrez, Source | neurofilament, light polypeptide 68kDa | 13304 | -0.959 | -0.1470 | Yes |
| 121 | DBN1 | DBN1 Entrez, Source | drebrin 1 | 13319 | -1.054 | -0.0882 | Yes |
| 122 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.581 | 0.0002 | Yes |
