Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | FSH_GRANULOSA_DN |
| Enrichment Score (ES) | -0.58334494 |
| Normalized Enrichment Score (NES) | -1.7813717 |
| Nominal p-value | 0.0035906644 |
| FDR q-value | 0.053130466 |
| FWER p-Value | 0.956 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RGS5 | RGS5 Entrez, Source | regulator of G-protein signalling 5 | 59 | 0.722 | 0.0776 | No |
| 2 | PLCL1 | PLCL1 Entrez, Source | phospholipase C-like 1 | 542 | 0.286 | 0.0738 | No |
| 3 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 1058 | 0.187 | 0.0563 | No |
| 4 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 1700 | 0.137 | 0.0237 | No |
| 5 | PRKD1 | PRKD1 Entrez, Source | protein kinase D1 | 2943 | 0.087 | -0.0598 | No |
| 6 | MAPK14 | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 2979 | 0.086 | -0.0527 | No |
| 7 | CASP4 | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 3096 | 0.082 | -0.0521 | No |
| 8 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 3577 | 0.069 | -0.0804 | No |
| 9 | MAP2K3 | MAP2K3 Entrez, Source | mitogen-activated protein kinase kinase 3 | 3755 | 0.065 | -0.0863 | No |
| 10 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 3998 | 0.059 | -0.0977 | No |
| 11 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 4433 | 0.050 | -0.1247 | No |
| 12 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 4819 | 0.041 | -0.1489 | No |
| 13 | AKAP12 | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 5084 | 0.036 | -0.1647 | No |
| 14 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 5577 | 0.026 | -0.1987 | No |
| 15 | RANGAP1 | RANGAP1 Entrez, Source | Ran GTPase activating protein 1 | 6082 | 0.017 | -0.2347 | No |
| 16 | MAPK6 | MAPK6 Entrez, Source | mitogen-activated protein kinase 6 | 7114 | -0.004 | -0.3117 | No |
| 17 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 7355 | -0.009 | -0.3287 | No |
| 18 | TRIB1 | TRIB1 Entrez, Source | tribbles homolog 1 (Drosophila) | 8789 | -0.041 | -0.4318 | No |
| 19 | PTPRE | PTPRE Entrez, Source | protein tyrosine phosphatase, receptor type, E | 9160 | -0.050 | -0.4539 | No |
| 20 | ATP2A2 | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 9620 | -0.063 | -0.4812 | No |
| 21 | BECN1 | BECN1 Entrez, Source | beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) | 10058 | -0.076 | -0.5054 | No |
| 22 | TYRO3 | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 10473 | -0.091 | -0.5262 | No |
| 23 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 11110 | -0.117 | -0.5607 | No |
| 24 | TLN1 | TLN1 Entrez, Source | talin 1 | 11127 | -0.118 | -0.5485 | No |
| 25 | SMARCA4 | SMARCA4 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 11592 | -0.143 | -0.5671 | Yes |
| 26 | PAWR | PAWR Entrez, Source | PRKC, apoptosis, WT1, regulator | 11680 | -0.149 | -0.5568 | Yes |
| 27 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.5405 | Yes |
| 28 | ACTG2 | ACTG2 Entrez, Source | actin, gamma 2, smooth muscle, enteric | 11806 | -0.157 | -0.5313 | Yes |
| 29 | NPC2 | NPC2 Entrez, Source | Niemann-Pick disease, type C2 | 11880 | -0.163 | -0.5182 | Yes |
| 30 | PPP3R1 | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 12092 | -0.181 | -0.5135 | Yes |
| 31 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12216 | -0.193 | -0.5008 | Yes |
| 32 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 12291 | -0.203 | -0.4832 | Yes |
| 33 | ARL6IP5 | ARL6IP5 Entrez, Source | ADP-ribosylation-like factor 6 interacting protein 5 | 12296 | -0.204 | -0.4604 | Yes |
| 34 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 12316 | -0.206 | -0.4384 | Yes |
| 35 | KIDINS220 | KIDINS220 Entrez, Source | - | 12487 | -0.226 | -0.4255 | Yes |
| 36 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 12725 | -0.270 | -0.4126 | Yes |
| 37 | DYRK3 | DYRK3 Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 13146 | -0.472 | -0.3905 | Yes |
| 38 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 13219 | -0.601 | -0.3277 | Yes |
| 39 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13226 | -0.619 | -0.2578 | Yes |
| 40 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13271 | -0.763 | -0.1744 | Yes |
| 41 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.581 | 0.0002 | Yes |
