Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | GLUCONEOGENESIS |
| Enrichment Score (ES) | 0.543118 |
| Normalized Enrichment Score (NES) | 1.7525138 |
| Nominal p-value | 0.006198347 |
| FDR q-value | 0.020871874 |
| FWER p-Value | 0.978 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | G6PC | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 21 | 0.893 | 0.1022 | Yes |
| 2 | ADH7 | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 50 | 0.751 | 0.1874 | Yes |
| 3 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 66 | 0.702 | 0.2680 | Yes |
| 4 | ADHFE1 | ADHFE1 Entrez, Source | alcohol dehydrogenase, iron containing, 1 | 89 | 0.633 | 0.3399 | Yes |
| 5 | PKLR | PKLR Entrez, Source | pyruvate kinase, liver and RBC | 184 | 0.487 | 0.3896 | Yes |
| 6 | ADH1A | ADH1A Entrez, Source | alcohol dehydrogenase 1A (class I), alpha polypeptide | 214 | 0.460 | 0.4409 | Yes |
| 7 | GCK | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 259 | 0.427 | 0.4873 | Yes |
| 8 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 663 | 0.250 | 0.4860 | Yes |
| 9 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 666 | 0.249 | 0.5148 | Yes |
| 10 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 858 | 0.213 | 0.5251 | Yes |
| 11 | ALDOC | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 1047 | 0.187 | 0.5328 | Yes |
| 12 | PGM1 | PGM1 Entrez, Source | phosphoglucomutase 1 | 1344 | 0.161 | 0.5292 | Yes |
| 13 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 1403 | 0.157 | 0.5431 | Yes |
| 14 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 1628 | 0.141 | 0.5427 | No |
| 15 | LDHA | LDHA Entrez, Source | lactate dehydrogenase A | 2134 | 0.117 | 0.5183 | No |
| 16 | ADH6 | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 2402 | 0.107 | 0.5106 | No |
| 17 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 2627 | 0.098 | 0.5052 | No |
| 18 | FBP2 | FBP2 Entrez, Source | fructose-1,6-bisphosphatase 2 | 2767 | 0.093 | 0.5056 | No |
| 19 | TPI1 | TPI1 Entrez, Source | triosephosphate isomerase 1 | 3163 | 0.080 | 0.4851 | No |
| 20 | PGK1 | PGK1 Entrez, Source | phosphoglycerate kinase 1 | 3566 | 0.069 | 0.4629 | No |
| 21 | LDHC | LDHC Entrez, Source | lactate dehydrogenase C | 3707 | 0.066 | 0.4601 | No |
| 22 | GPI | GPI Entrez, Source | glucose phosphate isomerase | 3857 | 0.063 | 0.4562 | No |
| 23 | PFKP | PFKP Entrez, Source | phosphofructokinase, platelet | 4054 | 0.058 | 0.4483 | No |
| 24 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 4305 | 0.053 | 0.4356 | No |
| 25 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 4772 | 0.042 | 0.4055 | No |
| 26 | GAPDH | GAPDH Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase | 5744 | 0.023 | 0.3352 | No |
| 27 | ADH4 | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 5822 | 0.022 | 0.3319 | No |
| 28 | ENO3 | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 6027 | 0.018 | 0.3186 | No |
| 29 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6279 | 0.012 | 0.3012 | No |
| 30 | ALDH1A2 | ALDH1A2 Entrez, Source | aldehyde dehydrogenase 1 family, member A2 | 6602 | 0.006 | 0.2777 | No |
| 31 | HK2 | HK2 Entrez, Source | hexokinase 2 | 6922 | -0.000 | 0.2537 | No |
| 32 | PGAM1 | PGAM1 Entrez, Source | phosphoglycerate mutase 1 (brain) | 9249 | -0.053 | 0.0850 | No |
| 33 | BPGM | BPGM Entrez, Source | 2,3-bisphosphoglycerate mutase | 9399 | -0.057 | 0.0804 | No |
| 34 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 9745 | -0.066 | 0.0622 | No |
| 35 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 10696 | -0.098 | 0.0022 | No |
| 36 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 10723 | -0.099 | 0.0118 | No |
| 37 | AKR1A1 | AKR1A1 Entrez, Source | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 10743 | -0.100 | 0.0220 | No |
| 38 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 11723 | -0.150 | -0.0341 | No |
| 39 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 11983 | -0.171 | -0.0337 | No |
| 40 | ALDH3B1 | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 12169 | -0.189 | -0.0256 | No |
| 41 | HK1 | HK1 Entrez, Source | hexokinase 1 | 12636 | -0.251 | -0.0315 | No |
| 42 | ALDH1A1 | ALDH1A1 Entrez, Source | aldehyde dehydrogenase 1 family, member A1 | 12985 | -0.357 | -0.0162 | No |
| 43 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 13007 | -0.369 | 0.0252 | No |
