Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | GLYCINE_SERINE_AND_THREONINE_METABOLISM |
| Enrichment Score (ES) | 0.74383515 |
| Normalized Enrichment Score (NES) | 2.212293 |
| Nominal p-value | 0.0 |
| FDR q-value | 8.489502E-5 |
| FWER p-Value | 0.0030 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PEMT | PEMT Entrez, Source | phosphatidylethanolamine N-methyltransferase | 26 | 0.861 | 0.1012 | Yes |
| 2 | CHDH | CHDH Entrez, Source | choline dehydrogenase | 78 | 0.664 | 0.1771 | Yes |
| 3 | AGXT | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 108 | 0.606 | 0.2475 | Yes |
| 4 | ABP1 | ABP1 Entrez, Source | amiloride binding protein 1 (amine oxidase (copper-containing)) | 109 | 0.606 | 0.3202 | Yes |
| 5 | DMGDH | DMGDH Entrez, Source | dimethylglycine dehydrogenase | 128 | 0.569 | 0.3871 | Yes |
| 6 | BHMT | BHMT Entrez, Source | betaine-homocysteine methyltransferase | 140 | 0.550 | 0.4522 | Yes |
| 7 | CTH | CTH Entrez, Source | cystathionase (cystathionine gamma-lyase) | 148 | 0.535 | 0.5159 | Yes |
| 8 | CBS | CBS Entrez, Source | cystathionine-beta-synthase | 158 | 0.523 | 0.5779 | Yes |
| 9 | AGXT2 | AGXT2 Entrez, Source | alanine-glyoxylate aminotransferase 2 | 233 | 0.448 | 0.6262 | Yes |
| 10 | SARDH | SARDH Entrez, Source | sarcosine dehydrogenase | 245 | 0.438 | 0.6778 | Yes |
| 11 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 753 | 0.227 | 0.6670 | Yes |
| 12 | GCAT | GCAT Entrez, Source | glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) | 767 | 0.225 | 0.6929 | Yes |
| 13 | ALAS1 | ALAS1 Entrez, Source | aminolevulinate, delta-, synthase 1 | 839 | 0.215 | 0.7134 | Yes |
| 14 | CHKA | CHKA Entrez, Source | choline kinase alpha | 984 | 0.196 | 0.7261 | Yes |
| 15 | SHMT2 | SHMT2 Entrez, Source | serine hydroxymethyltransferase 2 (mitochondrial) | 1105 | 0.181 | 0.7388 | Yes |
| 16 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 1628 | 0.141 | 0.7165 | Yes |
| 17 | MAOB | MAOB Entrez, Source | monoamine oxidase B | 1712 | 0.137 | 0.7267 | Yes |
| 18 | PSPH | PSPH Entrez, Source | phosphoserine phosphatase | 1863 | 0.128 | 0.7308 | Yes |
| 19 | SHMT1 | SHMT1 Entrez, Source | serine hydroxymethyltransferase 1 (soluble) | 1892 | 0.127 | 0.7438 | Yes |
| 20 | ALAS2 | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 2203 | 0.114 | 0.7343 | No |
| 21 | TARS | TARS Entrez, Source | threonyl-tRNA synthetase | 2704 | 0.095 | 0.7081 | No |
| 22 | MAOA | MAOA Entrez, Source | monoamine oxidase A | 2802 | 0.091 | 0.7118 | No |
| 23 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 3691 | 0.067 | 0.6531 | No |
| 24 | AMT | AMT Entrez, Source | aminomethyltransferase | 3875 | 0.063 | 0.6468 | No |
| 25 | AOC3 | AOC3 Entrez, Source | amine oxidase, copper containing 3 (vascular adhesion protein 1) | 4870 | 0.040 | 0.5770 | No |
| 26 | PLCB2 | PLCB2 Entrez, Source | phospholipase C, beta 2 | 4924 | 0.039 | 0.5778 | No |
| 27 | GARS | GARS Entrez, Source | glycyl-tRNA synthetase | 5484 | 0.028 | 0.5392 | No |
| 28 | CHKB | CHKB Entrez, Source | choline kinase beta | 6203 | 0.014 | 0.4869 | No |
| 29 | PLCG2 | PLCG2 Entrez, Source | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 9629 | -0.063 | 0.2373 | No |
| 30 | PLCG1 | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 12969 | -0.347 | 0.0280 | No |
