Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA00100_BIOSYNTHESIS_OF_STEROIDS |
| Enrichment Score (ES) | 0.929562 |
| Normalized Enrichment Score (NES) | 2.5666153 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 74 | 0.685 | 0.0802 | Yes |
| 2 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 110 | 0.603 | 0.1531 | Yes |
| 3 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 126 | 0.572 | 0.2236 | Yes |
| 4 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 157 | 0.524 | 0.2870 | Yes |
| 5 | SQLE | SQLE Entrez, Source | squalene epoxidase | 188 | 0.485 | 0.3455 | Yes |
| 6 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 194 | 0.481 | 0.4054 | Yes |
| 7 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 258 | 0.428 | 0.4542 | Yes |
| 8 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 282 | 0.412 | 0.5041 | Yes |
| 9 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 284 | 0.409 | 0.5552 | Yes |
| 10 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 315 | 0.386 | 0.6013 | Yes |
| 11 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 324 | 0.381 | 0.6484 | Yes |
| 12 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 328 | 0.380 | 0.6958 | Yes |
| 13 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 333 | 0.375 | 0.7425 | Yes |
| 14 | VKORC1 | VKORC1 Entrez, Source | vitamin K epoxide reductase complex, subunit 1 | 371 | 0.354 | 0.7841 | Yes |
| 15 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 434 | 0.327 | 0.8204 | Yes |
| 16 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 452 | 0.319 | 0.8592 | Yes |
| 17 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 482 | 0.309 | 0.8957 | Yes |
| 18 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 617 | 0.261 | 0.9183 | Yes |
| 19 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 829 | 0.216 | 0.9296 | Yes |
| 20 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 5248 | 0.033 | 0.6020 | No |
| 21 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 6707 | 0.004 | 0.4930 | No |
| 22 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 7840 | -0.020 | 0.4105 | No |
| 23 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 7862 | -0.020 | 0.4114 | No |
