Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA00252_ALANINE_AND_ASPARTATE_METABOLISM |
| Enrichment Score (ES) | 0.78090656 |
| Normalized Enrichment Score (NES) | 2.1948261 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.611278E-5 |
| FWER p-Value | 0.0030 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 56 | 0.731 | 0.1258 | Yes |
| 2 | PC | PC Entrez, Source | pyruvate carboxylase | 79 | 0.652 | 0.2402 | Yes |
| 3 | AGXT | AGXT Entrez, Source | alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) | 108 | 0.606 | 0.3460 | Yes |
| 4 | ASL | ASL Entrez, Source | argininosuccinate lyase | 122 | 0.586 | 0.4492 | Yes |
| 5 | GPT | GPT Entrez, Source | glutamic-pyruvate transaminase (alanine aminotransferase) | 137 | 0.555 | 0.5470 | Yes |
| 6 | AGXT2 | AGXT2 Entrez, Source | alanine-glyoxylate aminotransferase 2 | 233 | 0.448 | 0.6196 | Yes |
| 7 | ABAT | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 450 | 0.320 | 0.6604 | Yes |
| 8 | ASS1 | ASS1 Entrez, Source | argininosuccinate synthetase 1 | 598 | 0.267 | 0.6969 | Yes |
| 9 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 663 | 0.250 | 0.7365 | Yes |
| 10 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 858 | 0.213 | 0.7598 | Yes |
| 11 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 1027 | 0.189 | 0.7809 | Yes |
| 12 | DLD | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 1628 | 0.141 | 0.7610 | No |
| 13 | ASNS | ASNS Entrez, Source | asparagine synthetase | 2424 | 0.106 | 0.7201 | No |
| 14 | ASRGL1 | ASRGL1 Entrez, Source | asparaginase like 1 | 2968 | 0.086 | 0.6946 | No |
| 15 | ACY3 | ACY3 Entrez, Source | aspartoacylase (aminocyclase) 3 | 3695 | 0.067 | 0.6520 | No |
| 16 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 4772 | 0.042 | 0.5787 | No |
| 17 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 5183 | 0.034 | 0.5540 | No |
| 18 | CRAT | CRAT Entrez, Source | carnitine acetyltransferase | 5716 | 0.023 | 0.5182 | No |
| 19 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 7234 | -0.007 | 0.4056 | No |
| 20 | DARS2 | DARS2 Entrez, Source | aspartyl-tRNA synthetase 2 (mitochondrial) | 7608 | -0.015 | 0.3802 | No |
| 21 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 7757 | -0.018 | 0.3722 | No |
| 22 | NARS | NARS Entrez, Source | asparaginyl-tRNA synthetase | 8055 | -0.025 | 0.3543 | No |
| 23 | AARS | AARS Entrez, Source | alanyl-tRNA synthetase | 8177 | -0.027 | 0.3500 | No |
| 24 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 9551 | -0.061 | 0.2578 | No |
| 25 | DLAT | DLAT Entrez, Source | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 11723 | -0.150 | 0.1216 | No |
