Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | HSA04115_P53_SIGNALING_PATHWAY |
| Enrichment Score (ES) | -0.5329819 |
| Normalized Enrichment Score (NES) | -1.629025 |
| Nominal p-value | 0.02014652 |
| FDR q-value | 0.10458957 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 236 | 0.445 | 0.0518 | No |
| 2 | MDM4 | MDM4 Entrez, Source | Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) | 605 | 0.265 | 0.0657 | No |
| 3 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 1068 | 0.186 | 0.0599 | No |
| 4 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1938 | 0.125 | 0.0141 | No |
| 5 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2067 | 0.119 | 0.0231 | No |
| 6 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 3808 | 0.064 | -0.0977 | No |
| 7 | CD82 | CD82 Entrez, Source | CD82 molecule | 3908 | 0.062 | -0.0955 | No |
| 8 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 4056 | 0.058 | -0.0975 | No |
| 9 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 4323 | 0.052 | -0.1093 | No |
| 10 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 5320 | 0.032 | -0.1792 | No |
| 11 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 5368 | 0.031 | -0.1779 | No |
| 12 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 6247 | 0.013 | -0.2419 | No |
| 13 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 7859 | -0.020 | -0.3599 | No |
| 14 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8410 | -0.033 | -0.3961 | No |
| 15 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 8700 | -0.039 | -0.4117 | No |
| 16 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8748 | -0.040 | -0.4090 | No |
| 17 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9083 | -0.048 | -0.4266 | No |
| 18 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 9345 | -0.056 | -0.4375 | No |
| 19 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 10034 | -0.076 | -0.4774 | No |
| 20 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 10406 | -0.088 | -0.4915 | No |
| 21 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10699 | -0.098 | -0.4980 | No |
| 22 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 10823 | -0.104 | -0.4910 | No |
| 23 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 11382 | -0.130 | -0.5126 | Yes |
| 24 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 11401 | -0.131 | -0.4935 | Yes |
| 25 | STEAP3 | STEAP3 Entrez, Source | STEAP family member 3 | 11634 | -0.146 | -0.4881 | Yes |
| 26 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.4689 | Yes |
| 27 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 11744 | -0.152 | -0.4492 | Yes |
| 28 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 11783 | -0.155 | -0.4278 | Yes |
| 29 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 12031 | -0.176 | -0.4189 | Yes |
| 30 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.3993 | Yes |
| 31 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 12510 | -0.230 | -0.3894 | Yes |
| 32 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12794 | -0.284 | -0.3661 | Yes |
| 33 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12821 | -0.294 | -0.3222 | Yes |
| 34 | ZMAT3 | ZMAT3 Entrez, Source | zinc finger, matrin type 3 | 12878 | -0.312 | -0.2776 | Yes |
| 35 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12954 | -0.340 | -0.2301 | Yes |
| 36 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 12986 | -0.357 | -0.1766 | Yes |
| 37 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13016 | -0.374 | -0.1202 | Yes |
| 38 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 13099 | -0.425 | -0.0600 | Yes |
| 39 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13162 | -0.500 | 0.0135 | Yes |
