Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | HSA04530_TIGHT_JUNCTION |
| Enrichment Score (ES) | -0.48476815 |
| Normalized Enrichment Score (NES) | -1.6795175 |
| Nominal p-value | 0.0017793594 |
| FDR q-value | 0.081221804 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MYH14 | MYH14 Entrez, Source | myosin, heavy chain 14 | 266 | 0.422 | 0.0175 | No |
| 2 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 736 | 0.230 | 0.0026 | No |
| 3 | CLDN14 | CLDN14 Entrez, Source | claudin 14 | 802 | 0.220 | 0.0173 | No |
| 4 | MYH1 | MYH1 Entrez, Source | myosin, heavy chain 1, skeletal muscle, adult | 1512 | 0.148 | -0.0230 | No |
| 5 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 1554 | 0.145 | -0.0131 | No |
| 6 | MYH13 | MYH13 Entrez, Source | myosin, heavy chain 13, skeletal muscle | 1797 | 0.131 | -0.0197 | No |
| 7 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 2073 | 0.118 | -0.0299 | No |
| 8 | MAGI3 | MAGI3 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 2531 | 0.102 | -0.0553 | No |
| 9 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 2563 | 0.101 | -0.0487 | No |
| 10 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2581 | 0.100 | -0.0411 | No |
| 11 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 2898 | 0.088 | -0.0571 | No |
| 12 | PPP2CA | PPP2CA Entrez, Source | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 3355 | 0.075 | -0.0848 | No |
| 13 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 3603 | 0.069 | -0.0974 | No |
| 14 | MYH3 | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 3820 | 0.064 | -0.1080 | No |
| 15 | PRKCE | PRKCE Entrez, Source | protein kinase C, epsilon | 4038 | 0.059 | -0.1192 | No |
| 16 | CRB3 | CRB3 Entrez, Source | crumbs homolog 3 (Drosophila) | 4060 | 0.058 | -0.1156 | No |
| 17 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 4062 | 0.058 | -0.1105 | No |
| 18 | MYH8 | MYH8 Entrez, Source | myosin, heavy chain 8, skeletal muscle, perinatal | 4145 | 0.056 | -0.1117 | No |
| 19 | PPM1J | PPM1J Entrez, Source | protein phosphatase 1J (PP2C domain containing) | 4434 | 0.050 | -0.1289 | No |
| 20 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 4923 | 0.039 | -0.1622 | No |
| 21 | GNAI3 | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 5025 | 0.037 | -0.1665 | No |
| 22 | ACTN3 | ACTN3 Entrez, Source | actinin, alpha 3 | 5159 | 0.035 | -0.1735 | No |
| 23 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 5315 | 0.032 | -0.1823 | No |
| 24 | PARD6A | PARD6A Entrez, Source | par-6 partitioning defective 6 homolog alpha (C.elegans) | 5596 | 0.026 | -0.2012 | No |
| 25 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 5758 | 0.023 | -0.2113 | No |
| 26 | MYH4 | MYH4 Entrez, Source | myosin, heavy chain 4, skeletal muscle | 5810 | 0.022 | -0.2132 | No |
| 27 | JAM2 | JAM2 Entrez, Source | junctional adhesion molecule 2 | 5847 | 0.021 | -0.2140 | No |
| 28 | CLDN8 | CLDN8 Entrez, Source | claudin 8 | 5910 | 0.020 | -0.2169 | No |
| 29 | VAPA | VAPA Entrez, Source | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 6041 | 0.017 | -0.2251 | No |
| 30 | HCLS1 | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 6043 | 0.017 | -0.2237 | No |
| 31 | MYH2 | MYH2 Entrez, Source | myosin, heavy chain 2, skeletal muscle, adult | 6204 | 0.014 | -0.2345 | No |
| 32 | CLDN5 | CLDN5 Entrez, Source | claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) | 6250 | 0.013 | -0.2367 | No |
| 33 | MYL2 | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 6293 | 0.012 | -0.2388 | No |
| 34 | CLDN19 | CLDN19 Entrez, Source | claudin 19 | 6363 | 0.010 | -0.2431 | No |
| 35 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 6436 | 0.009 | -0.2477 | No |
| 36 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7024 | -0.003 | -0.2918 | No |
| 37 | CSDA | CSDA Entrez, Source | cold shock domain protein A | 7299 | -0.008 | -0.3117 | No |
| 38 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 7384 | -0.010 | -0.3172 | No |
| 39 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7461 | -0.012 | -0.3219 | No |
| 40 | PRKCH | PRKCH Entrez, Source | protein kinase C, eta | 7749 | -0.018 | -0.3419 | No |
| 41 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 7898 | -0.021 | -0.3512 | No |
| 42 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 8009 | -0.024 | -0.3574 | No |
| 43 | F11R | F11R Entrez, Source | F11 receptor | 8090 | -0.025 | -0.3612 | No |
| 44 | PRKCZ | PRKCZ Entrez, Source | protein kinase C, zeta | 8292 | -0.030 | -0.3737 | No |
| 45 | GNAI2 | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 8673 | -0.038 | -0.3990 | No |
| 46 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 8690 | -0.039 | -0.3967 | No |
| 47 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 9345 | -0.056 | -0.4411 | No |
| 48 | CLDN11 | CLDN11 Entrez, Source | claudin 11 (oligodendrocyte transmembrane protein) | 9454 | -0.058 | -0.4441 | No |
| 49 | SYMPK | SYMPK Entrez, Source | symplekin | 9466 | -0.059 | -0.4397 | No |
| 50 | PPP2R2C | PPP2R2C Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform | 9555 | -0.061 | -0.4409 | No |
| 51 | PPP2R1A | PPP2R1A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform | 9656 | -0.064 | -0.4427 | No |
| 52 | CLDN16 | CLDN16 Entrez, Source | claudin 16 | 9988 | -0.074 | -0.4610 | No |
| 53 | CSNK2B | CSNK2B Entrez, Source | casein kinase 2, beta polypeptide | 10221 | -0.082 | -0.4712 | No |
| 54 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10292 | -0.084 | -0.4690 | No |
| 55 | MAGI2 | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 10299 | -0.085 | -0.4619 | No |
| 56 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 10376 | -0.087 | -0.4599 | No |
| 57 | PPP2CB | PPP2CB Entrez, Source | protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | 10468 | -0.091 | -0.4587 | No |
| 58 | ACTB | ACTB Entrez, Source | actin, beta | 10590 | -0.095 | -0.4594 | No |
| 59 | CTTN | CTTN Entrez, Source | cortactin | 10911 | -0.107 | -0.4739 | No |
| 60 | PPP2R1B | PPP2R1B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform | 11027 | -0.113 | -0.4726 | No |
| 61 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11190 | -0.121 | -0.4740 | Yes |
| 62 | PPP2R2A | PPP2R2A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform | 11243 | -0.124 | -0.4669 | Yes |
| 63 | PPP2R2B | PPP2R2B Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform | 11431 | -0.133 | -0.4692 | Yes |
| 64 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 11608 | -0.144 | -0.4697 | Yes |
| 65 | EXOC3 | EXOC3 Entrez, Source | exocyst complex component 3 | 11644 | -0.147 | -0.4593 | Yes |
| 66 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11801 | -0.156 | -0.4571 | Yes |
| 67 | EXOC4 | EXOC4 Entrez, Source | exocyst complex component 4 | 11967 | -0.170 | -0.4545 | Yes |
| 68 | RAB13 | RAB13 Entrez, Source | RAB13, member RAS oncogene family | 11994 | -0.172 | -0.4411 | Yes |
| 69 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 11999 | -0.173 | -0.4260 | Yes |
| 70 | TJP2 | TJP2 Entrez, Source | tight junction protein 2 (zona occludens 2) | 12109 | -0.182 | -0.4180 | Yes |
| 71 | ACTN4 | ACTN4 Entrez, Source | actinin, alpha 4 | 12269 | -0.201 | -0.4122 | Yes |
| 72 | PRKCI | PRKCI Entrez, Source | protein kinase C, iota | 12399 | -0.215 | -0.4028 | Yes |
| 73 | MLLT4 | MLLT4 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 12569 | -0.239 | -0.3943 | Yes |
| 74 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12585 | -0.241 | -0.3739 | Yes |
| 75 | CASK | CASK Entrez, Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 12614 | -0.247 | -0.3540 | Yes |
| 76 | RRAS2 | RRAS2 Entrez, Source | related RAS viral (r-ras) oncogene homolog 2 | 12665 | -0.257 | -0.3350 | Yes |
| 77 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12794 | -0.284 | -0.3193 | Yes |
| 78 | JAM3 | JAM3 Entrez, Source | junctional adhesion molecule 3 | 12952 | -0.339 | -0.3010 | Yes |
| 79 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13055 | -0.401 | -0.2729 | Yes |
| 80 | PARD3 | PARD3 Entrez, Source | par-3 partitioning defective 3 homolog (C. elegans) | 13124 | -0.445 | -0.2385 | Yes |
| 81 | MPDZ | MPDZ Entrez, Source | multiple PDZ domain protein | 13220 | -0.602 | -0.1921 | Yes |
| 82 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13226 | -0.619 | -0.1374 | Yes |
| 83 | PPP2R3A | PPP2R3A Entrez, Source | protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha | 13267 | -0.745 | -0.0741 | Yes |
| 84 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 13296 | -0.895 | 0.0035 | Yes |
