Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | 0.5155778 |
| Normalized Enrichment Score (NES) | 1.7200234 |
| Nominal p-value | 0.0062370063 |
| FDR q-value | 0.02765578 |
| FWER p-Value | 0.996 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PLG | PLG Entrez, Source | plasminogen | 44 | 0.773 | 0.0600 | Yes |
| 2 | CFB | CFB Entrez, Source | complement factor B | 112 | 0.599 | 0.1040 | Yes |
| 3 | F10 | F10 Entrez, Source | coagulation factor X | 141 | 0.550 | 0.1468 | Yes |
| 4 | SERPIND1 | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 144 | 0.544 | 0.1912 | Yes |
| 5 | F9 | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 203 | 0.468 | 0.2252 | Yes |
| 6 | MBL2 | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 263 | 0.424 | 0.2555 | Yes |
| 7 | KLKB1 | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 297 | 0.399 | 0.2857 | Yes |
| 8 | MASP2 | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 308 | 0.392 | 0.3170 | Yes |
| 9 | F2 | F2 Entrez, Source | coagulation factor II (thrombin) | 413 | 0.335 | 0.3366 | Yes |
| 10 | C4BPA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 417 | 0.334 | 0.3637 | Yes |
| 11 | SERPINA5 | SERPINA5 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 474 | 0.311 | 0.3850 | Yes |
| 12 | PROC | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 476 | 0.310 | 0.4103 | Yes |
| 13 | SERPINC1 | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 522 | 0.293 | 0.4309 | Yes |
| 14 | C3 | C3 Entrez, Source | complement component 3 | 636 | 0.257 | 0.4434 | Yes |
| 15 | SERPINF2 | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 719 | 0.235 | 0.4565 | Yes |
| 16 | C4BPB | C4BPB Entrez, Source | complement component 4 binding protein, beta | 763 | 0.225 | 0.4717 | Yes |
| 17 | CFI | CFI Entrez, Source | complement factor I | 787 | 0.221 | 0.4880 | Yes |
| 18 | CPB2 | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 898 | 0.208 | 0.4968 | Yes |
| 19 | F12 | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 970 | 0.198 | 0.5077 | Yes |
| 20 | C6 | C6 Entrez, Source | complement component 6 | 1081 | 0.184 | 0.5144 | Yes |
| 21 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 1259 | 0.167 | 0.5148 | Yes |
| 22 | A2M | A2M Entrez, Source | alpha-2-macroglobulin | 1433 | 0.155 | 0.5145 | Yes |
| 23 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 1576 | 0.144 | 0.5156 | Yes |
| 24 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1938 | 0.125 | 0.4986 | No |
| 25 | C9 | C9 Entrez, Source | complement component 9 | 2167 | 0.116 | 0.4909 | No |
| 26 | CFH | CFH Entrez, Source | complement factor H | 2176 | 0.115 | 0.4998 | No |
| 27 | PROS1 | PROS1 Entrez, Source | protein S (alpha) | 2217 | 0.114 | 0.5061 | No |
| 28 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 2588 | 0.100 | 0.4864 | No |
| 29 | F13A1 | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 3304 | 0.076 | 0.4388 | No |
| 30 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3378 | 0.074 | 0.4394 | No |
| 31 | VWF | VWF Entrez, Source | von Willebrand factor | 4369 | 0.051 | 0.3691 | No |
| 32 | BDKRB1 | BDKRB1 Entrez, Source | bradykinin receptor B1 | 4468 | 0.049 | 0.3657 | No |
| 33 | FGA | FGA Entrez, Source | fibrinogen alpha chain | 4658 | 0.045 | 0.3552 | No |
| 34 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 4761 | 0.043 | 0.3510 | No |
| 35 | CFD | CFD Entrez, Source | complement factor D (adipsin) | 4814 | 0.042 | 0.3505 | No |
| 36 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 4933 | 0.039 | 0.3449 | No |
| 37 | FGB | FGB Entrez, Source | fibrinogen beta chain | 5019 | 0.038 | 0.3415 | No |
| 38 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 5189 | 0.034 | 0.3316 | No |
| 39 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 5843 | 0.021 | 0.2842 | No |
| 40 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 7447 | -0.011 | 0.1645 | No |
| 41 | F8 | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 7497 | -0.012 | 0.1619 | No |
| 42 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 8677 | -0.038 | 0.0763 | No |
| 43 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 9503 | -0.060 | 0.0191 | No |
| 44 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 10987 | -0.111 | -0.0834 | No |
| 45 | C2 | C2 Entrez, Source | complement component 2 | 11264 | -0.125 | -0.0939 | No |
| 46 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 11683 | -0.149 | -0.1132 | No |
| 47 | THBD | THBD Entrez, Source | thrombomodulin | 12150 | -0.186 | -0.1330 | No |
| 48 | MASP1 | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 12320 | -0.207 | -0.1288 | No |
| 49 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 12662 | -0.256 | -0.1334 | No |
| 50 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13010 | -0.371 | -0.1292 | No |
| 51 | F2R | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 13270 | -0.762 | -0.0863 | No |
| 52 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13324 | -1.119 | 0.0014 | No |
