Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.5246631 |
| Normalized Enrichment Score (NES) | 1.78685 |
| Nominal p-value | 0.0023255814 |
| FDR q-value | 0.015588155 |
| FWER p-Value | 0.922 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | G6PC | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 21 | 0.893 | 0.0970 | Yes |
| 2 | LEPR | LEPR Entrez, Source | leptin receptor | 85 | 0.639 | 0.1628 | Yes |
| 3 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 167 | 0.505 | 0.2125 | Yes |
| 4 | CPT2 | CPT2 Entrez, Source | carnitine palmitoyltransferase II | 292 | 0.402 | 0.2476 | Yes |
| 5 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 335 | 0.375 | 0.2858 | Yes |
| 6 | NPY | NPY Entrez, Source | neuropeptide Y | 342 | 0.371 | 0.3263 | Yes |
| 7 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 375 | 0.353 | 0.3629 | Yes |
| 8 | RXRG | RXRG Entrez, Source | retinoid X receptor, gamma | 490 | 0.304 | 0.3879 | Yes |
| 9 | ACSL3 | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 546 | 0.284 | 0.4151 | Yes |
| 10 | PRKAA2 | PRKAA2 Entrez, Source | protein kinase, AMP-activated, alpha 2 catalytic subunit | 649 | 0.252 | 0.4352 | Yes |
| 11 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 670 | 0.247 | 0.4610 | Yes |
| 12 | PPARA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 732 | 0.231 | 0.4819 | Yes |
| 13 | PRKAA1 | PRKAA1 Entrez, Source | protein kinase, AMP-activated, alpha 1 catalytic subunit | 796 | 0.220 | 0.5015 | Yes |
| 14 | CPT1A | CPT1A Entrez, Source | carnitine palmitoyltransferase 1A (liver) | 950 | 0.200 | 0.5121 | Yes |
| 15 | CPT1B | CPT1B Entrez, Source | carnitine palmitoyltransferase 1B (muscle) | 1278 | 0.165 | 0.5058 | Yes |
| 16 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 1551 | 0.146 | 0.5014 | Yes |
| 17 | ACSL4 | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 1566 | 0.144 | 0.5163 | Yes |
| 18 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 1770 | 0.133 | 0.5157 | Yes |
| 19 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 1920 | 0.125 | 0.5183 | Yes |
| 20 | ACACB | ACACB Entrez, Source | acetyl-Coenzyme A carboxylase beta | 2014 | 0.121 | 0.5247 | Yes |
| 21 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 2309 | 0.110 | 0.5147 | No |
| 22 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 2562 | 0.101 | 0.5068 | No |
| 23 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2581 | 0.100 | 0.5165 | No |
| 24 | ACSL6 | ACSL6 Entrez, Source | acyl-CoA synthetase long-chain family member 6 | 2800 | 0.091 | 0.5102 | No |
| 25 | JAK3 | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 2892 | 0.088 | 0.5131 | No |
| 26 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 2914 | 0.088 | 0.5212 | No |
| 27 | SLC2A4 | SLC2A4 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 4 | 3091 | 0.082 | 0.5170 | No |
| 28 | ADIPOR2 | ADIPOR2 Entrez, Source | adiponectin receptor 2 | 3114 | 0.081 | 0.5243 | No |
| 29 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 3319 | 0.076 | 0.5173 | No |
| 30 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 3489 | 0.071 | 0.5124 | No |
| 31 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3646 | 0.068 | 0.5082 | No |
| 32 | POMC | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 4293 | 0.053 | 0.4654 | No |
| 33 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 4319 | 0.052 | 0.4693 | No |
| 34 | ACSL5 | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 4466 | 0.049 | 0.4637 | No |
| 35 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 4923 | 0.039 | 0.4337 | No |
| 36 | PRKAB2 | PRKAB2 Entrez, Source | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 5547 | 0.027 | 0.3898 | No |
| 37 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 6061 | 0.017 | 0.3531 | No |
| 38 | ADIPOQ | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 6570 | 0.007 | 0.3156 | No |
| 39 | PRKAG1 | PRKAG1 Entrez, Source | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 6702 | 0.004 | 0.3061 | No |
| 40 | PRKAB1 | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 6723 | 0.004 | 0.3050 | No |
| 41 | CAMKK2 | CAMKK2 Entrez, Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 6725 | 0.004 | 0.3054 | No |
| 42 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7024 | -0.003 | 0.2832 | No |
| 43 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 7310 | -0.008 | 0.2627 | No |
| 44 | ADIPOR1 | ADIPOR1 Entrez, Source | adiponectin receptor 1 | 7451 | -0.011 | 0.2534 | No |
| 45 | LEP | LEP Entrez, Source | leptin (obesity homolog, mouse) | 8144 | -0.026 | 0.2043 | No |
| 46 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 8465 | -0.033 | 0.1839 | No |
| 47 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 9419 | -0.058 | 0.1185 | No |
| 48 | PRKAG2 | PRKAG2 Entrez, Source | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 9644 | -0.064 | 0.1087 | No |
| 49 | RXRB | RXRB Entrez, Source | retinoid X receptor, beta | 9739 | -0.066 | 0.1089 | No |
| 50 | CAMKK1 | CAMKK1 Entrez, Source | calcium/calmodulin-dependent protein kinase kinase 1, alpha | 10313 | -0.085 | 0.0752 | No |
| 51 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10464 | -0.090 | 0.0739 | No |
| 52 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 10998 | -0.112 | 0.0461 | No |
| 53 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 11775 | -0.155 | 0.0048 | No |
| 54 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11801 | -0.156 | 0.0202 | No |
| 55 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 11891 | -0.164 | 0.0316 | No |
| 56 | CPT1C | CPT1C Entrez, Source | carnitine palmitoyltransferase 1C | 12829 | -0.296 | -0.0063 | No |
| 57 | JAK2 | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 13065 | -0.406 | 0.0208 | No |
