Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | HSA05212_PANCREATIC_CANCER |
| Enrichment Score (ES) | -0.48609075 |
| Normalized Enrichment Score (NES) | -1.6229848 |
| Nominal p-value | 0.008992806 |
| FDR q-value | 0.10734765 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ACVR1C | ACVR1C Entrez, Source | activin A receptor, type IC | 641 | 0.255 | -0.0153 | No |
| 2 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 740 | 0.230 | 0.0069 | No |
| 3 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 1471 | 0.151 | -0.0285 | No |
| 4 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1695 | 0.137 | -0.0276 | No |
| 5 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 1896 | 0.126 | -0.0264 | No |
| 6 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2067 | 0.119 | -0.0239 | No |
| 7 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2307 | 0.110 | -0.0277 | No |
| 8 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 2562 | 0.101 | -0.0338 | No |
| 9 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2581 | 0.100 | -0.0223 | No |
| 10 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 2914 | 0.088 | -0.0360 | No |
| 11 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3646 | 0.068 | -0.0823 | No |
| 12 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3759 | 0.065 | -0.0823 | No |
| 13 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 3847 | 0.063 | -0.0808 | No |
| 14 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 3876 | 0.062 | -0.0748 | No |
| 15 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 4319 | 0.052 | -0.1013 | No |
| 16 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4611 | 0.046 | -0.1173 | No |
| 17 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 4819 | 0.041 | -0.1275 | No |
| 18 | RALA | RALA Entrez, Source | v-ral simian leukemia viral oncogene homolog A (ras related) | 5473 | 0.028 | -0.1730 | No |
| 19 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 5502 | 0.028 | -0.1716 | No |
| 20 | FIGF | FIGF Entrez, Source | c-fos induced growth factor (vascular endothelial growth factor D) | 5779 | 0.022 | -0.1895 | No |
| 21 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 6061 | 0.017 | -0.2084 | No |
| 22 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 6727 | 0.004 | -0.2580 | No |
| 23 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7024 | -0.003 | -0.2799 | No |
| 24 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 7310 | -0.008 | -0.3003 | No |
| 25 | RALBP1 | RALBP1 Entrez, Source | ralA binding protein 1 | 7318 | -0.009 | -0.2997 | No |
| 26 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7461 | -0.012 | -0.3089 | No |
| 27 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 7490 | -0.012 | -0.3095 | No |
| 28 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 8009 | -0.024 | -0.3454 | No |
| 29 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 8585 | -0.037 | -0.3840 | No |
| 30 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8748 | -0.040 | -0.3911 | No |
| 31 | RALGDS | RALGDS Entrez, Source | ral guanine nucleotide dissociation stimulator | 8825 | -0.042 | -0.3914 | No |
| 32 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9515 | -0.060 | -0.4355 | No |
| 33 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 9602 | -0.063 | -0.4340 | No |
| 34 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9885 | -0.071 | -0.4460 | No |
| 35 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 10026 | -0.075 | -0.4468 | No |
| 36 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 10053 | -0.076 | -0.4390 | No |
| 37 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 10171 | -0.080 | -0.4374 | No |
| 38 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10464 | -0.090 | -0.4477 | No |
| 39 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10731 | -0.100 | -0.4549 | No |
| 40 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 11069 | -0.115 | -0.4655 | No |
| 41 | RALB | RALB Entrez, Source | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 11344 | -0.128 | -0.4695 | Yes |
| 42 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 11438 | -0.133 | -0.4593 | Yes |
| 43 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 11475 | -0.136 | -0.4445 | Yes |
| 44 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 11501 | -0.137 | -0.4287 | Yes |
| 45 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11527 | -0.139 | -0.4127 | Yes |
| 46 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11673 | -0.148 | -0.4045 | Yes |
| 47 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.3865 | Yes |
| 48 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11752 | -0.152 | -0.3714 | Yes |
| 49 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11801 | -0.156 | -0.3549 | Yes |
| 50 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 11891 | -0.164 | -0.3405 | Yes |
| 51 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 11978 | -0.171 | -0.3249 | Yes |
| 52 | PLD1 | PLD1 Entrez, Source | phospholipase D1, phosphatidylcholine-specific | 12228 | -0.196 | -0.3183 | Yes |
| 53 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 12237 | -0.197 | -0.2935 | Yes |
| 54 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12538 | -0.234 | -0.2859 | Yes |
| 55 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12794 | -0.284 | -0.2684 | Yes |
| 56 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 12832 | -0.296 | -0.2331 | Yes |
| 57 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 13047 | -0.395 | -0.1983 | Yes |
| 58 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 13099 | -0.425 | -0.1473 | Yes |
| 59 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13162 | -0.500 | -0.0875 | Yes |
| 60 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13277 | -0.783 | 0.0049 | Yes |
