Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | HSA05220_CHRONIC_MYELOID_LEUKEMIA |
| Enrichment Score (ES) | -0.55336356 |
| Normalized Enrichment Score (NES) | -1.8076401 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.046050917 |
| FWER p-Value | 0.895 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ACVR1C | ACVR1C Entrez, Source | activin A receptor, type IC | 641 | 0.255 | -0.0178 | No |
| 2 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 670 | 0.247 | 0.0096 | No |
| 3 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 1896 | 0.126 | -0.0676 | No |
| 4 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2067 | 0.119 | -0.0662 | No |
| 5 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2307 | 0.110 | -0.0711 | No |
| 6 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 2581 | 0.100 | -0.0797 | No |
| 7 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 2898 | 0.088 | -0.0930 | No |
| 8 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 3311 | 0.076 | -0.1150 | No |
| 9 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3646 | 0.068 | -0.1321 | No |
| 10 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 3805 | 0.064 | -0.1364 | No |
| 11 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 3847 | 0.063 | -0.1319 | No |
| 12 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 3876 | 0.062 | -0.1266 | No |
| 13 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 4217 | 0.055 | -0.1457 | No |
| 14 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4611 | 0.046 | -0.1698 | No |
| 15 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 5502 | 0.028 | -0.2334 | No |
| 16 | GAB2 | GAB2 Entrez, Source | GRB2-associated binding protein 2 | 6013 | 0.018 | -0.2697 | No |
| 17 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 6061 | 0.017 | -0.2712 | No |
| 18 | CBLC | CBLC Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 6673 | 0.005 | -0.3166 | No |
| 19 | MAP2K2 | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 6934 | -0.001 | -0.3361 | No |
| 20 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7024 | -0.003 | -0.3425 | No |
| 21 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 7310 | -0.008 | -0.3630 | No |
| 22 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 7490 | -0.012 | -0.3750 | No |
| 23 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 8009 | -0.024 | -0.4111 | No |
| 24 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 8184 | -0.027 | -0.4210 | No |
| 25 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 8585 | -0.037 | -0.4468 | No |
| 26 | STAT5B | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 8858 | -0.043 | -0.4622 | No |
| 27 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 9176 | -0.051 | -0.4800 | No |
| 28 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 9419 | -0.058 | -0.4913 | No |
| 29 | CRKL | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 9536 | -0.061 | -0.4928 | No |
| 30 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 9602 | -0.063 | -0.4903 | No |
| 31 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 9756 | -0.067 | -0.4938 | No |
| 32 | CTBP1 | CTBP1 Entrez, Source | C-terminal binding protein 1 | 9803 | -0.068 | -0.4892 | No |
| 33 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 10053 | -0.076 | -0.4988 | No |
| 34 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 10464 | -0.090 | -0.5189 | No |
| 35 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10731 | -0.100 | -0.5270 | No |
| 36 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 10938 | -0.109 | -0.5296 | No |
| 37 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 11069 | -0.115 | -0.5257 | No |
| 38 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 11438 | -0.133 | -0.5375 | Yes |
| 39 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 11501 | -0.137 | -0.5257 | Yes |
| 40 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11527 | -0.139 | -0.5111 | Yes |
| 41 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11673 | -0.148 | -0.5043 | Yes |
| 42 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.4877 | Yes |
| 43 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11752 | -0.152 | -0.4742 | Yes |
| 44 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11801 | -0.156 | -0.4591 | Yes |
| 45 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 11978 | -0.171 | -0.4520 | Yes |
| 46 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 11999 | -0.173 | -0.4329 | Yes |
| 47 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.4228 | Yes |
| 48 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12251 | -0.199 | -0.4056 | Yes |
| 49 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12538 | -0.234 | -0.3993 | Yes |
| 50 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 12630 | -0.250 | -0.3763 | Yes |
| 51 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12794 | -0.284 | -0.3547 | Yes |
| 52 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 12832 | -0.296 | -0.3222 | Yes |
| 53 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 12949 | -0.338 | -0.2906 | Yes |
| 54 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 13047 | -0.395 | -0.2509 | Yes |
| 55 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 13099 | -0.425 | -0.2041 | Yes |
| 56 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13162 | -0.500 | -0.1491 | Yes |
| 57 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 13212 | -0.580 | -0.0837 | Yes |
| 58 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13277 | -0.783 | 0.0049 | Yes |
