Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_single_gel_8d.class.cls
#double_gel_8d_versus_single_gel_8d_repos
Phenotypeclass.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in classdouble_gel_8d
GeneSetHSIAO_LIVER_SPECIFIC_GENES
Enrichment Score (ES)0.7786593
Normalized Enrichment Score (NES)3.1869688
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HSIAO_LIVER_SPECIFIC_GENES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 141.2460.0227Yes
2APOA2APOA2
Entrez,  Source
apolipoprotein A-II71.2060.0449Yes
3FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver81.2050.0671Yes
4HGDHGD
Entrez,  Source
homogentisate 1,2-dioxygenase (homogentisate oxidase)170.9300.0837Yes
5G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit210.8930.1000Yes
6HRGHRG
Entrez,  Source
histidine-rich glycoprotein330.8210.1143Yes
7APOC1APOC1
Entrez,  Source
apolipoprotein C-I360.8090.1291Yes
8PLGPLG
Entrez,  Source
plasminogen440.7730.1429Yes
9OTCOTC
Entrez,  Source
ornithine carbamoyltransferase490.7650.1567Yes
10GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)520.7480.1704Yes
11ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain600.7210.1832Yes
12FBP1FBP1
Entrez,  Source
fructose-1,6-bisphosphatase 1660.7020.1958Yes
13LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase760.6770.2076Yes
14CYP2E1CYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 1870.6370.2186Yes
15ASGR1ASGR1
Entrez,  Source
asialoglycoprotein receptor 1900.6320.2301Yes
16CPS1CPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial910.6310.2418Yes
17ASGR2ASGR2
Entrez,  Source
asialoglycoprotein receptor 2920.6270.2534Yes
18AADACAADAC
Entrez,  Source
arylacetamide deacetylase (esterase)970.6190.2645Yes
19CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I1040.6120.2754Yes
20AGXTAGXT
Entrez,  Source
alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)1080.6060.2864Yes
21SERPINA4SERPINA4
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 41110.6020.2973Yes
22CFBCFB
Entrez,  Source
complement factor B1120.5990.3084Yes
23MTTPMTTP
Entrez,  Source
microsomal triglyceride transfer protein1140.5930.3193Yes
24ASLASL
Entrez,  Source
argininosuccinate lyase1220.5860.3296Yes
25AZGP1AZGP1
Entrez,  Source
alpha-2-glycoprotein 1, zinc1250.5750.3401Yes
26GPTGPT
Entrez,  Source
glutamic-pyruvate transaminase (alanine aminotransferase)1370.5550.3495Yes
27BHMTBHMT
Entrez,  Source
betaine-homocysteine methyltransferase1400.5500.3595Yes
28F10F10
Entrez,  Source
coagulation factor X1410.5500.3697Yes
29SERPIND1SERPIND1
Entrez,  Source
serpin peptidase inhibitor, clade D (heparin cofactor), member 11440.5440.3796Yes
30FGL1FGL1
Entrez,  Source
fibrinogen-like 11490.5340.3891Yes
31CBSCBS
Entrez,  Source
cystathionine-beta-synthase1580.5230.3982Yes
32PCK1PCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)1670.5050.4069Yes
33ACAT2ACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)1720.4990.4159Yes
34NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 21870.4860.4238Yes
35GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)1920.4820.4324Yes
36HPNHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)1980.4780.4408Yes
37F9F9
Entrez,  Source
coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)2030.4680.4492Yes
38TFTF
Entrez,  Source
transferrin2110.4610.4572Yes
39TATTAT
Entrez,  Source
tyrosine aminotransferase2210.4570.4649Yes
40ARG1ARG1
Entrez,  Source
arginase, liver2460.4380.4712Yes
41DPYSDPYS
Entrez,  Source
dihydropyrimidinase2530.4320.4787Yes
42MBL2MBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)2630.4240.4859Yes
43FAHFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)2770.4160.4926Yes
44PCSK6PCSK6
Entrez,  Source
proprotein convertase subtilisin/kexin type 62790.4160.5002Yes
45DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase2820.4120.5077Yes
46SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like2840.4090.5152Yes
47SAA4SAA4
Entrez,  Source
serum amyloid A4, constitutive2890.4040.5223Yes
48KLKB1KLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 12970.3990.5292Yes
49GHRGHR
Entrez,  Source
growth hormone receptor3120.3890.5353Yes
50SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 33190.3840.5419Yes
51ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 13350.3750.5477Yes
52AGTR1AGTR1
Entrez,  Source
angiotensin II receptor, type 13410.3720.5542Yes
53HMGCLHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)3440.3710.5609Yes
54CFHR1CFHR1
Entrez,  Source
complement factor H-related 13500.3620.5672Yes
55RBP4RBP4
Entrez,  Source
retinol binding protein 4, plasma3510.3610.5739Yes
56TDO2TDO2
Entrez,  Source
tryptophan 2,3-dioxygenase3550.3600.5803Yes
57HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)3600.3580.5866Yes
58ACAA2ACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)3740.3530.5922Yes
59PORPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase3840.3460.5979Yes
60CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 24030.3370.6028Yes
61F2F2
Entrez,  Source
coagulation factor II (thrombin)4130.3350.6083Yes
62C4BPAC4BPA
Entrez,  Source
complement component 4 binding protein, alpha4170.3340.6142Yes
63ABCB4ABCB4
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 44260.3300.6197Yes
64ACAT1ACAT1
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)4300.3290.6256Yes
65SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 54740.3110.6280Yes
66PROCPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)4760.3100.6337Yes
67HSD11B1HSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 14870.3060.6386Yes
68CES2CES2
Entrez,  Source
carboxylesterase 2 (intestine, liver)4890.3050.6441Yes
69AGTAGT
Entrez,  Source
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)5140.2950.6478Yes
70SERPINC1SERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 15220.2930.6527Yes
71ALDH6A1ALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A15240.2920.6580Yes
72CRPCRP
Entrez,  Source
C-reactive protein, pentraxin-related5340.2890.6626Yes
73NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 45430.2850.6673Yes
74KYNUKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)5480.2830.6722Yes
75HALHAL
Entrez,  Source
histidine ammonia-lyase5490.2820.6774Yes
76PYGLPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)5680.2780.6812Yes
77CYP27A1CYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 15780.2740.6856Yes
78BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)5800.2730.6906Yes
79DDTDDT
Entrez,  Source
D-dopachrome tautomerase5830.2710.6954Yes
80ASS1ASS1
Entrez,  Source
argininosuccinate synthetase 15980.2670.6993Yes
81PZPPZP
Entrez,  Source
pregnancy-zone protein6210.2600.7025Yes
82C3C3
Entrez,  Source
complement component 36360.2570.7061Yes
83AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)6560.2510.7093Yes
84APOHAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)6580.2510.7139Yes
85HGFACHGFAC
Entrez,  Source
HGF activator6650.2490.7180Yes
86ALDOBALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate6660.2490.7226Yes
87SERPINA7SERPINA7
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 77000.2380.7245Yes
88LBPLBP
Entrez,  Source
lipopolysaccharide binding protein7010.2380.7289Yes
89SERPINF2SERPINF2
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 27190.2350.7320Yes
90MST1MST1
Entrez,  Source
macrophage stimulating 1 (hepatocyte growth factor-like)7280.2330.7357Yes
91HRSP12HRSP12
Entrez,  Source
heat-responsive protein 127370.2300.7393Yes
92VTNVTN
Entrez,  Source
vitronectin7660.2250.7414Yes
93ABCC6ABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 67750.2240.7449Yes
94CFICFI
Entrez,  Source
complement factor I7870.2210.7481Yes
95SEPHS2SEPHS2
Entrez,  Source
selenophosphate synthetase 28360.2160.7485Yes
96ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 18390.2150.7523Yes
97CATCAT
Entrez,  Source
catalase8840.2090.7528Yes
98CPB2CPB2
Entrez,  Source
carboxypeptidase B2 (plasma, carboxypeptidase U)8980.2080.7557Yes
99TSTTST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)9260.2030.7574Yes
100PCBD1PCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)9360.2020.7604Yes
101FMO3FMO3
Entrez,  Source
flavin containing monooxygenase 39610.1990.7623Yes
102F12F12
Entrez,  Source
coagulation factor XII (Hageman factor)9700.1980.7653Yes
103MTHFD1MTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase10500.1870.7628Yes
104APOA1APOA1
Entrez,  Source
apolipoprotein A-I10520.1870.7662Yes
105PON3PON3
Entrez,  Source
paraoxonase 310550.1870.7695Yes
106ADFPADFP
Entrez,  Source
adipose differentiation-related protein10690.1850.7719Yes
107HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 410740.1850.7750Yes
108APOBAPOB
Entrez,  Source
apolipoprotein B (including Ag(x) antigen)11250.1800.7745Yes
109GJB1GJB1
Entrez,  Source
gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)11500.1760.7760Yes
110ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain11580.1750.7787Yes
111SDSSDS
Entrez,  Source
serine dehydratase12220.1690.7770No
112HPDHPD
Entrez,  Source
4-hydroxyphenylpyruvate dioxygenase12520.1670.7779No
113DECR1DECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial13150.1630.7762No
114ITIH3ITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H314300.1550.7704No
115IL13RA1IL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 114460.1530.7721No
116APOC3APOC3
Entrez,  Source
apolipoprotein C-III14780.1510.7725No
117HPHP
Entrez,  Source
haptoglobin14800.1510.7752No
118PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 115580.1450.7720No
119PCCBPCCB
Entrez,  Source
propionyl Coenzyme A carboxylase, beta polypeptide16200.1420.7700No
120IGFBP1IGFBP1
Entrez,  Source
insulin-like growth factor binding protein 116700.1390.7689No
121BDH1BDH1
Entrez,  Source
3-hydroxybutyrate dehydrogenase, type 116860.1380.7703No
122SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 117870.1320.7651No
123GLUD1GLUD1
Entrez,  Source
glutamate dehydrogenase 118640.1280.7617No
124SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)18920.1270.7620No
125SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 119380.1250.7609No
126FMO5FMO5
Entrez,  Source
flavin containing monooxygenase 521360.1170.7480No
127PROS1PROS1
Entrez,  Source
protein S (alpha)22170.1140.7441No
128CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)24090.1060.7315No
129MGST1MGST1
Entrez,  Source
microsomal glutathione S-transferase 124630.1040.7294No
130CPCP
Entrez,  Source
ceruloplasmin (ferroxidase)25230.1020.7268No
131CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)26080.0990.7222No
132APCSAPCS
Entrez,  Source
amyloid P component, serum26250.0980.7228No
133SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 127310.0940.7166No
134HPXHPX
Entrez,  Source
hemopexin29320.0870.7030No
135SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 229690.0860.7019No
136GSTA2GSTA2
Entrez,  Source
glutathione S-transferase A231730.0790.6879No
137ORM1ORM1
Entrez,  Source
orosomucoid 133280.0750.6776No
138SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)33780.0740.6752No
139GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)36910.0670.6527No
140HNMTHNMT
Entrez,  Source
histamine N-methyltransferase37890.0640.6465No
141CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)39840.0600.6329No
142CRHBPCRHBP
Entrez,  Source
corticotropin releasing hormone binding protein44780.0490.5963No
143FGAFGA
Entrez,  Source
fibrinogen alpha chain46580.0450.5835No
144SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 147610.0430.5766No
145ACSM3ACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 347860.0420.5755No
146FGGFGG
Entrez,  Source
fibrinogen gamma chain49330.0390.5651No
147FGBFGB
Entrez,  Source
fibrinogen beta chain50190.0380.5594No
148IL13IL13
Entrez,  Source
interleukin 1350640.0370.5567No
149SORDSORD
Entrez,  Source
sorbitol dehydrogenase54560.0290.5275No
150IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta55370.0270.5219No
151ADH4ADH4
Entrez,  Source
alcohol dehydrogenase 4 (class II), pi polypeptide58220.0220.5007No
152TFPITFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)58430.0210.4996No
153CYP3A4CYP3A4
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 458600.0210.4988No
154ALDH2ALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)62790.0120.4672No
155LSRLSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor62980.0120.4661No
156TOMM40TOMM40
Entrez,  Source
translocase of outer mitochondrial membrane 40 homolog (yeast)65980.0060.4435No
157ALBALB
Entrez,  Source
albumin67390.0040.4329No
158CYP2C9CYP2C9
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 96932-0.0010.4183No
159AHSGAHSG
Entrez,  Source
alpha-2-HS-glycoprotein7259-0.0080.3937No
160SEPP1SEPP1
Entrez,  Source
selenoprotein P, plasma, 17281-0.0080.3922No
161KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 27491-0.0120.3765No
162FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 47668-0.0160.3635No
163SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7856-0.0200.3496No
164GGCXGGCX
Entrez,  Source
gamma-glutamyl carboxylase7862-0.0200.3496No
165LAMP2LAMP2
Entrez,  Source
lysosomal-associated membrane protein 27865-0.0200.3498No
166LGALS4LGALS4
Entrez,  Source
lectin, galactoside-binding, soluble, 4 (galectin 4)8066-0.0250.3351No
167PGRMC1PGRMC1
Entrez,  Source
progesterone receptor membrane component 18187-0.0270.3264No
168AOX1AOX1
Entrez,  Source
aldehyde oxidase 18449-0.0330.3072No
169SPP2SPP2
Entrez,  Source
secreted phosphoprotein 2, 24kDa8475-0.0340.3059No
170EPHX1EPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)9718-0.0660.2127No
171BZW1BZW1
Entrez,  Source
basic leucine zipper and W2 domains 19724-0.0660.2136No
172FN1FN1
Entrez,  Source
fibronectin 19917-0.0720.2003No
173GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 110091-0.0780.1886No
174NAT2NAT2
Entrez,  Source
N-acetyltransferase 2 (arylamine N-acetyltransferase)10308-0.0850.1737No
175DAB2DAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)10515-0.0920.1598No
176SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 110636-0.0960.1524No
177RGL2RGL2
Entrez,  Source
ral guanine nucleotide dissociation stimulator-like 210808-0.1030.1413No
178C1RC1R
Entrez,  Source
complement component 1, r subcomponent10987-0.1110.1298No
179TAF6TAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa11155-0.1190.1194No
180C2C2
Entrez,  Source
complement component 211264-0.1250.1134No
181LTB4DHLTB4DH
Entrez,  Source
leukotriene B4 12-hydroxydehydrogenase11276-0.1250.1149No
182TM4SF4TM4SF4
Entrez,  Source
transmembrane 4 L six family member 411537-0.1400.0977No
183PRDX4PRDX4
Entrez,  Source
peroxiredoxin 411707-0.1500.0877No
184FSTFST
Entrez,  Source
follistatin12041-0.1770.0656No
185CASC3CASC3
Entrez,  Source
cancer susceptibility candidate 312101-0.1820.0645No
186RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 412272-0.2010.0553No
187ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 212438-0.2200.0468No
188ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A112985-0.3570.0119No
189RGNRGN
Entrez,  Source
regucalcin (senescence marker protein-30)13038-0.3860.0150No
190LIPCLIPC
Entrez,  Source
lipase, hepatic13109-0.4330.0177No
Table: GSEA details [plain text format]



Fig 2: HSIAO_LIVER_SPECIFIC_GENES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HSIAO_LIVER_SPECIFIC_GENES: Random ES distribution   
Gene set null distribution of ES for HSIAO_LIVER_SPECIFIC_GENES