Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | IGLESIAS_E2FMINUS_UP |
| Enrichment Score (ES) | -0.49338046 |
| Normalized Enrichment Score (NES) | -1.7507956 |
| Nominal p-value | 0.0017699115 |
| FDR q-value | 0.06352019 |
| FWER p-Value | 0.992 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 104 | 0.612 | 0.0263 | No |
| 2 | LPL | LPL Entrez, Source | lipoprotein lipase | 230 | 0.451 | 0.0421 | No |
| 3 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 456 | 0.317 | 0.0429 | No |
| 4 | CD9 | CD9 Entrez, Source | CD9 molecule | 512 | 0.295 | 0.0552 | No |
| 5 | C3 | C3 Entrez, Source | complement component 3 | 636 | 0.257 | 0.0603 | No |
| 6 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 670 | 0.247 | 0.0716 | No |
| 7 | IGSF4 | IGSF4 Entrez, Source | immunoglobulin superfamily, member 4 | 821 | 0.218 | 0.0725 | No |
| 8 | CES3 | CES3 Entrez, Source | carboxylesterase 3 (brain) | 1130 | 0.179 | 0.0592 | No |
| 9 | ENPP2 | ENPP2 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) | 1416 | 0.156 | 0.0464 | No |
| 10 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 1787 | 0.132 | 0.0258 | No |
| 11 | ACADL | ACADL Entrez, Source | acyl-Coenzyme A dehydrogenase, long chain | 2024 | 0.121 | 0.0147 | No |
| 12 | COL6A2 | COL6A2 Entrez, Source | collagen, type VI, alpha 2 | 2097 | 0.118 | 0.0159 | No |
| 13 | ALAS2 | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 2203 | 0.114 | 0.0143 | No |
| 14 | IGFBP5 | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 2222 | 0.114 | 0.0193 | No |
| 15 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 2588 | 0.100 | -0.0027 | No |
| 16 | APLP2 | APLP2 Entrez, Source | amyloid beta (A4) precursor-like protein 2 | 3389 | 0.074 | -0.0590 | No |
| 17 | LAPTM5 | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 3735 | 0.066 | -0.0814 | No |
| 18 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 3872 | 0.063 | -0.0882 | No |
| 19 | ARSA | ARSA Entrez, Source | arylsulfatase A | 4109 | 0.057 | -0.1028 | No |
| 20 | ACADM | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 4310 | 0.053 | -0.1150 | No |
| 21 | ELN | ELN Entrez, Source | elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) | 4595 | 0.046 | -0.1339 | No |
| 22 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 4715 | 0.044 | -0.1404 | No |
| 23 | CFD | CFD Entrez, Source | complement factor D (adipsin) | 4814 | 0.042 | -0.1455 | No |
| 24 | CLK1 | CLK1 Entrez, Source | CDC-like kinase 1 | 4880 | 0.040 | -0.1481 | No |
| 25 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 4881 | 0.040 | -0.1459 | No |
| 26 | APOE | APOE Entrez, Source | apolipoprotein E | 5056 | 0.037 | -0.1570 | No |
| 27 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5460 | 0.029 | -0.1858 | No |
| 28 | TYROBP | TYROBP Entrez, Source | TYRO protein tyrosine kinase binding protein | 5564 | 0.026 | -0.1921 | No |
| 29 | LYL1 | LYL1 Entrez, Source | lymphoblastic leukemia derived sequence 1 | 5624 | 0.025 | -0.1952 | No |
| 30 | NID2 | NID2 Entrez, Source | nidogen 2 (osteonidogen) | 6093 | 0.016 | -0.2296 | No |
| 31 | SCG2 | SCG2 Entrez, Source | secretogranin II (chromogranin C) | 6564 | 0.007 | -0.2648 | No |
| 32 | ADIPOQ | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 6570 | 0.007 | -0.2648 | No |
| 33 | NID1 | NID1 Entrez, Source | nidogen 1 | 6775 | 0.003 | -0.2800 | No |
| 34 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 7328 | -0.009 | -0.3213 | No |
| 35 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7461 | -0.012 | -0.3306 | No |
| 36 | FMO1 | FMO1 Entrez, Source | flavin containing monooxygenase 1 | 7782 | -0.018 | -0.3537 | No |
| 37 | CACYBP | CACYBP Entrez, Source | calcyclin binding protein | 7821 | -0.019 | -0.3555 | No |
| 38 | SKP1A | SKP1A Entrez, Source | S-phase kinase-associated protein 1A (p19A) | 8149 | -0.026 | -0.3788 | No |
| 39 | DCN | DCN Entrez, Source | decorin | 8220 | -0.028 | -0.3825 | No |
| 40 | CTSS | CTSS Entrez, Source | cathepsin S | 8459 | -0.033 | -0.3986 | No |
| 41 | GAS6 | GAS6 Entrez, Source | growth arrest-specific 6 | 8485 | -0.034 | -0.3986 | No |
| 42 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 8592 | -0.037 | -0.4046 | No |
| 43 | LUM | LUM Entrez, Source | lumican | 8618 | -0.037 | -0.4044 | No |
| 44 | B2M | B2M Entrez, Source | beta-2-microglobulin | 8650 | -0.038 | -0.4046 | No |
| 45 | GNAI2 | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 8673 | -0.038 | -0.4041 | No |
| 46 | RPS14 | RPS14 Entrez, Source | ribosomal protein S14 | 8780 | -0.040 | -0.4099 | No |
| 47 | PMP22 | PMP22 Entrez, Source | peripheral myelin protein 22 | 9250 | -0.053 | -0.4423 | No |
| 48 | MORF4L1 | MORF4L1 Entrez, Source | mortality factor 4 like 1 | 9275 | -0.054 | -0.4411 | No |
| 49 | TIMM22 | TIMM22 Entrez, Source | translocase of inner mitochondrial membrane 22 homolog (yeast) | 9516 | -0.060 | -0.4559 | No |
| 50 | BZW1 | BZW1 Entrez, Source | basic leucine zipper and W2 domains 1 | 9724 | -0.066 | -0.4679 | No |
| 51 | RBBP7 | RBBP7 Entrez, Source | retinoblastoma binding protein 7 | 9796 | -0.068 | -0.4694 | No |
| 52 | CAPZA2 | CAPZA2 Entrez, Source | capping protein (actin filament) muscle Z-line, alpha 2 | 9837 | -0.069 | -0.4686 | No |
| 53 | CTSE | CTSE Entrez, Source | cathepsin E | 9910 | -0.072 | -0.4700 | No |
| 54 | NPTN | NPTN Entrez, Source | neuroplastin | 9949 | -0.073 | -0.4688 | No |
| 55 | HBA-A1 | 10079 | -0.077 | -0.4742 | No | ||
| 56 | CD53 | CD53 Entrez, Source | CD53 molecule | 10105 | -0.078 | -0.4717 | No |
| 57 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 10393 | -0.088 | -0.4885 | Yes |
| 58 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 10444 | -0.090 | -0.4872 | Yes |
| 59 | DAB2 | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 10515 | -0.092 | -0.4874 | Yes |
| 60 | DNAJA1 | DNAJA1 Entrez, Source | DnaJ (Hsp40) homolog, subfamily A, member 1 | 10557 | -0.094 | -0.4852 | Yes |
| 61 | SLC25A4 | SLC25A4 Entrez, Source | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | 10578 | -0.094 | -0.4815 | Yes |
| 62 | PCNA | PCNA Entrez, Source | proliferating cell nuclear antigen | 10651 | -0.097 | -0.4815 | Yes |
| 63 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10699 | -0.098 | -0.4795 | Yes |
| 64 | TMSB4X | TMSB4X Entrez, Source | thymosin, beta 4, X-linked | 10806 | -0.103 | -0.4818 | Yes |
| 65 | CSRP1 | CSRP1 Entrez, Source | cysteine and glycine-rich protein 1 | 10850 | -0.105 | -0.4792 | Yes |
| 66 | SMAD1 | SMAD1 Entrez, Source | SMAD, mothers against DPP homolog 1 (Drosophila) | 10869 | -0.105 | -0.4746 | Yes |
| 67 | SEPT2 | SEPT2 Entrez, Source | septin 2 | 10902 | -0.107 | -0.4711 | Yes |
| 68 | CTSZ | CTSZ Entrez, Source | cathepsin Z | 10924 | -0.108 | -0.4666 | Yes |
| 69 | UGDH | UGDH Entrez, Source | UDP-glucose dehydrogenase | 11033 | -0.113 | -0.4684 | Yes |
| 70 | ITM2B | ITM2B Entrez, Source | integral membrane protein 2B | 11047 | -0.114 | -0.4630 | Yes |
| 71 | CNN3 | CNN3 Entrez, Source | calponin 3, acidic | 11257 | -0.124 | -0.4719 | Yes |
| 72 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 11298 | -0.126 | -0.4678 | Yes |
| 73 | SS18 | SS18 Entrez, Source | synovial sarcoma translocation, chromosome 18 | 11353 | -0.129 | -0.4647 | Yes |
| 74 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 11366 | -0.129 | -0.4584 | Yes |
| 75 | CD47 | CD47 Entrez, Source | CD47 molecule | 11473 | -0.136 | -0.4588 | Yes |
| 76 | GNB1 | GNB1 Entrez, Source | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 11595 | -0.143 | -0.4599 | Yes |
| 77 | CALM2 | CALM2 Entrez, Source | calmodulin 2 (phosphorylase kinase, delta) | 11648 | -0.147 | -0.4557 | Yes |
| 78 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 11744 | -0.152 | -0.4544 | Yes |
| 79 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 11783 | -0.155 | -0.4485 | Yes |
| 80 | LAPTM4A | LAPTM4A Entrez, Source | lysosomal-associated protein transmembrane 4 alpha | 11897 | -0.165 | -0.4478 | Yes |
| 81 | NFIB | NFIB Entrez, Source | nuclear factor I/B | 12064 | -0.179 | -0.4504 | Yes |
| 82 | LGALS1 | LGALS1 Entrez, Source | lectin, galactoside-binding, soluble, 1 (galectin 1) | 12094 | -0.181 | -0.4425 | Yes |
| 83 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 12100 | -0.181 | -0.4327 | Yes |
| 84 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12216 | -0.193 | -0.4306 | Yes |
| 85 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12275 | -0.202 | -0.4237 | Yes |
| 86 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12307 | -0.205 | -0.4145 | Yes |
| 87 | LCP1 | LCP1 Entrez, Source | lymphocyte cytosolic protein 1 (L-plastin) | 12308 | -0.205 | -0.4031 | Yes |
| 88 | LMNA | LMNA Entrez, Source | lamin A/C | 12337 | -0.209 | -0.3935 | Yes |
| 89 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 12405 | -0.215 | -0.3865 | Yes |
| 90 | S100A10 | S100A10 Entrez, Source | S100 calcium binding protein A10 | 12432 | -0.219 | -0.3763 | Yes |
| 91 | S100A11 | S100A11 Entrez, Source | S100 calcium binding protein A11 | 12634 | -0.251 | -0.3774 | Yes |
| 92 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 12725 | -0.270 | -0.3691 | Yes |
| 93 | ANXA3 | ANXA3 Entrez, Source | annexin A3 | 12750 | -0.275 | -0.3555 | Yes |
| 94 | COL5A2 | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 12760 | -0.277 | -0.3407 | Yes |
| 95 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 12818 | -0.293 | -0.3287 | Yes |
| 96 | S100A6 | S100A6 Entrez, Source | S100 calcium binding protein A6 | 12854 | -0.305 | -0.3143 | Yes |
| 97 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12902 | -0.323 | -0.2997 | Yes |
| 98 | TUBB | TUBB Entrez, Source | tubulin, beta | 12961 | -0.344 | -0.2849 | Yes |
| 99 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 13000 | -0.365 | -0.2674 | Yes |
| 100 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13016 | -0.374 | -0.2476 | Yes |
| 101 | MCM7 | MCM7 Entrez, Source | MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) | 13028 | -0.381 | -0.2271 | Yes |
| 102 | SERPINB6A | 13179 | -0.524 | -0.2092 | Yes | ||
| 103 | ANGPTL2 | ANGPTL2 Entrez, Source | angiopoietin-like 2 | 13205 | -0.574 | -0.1789 | Yes |
| 104 | SERPINH1 | SERPINH1 Entrez, Source | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 13222 | -0.606 | -0.1463 | Yes |
| 105 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 13269 | -0.760 | -0.1072 | Yes |
| 106 | KITLG | KITLG Entrez, Source | KIT ligand | 13294 | -0.868 | -0.0605 | Yes |
| 107 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13327 | -1.146 | 0.0011 | Yes |
