Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | IRITANI_ADPROX_VASC |
| Enrichment Score (ES) | -0.5768416 |
| Normalized Enrichment Score (NES) | -2.049658 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004864142 |
| FWER p-Value | 0.051 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 309 | 0.392 | -0.0004 | No |
| 2 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 724 | 0.234 | -0.0180 | No |
| 3 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 818 | 0.218 | -0.0122 | No |
| 4 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 1058 | 0.187 | -0.0193 | No |
| 5 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 1217 | 0.169 | -0.0214 | No |
| 6 | SELP | SELP Entrez, Source | selectin P (granule membrane protein 140kDa, antigen CD62) | 1408 | 0.156 | -0.0266 | No |
| 7 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 1653 | 0.140 | -0.0368 | No |
| 8 | MT1A | MT1A Entrez, Source | metallothionein 1A (functional) | 1658 | 0.139 | -0.0290 | No |
| 9 | PROCR | PROCR Entrez, Source | protein C receptor, endothelial (EPCR) | 1750 | 0.134 | -0.0280 | No |
| 10 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 1835 | 0.129 | -0.0268 | No |
| 11 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1938 | 0.125 | -0.0272 | No |
| 12 | TXNRD2 | TXNRD2 Entrez, Source | thioredoxin reductase 2 | 2200 | 0.114 | -0.0402 | No |
| 13 | CDH2 | CDH2 Entrez, Source | cadherin 2, type 1, N-cadherin (neuronal) | 2409 | 0.106 | -0.0497 | No |
| 14 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 2530 | 0.102 | -0.0528 | No |
| 15 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 2563 | 0.101 | -0.0493 | No |
| 16 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 2627 | 0.098 | -0.0483 | No |
| 17 | NRCAM | NRCAM Entrez, Source | neuronal cell adhesion molecule | 3263 | 0.077 | -0.0918 | No |
| 18 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 3320 | 0.076 | -0.0916 | No |
| 19 | IER3 | IER3 Entrez, Source | immediate early response 3 | 3649 | 0.068 | -0.1124 | No |
| 20 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3759 | 0.065 | -0.1168 | No |
| 21 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 3774 | 0.065 | -0.1141 | No |
| 22 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 3872 | 0.063 | -0.1177 | No |
| 23 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 3998 | 0.059 | -0.1237 | No |
| 24 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 4003 | 0.059 | -0.1205 | No |
| 25 | UPP1 | UPP1 Entrez, Source | uridine phosphorylase 1 | 4021 | 0.059 | -0.1184 | No |
| 26 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 4433 | 0.050 | -0.1465 | No |
| 27 | IL4R | IL4R Entrez, Source | interleukin 4 receptor | 4588 | 0.047 | -0.1554 | No |
| 28 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 4680 | 0.044 | -0.1597 | No |
| 29 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 4898 | 0.040 | -0.1737 | No |
| 30 | MAPKAPK3 | MAPKAPK3 Entrez, Source | mitogen-activated protein kinase-activated protein kinase 3 | 5140 | 0.035 | -0.1898 | No |
| 31 | CXCR4 | CXCR4 Entrez, Source | chemokine (C-X-C motif) receptor 4 | 5204 | 0.034 | -0.1926 | No |
| 32 | LPXN | LPXN Entrez, Source | leupaxin | 5312 | 0.032 | -0.1988 | No |
| 33 | SORD | SORD Entrez, Source | sorbitol dehydrogenase | 5456 | 0.029 | -0.2079 | No |
| 34 | LYL1 | LYL1 Entrez, Source | lymphoblastic leukemia derived sequence 1 | 5624 | 0.025 | -0.2191 | No |
| 35 | CTSC | CTSC Entrez, Source | cathepsin C | 6008 | 0.018 | -0.2469 | No |
| 36 | ANPEP | ANPEP Entrez, Source | alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) | 6255 | 0.013 | -0.2648 | No |
| 37 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6279 | 0.012 | -0.2658 | No |
| 38 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 6727 | 0.004 | -0.2993 | No |
| 39 | PFN2 | PFN2 Entrez, Source | profilin 2 | 6745 | 0.003 | -0.3004 | No |
| 40 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 7160 | -0.005 | -0.3314 | No |
| 41 | MVP | MVP Entrez, Source | major vault protein | 7452 | -0.011 | -0.3527 | No |
| 42 | LTBP2 | LTBP2 Entrez, Source | latent transforming growth factor beta binding protein 2 | 7613 | -0.015 | -0.3639 | No |
| 43 | ICAM2 | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 7636 | -0.015 | -0.3647 | No |
| 44 | SLC38A6 | SLC38A6 Entrez, Source | solute carrier family 38, member 6 | 7813 | -0.019 | -0.3768 | No |
| 45 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 7842 | -0.020 | -0.3778 | No |
| 46 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 7865 | -0.020 | -0.3783 | No |
| 47 | SLC1A1 | SLC1A1 Entrez, Source | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 8024 | -0.024 | -0.3888 | No |
| 48 | TFEC | TFEC Entrez, Source | transcription factor EC | 8147 | -0.026 | -0.3965 | No |
| 49 | EIF2B2 | EIF2B2 Entrez, Source | eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa | 8183 | -0.027 | -0.3975 | No |
| 50 | FAP | FAP Entrez, Source | fibroblast activation protein, alpha | 8649 | -0.038 | -0.4304 | No |
| 51 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9083 | -0.048 | -0.4603 | No |
| 52 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 9375 | -0.057 | -0.4790 | No |
| 53 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9515 | -0.060 | -0.4860 | No |
| 54 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 9527 | -0.061 | -0.4832 | No |
| 55 | JUN | JUN Entrez, Source | jun oncogene | 9748 | -0.066 | -0.4960 | No |
| 56 | SELE | SELE Entrez, Source | selectin E (endothelial adhesion molecule 1) | 9951 | -0.073 | -0.5069 | No |
| 57 | RGS10 | RGS10 Entrez, Source | regulator of G-protein signalling 10 | 9975 | -0.074 | -0.5043 | No |
| 58 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 10001 | -0.075 | -0.5019 | No |
| 59 | CHST1 | CHST1 Entrez, Source | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 10469 | -0.091 | -0.5318 | No |
| 60 | LDHB | LDHB Entrez, Source | lactate dehydrogenase B | 10723 | -0.099 | -0.5451 | No |
| 61 | BGN | BGN Entrez, Source | biglycan | 10918 | -0.108 | -0.5534 | No |
| 62 | PDLIM4 | PDLIM4 Entrez, Source | PDZ and LIM domain 4 | 11133 | -0.119 | -0.5627 | No |
| 63 | NMT2 | NMT2 Entrez, Source | N-myristoyltransferase 2 | 11274 | -0.125 | -0.5659 | No |
| 64 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 11420 | -0.132 | -0.5691 | Yes |
| 65 | SRPX | SRPX Entrez, Source | sushi-repeat-containing protein, X-linked | 11499 | -0.137 | -0.5670 | Yes |
| 66 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11527 | -0.139 | -0.5609 | Yes |
| 67 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 11599 | -0.144 | -0.5578 | Yes |
| 68 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 11683 | -0.149 | -0.5554 | Yes |
| 69 | CLU | CLU Entrez, Source | clusterin | 11779 | -0.155 | -0.5535 | Yes |
| 70 | TCN2 | TCN2 Entrez, Source | transcobalamin II; macrocytic anemia | 11922 | -0.167 | -0.5544 | Yes |
| 71 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.5615 | Yes |
| 72 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 12177 | -0.189 | -0.5514 | Yes |
| 73 | SLC3A2 | SLC3A2 Entrez, Source | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 12198 | -0.191 | -0.5418 | Yes |
| 74 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12216 | -0.193 | -0.5317 | Yes |
| 75 | ANXA6 | ANXA6 Entrez, Source | annexin A6 | 12248 | -0.199 | -0.5224 | Yes |
| 76 | ARL6IP5 | ARL6IP5 Entrez, Source | ADP-ribosylation-like factor 6 interacting protein 5 | 12296 | -0.204 | -0.5140 | Yes |
| 77 | PKIA | PKIA Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 12310 | -0.205 | -0.5030 | Yes |
| 78 | PRNP | PRNP Entrez, Source | prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 12376 | -0.212 | -0.4955 | Yes |
| 79 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 12594 | -0.244 | -0.4976 | Yes |
| 80 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 12640 | -0.252 | -0.4862 | Yes |
| 81 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 12662 | -0.256 | -0.4728 | Yes |
| 82 | AGRIN | AGRIN Entrez, Source | agrin | 12664 | -0.257 | -0.4579 | Yes |
| 83 | SLC6A8 | SLC6A8 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | 12677 | -0.260 | -0.4435 | Yes |
| 84 | NISCH | NISCH Entrez, Source | nischarin | 12686 | -0.261 | -0.4288 | Yes |
| 85 | MLLT11 | MLLT11 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 12710 | -0.266 | -0.4150 | Yes |
| 86 | ANXA3 | ANXA3 Entrez, Source | annexin A3 | 12750 | -0.275 | -0.4018 | Yes |
| 87 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 12773 | -0.279 | -0.3871 | Yes |
| 88 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 12818 | -0.293 | -0.3733 | Yes |
| 89 | PLA2G4A | PLA2G4A Entrez, Source | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 12946 | -0.338 | -0.3631 | Yes |
| 90 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 12998 | -0.364 | -0.3457 | Yes |
| 91 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 13007 | -0.369 | -0.3247 | Yes |
| 92 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 13018 | -0.375 | -0.3034 | Yes |
| 93 | UCHL1 | UCHL1 Entrez, Source | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 13032 | -0.382 | -0.2820 | Yes |
| 94 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 13171 | -0.510 | -0.2626 | Yes |
| 95 | FHL2 | FHL2 Entrez, Source | four and a half LIM domains 2 | 13196 | -0.560 | -0.2316 | Yes |
| 96 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13197 | -0.560 | -0.1989 | Yes |
| 97 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 13219 | -0.601 | -0.1653 | Yes |
| 98 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 13233 | -0.633 | -0.1292 | Yes |
| 99 | TAGLN | TAGLN Entrez, Source | transgelin | 13326 | -1.131 | -0.0699 | Yes |
| 100 | GBP2 | GBP2 Entrez, Source | guanylate binding protein 2, interferon-inducible | 13329 | -1.214 | 0.0010 | Yes |
