Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | IRS1_KO_ADIP_DN |
| Enrichment Score (ES) | -0.47678134 |
| Normalized Enrichment Score (NES) | -1.6141411 |
| Nominal p-value | 0.009920635 |
| FDR q-value | 0.111496165 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PPAP2B | PPAP2B Entrez, Source | phosphatidic acid phosphatase type 2B | 205 | 0.467 | 0.0236 | No |
| 2 | FAH | FAH Entrez, Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 277 | 0.416 | 0.0531 | No |
| 3 | CD40 | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 586 | 0.271 | 0.0526 | No |
| 4 | RAB9 | RAB9 Entrez, Source | RAB9, member RAS oncogene family | 678 | 0.245 | 0.0662 | No |
| 5 | LIFR | LIFR Entrez, Source | leukemia inhibitory factor receptor alpha | 966 | 0.198 | 0.0611 | No |
| 6 | IL6ST | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 1026 | 0.189 | 0.0725 | No |
| 7 | ITPR1 | ITPR1 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 1 | 1073 | 0.185 | 0.0845 | No |
| 8 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 1217 | 0.169 | 0.0879 | No |
| 9 | GSTT1 | GSTT1 Entrez, Source | glutathione S-transferase theta 1 | 1394 | 0.157 | 0.0878 | No |
| 10 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 1598 | 0.143 | 0.0845 | No |
| 11 | TNNC1 | TNNC1 Entrez, Source | troponin C type 1 (slow) | 1752 | 0.134 | 0.0842 | No |
| 12 | DHRS8 | DHRS8 Entrez, Source | dehydrogenase/reductase (SDR family) member 8 | 1831 | 0.130 | 0.0891 | No |
| 13 | TNNT3 | TNNT3 Entrez, Source | troponin T type 3 (skeletal, fast) | 2118 | 0.117 | 0.0774 | No |
| 14 | GHITM | GHITM Entrez, Source | growth hormone inducible transmembrane protein | 2466 | 0.104 | 0.0600 | No |
| 15 | RAB14 | RAB14 Entrez, Source | RAB14, member RAS oncogene family | 2668 | 0.097 | 0.0529 | No |
| 16 | MAOA | MAOA Entrez, Source | monoamine oxidase A | 2802 | 0.091 | 0.0505 | No |
| 17 | HSBP1 | HSBP1 Entrez, Source | heat shock factor binding protein 1 | 3189 | 0.079 | 0.0281 | No |
| 18 | PIP5K1B | PIP5K1B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type I, beta | 3286 | 0.076 | 0.0272 | No |
| 19 | TSPAN31 | TSPAN31 Entrez, Source | tetraspanin 31 | 3955 | 0.061 | -0.0180 | No |
| 20 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 4526 | 0.048 | -0.0569 | No |
| 21 | TNNT2 | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 4572 | 0.047 | -0.0564 | No |
| 22 | EDG2 | EDG2 Entrez, Source | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 | 4894 | 0.040 | -0.0772 | No |
| 23 | LITAF | LITAF Entrez, Source | lipopolysaccharide-induced TNF factor | 4957 | 0.039 | -0.0787 | No |
| 24 | GPR37L1 | GPR37L1 Entrez, Source | G protein-coupled receptor 37 like 1 | 5017 | 0.038 | -0.0800 | No |
| 25 | TNNI1 | TNNI1 Entrez, Source | troponin I type 1 (skeletal, slow) | 5503 | 0.028 | -0.1142 | No |
| 26 | RAB3B | RAB3B Entrez, Source | RAB3B, member RAS oncogene family | 5758 | 0.023 | -0.1314 | No |
| 27 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 5893 | 0.020 | -0.1398 | No |
| 28 | THRA | THRA Entrez, Source | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | 5968 | 0.019 | -0.1438 | No |
| 29 | PAX3 | PAX3 Entrez, Source | paired box gene 3 (Waardenburg syndrome 1) | 6318 | 0.012 | -0.1691 | No |
| 30 | CAPN6 | CAPN6 Entrez, Source | calpain 6 | 7052 | -0.003 | -0.2240 | No |
| 31 | SFRP2 | SFRP2 Entrez, Source | secreted frizzled-related protein 2 | 7256 | -0.008 | -0.2387 | No |
| 32 | FMO1 | FMO1 Entrez, Source | flavin containing monooxygenase 1 | 7782 | -0.018 | -0.2767 | No |
| 33 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 8061 | -0.025 | -0.2956 | No |
| 34 | CARHSP1 | CARHSP1 Entrez, Source | calcium regulated heat stable protein 1, 24kDa | 8179 | -0.027 | -0.3021 | No |
| 35 | CDKN2C | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 8322 | -0.030 | -0.3103 | No |
| 36 | RBM10 | RBM10 Entrez, Source | RNA binding motif protein 10 | 9580 | -0.062 | -0.3998 | No |
| 37 | SIX1 | SIX1 Entrez, Source | sine oculis homeobox homolog 1 (Drosophila) | 9691 | -0.065 | -0.4026 | No |
| 38 | ACTC1 | ACTC1 Entrez, Source | actin, alpha, cardiac muscle 1 | 9699 | -0.065 | -0.3977 | No |
| 39 | EPHX1 | EPHX1 Entrez, Source | epoxide hydrolase 1, microsomal (xenobiotic) | 9718 | -0.066 | -0.3936 | No |
| 40 | ENPP1 | ENPP1 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 9921 | -0.072 | -0.4027 | No |
| 41 | MESDC2 | MESDC2 Entrez, Source | mesoderm development candidate 2 | 10392 | -0.088 | -0.4308 | No |
| 42 | DAB2 | DAB2 Entrez, Source | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 10515 | -0.092 | -0.4323 | No |
| 43 | MRFAP1 | MRFAP1 Entrez, Source | Mof4 family associated protein 1 | 10516 | -0.092 | -0.4246 | No |
| 44 | CNDP2 | CNDP2 Entrez, Source | CNDP dipeptidase 2 (metallopeptidase M20 family) | 10733 | -0.100 | -0.4325 | No |
| 45 | ADARB1 | ADARB1 Entrez, Source | adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) | 11216 | -0.122 | -0.4586 | No |
| 46 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 11390 | -0.131 | -0.4607 | Yes |
| 47 | TLE3 | TLE3 Entrez, Source | transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) | 11492 | -0.137 | -0.4569 | Yes |
| 48 | CD63 | CD63 Entrez, Source | CD63 molecule | 11668 | -0.148 | -0.4577 | Yes |
| 49 | NFYB | NFYB Entrez, Source | nuclear transcription factor Y, beta | 11751 | -0.152 | -0.4511 | Yes |
| 50 | SMAD6 | SMAD6 Entrez, Source | SMAD, mothers against DPP homolog 6 (Drosophila) | 12050 | -0.177 | -0.4587 | Yes |
| 51 | THBD | THBD Entrez, Source | thrombomodulin | 12150 | -0.186 | -0.4506 | Yes |
| 52 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 12499 | -0.229 | -0.4576 | Yes |
| 53 | CAND1 | CAND1 Entrez, Source | cullin-associated and neddylation-dissociated 1 | 12642 | -0.252 | -0.4473 | Yes |
| 54 | ADM | ADM Entrez, Source | adrenomedullin | 12796 | -0.285 | -0.4350 | Yes |
| 55 | IL1R1 | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 12840 | -0.300 | -0.4131 | Yes |
| 56 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 13000 | -0.365 | -0.3946 | Yes |
| 57 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 13018 | -0.375 | -0.3645 | Yes |
| 58 | CIRBP | CIRBP Entrez, Source | cold inducible RNA binding protein | 13049 | -0.397 | -0.3336 | Yes |
| 59 | EPHB6 | EPHB6 Entrez, Source | EPH receptor B6 | 13050 | -0.399 | -0.3002 | Yes |
| 60 | TSPAN6 | TSPAN6 Entrez, Source | tetraspanin 6 | 13052 | -0.400 | -0.2668 | Yes |
| 61 | SMS | SMS Entrez, Source | spermine synthase | 13083 | -0.414 | -0.2344 | Yes |
| 62 | RAMP2 | RAMP2 Entrez, Source | receptor (calcitonin) activity modifying protein 2 | 13129 | -0.450 | -0.2002 | Yes |
| 63 | CASP2 | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 13202 | -0.565 | -0.1583 | Yes |
| 64 | CRIP2 | CRIP2 Entrez, Source | cysteine-rich protein 2 | 13214 | -0.582 | -0.1105 | Yes |
| 65 | TSC22D1 | TSC22D1 Entrez, Source | TSC22 domain family, member 1 | 13246 | -0.674 | -0.0565 | Yes |
| 66 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 13269 | -0.760 | 0.0055 | Yes |
