Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | LIGASE_ACTIVITY |
| Enrichment Score (ES) | 0.51671827 |
| Normalized Enrichment Score (NES) | 1.6575543 |
| Nominal p-value | 0.0062761507 |
| FDR q-value | 0.04638983 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PC | PC Entrez, Source | pyruvate carboxylase | 79 | 0.652 | 0.1091 | Yes |
| 2 | CPS1 | CPS1 Entrez, Source | carbamoyl-phosphate synthetase 1, mitochondrial | 91 | 0.631 | 0.2197 | Yes |
| 3 | ACACA | ACACA Entrez, Source | acetyl-Coenzyme A carboxylase alpha | 154 | 0.527 | 0.3080 | Yes |
| 4 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 335 | 0.375 | 0.3606 | Yes |
| 5 | SLC27A5 | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 392 | 0.341 | 0.4166 | Yes |
| 6 | BTD | BTD Entrez, Source | biotinidase | 768 | 0.225 | 0.4280 | Yes |
| 7 | MTHFD1 | MTHFD1 Entrez, Source | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 1050 | 0.187 | 0.4399 | Yes |
| 8 | WWP1 | WWP1 Entrez, Source | WW domain containing E3 ubiquitin protein ligase 1 | 1206 | 0.170 | 0.4582 | Yes |
| 9 | YARS | YARS Entrez, Source | tyrosyl-tRNA synthetase | 1355 | 0.160 | 0.4754 | Yes |
| 10 | ACSL4 | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 1566 | 0.144 | 0.4851 | Yes |
| 11 | PCCB | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 1620 | 0.142 | 0.5061 | Yes |
| 12 | UBE2L6 | UBE2L6 Entrez, Source | ubiquitin-conjugating enzyme E2L 6 | 1789 | 0.132 | 0.5167 | Yes |
| 13 | ASNS | ASNS Entrez, Source | asparagine synthetase | 2424 | 0.106 | 0.4877 | No |
| 14 | RNF14 | RNF14 Entrez, Source | ring finger protein 14 | 2739 | 0.094 | 0.4807 | No |
| 15 | GSS | GSS Entrez, Source | glutathione synthetase | 3596 | 0.069 | 0.4285 | No |
| 16 | FBXO22 | FBXO22 Entrez, Source | F-box protein 22 | 3823 | 0.063 | 0.4227 | No |
| 17 | UBE2D2 | UBE2D2 Entrez, Source | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | 3892 | 0.062 | 0.4285 | No |
| 18 | FBXO7 | FBXO7 Entrez, Source | F-box protein 7 | 4032 | 0.059 | 0.4284 | No |
| 19 | SYVN1 | SYVN1 Entrez, Source | synovial apoptosis inhibitor 1, synoviolin | 4157 | 0.056 | 0.4290 | No |
| 20 | PARK2 | PARK2 Entrez, Source | Parkinson disease (autosomal recessive, juvenile) 2, parkin | 4568 | 0.047 | 0.4064 | No |
| 21 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 5294 | 0.032 | 0.3576 | No |
| 22 | GARS | GARS Entrez, Source | glycyl-tRNA synthetase | 5484 | 0.028 | 0.3483 | No |
| 23 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 5560 | 0.026 | 0.3473 | No |
| 24 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 6042 | 0.017 | 0.3142 | No |
| 25 | FARS2 | FARS2 Entrez, Source | phenylalanine-tRNA synthetase 2 (mitochondrial) | 6420 | 0.009 | 0.2875 | No |
| 26 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 6525 | 0.007 | 0.2810 | No |
| 27 | CTPS2 | CTPS2 Entrez, Source | CTP synthase II | 7130 | -0.005 | 0.2364 | No |
| 28 | XRCC4 | XRCC4 Entrez, Source | X-ray repair complementing defective repair in Chinese hamster cells 4 | 7672 | -0.016 | 0.1985 | No |
| 29 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 7757 | -0.018 | 0.1954 | No |
| 30 | NARS | NARS Entrez, Source | asparaginyl-tRNA synthetase | 8055 | -0.025 | 0.1774 | No |
| 31 | GCLM | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 8939 | -0.045 | 0.1188 | No |
| 32 | KARS | KARS Entrez, Source | lysyl-tRNA synthetase | 9206 | -0.051 | 0.1079 | No |
| 33 | ARIH1 | ARIH1 Entrez, Source | ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) | 9421 | -0.058 | 0.1020 | No |
| 34 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 9754 | -0.067 | 0.0888 | No |
| 35 | FBXL6 | FBXL6 Entrez, Source | F-box and leucine-rich repeat protein 6 | 9793 | -0.068 | 0.0979 | No |
| 36 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 9814 | -0.069 | 0.1085 | No |
| 37 | FBXO2 | FBXO2 Entrez, Source | F-box protein 2 | 9970 | -0.074 | 0.1098 | No |
| 38 | PAICS | PAICS Entrez, Source | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 10338 | -0.086 | 0.0974 | No |
| 39 | GMPS | GMPS Entrez, Source | guanine monphosphate synthetase | 10477 | -0.091 | 0.1031 | No |
| 40 | TRIM23 | TRIM23 Entrez, Source | tripartite motif-containing 23 | 10865 | -0.105 | 0.0926 | No |
| 41 | RTCD1 | RTCD1 Entrez, Source | RNA terminal phosphate cyclase domain 1 | 11561 | -0.141 | 0.0652 | No |
| 42 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 12182 | -0.190 | 0.0520 | No |
| 43 | ANAPC2 | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 12258 | -0.199 | 0.0815 | No |
