Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | LIPID_BIOSYNTHETIC_PROCESS |
| Enrichment Score (ES) | 0.59297866 |
| Normalized Enrichment Score (NES) | 1.9818258 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.002072828 |
| FWER p-Value | 0.168 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PEMT | PEMT Entrez, Source | phosphatidylethanolamine N-methyltransferase | 26 | 0.861 | 0.0801 | Yes |
| 2 | LCAT | LCAT Entrez, Source | lecithin-cholesterol acyltransferase | 76 | 0.677 | 0.1410 | Yes |
| 3 | FADS2 | FADS2 Entrez, Source | fatty acid desaturase 2 | 98 | 0.617 | 0.1982 | Yes |
| 4 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 110 | 0.603 | 0.2548 | Yes |
| 5 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 282 | 0.412 | 0.2812 | Yes |
| 6 | HSD3B1 | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 293 | 0.402 | 0.3187 | Yes |
| 7 | CHPT1 | CHPT1 Entrez, Source | choline phosphotransferase 1 | 302 | 0.396 | 0.3558 | Yes |
| 8 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 315 | 0.386 | 0.3917 | Yes |
| 9 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 333 | 0.375 | 0.4262 | Yes |
| 10 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 401 | 0.338 | 0.4534 | Yes |
| 11 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 482 | 0.309 | 0.4768 | Yes |
| 12 | SCP2 | SCP2 Entrez, Source | sterol carrier protein 2 | 624 | 0.260 | 0.4909 | Yes |
| 13 | PCYT2 | PCYT2 Entrez, Source | phosphate cytidylyltransferase 2, ethanolamine | 625 | 0.260 | 0.5157 | Yes |
| 14 | DGAT2 | DGAT2 Entrez, Source | diacylglycerol O-acyltransferase homolog 2 (mouse) | 627 | 0.259 | 0.5403 | Yes |
| 15 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 656 | 0.251 | 0.5622 | Yes |
| 16 | PEX7 | PEX7 Entrez, Source | peroxisomal biogenesis factor 7 | 738 | 0.230 | 0.5780 | Yes |
| 17 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 829 | 0.216 | 0.5919 | Yes |
| 18 | APOA1 | APOA1 Entrez, Source | apolipoprotein A-I | 1052 | 0.187 | 0.5930 | Yes |
| 19 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 1653 | 0.140 | 0.5611 | No |
| 20 | MIF | MIF Entrez, Source | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 2352 | 0.108 | 0.5189 | No |
| 21 | HPGD | HPGD Entrez, Source | hydroxyprostaglandin dehydrogenase 15-(NAD) | 2832 | 0.090 | 0.4915 | No |
| 22 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 2909 | 0.088 | 0.4942 | No |
| 23 | PIGC | PIGC Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class C | 3012 | 0.084 | 0.4945 | No |
| 24 | PIGK | PIGK Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class K | 3142 | 0.080 | 0.4925 | No |
| 25 | PI4K2A | 3350 | 0.075 | 0.4840 | No | ||
| 26 | ST6GALNAC6 | ST6GALNAC6 Entrez, Source | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | 3421 | 0.073 | 0.4857 | No |
| 27 | ST8SIA5 | ST8SIA5 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 | 4440 | 0.050 | 0.4139 | No |
| 28 | NR0B1 | NR0B1 Entrez, Source | nuclear receptor subfamily 0, group B, member 1 | 4557 | 0.047 | 0.4096 | No |
| 29 | PTGDS | PTGDS Entrez, Source | prostaglandin D2 synthase 21kDa (brain) | 5784 | 0.022 | 0.3195 | No |
| 30 | PTGS1 | PTGS1 Entrez, Source | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 6103 | 0.016 | 0.2971 | No |
| 31 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 6111 | 0.016 | 0.2981 | No |
| 32 | PIGS | PIGS Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class S | 7220 | -0.007 | 0.2153 | No |
| 33 | CYP7B1 | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 7432 | -0.011 | 0.2005 | No |
| 34 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7856 | -0.020 | 0.1706 | No |
| 35 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 7908 | -0.021 | 0.1688 | No |
| 36 | DPM2 | DPM2 Entrez, Source | dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit | 8278 | -0.029 | 0.1438 | No |
| 37 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 8334 | -0.031 | 0.1426 | No |
| 38 | ST8SIA1 | ST8SIA1 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 | 8578 | -0.036 | 0.1278 | No |
| 39 | IMPA1 | IMPA1 Entrez, Source | inositol(myo)-1(or 4)-monophosphatase 1 | 9105 | -0.049 | 0.0928 | No |
| 40 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 9302 | -0.054 | 0.0833 | No |
| 41 | AGPS | AGPS Entrez, Source | alkylglycerone phosphate synthase | 9442 | -0.058 | 0.0784 | No |
| 42 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 10024 | -0.075 | 0.0418 | No |
| 43 | AGPAT1 | AGPAT1 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) | 10638 | -0.097 | 0.0049 | No |
| 44 | CD81 | CD81 Entrez, Source | CD81 molecule | 10933 | -0.108 | -0.0069 | No |
| 45 | CD74 | CD74 Entrez, Source | CD74 molecule, major histocompatibility complex, class II invariant chain | 10944 | -0.109 | 0.0027 | No |
| 46 | PCYT1B | PCYT1B Entrez, Source | phosphate cytidylyltransferase 1, choline, beta | 11101 | -0.117 | 0.0021 | No |
| 47 | AGPAT6 | AGPAT6 Entrez, Source | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) | 11302 | -0.127 | -0.0009 | No |
| 48 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11523 | -0.139 | -0.0042 | No |
| 49 | CYP11A1 | CYP11A1 Entrez, Source | cytochrome P450, family 11, subfamily A, polypeptide 1 | 11705 | -0.150 | -0.0036 | No |
| 50 | PIGV | PIGV Entrez, Source | phosphatidylinositol glycan anchor biosynthesis, class V | 11904 | -0.166 | -0.0027 | No |
| 51 | ST8SIA3 | ST8SIA3 Entrez, Source | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 | 11933 | -0.167 | 0.0112 | No |
| 52 | LTA4H | LTA4H Entrez, Source | leukotriene A4 hydrolase | 12246 | -0.198 | 0.0066 | No |
| 53 | PLCE1 | PLCE1 Entrez, Source | phospholipase C, epsilon 1 | 12575 | -0.239 | 0.0047 | No |
| 54 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 12723 | -0.270 | 0.0194 | No |
| 55 | ADM | ADM Entrez, Source | adrenomedullin | 12796 | -0.285 | 0.0411 | No |
