Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | LYASE_ACTIVITY |
| Enrichment Score (ES) | 0.56484306 |
| Normalized Enrichment Score (NES) | 1.8946344 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0058299946 |
| FWER p-Value | 0.488 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | EHHADH | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 24 | 0.864 | 0.0750 | Yes |
| 2 | GUCY2C | GUCY2C Entrez, Source | guanylate cyclase 2C (heat stable enterotoxin receptor) | 115 | 0.593 | 0.1208 | Yes |
| 3 | ASL | ASL Entrez, Source | argininosuccinate lyase | 122 | 0.586 | 0.1724 | Yes |
| 4 | CBS | CBS Entrez, Source | cystathionine-beta-synthase | 158 | 0.523 | 0.2162 | Yes |
| 5 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 167 | 0.505 | 0.2605 | Yes |
| 6 | HACL1 | HACL1 Entrez, Source | 2-hydroxyacyl-CoA lyase 1 | 177 | 0.496 | 0.3039 | Yes |
| 7 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 260 | 0.427 | 0.3356 | Yes |
| 8 | ACMSD | ACMSD Entrez, Source | aminocarboxymuconate semialdehyde decarboxylase | 269 | 0.420 | 0.3723 | Yes |
| 9 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 271 | 0.419 | 0.4094 | Yes |
| 10 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 328 | 0.380 | 0.4390 | Yes |
| 11 | BCKDHA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 389 | 0.344 | 0.4650 | Yes |
| 12 | MLYCD | MLYCD Entrez, Source | malonyl-CoA decarboxylase | 584 | 0.271 | 0.4745 | Yes |
| 13 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 666 | 0.249 | 0.4905 | Yes |
| 14 | CRYM | CRYM Entrez, Source | crystallin, mu | 945 | 0.201 | 0.4874 | Yes |
| 15 | ALDOC | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 1047 | 0.187 | 0.4964 | Yes |
| 16 | ODC1 | ODC1 Entrez, Source | ornithine decarboxylase 1 | 1205 | 0.170 | 0.4997 | Yes |
| 17 | SDS | SDS Entrez, Source | serine dehydratase | 1222 | 0.169 | 0.5135 | Yes |
| 18 | HDC | HDC Entrez, Source | histidine decarboxylase | 1256 | 0.167 | 0.5258 | Yes |
| 19 | SCLY | SCLY Entrez, Source | selenocysteine lyase | 1345 | 0.161 | 0.5335 | Yes |
| 20 | HADHA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 1399 | 0.157 | 0.5435 | Yes |
| 21 | ALAD | ALAD Entrez, Source | aminolevulinate, delta-, dehydratase | 1424 | 0.155 | 0.5555 | Yes |
| 22 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 1608 | 0.143 | 0.5544 | Yes |
| 23 | HADHB | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 1747 | 0.134 | 0.5559 | Yes |
| 24 | PTS | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 1785 | 0.132 | 0.5648 | Yes |
| 25 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 2294 | 0.111 | 0.5364 | No |
| 26 | CA4 | CA4 Entrez, Source | carbonic anhydrase IV | 2445 | 0.105 | 0.5345 | No |
| 27 | ENO2 | ENO2 Entrez, Source | enolase 2 (gamma, neuronal) | 2627 | 0.098 | 0.5296 | No |
| 28 | OGG1 | OGG1 Entrez, Source | 8-oxoguanine DNA glycosylase | 2677 | 0.096 | 0.5344 | No |
| 29 | DDC | DDC Entrez, Source | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 3130 | 0.081 | 0.5076 | No |
| 30 | GUCY1A3 | GUCY1A3 Entrez, Source | guanylate cyclase 1, soluble, alpha 3 | 3179 | 0.079 | 0.5110 | No |
| 31 | ACO1 | ACO1 Entrez, Source | aconitase 1, soluble | 3429 | 0.073 | 0.4988 | No |
| 32 | ADCY8 | ADCY8 Entrez, Source | adenylate cyclase 8 (brain) | 4447 | 0.049 | 0.4267 | No |
| 33 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 5183 | 0.034 | 0.3744 | No |
| 34 | GUCY1A2 | GUCY1A2 Entrez, Source | guanylate cyclase 1, soluble, alpha 2 | 5508 | 0.028 | 0.3525 | No |
| 35 | ENO3 | ENO3 Entrez, Source | enolase 3 (beta, muscle) | 6027 | 0.018 | 0.3151 | No |
| 36 | LTC4S | LTC4S Entrez, Source | leukotriene C4 synthase | 6566 | 0.007 | 0.2752 | No |
| 37 | UMPS | UMPS Entrez, Source | uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) | 7149 | -0.005 | 0.2319 | No |
| 38 | GUCY2D | GUCY2D Entrez, Source | guanylate cyclase 2D, membrane (retina-specific) | 7252 | -0.007 | 0.2249 | No |
| 39 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 7862 | -0.020 | 0.1808 | No |
| 40 | GUCY1B3 | GUCY1B3 Entrez, Source | guanylate cyclase 1, soluble, beta 3 | 8595 | -0.037 | 0.1290 | No |
| 41 | CA5B | CA5B Entrez, Source | carbonic anhydrase VB, mitochondrial | 8760 | -0.040 | 0.1202 | No |
| 42 | UROD | UROD Entrez, Source | uroporphyrinogen decarboxylase | 8955 | -0.045 | 0.1096 | No |
| 43 | GLO1 | GLO1 Entrez, Source | glyoxalase I | 8965 | -0.045 | 0.1130 | No |
| 44 | ADCY10 | 9150 | -0.050 | 0.1036 | No | ||
| 45 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 9745 | -0.066 | 0.0648 | No |
| 46 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 10323 | -0.086 | 0.0290 | No |
| 47 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 10674 | -0.098 | 0.0113 | No |
| 48 | GUCY2F | GUCY2F Entrez, Source | guanylate cyclase 2F, retinal | 10893 | -0.106 | 0.0043 | No |
| 49 | CA5A | CA5A Entrez, Source | carbonic anhydrase VA, mitochondrial | 12440 | -0.220 | -0.0925 | No |
| 50 | GMDS | GMDS Entrez, Source | GDP-mannose 4,6-dehydratase | 12474 | -0.224 | -0.0751 | No |
| 51 | CA3 | CA3 Entrez, Source | carbonic anhydrase III, muscle specific | 13339 | -1.580 | 0.0002 | No |
