Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | METALLOENDOPEPTIDASE_ACTIVITY |
| Enrichment Score (ES) | -0.6766075 |
| Normalized Enrichment Score (NES) | -1.7080344 |
| Nominal p-value | 0.009560229 |
| FDR q-value | 0.075137876 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SPG7 | SPG7 Entrez, Source | spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) | 1792 | 0.132 | -0.0968 | No |
| 2 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 2981 | 0.085 | -0.1615 | No |
| 3 | MMP12 | MMP12 Entrez, Source | matrix metallopeptidase 12 (macrophage elastase) | 4703 | 0.044 | -0.2781 | No |
| 4 | MMP8 | MMP8 Entrez, Source | matrix metallopeptidase 8 (neutrophil collagenase) | 6715 | 0.004 | -0.4279 | No |
| 5 | MEP1A | MEP1A Entrez, Source | meprin A, alpha (PABA peptide hydrolase) | 8086 | -0.025 | -0.5235 | No |
| 6 | FAP | FAP Entrez, Source | fibroblast activation protein, alpha | 8649 | -0.038 | -0.5549 | No |
| 7 | THOP1 | THOP1 Entrez, Source | thimet oligopeptidase 1 | 8812 | -0.041 | -0.5552 | No |
| 8 | IDE | IDE Entrez, Source | insulin-degrading enzyme | 8919 | -0.044 | -0.5506 | No |
| 9 | PMPCA | PMPCA Entrez, Source | peptidase (mitochondrial processing) alpha | 9532 | -0.061 | -0.5791 | No |
| 10 | ECE2 | ECE2 Entrez, Source | endothelin converting enzyme 2 | 9937 | -0.073 | -0.5886 | No |
| 11 | RCE1 | RCE1 Entrez, Source | RCE1 homolog, prenyl protein peptidase (S. cerevisiae) | 10475 | -0.091 | -0.6029 | No |
| 12 | MBTPS2 | MBTPS2 Entrez, Source | membrane-bound transcription factor peptidase, site 2 | 10788 | -0.102 | -0.5971 | No |
| 13 | MMP16 | MMP16 Entrez, Source | matrix metallopeptidase 16 (membrane-inserted) | 11849 | -0.160 | -0.6307 | Yes |
| 14 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 12039 | -0.176 | -0.5944 | Yes |
| 15 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 12177 | -0.189 | -0.5505 | Yes |
| 16 | MMP24 | MMP24 Entrez, Source | matrix metallopeptidase 24 (membrane-inserted) | 13076 | -0.411 | -0.5002 | Yes |
| 17 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13273 | -0.768 | -0.2951 | Yes |
| 18 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 13316 | -1.048 | 0.0020 | Yes |
