Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | METAL_ION_TRANSPORT |
| Enrichment Score (ES) | 0.4181183 |
| Normalized Enrichment Score (NES) | 1.5544785 |
| Nominal p-value | 0.008791209 |
| FDR q-value | 0.091776066 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TRPM2 | TRPM2 Entrez, Source | transient receptor potential cation channel, subfamily M, member 2 | 161 | 0.520 | 0.0463 | Yes |
| 2 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 331 | 0.377 | 0.0759 | Yes |
| 3 | NPY | NPY Entrez, Source | neuropeptide Y | 342 | 0.371 | 0.1169 | Yes |
| 4 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 500 | 0.300 | 0.1387 | Yes |
| 5 | SLC11A2 | SLC11A2 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 538 | 0.287 | 0.1683 | Yes |
| 6 | ATOX1 | ATOX1 Entrez, Source | ATX1 antioxidant protein 1 homolog (yeast) | 653 | 0.251 | 0.1879 | Yes |
| 7 | SLC17A3 | SLC17A3 Entrez, Source | solute carrier family 17 (sodium phosphate), member 3 | 687 | 0.241 | 0.2126 | Yes |
| 8 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 874 | 0.211 | 0.2222 | Yes |
| 9 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 888 | 0.209 | 0.2447 | Yes |
| 10 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 912 | 0.206 | 0.2661 | Yes |
| 11 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 1053 | 0.187 | 0.2766 | Yes |
| 12 | KCNK3 | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 1094 | 0.183 | 0.2941 | Yes |
| 13 | HFE | HFE Entrez, Source | hemochromatosis | 1164 | 0.175 | 0.3085 | Yes |
| 14 | CHP | CHP Entrez, Source | - | 1193 | 0.171 | 0.3256 | Yes |
| 15 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 1332 | 0.162 | 0.3334 | Yes |
| 16 | KCNJ11 | KCNJ11 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 11 | 1333 | 0.162 | 0.3516 | Yes |
| 17 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 1475 | 0.151 | 0.3580 | Yes |
| 18 | ATP2A3 | ATP2A3 Entrez, Source | ATPase, Ca++ transporting, ubiquitous | 1600 | 0.143 | 0.3647 | Yes |
| 19 | SLC34A3 | SLC34A3 Entrez, Source | solute carrier family 34 (sodium phosphate), member 3 | 1661 | 0.139 | 0.3758 | Yes |
| 20 | ATP1A4 | ATP1A4 Entrez, Source | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 1823 | 0.130 | 0.3783 | Yes |
| 21 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 1904 | 0.126 | 0.3864 | Yes |
| 22 | COX17 | COX17 Entrez, Source | COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) | 1921 | 0.125 | 0.3993 | Yes |
| 23 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 2034 | 0.120 | 0.4044 | Yes |
| 24 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 2201 | 0.114 | 0.4047 | Yes |
| 25 | SLC31A1 | SLC31A1 Entrez, Source | solute carrier family 31 (copper transporters), member 1 | 2237 | 0.113 | 0.4148 | Yes |
| 26 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 2449 | 0.105 | 0.4106 | Yes |
| 27 | ATP7B | ATP7B Entrez, Source | ATPase, Cu++ transporting, beta polypeptide | 2900 | 0.088 | 0.3866 | Yes |
| 28 | ATP2A1 | ATP2A1 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 2970 | 0.086 | 0.3910 | Yes |
| 29 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 3015 | 0.084 | 0.3972 | Yes |
| 30 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 3083 | 0.082 | 0.4013 | Yes |
| 31 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 3089 | 0.082 | 0.4102 | Yes |
| 32 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 3341 | 0.075 | 0.3996 | Yes |
| 33 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 3348 | 0.075 | 0.4076 | Yes |
| 34 | TRPV5 | TRPV5 Entrez, Source | transient receptor potential cation channel, subfamily V, member 5 | 3539 | 0.070 | 0.4011 | Yes |
| 35 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 3659 | 0.067 | 0.3997 | Yes |
| 36 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 3661 | 0.067 | 0.4072 | Yes |
| 37 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 3729 | 0.066 | 0.4096 | Yes |
| 38 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 3777 | 0.065 | 0.4133 | Yes |
| 39 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 3882 | 0.062 | 0.4124 | Yes |
| 40 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 3900 | 0.062 | 0.4181 | Yes |
| 41 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 4053 | 0.058 | 0.4132 | No |
| 42 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 4154 | 0.056 | 0.4120 | No |
| 43 | KCNN1 | KCNN1 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 | 4397 | 0.051 | 0.3994 | No |
| 44 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 4463 | 0.049 | 0.4000 | No |
| 45 | KCNJ2 | KCNJ2 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 2 | 4465 | 0.049 | 0.4054 | No |
| 46 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 4581 | 0.047 | 0.4020 | No |
| 47 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 4725 | 0.043 | 0.3961 | No |
| 48 | SCNN1A | SCNN1A Entrez, Source | sodium channel, nonvoltage-gated 1 alpha | 4857 | 0.041 | 0.3908 | No |
| 49 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 4885 | 0.040 | 0.3932 | No |
| 50 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 4936 | 0.039 | 0.3939 | No |
| 51 | SLN | SLN Entrez, Source | sarcolipin | 4980 | 0.038 | 0.3949 | No |
| 52 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 5106 | 0.036 | 0.3895 | No |
| 53 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 5201 | 0.034 | 0.3862 | No |
| 54 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 5251 | 0.033 | 0.3862 | No |
| 55 | ABCC9 | ABCC9 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | 5534 | 0.027 | 0.3680 | No |
| 56 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 5571 | 0.026 | 0.3682 | No |
| 57 | KCNAB3 | KCNAB3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, beta member 3 | 5639 | 0.025 | 0.3660 | No |
| 58 | SCN10A | SCN10A Entrez, Source | sodium channel, voltage-gated, type X, alpha | 5726 | 0.023 | 0.3621 | No |
| 59 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 5737 | 0.023 | 0.3639 | No |
| 60 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 5759 | 0.023 | 0.3649 | No |
| 61 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 5774 | 0.022 | 0.3663 | No |
| 62 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 5907 | 0.020 | 0.3586 | No |
| 63 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 5930 | 0.020 | 0.3592 | No |
| 64 | ABCC8 | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 6113 | 0.016 | 0.3472 | No |
| 65 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 6322 | 0.011 | 0.3328 | No |
| 66 | PLN | PLN Entrez, Source | phospholamban | 6355 | 0.011 | 0.3316 | No |
| 67 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 6533 | 0.007 | 0.3190 | No |
| 68 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 6736 | 0.004 | 0.3042 | No |
| 69 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 6910 | -0.000 | 0.2911 | No |
| 70 | NMUR2 | NMUR2 Entrez, Source | neuromedin U receptor 2 | 7018 | -0.003 | 0.2833 | No |
| 71 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 7121 | -0.004 | 0.2762 | No |
| 72 | KCNV1 | KCNV1 Entrez, Source | potassium channel, subfamily V, member 1 | 7139 | -0.005 | 0.2754 | No |
| 73 | NMUR1 | NMUR1 Entrez, Source | neuromedin U receptor 1 | 7154 | -0.005 | 0.2750 | No |
| 74 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 7175 | -0.006 | 0.2741 | No |
| 75 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 7210 | -0.006 | 0.2723 | No |
| 76 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 7275 | -0.008 | 0.2683 | No |
| 77 | CCS | CCS Entrez, Source | copper chaperone for superoxide dismutase | 7339 | -0.009 | 0.2646 | No |
| 78 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 7491 | -0.012 | 0.2546 | No |
| 79 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 7874 | -0.020 | 0.2280 | No |
| 80 | KCNAB1 | KCNAB1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | 8172 | -0.027 | 0.2086 | No |
| 81 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 8499 | -0.034 | 0.1879 | No |
| 82 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 8615 | -0.037 | 0.1834 | No |
| 83 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 8788 | -0.041 | 0.1750 | No |
| 84 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 8974 | -0.045 | 0.1661 | No |
| 85 | CSN2 | CSN2 Entrez, Source | casein beta | 9471 | -0.059 | 0.1353 | No |
| 86 | SLC8A1 | SLC8A1 Entrez, Source | solute carrier family 8 (sodium/calcium exchanger), member 1 | 9583 | -0.062 | 0.1339 | No |
| 87 | ATP7A | ATP7A Entrez, Source | ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome) | 9722 | -0.066 | 0.1309 | No |
| 88 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 10536 | -0.093 | 0.0799 | No |
| 89 | SLC31A2 | SLC31A2 Entrez, Source | solute carrier family 31 (copper transporters), member 2 | 12274 | -0.201 | -0.0285 | No |
| 90 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 12816 | -0.291 | -0.0366 | No |
| 91 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 12940 | -0.335 | -0.0081 | No |
| 92 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 12957 | -0.341 | 0.0291 | No |
