Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | MICROTUBULE_CYTOSKELETON |
| Enrichment Score (ES) | -0.64713943 |
| Normalized Enrichment Score (NES) | -2.2084064 |
| Nominal p-value | 0.0 |
| FDR q-value | 6.4394093E-4 |
| FWER p-Value | 0.0020 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | UXT | UXT Entrez, Source | ubiquitously-expressed transcript | 1225 | 0.169 | -0.0734 | No |
| 2 | ABCA2 | ABCA2 Entrez, Source | ATP-binding cassette, sub-family A (ABC1), member 2 | 2754 | 0.094 | -0.1780 | No |
| 3 | DNALI1 | DNALI1 Entrez, Source | dynein, axonemal, light intermediate chain 1 | 3330 | 0.075 | -0.2129 | No |
| 4 | DYNC1I1 | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 3708 | 0.066 | -0.2339 | No |
| 5 | NUDT21 | NUDT21 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 3927 | 0.061 | -0.2434 | No |
| 6 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 4812 | 0.042 | -0.3054 | No |
| 7 | DCX | DCX Entrez, Source | doublecortex; lissencephaly, X-linked (doublecortin) | 5004 | 0.038 | -0.3155 | No |
| 8 | ACTR1B | ACTR1B Entrez, Source | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | 5068 | 0.037 | -0.3161 | No |
| 9 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 5141 | 0.035 | -0.3176 | No |
| 10 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 5345 | 0.031 | -0.3294 | No |
| 11 | EML2 | EML2 Entrez, Source | echinoderm microtubule associated protein like 2 | 5714 | 0.023 | -0.3545 | No |
| 12 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 6709 | 0.004 | -0.4290 | No |
| 13 | ATG4B | ATG4B Entrez, Source | ATG4 autophagy related 4 homolog B (S. cerevisiae) | 6786 | 0.003 | -0.4344 | No |
| 14 | CETN3 | CETN3 Entrez, Source | centrin, EF-hand protein, 3 (CDC31 homolog, yeast) | 6856 | 0.001 | -0.4395 | No |
| 15 | TPT1 | TPT1 Entrez, Source | tumor protein, translationally-controlled 1 | 6974 | -0.002 | -0.4482 | No |
| 16 | MEFV | MEFV Entrez, Source | Mediterranean fever | 7026 | -0.003 | -0.4517 | No |
| 17 | ALS2 | ALS2 Entrez, Source | amyotrophic lateral sclerosis 2 (juvenile) | 7100 | -0.004 | -0.4568 | No |
| 18 | MAP1A | MAP1A Entrez, Source | microtubule-associated protein 1A | 7727 | -0.017 | -0.5020 | No |
| 19 | KATNA1 | KATNA1 Entrez, Source | katanin p60 (ATPase-containing) subunit A 1 | 7746 | -0.018 | -0.5014 | No |
| 20 | STAU1 | STAU1 Entrez, Source | staufen, RNA binding protein, homolog 1 (Drosophila) | 8162 | -0.027 | -0.5297 | No |
| 21 | KIF1B | KIF1B Entrez, Source | kinesin family member 1B | 8176 | -0.027 | -0.5276 | No |
| 22 | NPM1 | NPM1 Entrez, Source | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 8204 | -0.028 | -0.5265 | No |
| 23 | KIF4A | KIF4A Entrez, Source | kinesin family member 4A | 8274 | -0.029 | -0.5285 | No |
| 24 | MARK1 | MARK1 Entrez, Source | MAP/microtubule affinity-regulating kinase 1 | 8437 | -0.033 | -0.5370 | No |
| 25 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 8842 | -0.042 | -0.5627 | No |
| 26 | ZW10 | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 9627 | -0.063 | -0.6147 | No |
| 27 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 9827 | -0.069 | -0.6219 | No |
| 28 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 10026 | -0.075 | -0.6284 | No |
| 29 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 10276 | -0.084 | -0.6377 | Yes |
| 30 | SIRT2 | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 10295 | -0.085 | -0.6296 | Yes |
| 31 | APC | APC Entrez, Source | adenomatosis polyposis coli | 10296 | -0.085 | -0.6201 | Yes |
| 32 | DCTN2 | DCTN2 Entrez, Source | dynactin 2 (p50) | 10303 | -0.085 | -0.6110 | Yes |
| 33 | CETN1 | CETN1 Entrez, Source | centrin, EF-hand protein, 1 | 10599 | -0.095 | -0.6226 | Yes |
| 34 | KIF5A | KIF5A Entrez, Source | kinesin family member 5A | 10741 | -0.100 | -0.6220 | Yes |
| 35 | KATNB1 | KATNB1 Entrez, Source | katanin p80 (WD repeat containing) subunit B 1 | 10749 | -0.101 | -0.6112 | Yes |
| 36 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10819 | -0.104 | -0.6048 | Yes |
| 37 | LYST | LYST Entrez, Source | lysosomal trafficking regulator | 10864 | -0.105 | -0.5962 | Yes |
| 38 | CDC20 | CDC20 Entrez, Source | CDC20 cell division cycle 20 homolog (S. cerevisiae) | 11099 | -0.117 | -0.6008 | Yes |
| 39 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 11105 | -0.117 | -0.5880 | Yes |
| 40 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 11117 | -0.118 | -0.5756 | Yes |
| 41 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 11273 | -0.125 | -0.5732 | Yes |
| 42 | POLB | POLB Entrez, Source | polymerase (DNA directed), beta | 11294 | -0.126 | -0.5606 | Yes |
| 43 | TBCE | TBCE Entrez, Source | tubulin-specific chaperone e | 11303 | -0.127 | -0.5470 | Yes |
| 44 | DYNC1LI2 | DYNC1LI2 Entrez, Source | dynein, cytoplasmic 1, light intermediate chain 2 | 11327 | -0.128 | -0.5344 | Yes |
| 45 | DCTN1 | DCTN1 Entrez, Source | dynactin 1 (p150, glued homolog, Drosophila) | 11343 | -0.128 | -0.5211 | Yes |
| 46 | CDC16 | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 11467 | -0.135 | -0.5152 | Yes |
| 47 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 11484 | -0.136 | -0.5011 | Yes |
| 48 | GAS8 | GAS8 Entrez, Source | growth arrest-specific 8 | 11506 | -0.138 | -0.4872 | Yes |
| 49 | NDE1 | NDE1 Entrez, Source | nudE nuclear distribution gene E homolog 1 (A. nidulans) | 11603 | -0.144 | -0.4783 | Yes |
| 50 | SEPT9 | SEPT9 Entrez, Source | septin 9 | 11618 | -0.145 | -0.4631 | Yes |
| 51 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 11658 | -0.148 | -0.4495 | Yes |
| 52 | NEDD9 | NEDD9 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 9 | 11695 | -0.149 | -0.4355 | Yes |
| 53 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 11702 | -0.150 | -0.4191 | Yes |
| 54 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 11762 | -0.153 | -0.4063 | Yes |
| 55 | PXN | PXN Entrez, Source | paxillin | 11831 | -0.159 | -0.3936 | Yes |
| 56 | PCM1 | PCM1 Entrez, Source | pericentriolar material 1 | 11860 | -0.161 | -0.3777 | Yes |
| 57 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 11889 | -0.164 | -0.3614 | Yes |
| 58 | KIFC3 | KIFC3 Entrez, Source | kinesin family member C3 | 11973 | -0.171 | -0.3485 | Yes |
| 59 | CDK5RAP2 | CDK5RAP2 Entrez, Source | CDK5 regulatory subunit associated protein 2 | 11990 | -0.172 | -0.3303 | Yes |
| 60 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12021 | -0.175 | -0.3130 | Yes |
| 61 | TSGA14 | TSGA14 Entrez, Source | testis specific, 14 | 12175 | -0.189 | -0.3033 | Yes |
| 62 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 12234 | -0.197 | -0.2855 | Yes |
| 63 | HDAC6 | HDAC6 Entrez, Source | histone deacetylase 6 | 12329 | -0.208 | -0.2693 | Yes |
| 64 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 12463 | -0.223 | -0.2543 | Yes |
| 65 | KIF3C | KIF3C Entrez, Source | kinesin family member 3C | 12481 | -0.225 | -0.2303 | Yes |
| 66 | DCTN4 | DCTN4 Entrez, Source | dynactin 4 (p62) | 12513 | -0.230 | -0.2068 | Yes |
| 67 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 12531 | -0.233 | -0.1820 | Yes |
| 68 | CLASP2 | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 12533 | -0.233 | -0.1559 | Yes |
| 69 | AURKA | AURKA Entrez, Source | aurora kinase A | 12548 | -0.235 | -0.1305 | Yes |
| 70 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 12613 | -0.247 | -0.1076 | Yes |
| 71 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 12909 | -0.326 | -0.0932 | Yes |
| 72 | MAP1B | MAP1B Entrez, Source | microtubule-associated protein 1B | 12944 | -0.337 | -0.0580 | Yes |
| 73 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12954 | -0.340 | -0.0205 | Yes |
| 74 | CEP57 | CEP57 Entrez, Source | centrosomal protein 57kDa | 13119 | -0.442 | 0.0168 | Yes |
