Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | MITOTIC_CELL_CYCLE |
| Enrichment Score (ES) | -0.550692 |
| Normalized Enrichment Score (NES) | -1.8993059 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.02204811 |
| FWER p-Value | 0.472 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 740 | 0.230 | -0.0354 | No |
| 2 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 1695 | 0.137 | -0.0951 | No |
| 3 | SPDYA | SPDYA Entrez, Source | speedy homolog A (Drosophila) | 1994 | 0.122 | -0.1067 | No |
| 4 | ZWINT | ZWINT Entrez, Source | ZW10 interactor | 2055 | 0.119 | -0.1006 | No |
| 5 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 2067 | 0.119 | -0.0909 | No |
| 6 | ASNS | ASNS Entrez, Source | asparagine synthetase | 2424 | 0.106 | -0.1084 | No |
| 7 | RAD17 | RAD17 Entrez, Source | RAD17 homolog (S. pombe) | 2601 | 0.099 | -0.1128 | No |
| 8 | PPP5C | PPP5C Entrez, Source | protein phosphatase 5, catalytic subunit | 2945 | 0.087 | -0.1310 | No |
| 9 | TBRG4 | TBRG4 Entrez, Source | transforming growth factor beta regulator 4 | 3101 | 0.081 | -0.1354 | No |
| 10 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 3109 | 0.081 | -0.1287 | No |
| 11 | SUGT1 | SUGT1 Entrez, Source | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | 3198 | 0.079 | -0.1284 | No |
| 12 | USH1C | USH1C Entrez, Source | Usher syndrome 1C (autosomal recessive, severe) | 3303 | 0.076 | -0.1295 | No |
| 13 | EREG | EREG Entrez, Source | epiregulin | 3625 | 0.068 | -0.1476 | No |
| 14 | KPNA2 | KPNA2 Entrez, Source | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 3717 | 0.066 | -0.1486 | No |
| 15 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 3808 | 0.064 | -0.1497 | No |
| 16 | TTN | TTN Entrez, Source | titin | 4401 | 0.050 | -0.1898 | No |
| 17 | MAD2L2 | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 4562 | 0.047 | -0.1977 | No |
| 18 | NEK6 | NEK6 Entrez, Source | NIMA (never in mitosis gene a)-related kinase 6 | 5393 | 0.030 | -0.2576 | No |
| 19 | GFI1 | GFI1 Entrez, Source | growth factor independent 1 | 5640 | 0.025 | -0.2739 | No |
| 20 | CDC2L5 | CDC2L5 Entrez, Source | cell division cycle 2-like 5 (cholinesterase-related cell division controller) | 5925 | 0.020 | -0.2936 | No |
| 21 | SNF1LK | SNF1LK Entrez, Source | SNF1-like kinase | 6978 | -0.002 | -0.3727 | No |
| 22 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 7375 | -0.010 | -0.4017 | No |
| 23 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 7589 | -0.014 | -0.4165 | No |
| 24 | KATNA1 | KATNA1 Entrez, Source | katanin p60 (ATPase-containing) subunit A 1 | 7746 | -0.018 | -0.4267 | No |
| 25 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 8008 | -0.024 | -0.4443 | No |
| 26 | CDKN2C | CDKN2C Entrez, Source | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 8322 | -0.030 | -0.4652 | No |
| 27 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 8842 | -0.042 | -0.5006 | No |
| 28 | PPP6C | PPP6C Entrez, Source | protein phosphatase 6, catalytic subunit | 8915 | -0.044 | -0.5021 | No |
| 29 | NOLC1 | NOLC1 Entrez, Source | nucleolar and coiled-body phosphoprotein 1 | 9128 | -0.050 | -0.5137 | No |
| 30 | NPM2 | NPM2 Entrez, Source | nucleophosmin/nucleoplasmin, 2 | 9187 | -0.051 | -0.5135 | No |
| 31 | CUL5 | CUL5 Entrez, Source | cullin 5 | 9220 | -0.052 | -0.5114 | No |
| 32 | CDKN3 | CDKN3 Entrez, Source | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | 9252 | -0.053 | -0.5090 | No |
| 33 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 9534 | -0.061 | -0.5248 | No |
| 34 | GSPT1 | GSPT1 Entrez, Source | G1 to S phase transition 1 | 9560 | -0.061 | -0.5212 | No |
| 35 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 9617 | -0.063 | -0.5198 | No |
| 36 | ZW10 | ZW10 Entrez, Source | ZW10, kinetochore associated, homolog (Drosophila) | 9627 | -0.063 | -0.5149 | No |
| 37 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 9788 | -0.068 | -0.5209 | No |
| 38 | ANAPC4 | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 9814 | -0.069 | -0.5167 | No |
| 39 | NBN | NBN Entrez, Source | nibrin | 10122 | -0.079 | -0.5328 | No |
| 40 | APBB1 | APBB1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | 10220 | -0.082 | -0.5328 | No |
| 41 | PLK1 | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 10276 | -0.084 | -0.5295 | No |
| 42 | DCTN2 | DCTN2 Entrez, Source | dynactin 2 (p50) | 10303 | -0.085 | -0.5240 | No |
| 43 | BUB1B | BUB1B Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 10391 | -0.088 | -0.5227 | No |
| 44 | CETN1 | CETN1 Entrez, Source | centrin, EF-hand protein, 1 | 10599 | -0.095 | -0.5299 | No |
| 45 | CHFR | CHFR Entrez, Source | checkpoint with forkhead and ring finger domains | 10712 | -0.099 | -0.5295 | No |
| 46 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 10819 | -0.104 | -0.5283 | No |
| 47 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 11117 | -0.118 | -0.5402 | Yes |
| 48 | AKAP8 | AKAP8 Entrez, Source | A kinase (PRKA) anchor protein 8 | 11248 | -0.124 | -0.5390 | Yes |
| 49 | CDC25B | CDC25B Entrez, Source | cell division cycle 25B | 11352 | -0.129 | -0.5353 | Yes |
| 50 | CDC16 | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 11467 | -0.135 | -0.5319 | Yes |
| 51 | CDK10 | CDK10 Entrez, Source | cyclin-dependent kinase (CDC2-like) 10 | 11493 | -0.137 | -0.5216 | Yes |
| 52 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11527 | -0.139 | -0.5118 | Yes |
| 53 | CIT | CIT Entrez, Source | citron (rho-interacting, serine/threonine kinase 21) | 11639 | -0.146 | -0.5071 | Yes |
| 54 | CDC27 | CDC27 Entrez, Source | cell division cycle 27 | 11658 | -0.148 | -0.4954 | Yes |
| 55 | BTG3 | BTG3 Entrez, Source | BTG family, member 3 | 11661 | -0.148 | -0.4824 | Yes |
| 56 | POLD1 | POLD1 Entrez, Source | polymerase (DNA directed), delta 1, catalytic subunit 125kDa | 11672 | -0.148 | -0.4700 | Yes |
| 57 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11673 | -0.148 | -0.4568 | Yes |
| 58 | CD28 | CD28 Entrez, Source | CD28 molecule | 11745 | -0.152 | -0.4487 | Yes |
| 59 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 11889 | -0.164 | -0.4449 | Yes |
| 60 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 11916 | -0.167 | -0.4321 | Yes |
| 61 | ACVR1 | ACVR1 Entrez, Source | activin A receptor, type I | 11998 | -0.173 | -0.4228 | Yes |
| 62 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12021 | -0.175 | -0.4089 | Yes |
| 63 | KHDRBS1 | KHDRBS1 Entrez, Source | KH domain containing, RNA binding, signal transduction associated 1 | 12056 | -0.178 | -0.3957 | Yes |
| 64 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.3870 | Yes |
| 65 | CDC23 | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 12182 | -0.190 | -0.3715 | Yes |
| 66 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12251 | -0.199 | -0.3590 | Yes |
| 67 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 12531 | -0.233 | -0.3593 | Yes |
| 68 | AURKA | AURKA Entrez, Source | aurora kinase A | 12548 | -0.235 | -0.3396 | Yes |
| 69 | SPHK1 | SPHK1 Entrez, Source | sphingosine kinase 1 | 12700 | -0.264 | -0.3275 | Yes |
| 70 | KIF22 | KIF22 Entrez, Source | kinesin family member 22 | 12713 | -0.267 | -0.3047 | Yes |
| 71 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 12725 | -0.270 | -0.2815 | Yes |
| 72 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12794 | -0.284 | -0.2614 | Yes |
| 73 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 13047 | -0.395 | -0.2453 | Yes |
| 74 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 13099 | -0.425 | -0.2114 | Yes |
| 75 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 13167 | -0.505 | -0.1715 | Yes |
| 76 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13208 | -0.576 | -0.1234 | Yes |
| 77 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13247 | -0.677 | -0.0661 | Yes |
| 78 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 13288 | -0.823 | 0.0041 | Yes |
