Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | NADLER_OBESITY_UP |
| Enrichment Score (ES) | -0.55162394 |
| Normalized Enrichment Score (NES) | -1.749392 |
| Nominal p-value | 0.003929273 |
| FDR q-value | 0.06321493 |
| FWER p-Value | 0.994 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LBP | LBP Entrez, Source | lipopolysaccharide binding protein | 701 | 0.238 | -0.0214 | No |
| 2 | ALOX5AP | ALOX5AP Entrez, Source | arachidonate 5-lipoxygenase-activating protein | 764 | 0.225 | 0.0036 | No |
| 3 | ADFP | ADFP Entrez, Source | adipose differentiation-related protein | 1069 | 0.185 | 0.0051 | No |
| 4 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 1787 | 0.132 | -0.0315 | No |
| 5 | IFI30 | IFI30 Entrez, Source | interferon, gamma-inducible protein 30 | 2379 | 0.107 | -0.0618 | No |
| 6 | CSF1R | CSF1R Entrez, Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 2382 | 0.107 | -0.0479 | No |
| 7 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 2588 | 0.100 | -0.0502 | No |
| 8 | DUSP1 | DUSP1 Entrez, Source | dual specificity phosphatase 1 | 3275 | 0.077 | -0.0917 | No |
| 9 | LAPTM5 | LAPTM5 Entrez, Source | lysosomal associated multispanning membrane protein 5 | 3735 | 0.066 | -0.1176 | No |
| 10 | DAD1 | DAD1 Entrez, Source | defender against cell death 1 | 4820 | 0.041 | -0.1937 | No |
| 11 | HCLS1 | HCLS1 Entrez, Source | hematopoietic cell-specific Lyn substrate 1 | 6043 | 0.017 | -0.2833 | No |
| 12 | CTSK | CTSK Entrez, Source | cathepsin K (pycnodysostosis) | 6620 | 0.006 | -0.3259 | No |
| 13 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 7328 | -0.009 | -0.3779 | No |
| 14 | MPEG1 | MPEG1 Entrez, Source | - | 7644 | -0.015 | -0.3996 | No |
| 15 | PABPC1 | PABPC1 Entrez, Source | poly(A) binding protein, cytoplasmic 1 | 8087 | -0.025 | -0.4295 | No |
| 16 | FCGR3A | FCGR3A Entrez, Source | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 8131 | -0.026 | -0.4293 | No |
| 17 | LEP | LEP Entrez, Source | leptin (obesity homolog, mouse) | 8144 | -0.026 | -0.4267 | No |
| 18 | CTSL | CTSL Entrez, Source | cathepsin L | 8440 | -0.033 | -0.4446 | No |
| 19 | CTSS | CTSS Entrez, Source | cathepsin S | 8459 | -0.033 | -0.4415 | No |
| 20 | SEC13L1 | SEC13L1 Entrez, Source | SEC13-like 1 (S. cerevisiae) | 8483 | -0.034 | -0.4388 | No |
| 21 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 8598 | -0.037 | -0.4425 | No |
| 22 | PSAP | PSAP Entrez, Source | prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | 8783 | -0.040 | -0.4511 | No |
| 23 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 9444 | -0.058 | -0.4930 | No |
| 24 | NEDD8 | NEDD8 Entrez, Source | neural precursor cell expressed, developmentally down-regulated 8 | 9792 | -0.068 | -0.5102 | No |
| 25 | CD53 | CD53 Entrez, Source | CD53 molecule | 10105 | -0.078 | -0.5234 | No |
| 26 | PITPNA | PITPNA Entrez, Source | phosphatidylinositol transfer protein, alpha | 10116 | -0.079 | -0.5138 | No |
| 27 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 10393 | -0.088 | -0.5230 | No |
| 28 | CSTB | CSTB Entrez, Source | cystatin B (stefin B) | 10524 | -0.092 | -0.5206 | No |
| 29 | CTSZ | CTSZ Entrez, Source | cathepsin Z | 10924 | -0.108 | -0.5364 | Yes |
| 30 | TLN1 | TLN1 Entrez, Source | talin 1 | 11127 | -0.118 | -0.5361 | Yes |
| 31 | ATP6V1C1 | ATP6V1C1 Entrez, Source | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 11130 | -0.118 | -0.5206 | Yes |
| 32 | PFN1 | PFN1 Entrez, Source | profilin 1 | 11162 | -0.120 | -0.5072 | Yes |
| 33 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11372 | -0.130 | -0.5059 | Yes |
| 34 | CTSB | CTSB Entrez, Source | cathepsin B | 11532 | -0.139 | -0.4996 | Yes |
| 35 | LGMN | LGMN Entrez, Source | legumain | 11659 | -0.148 | -0.4896 | Yes |
| 36 | PLD3 | PLD3 Entrez, Source | phospholipase D family, member 3 | 12403 | -0.215 | -0.5172 | Yes |
| 37 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12500 | -0.229 | -0.4943 | Yes |
| 38 | PPGB | PPGB Entrez, Source | protective protein for beta-galactosidase (galactosialidosis) | 12547 | -0.235 | -0.4669 | Yes |
| 39 | TPM4 | TPM4 Entrez, Source | tropomyosin 4 | 12551 | -0.235 | -0.4361 | Yes |
| 40 | BASP1 | BASP1 Entrez, Source | brain abundant, membrane attached signal protein 1 | 12594 | -0.244 | -0.4072 | Yes |
| 41 | CD68 | CD68 Entrez, Source | CD68 molecule | 12654 | -0.254 | -0.3783 | Yes |
| 42 | CRYAB | CRYAB Entrez, Source | crystallin, alpha B | 12728 | -0.271 | -0.3481 | Yes |
| 43 | PEA15 | PEA15 Entrez, Source | phosphoprotein enriched in astrocytes 15 | 12899 | -0.321 | -0.3187 | Yes |
| 44 | GRN | GRN Entrez, Source | granulin | 12920 | -0.329 | -0.2770 | Yes |
| 45 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 13018 | -0.375 | -0.2349 | Yes |
| 46 | FXYD5 | FXYD5 Entrez, Source | FXYD domain containing ion transport regulator 5 | 13147 | -0.472 | -0.1824 | Yes |
| 47 | LGALS3 | LGALS3 Entrez, Source | lectin, galactoside-binding, soluble, 3 (galectin 3) | 13253 | -0.689 | -0.0997 | Yes |
| 48 | UCP2 | UCP2 Entrez, Source | uncoupling protein 2 (mitochondrial, proton carrier) | 13284 | -0.808 | 0.0044 | Yes |
