Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | NETPATH_ALPHA6_BETA4_INTEGRIN_PATHWAY |
| Enrichment Score (ES) | -0.54710937 |
| Normalized Enrichment Score (NES) | -1.7708879 |
| Nominal p-value | 0.0019607844 |
| FDR q-value | 0.055445503 |
| FWER p-Value | 0.972 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 736 | 0.230 | -0.0255 | No |
| 2 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 1135 | 0.178 | -0.0325 | No |
| 3 | EIF4EBP1 | EIF4EBP1 Entrez, Source | eukaryotic translation initiation factor 4E binding protein 1 | 1395 | 0.157 | -0.0316 | No |
| 4 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 1691 | 0.137 | -0.0360 | No |
| 5 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 1875 | 0.127 | -0.0333 | No |
| 6 | NTN1 | NTN1 Entrez, Source | netrin 1 | 2944 | 0.087 | -0.1024 | No |
| 7 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 3311 | 0.076 | -0.1201 | No |
| 8 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 3319 | 0.076 | -0.1109 | No |
| 9 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 3876 | 0.062 | -0.1446 | No |
| 10 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 3931 | 0.061 | -0.1407 | No |
| 11 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4611 | 0.046 | -0.1858 | No |
| 12 | EIF4E | EIF4E Entrez, Source | eukaryotic translation initiation factor 4E | 5186 | 0.034 | -0.2246 | No |
| 13 | CLCA2 | CLCA2 Entrez, Source | chloride channel, calcium activated, family member 2 | 5467 | 0.029 | -0.2419 | No |
| 14 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 7303 | -0.008 | -0.3789 | No |
| 15 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 7664 | -0.016 | -0.4040 | No |
| 16 | METAP2 | METAP2 Entrez, Source | methionyl aminopeptidase 2 | 7695 | -0.017 | -0.4041 | No |
| 17 | YWHAB | YWHAB Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | 8325 | -0.031 | -0.4474 | No |
| 18 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 8690 | -0.039 | -0.4698 | No |
| 19 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 8700 | -0.039 | -0.4654 | No |
| 20 | RPSA | RPSA Entrez, Source | ribosomal protein SA | 8938 | -0.045 | -0.4775 | No |
| 21 | YWHAE | YWHAE Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 8995 | -0.046 | -0.4758 | No |
| 22 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 9602 | -0.063 | -0.5133 | No |
| 23 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 9756 | -0.067 | -0.5162 | No |
| 24 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 9794 | -0.068 | -0.5102 | No |
| 25 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9885 | -0.071 | -0.5077 | No |
| 26 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 10171 | -0.080 | -0.5188 | No |
| 27 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10292 | -0.084 | -0.5169 | No |
| 28 | PLEC1 | PLEC1 Entrez, Source | plectin 1, intermediate filament binding protein 500kDa | 10694 | -0.098 | -0.5343 | Yes |
| 29 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10731 | -0.100 | -0.5241 | Yes |
| 30 | ITGB4BP | ITGB4BP Entrez, Source | integrin beta 4 binding protein | 10985 | -0.111 | -0.5288 | Yes |
| 31 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11190 | -0.121 | -0.5285 | Yes |
| 32 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 11438 | -0.133 | -0.5298 | Yes |
| 33 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 11475 | -0.136 | -0.5150 | Yes |
| 34 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11527 | -0.139 | -0.5008 | Yes |
| 35 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11752 | -0.152 | -0.4980 | Yes |
| 36 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 11775 | -0.155 | -0.4796 | Yes |
| 37 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11801 | -0.156 | -0.4612 | Yes |
| 38 | YWHAZ | YWHAZ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 11826 | -0.159 | -0.4425 | Yes |
| 39 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 11844 | -0.160 | -0.4231 | Yes |
| 40 | RTKN | RTKN Entrez, Source | rhotekin | 11968 | -0.170 | -0.4103 | Yes |
| 41 | YWHAQ | YWHAQ Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 12130 | -0.184 | -0.3986 | Yes |
| 42 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 12237 | -0.197 | -0.3810 | Yes |
| 43 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 12413 | -0.216 | -0.3661 | Yes |
| 44 | DSP | DSP Entrez, Source | desmoplakin | 12592 | -0.244 | -0.3480 | Yes |
| 45 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 12640 | -0.252 | -0.3190 | Yes |
| 46 | CD151 | CD151 Entrez, Source | CD151 molecule (Raph blood group) | 12718 | -0.268 | -0.2900 | Yes |
| 47 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12719 | -0.269 | -0.2551 | Yes |
| 48 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 12835 | -0.298 | -0.2252 | Yes |
| 49 | VIM | VIM Entrez, Source | vimentin | 13164 | -0.501 | -0.1850 | Yes |
| 50 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 13171 | -0.510 | -0.1194 | Yes |
| 51 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13313 | -1.021 | 0.0022 | Yes |
