Details for gene set ORGANIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos
Phenotype	class.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in class	double_gel_8d
GeneSet	ORGANIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.6793193
Normalized Enrichment Score (NES)	2.656097
Nominal p-value	0.0
FDR q-value	0.0
FWER p-Value	0.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	9	1.171	0.0361	Yes
2	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	10	1.121	0.0712	Yes
3	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	16	0.933	0.1001	Yes
4	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	17	0.930	0.1293	Yes
5	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	35	0.815	0.1535	Yes
6	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	56	0.731	0.1750	Yes
7	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	60	0.721	0.1973	Yes
8	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	95	0.621	0.2142	Yes
9	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	98	0.617	0.2334	Yes
10	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	104	0.612	0.2522	Yes
11	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	108	0.606	0.2710	Yes
12	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	113	0.597	0.2894	Yes
13	ASL	ASL Entrez, Source	argininosuccinate lyase	122	0.586	0.3072	Yes
14	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	135	0.556	0.3237	Yes
15	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	177	0.496	0.3362	Yes
16	ACLY	ACLY Entrez, Source	ATP citrate lyase	186	0.487	0.3509	Yes
17	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	201	0.472	0.3646	Yes
18	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	212	0.461	0.3783	Yes
19	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	223	0.456	0.3919	Yes
20	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	231	0.450	0.4055	Yes
21	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	236	0.445	0.4191	Yes
22	ARG1	ARG1 Entrez, Source	arginase, liver	246	0.438	0.4322	Yes
23	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	247	0.438	0.4459	Yes
24	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	259	0.427	0.4585	Yes
25	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	260	0.427	0.4719	Yes
26	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	271	0.419	0.4842	Yes
27	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	277	0.416	0.4969	Yes
28	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	284	0.409	0.5093	Yes
29	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	291	0.403	0.5215	Yes
30	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	389	0.344	0.5249	Yes
31	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	392	0.341	0.5355	Yes
32	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	401	0.338	0.5455	Yes
33	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	403	0.337	0.5560	Yes
34	PAH	PAH Entrez, Source	phenylalanine hydroxylase	411	0.336	0.5660	Yes
35	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	501	0.299	0.5687	Yes
36	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	524	0.292	0.5762	Yes
37	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	537	0.288	0.5843	Yes
38	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	543	0.285	0.5928	Yes
39	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	580	0.273	0.5987	Yes
40	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	584	0.271	0.6070	Yes
41	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	623	0.260	0.6122	Yes
42	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	642	0.255	0.6189	Yes
43	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	656	0.251	0.6258	Yes
44	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	732	0.231	0.6274	Yes
45	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	750	0.228	0.6332	Yes
46	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	753	0.227	0.6402	Yes
47	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	870	0.211	0.6380	Yes
48	TST	TST Entrez, Source	thiosulfate sulfurtransferase (rhodanese)	926	0.203	0.6402	Yes
49	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	950	0.200	0.6448	Yes
50	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	1027	0.189	0.6449	Yes
51	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	1046	0.187	0.6495	Yes
52	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	1158	0.175	0.6465	Yes
53	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	1180	0.172	0.6504	Yes
54	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	1183	0.172	0.6556	Yes
55	SDS	SDS Entrez, Source	serine dehydratase	1222	0.169	0.6580	Yes
56	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	1252	0.167	0.6611	Yes
57	HDC	HDC Entrez, Source	histidine decarboxylase	1256	0.167	0.6661	Yes
58	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	1278	0.165	0.6697	Yes
59	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	1296	0.164	0.6736	Yes
60	SCLY	SCLY Entrez, Source	selenocysteine lyase	1345	0.161	0.6750	Yes
61	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	1355	0.160	0.6793	Yes
62	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	1535	0.147	0.6704	No
63	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	1598	0.143	0.6702	No
64	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	1617	0.142	0.6733	No
65	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	1680	0.138	0.6729	No
66	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	1747	0.134	0.6721	No
67	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	1770	0.133	0.6746	No
68	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	1785	0.132	0.6777	No
69	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	1864	0.128	0.6758	No
70	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	1920	0.125	0.6756	No
71	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	2183	0.115	0.6594	No
72	PTGES	PTGES Entrez, Source	prostaglandin E synthase	2249	0.113	0.6580	No
73	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	2294	0.111	0.6581	No
74	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	2352	0.108	0.6572	No
75	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	2527	0.102	0.6472	No
76	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	2832	0.090	0.6270	No
77	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	2968	0.086	0.6195	No
78	ARPP-19	ARPP-19 Entrez, Source	-	3013	0.084	0.6188	No
79	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	3082	0.082	0.6162	No
80	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	3114	0.081	0.6164	No
81	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	3231	0.078	0.6101	No
82	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	3429	0.073	0.5975	No
83	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	3436	0.073	0.5993	No
84	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	3545	0.070	0.5933	No
85	GSS	GSS Entrez, Source	glutathione synthetase	3596	0.069	0.5917	No
86	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	3691	0.067	0.5867	No
87	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	3774	0.065	0.5825	No
88	AMT	AMT Entrez, Source	aminomethyltransferase	3875	0.063	0.5769	No
89	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	4291	0.053	0.5471	No
90	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	4310	0.053	0.5474	No
91	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	4353	0.052	0.5459	No
92	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	4613	0.046	0.5277	No
93	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	4665	0.045	0.5252	No
94	MPST	MPST Entrez, Source	mercaptopyruvate sulfurtransferase	4713	0.044	0.5230	No
95	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	4874	0.040	0.5122	No
96	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	5183	0.034	0.4900	No
97	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	5784	0.022	0.4452	No
98	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	6103	0.016	0.4217	No
99	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	6381	0.010	0.4010	No
100	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	6397	0.010	0.4002	No
101	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	6420	0.009	0.3988	No
102	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	6525	0.007	0.3912	No
103	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	7015	-0.002	0.3542	No
104	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	7234	-0.007	0.3379	No
105	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	7432	-0.011	0.3234	No
106	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	7451	-0.011	0.3224	No
107	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	7757	-0.018	0.2998	No
108	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	7996	-0.023	0.2826	No
109	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	8124	-0.026	0.2738	No
110	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	8177	-0.027	0.2707	No
111	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8334	-0.031	0.2598	No
112	SLC3A1	SLC3A1 Entrez, Source	1	8542	-0.036	0.2453	No
113	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	8548	-0.036	0.2460	No
114	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	8939	-0.045	0.2179	No
115	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	9206	-0.051	0.1994	No
116	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	9551	-0.061	0.1752	No
117	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	9642	-0.064	0.1704	No
118	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	10024	-0.075	0.1439	No
119	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	10142	-0.079	0.1376	No
120	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	10462	-0.090	0.1163	No
121	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	10638	-0.097	0.1061	No
122	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	10791	-0.102	0.0978	No
123	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	10907	-0.107	0.0924	No
124	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	10944	-0.109	0.0931	No
125	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	10959	-0.110	0.0955	No
126	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	11033	-0.113	0.0935	No
127	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	11523	-0.139	0.0608	No
128	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	12246	-0.198	0.0124	No
129	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	12469	-0.223	0.0026	No
130	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	12983	-0.354	-0.0251	No
131	SMS	SMS Entrez, Source	spermine synthase	13083	-0.414	-0.0196	No
132	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	13167	-0.505	-0.0101	No
133	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	13266	-0.741	0.0058	No