Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | P53_SIGNALING |
| Enrichment Score (ES) | -0.5474099 |
| Normalized Enrichment Score (NES) | -1.8196656 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.04274759 |
| FWER p-Value | 0.845 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 736 | 0.230 | -0.0264 | No |
| 2 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 2102 | 0.118 | -0.1143 | No |
| 3 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2307 | 0.110 | -0.1158 | No |
| 4 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 2467 | 0.104 | -0.1147 | No |
| 5 | TEAD1 | TEAD1 Entrez, Source | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 2500 | 0.102 | -0.1042 | No |
| 6 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 3489 | 0.071 | -0.1695 | No |
| 7 | MAPK8IP2 | MAPK8IP2 Entrez, Source | mitogen-activated protein kinase 8 interacting protein 2 | 3638 | 0.068 | -0.1721 | No |
| 8 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 3646 | 0.068 | -0.1641 | No |
| 9 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 3805 | 0.064 | -0.1680 | No |
| 10 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 4062 | 0.058 | -0.1799 | No |
| 11 | PCAF | PCAF Entrez, Source | p300/CBP-associated factor | 4209 | 0.055 | -0.1840 | No |
| 12 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 4323 | 0.052 | -0.1859 | No |
| 13 | FAF1 | FAF1 Entrez, Source | Fas (TNFRSF6) associated factor 1 | 4712 | 0.044 | -0.2096 | No |
| 14 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 4923 | 0.039 | -0.2205 | No |
| 15 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 5444 | 0.029 | -0.2559 | No |
| 16 | TBP | TBP Entrez, Source | TATA box binding protein | 5588 | 0.026 | -0.2634 | No |
| 17 | THRA | THRA Entrez, Source | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | 5968 | 0.019 | -0.2896 | No |
| 18 | DAXX | DAXX Entrez, Source | death-associated protein 6 | 6115 | 0.016 | -0.2985 | No |
| 19 | NDRG2 | NDRG2 Entrez, Source | NDRG family member 2 | 6868 | 0.001 | -0.3550 | No |
| 20 | CCNH | CCNH Entrez, Source | cyclin H | 7280 | -0.008 | -0.3850 | No |
| 21 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 7310 | -0.008 | -0.3861 | No |
| 22 | CSNK2A1 | CSNK2A1 Entrez, Source | casein kinase 2, alpha 1 polypeptide | 7384 | -0.010 | -0.3903 | No |
| 23 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 7802 | -0.019 | -0.4194 | No |
| 24 | PPIA | PPIA Entrez, Source | peptidylprolyl isomerase A (cyclophilin A) | 8000 | -0.023 | -0.4312 | No |
| 25 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 8184 | -0.027 | -0.4416 | No |
| 26 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8410 | -0.033 | -0.4544 | No |
| 27 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 8446 | -0.033 | -0.4529 | No |
| 28 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8748 | -0.040 | -0.4705 | No |
| 29 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 9083 | -0.048 | -0.4896 | No |
| 30 | SP1 | SP1 Entrez, Source | Sp1 transcription factor | 9134 | -0.050 | -0.4871 | No |
| 31 | PMP22 | PMP22 Entrez, Source | peripheral myelin protein 22 | 9250 | -0.053 | -0.4891 | No |
| 32 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 9444 | -0.058 | -0.4963 | No |
| 33 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 9912 | -0.072 | -0.5224 | No |
| 34 | CSNK2B | CSNK2B Entrez, Source | casein kinase 2, beta polypeptide | 10221 | -0.082 | -0.5352 | Yes |
| 35 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 10267 | -0.084 | -0.5281 | Yes |
| 36 | APEX1 | APEX1 Entrez, Source | APEX nuclease (multifunctional DNA repair enzyme) 1 | 10323 | -0.086 | -0.5214 | Yes |
| 37 | ACTB | ACTB Entrez, Source | actin, beta | 10590 | -0.095 | -0.5295 | Yes |
| 38 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10699 | -0.098 | -0.5252 | Yes |
| 39 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 10778 | -0.102 | -0.5183 | Yes |
| 40 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 10823 | -0.104 | -0.5085 | Yes |
| 41 | RPL13A | RPL13A Entrez, Source | ribosomal protein L13a | 10925 | -0.108 | -0.5025 | Yes |
| 42 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11523 | -0.139 | -0.5300 | Yes |
| 43 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11673 | -0.148 | -0.5225 | Yes |
| 44 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.5049 | Yes |
| 45 | NUMB | NUMB Entrez, Source | numb homolog (Drosophila) | 11741 | -0.151 | -0.4896 | Yes |
| 46 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 11816 | -0.158 | -0.4753 | Yes |
| 47 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 12031 | -0.176 | -0.4693 | Yes |
| 48 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 12070 | -0.179 | -0.4496 | Yes |
| 49 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.4329 | Yes |
| 50 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 12496 | -0.228 | -0.4291 | Yes |
| 51 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 12510 | -0.230 | -0.4011 | Yes |
| 52 | HSPA4 | HSPA4 Entrez, Source | heat shock 70kDa protein 4 | 12608 | -0.247 | -0.3773 | Yes |
| 53 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12821 | -0.294 | -0.3563 | Yes |
| 54 | NDRG4 | NDRG4 Entrez, Source | NDRG family member 4 | 12943 | -0.337 | -0.3230 | Yes |
| 55 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 13099 | -0.425 | -0.2812 | Yes |
| 56 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 13282 | -0.795 | -0.1947 | Yes |
| 57 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13340 | -1.581 | 0.0002 | Yes |
