Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | PROTEINACEOUS_EXTRACELLULAR_MATRIX |
| Enrichment Score (ES) | -0.5204215 |
| Normalized Enrichment Score (NES) | -1.703411 |
| Nominal p-value | 0.0034482758 |
| FDR q-value | 0.07548506 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL5A3 | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 139 | 0.553 | 0.0549 | No |
| 2 | USH2A | USH2A Entrez, Source | Usher syndrome 2A (autosomal recessive, mild) | 643 | 0.255 | 0.0472 | No |
| 3 | COLQ | COLQ Entrez, Source | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 646 | 0.252 | 0.0769 | No |
| 4 | MATN1 | MATN1 Entrez, Source | matrilin 1, cartilage matrix protein | 1702 | 0.137 | 0.0137 | No |
| 5 | SPG7 | SPG7 Entrez, Source | spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive) | 1792 | 0.132 | 0.0226 | No |
| 6 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 1875 | 0.127 | 0.0315 | No |
| 7 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 2146 | 0.116 | 0.0249 | No |
| 8 | FBN2 | FBN2 Entrez, Source | fibrillin 2 (congenital contractural arachnodactyly) | 2408 | 0.106 | 0.0178 | No |
| 9 | DSPP | DSPP Entrez, Source | dentin sialophosphoprotein | 2418 | 0.106 | 0.0297 | No |
| 10 | DMP1 | DMP1 Entrez, Source | dentin matrix acidic phosphoprotein | 2525 | 0.102 | 0.0337 | No |
| 11 | COL11A1 | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 2613 | 0.099 | 0.0388 | No |
| 12 | HAPLN1 | HAPLN1 Entrez, Source | hyaluronan and proteoglycan link protein 1 | 2901 | 0.088 | 0.0276 | No |
| 13 | LTBP4 | LTBP4 Entrez, Source | latent transforming growth factor beta binding protein 4 | 3223 | 0.078 | 0.0127 | No |
| 14 | TINAG | TINAG Entrez, Source | tubulointerstitial nephritis antigen | 3359 | 0.075 | 0.0113 | No |
| 15 | MUC5AC | MUC5AC Entrez, Source | mucin 5AC, oligomeric mucus/gel-forming | 3465 | 0.072 | 0.0119 | No |
| 16 | IMPG1 | IMPG1 Entrez, Source | interphotoreceptor matrix proteoglycan 1 | 3796 | 0.064 | -0.0053 | No |
| 17 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 4122 | 0.057 | -0.0231 | No |
| 18 | MEPE | MEPE Entrez, Source | matrix, extracellular phosphoglycoprotein with ASARM motif (bone) | 4322 | 0.052 | -0.0319 | No |
| 19 | COL18A1 | COL18A1 Entrez, Source | collagen, type XVIII, alpha 1 | 4715 | 0.044 | -0.0562 | No |
| 20 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 4937 | 0.039 | -0.0682 | No |
| 21 | THBS4 | THBS4 Entrez, Source | thrombospondin 4 | 5218 | 0.034 | -0.0854 | No |
| 22 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 5317 | 0.032 | -0.0890 | No |
| 23 | COMP | COMP Entrez, Source | cartilage oligomeric matrix protein | 5328 | 0.031 | -0.0860 | No |
| 24 | IMPG2 | IMPG2 Entrez, Source | interphotoreceptor matrix proteoglycan 2 | 5572 | 0.026 | -0.1012 | No |
| 25 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 5666 | 0.024 | -0.1053 | No |
| 26 | NID2 | NID2 Entrez, Source | nidogen 2 (osteonidogen) | 6093 | 0.016 | -0.1355 | No |
| 27 | FMOD | FMOD Entrez, Source | fibromodulin | 6548 | 0.007 | -0.1688 | No |
| 28 | COL10A1 | COL10A1 Entrez, Source | collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) | 7059 | -0.003 | -0.2068 | No |
| 29 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 7382 | -0.010 | -0.2299 | No |
| 30 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 7444 | -0.011 | -0.2331 | No |
| 31 | LTBP2 | LTBP2 Entrez, Source | latent transforming growth factor beta binding protein 2 | 7613 | -0.015 | -0.2440 | No |
| 32 | PRELP | PRELP Entrez, Source | proline/arginine-rich end leucine-rich repeat protein | 7654 | -0.016 | -0.2452 | No |
| 33 | FBLN5 | FBLN5 Entrez, Source | fibulin 5 | 7698 | -0.017 | -0.2465 | No |
| 34 | ECM1 | ECM1 Entrez, Source | extracellular matrix protein 1 | 7713 | -0.017 | -0.2456 | No |
| 35 | CHAD | CHAD Entrez, Source | chondroadherin | 8079 | -0.025 | -0.2701 | No |
| 36 | COL9A1 | COL9A1 Entrez, Source | collagen, type IX, alpha 1 | 8152 | -0.027 | -0.2724 | No |
| 37 | MMP10 | MMP10 Entrez, Source | matrix metallopeptidase 10 (stromelysin 2) | 8565 | -0.036 | -0.2991 | No |
| 38 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 8592 | -0.037 | -0.2967 | No |
| 39 | LUM | LUM Entrez, Source | lumican | 8618 | -0.037 | -0.2942 | No |
| 40 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 9375 | -0.057 | -0.3444 | No |
| 41 | MGP | MGP Entrez, Source | matrix Gla protein | 9643 | -0.064 | -0.3570 | No |
| 42 | CAV3 | CAV3 Entrez, Source | caveolin 3 | 10132 | -0.079 | -0.3843 | No |
| 43 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 10393 | -0.088 | -0.3935 | No |
| 44 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 11278 | -0.125 | -0.4452 | No |
| 45 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 11390 | -0.131 | -0.4381 | No |
| 46 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 12021 | -0.175 | -0.4649 | No |
| 47 | COL5A2 | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 12760 | -0.277 | -0.4877 | Yes |
| 48 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 12818 | -0.293 | -0.4573 | Yes |
| 49 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 12835 | -0.298 | -0.4233 | Yes |
| 50 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12902 | -0.323 | -0.3901 | Yes |
| 51 | ADAMTS5 | ADAMTS5 Entrez, Source | ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) | 12912 | -0.326 | -0.3522 | Yes |
| 52 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 13047 | -0.395 | -0.3156 | Yes |
| 53 | SGCG | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 13113 | -0.440 | -0.2685 | Yes |
| 54 | EFEMP2 | EFEMP2 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 2 | 13229 | -0.627 | -0.2031 | Yes |
| 55 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13273 | -0.768 | -0.1156 | Yes |
| 56 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 13313 | -1.021 | 0.0022 | Yes |
