Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | SERUM_FIBROBLAST_CORE_DN |
| Enrichment Score (ES) | 0.47698468 |
| Normalized Enrichment Score (NES) | 1.7615012 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.01964115 |
| FWER p-Value | 0.965 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | LPIN1 | LPIN1 Entrez, Source | lipin 1 | 43 | 0.774 | 0.0341 | Yes |
| 2 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 74 | 0.685 | 0.0648 | Yes |
| 3 | INSIG1 | INSIG1 Entrez, Source | insulin induced gene 1 | 83 | 0.642 | 0.0952 | Yes |
| 4 | SCD | SCD Entrez, Source | stearoyl-CoA desaturase (delta-9-desaturase) | 84 | 0.641 | 0.1261 | Yes |
| 5 | FADS2 | FADS2 Entrez, Source | fatty acid desaturase 2 | 98 | 0.617 | 0.1549 | Yes |
| 6 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 110 | 0.603 | 0.1831 | Yes |
| 7 | CFB | CFB Entrez, Source | complement factor B | 112 | 0.599 | 0.2119 | Yes |
| 8 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 126 | 0.572 | 0.2386 | Yes |
| 9 | F10 | F10 Entrez, Source | coagulation factor X | 141 | 0.550 | 0.2640 | Yes |
| 10 | SQLE | SQLE Entrez, Source | squalene epoxidase | 188 | 0.485 | 0.2839 | Yes |
| 11 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 199 | 0.477 | 0.3061 | Yes |
| 12 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 284 | 0.409 | 0.3195 | Yes |
| 13 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 315 | 0.386 | 0.3358 | Yes |
| 14 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 328 | 0.380 | 0.3532 | Yes |
| 15 | GSTM2 | GSTM2 Entrez, Source | glutathione S-transferase M2 (muscle) | 345 | 0.369 | 0.3698 | Yes |
| 16 | POR | POR Entrez, Source | P450 (cytochrome) oxidoreductase | 384 | 0.346 | 0.3837 | Yes |
| 17 | SOD2 | SOD2 Entrez, Source | superoxide dismutase 2, mitochondrial | 391 | 0.343 | 0.3997 | Yes |
| 18 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 401 | 0.338 | 0.4154 | Yes |
| 19 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 500 | 0.300 | 0.4224 | Yes |
| 20 | ACSL3 | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 546 | 0.284 | 0.4327 | Yes |
| 21 | CYP27A1 | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 578 | 0.274 | 0.4436 | Yes |
| 22 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 581 | 0.272 | 0.4566 | Yes |
| 23 | LDLR | LDLR Entrez, Source | low density lipoprotein receptor (familial hypercholesterolemia) | 592 | 0.270 | 0.4688 | Yes |
| 24 | FUT8 | FUT8 Entrez, Source | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 762 | 0.225 | 0.4670 | Yes |
| 25 | ATP6V0A1 | ATP6V0A1 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a1 | 869 | 0.212 | 0.4692 | Yes |
| 26 | ABHD14B | ABHD14B Entrez, Source | abhydrolase domain containing 14B | 899 | 0.208 | 0.4770 | Yes |
| 27 | PDK2 | PDK2 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 2 | 1243 | 0.168 | 0.4592 | No |
| 28 | ERRFI1 | ERRFI1 Entrez, Source | ERBB receptor feedback inhibitor 1 | 1295 | 0.164 | 0.4632 | No |
| 29 | AXIN2 | AXIN2 Entrez, Source | axin 2 (conductin, axil) | 1488 | 0.151 | 0.4560 | No |
| 30 | CNTNAP1 | CNTNAP1 Entrez, Source | contactin associated protein 1 | 2078 | 0.118 | 0.4173 | No |
| 31 | APOD | APOD Entrez, Source | apolipoprotein D | 2491 | 0.103 | 0.3911 | No |
| 32 | IGBP1 | IGBP1 Entrez, Source | immunoglobulin (CD79A) binding protein 1 | 2784 | 0.092 | 0.3735 | No |
| 33 | ST6GAL1 | ST6GAL1 Entrez, Source | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 3300 | 0.076 | 0.3383 | No |
| 34 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3378 | 0.074 | 0.3361 | No |
| 35 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 3691 | 0.067 | 0.3157 | No |
| 36 | CSF1 | CSF1 Entrez, Source | colony stimulating factor 1 (macrophage) | 3716 | 0.066 | 0.3171 | No |
| 37 | SFTPB | SFTPB Entrez, Source | surfactant, pulmonary-associated protein B | 3861 | 0.063 | 0.3093 | No |
| 38 | CD82 | CD82 Entrez, Source | CD82 molecule | 3908 | 0.062 | 0.3088 | No |
| 39 | DPYSL2 | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 4035 | 0.059 | 0.3021 | No |
| 40 | HDAC5 | HDAC5 Entrez, Source | histone deacetylase 5 | 4333 | 0.052 | 0.2822 | No |
| 41 | MEF2D | MEF2D Entrez, Source | MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) | 4769 | 0.042 | 0.2514 | No |
| 42 | PTPRU | PTPRU Entrez, Source | protein tyrosine phosphatase, receptor type, U | 4946 | 0.039 | 0.2400 | No |
| 43 | AZI2 | AZI2 Entrez, Source | 5-azacytidine induced 2 | 5453 | 0.029 | 0.2032 | No |
| 44 | MAF | MAF Entrez, Source | v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) | 5634 | 0.025 | 0.1908 | No |
| 45 | ZBTB17 | ZBTB17 Entrez, Source | zinc finger and BTB domain containing 17 | 5859 | 0.021 | 0.1749 | No |
| 46 | LSR | LSR Entrez, Source | lipolysis stimulated lipoprotein receptor | 6298 | 0.012 | 0.1424 | No |
| 47 | PSMB7 | PSMB7 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 7 | 6920 | -0.000 | 0.0955 | No |
| 48 | PGCP | PGCP Entrez, Source | - | 7097 | -0.004 | 0.0824 | No |
| 49 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 7340 | -0.009 | 0.0646 | No |
| 50 | RPL37 | RPL37 Entrez, Source | ribosomal protein L37 | 7466 | -0.012 | 0.0557 | No |
| 51 | MBP | MBP Entrez, Source | myelin basic protein | 7470 | -0.012 | 0.0560 | No |
| 52 | WSB1 | WSB1 Entrez, Source | WD repeat and SOCS box-containing 1 | 7573 | -0.014 | 0.0490 | No |
| 53 | DNM1 | DNM1 Entrez, Source | dynamin 1 | 7697 | -0.017 | 0.0405 | No |
| 54 | PKIG | PKIG Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | 7811 | -0.019 | 0.0329 | No |
| 55 | EEF1A1 | EEF1A1 Entrez, Source | eukaryotic translation elongation factor 1 alpha 1 | 7913 | -0.021 | 0.0263 | No |
| 56 | FCGRT | FCGRT Entrez, Source | Fc fragment of IgG, receptor, transporter, alpha | 8110 | -0.026 | 0.0128 | No |
| 57 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8410 | -0.033 | -0.0082 | No |
| 58 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 8598 | -0.037 | -0.0206 | No |
| 59 | LUM | LUM Entrez, Source | lumican | 8618 | -0.037 | -0.0202 | No |
| 60 | ACIN1 | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 8761 | -0.040 | -0.0290 | No |
| 61 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 9756 | -0.067 | -0.1008 | No |
| 62 | CYBRD1 | CYBRD1 Entrez, Source | cytochrome b reductase 1 | 10038 | -0.076 | -0.1184 | No |
| 63 | EXOSC7 | EXOSC7 Entrez, Source | exosome component 7 | 10123 | -0.079 | -0.1209 | No |
| 64 | ADD3 | ADD3 Entrez, Source | adducin 3 (gamma) | 10162 | -0.080 | -0.1199 | No |
| 65 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 10171 | -0.080 | -0.1167 | No |
| 66 | MAGI2 | MAGI2 Entrez, Source | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 10299 | -0.085 | -0.1222 | No |
| 67 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 10363 | -0.087 | -0.1227 | No |
| 68 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 10427 | -0.089 | -0.1232 | No |
| 69 | ITPKB | ITPKB Entrez, Source | inositol 1,4,5-trisphosphate 3-kinase B | 10615 | -0.096 | -0.1327 | No |
| 70 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 10722 | -0.099 | -0.1359 | No |
| 71 | SLC29A2 | SLC29A2 Entrez, Source | solute carrier family 29 (nucleoside transporters), member 2 | 10955 | -0.109 | -0.1481 | No |
| 72 | SF3B1 | SF3B1 Entrez, Source | splicing factor 3b, subunit 1, 155kDa | 11008 | -0.112 | -0.1466 | No |
| 73 | SLC27A1 | SLC27A1 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 1 | 11015 | -0.113 | -0.1417 | No |
| 74 | KLHL5 | KLHL5 Entrez, Source | kelch-like 5 (Drosophila) | 11028 | -0.113 | -0.1371 | No |
| 75 | RNF146 | RNF146 Entrez, Source | ring finger protein 146 | 11245 | -0.124 | -0.1474 | No |
| 76 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11372 | -0.130 | -0.1507 | No |
| 77 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 11404 | -0.131 | -0.1467 | No |
| 78 | SLC22A17 | SLC22A17 Entrez, Source | solute carrier family 22 (organic cation transporter), member 17 | 11450 | -0.135 | -0.1436 | No |
| 79 | TBRG1 | TBRG1 Entrez, Source | transforming growth factor beta regulator 1 | 11701 | -0.150 | -0.1553 | No |
| 80 | CTSF | CTSF Entrez, Source | cathepsin F | 11996 | -0.172 | -0.1692 | No |
| 81 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 12163 | -0.188 | -0.1726 | No |
| 82 | GABBR1 | GABBR1 Entrez, Source | gamma-aminobutyric acid (GABA) B receptor, 1 | 12170 | -0.189 | -0.1640 | No |
| 83 | DDIT3 | DDIT3 Entrez, Source | DNA-damage-inducible transcript 3 | 12335 | -0.209 | -0.1663 | No |
| 84 | KLHL24 | KLHL24 Entrez, Source | kelch-like 24 (Drosophila) | 12386 | -0.213 | -0.1598 | No |
| 85 | PLD3 | PLD3 Entrez, Source | phospholipase D family, member 3 | 12403 | -0.215 | -0.1506 | No |
| 86 | BRF2 | BRF2 Entrez, Source | BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like | 12411 | -0.216 | -0.1408 | No |
| 87 | FABP3 | FABP3 Entrez, Source | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 12473 | -0.224 | -0.1346 | No |
| 88 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 12493 | -0.227 | -0.1251 | No |
| 89 | PBXIP1 | PBXIP1 Entrez, Source | pre-B-cell leukemia transcription factor interacting protein 1 | 12721 | -0.269 | -0.1292 | No |
| 90 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 12725 | -0.270 | -0.1164 | No |
| 91 | IL1R1 | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 12840 | -0.300 | -0.1106 | No |
| 92 | CALCOCO1 | CALCOCO1 Entrez, Source | calcium binding and coiled-coil domain 1 | 12960 | -0.344 | -0.1030 | No |
| 93 | TSC22D3 | TSC22D3 Entrez, Source | TSC22 domain family, member 3 | 13117 | -0.441 | -0.0935 | No |
| 94 | GLS | GLS Entrez, Source | glutaminase | 13118 | -0.442 | -0.0722 | No |
| 95 | DPP7 | DPP7 Entrez, Source | dipeptidyl-peptidase 7 | 13210 | -0.577 | -0.0512 | No |
| 96 | TIMP2 | TIMP2 Entrez, Source | TIMP metallopeptidase inhibitor 2 | 13217 | -0.592 | -0.0231 | No |
| 97 | TSC22D1 | TSC22D1 Entrez, Source | TSC22 domain family, member 1 | 13246 | -0.674 | 0.0072 | No |
