Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | STEROID_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.52806365 |
| Normalized Enrichment Score (NES) | 1.6864364 |
| Nominal p-value | 0.011337869 |
| FDR q-value | 0.036763668 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ACOX2 | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 60 | 0.721 | 0.0936 | Yes |
| 2 | NR0B2 | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 187 | 0.486 | 0.1503 | Yes |
| 3 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 282 | 0.412 | 0.1994 | Yes |
| 4 | HSD3B1 | HSD3B1 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | 293 | 0.402 | 0.2533 | Yes |
| 5 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 315 | 0.386 | 0.3043 | Yes |
| 6 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 333 | 0.375 | 0.3541 | Yes |
| 7 | NR1H4 | NR1H4 Entrez, Source | nuclear receptor subfamily 1, group H, member 4 | 543 | 0.285 | 0.3772 | Yes |
| 8 | BAAT | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 580 | 0.273 | 0.4117 | Yes |
| 9 | NR1I2 | NR1I2 Entrez, Source | nuclear receptor subfamily 1, group I, member 2 | 613 | 0.262 | 0.4450 | Yes |
| 10 | SCP2 | SCP2 Entrez, Source | sterol carrier protein 2 | 624 | 0.260 | 0.4797 | Yes |
| 11 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 656 | 0.251 | 0.5115 | Yes |
| 12 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 829 | 0.216 | 0.5281 | Yes |
| 13 | CLN8 | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 1178 | 0.173 | 0.5255 | No |
| 14 | BMP6 | BMP6 Entrez, Source | bone morphogenetic protein 6 | 1653 | 0.140 | 0.5089 | No |
| 15 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 1743 | 0.134 | 0.5205 | No |
| 16 | DHRS9 | DHRS9 Entrez, Source | dehydrogenase/reductase (SDR family) member 9 | 1998 | 0.122 | 0.5180 | No |
| 17 | SCARB1 | SCARB1 Entrez, Source | scavenger receptor class B, member 1 | 2252 | 0.112 | 0.5142 | No |
| 18 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 2678 | 0.096 | 0.4954 | No |
| 19 | SULT2A1 | SULT2A1 Entrez, Source | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 | 2731 | 0.094 | 0.5044 | No |
| 20 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 2909 | 0.088 | 0.5030 | No |
| 21 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 3231 | 0.078 | 0.4895 | No |
| 22 | AKR1B10 | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 4097 | 0.057 | 0.4322 | No |
| 23 | ACOX3 | ACOX3 Entrez, Source | acyl-Coenzyme A oxidase 3, pristanoyl | 4291 | 0.053 | 0.4249 | No |
| 24 | IL4 | IL4 Entrez, Source | interleukin 4 | 4550 | 0.047 | 0.4120 | No |
| 25 | NR0B1 | NR0B1 Entrez, Source | nuclear receptor subfamily 0, group B, member 1 | 4557 | 0.047 | 0.4180 | No |
| 26 | HDLBP | HDLBP Entrez, Source | high density lipoprotein binding protein (vigilin) | 5095 | 0.036 | 0.3825 | No |
| 27 | SHH | SHH Entrez, Source | sonic hedgehog homolog (Drosophila) | 5382 | 0.031 | 0.3652 | No |
| 28 | TSPO | TSPO Entrez, Source | translocator protein (18kDa) | 5475 | 0.028 | 0.3621 | No |
| 29 | HSD11B2 | HSD11B2 Entrez, Source | hydroxysteroid (11-beta) dehydrogenase 2 | 6111 | 0.016 | 0.3165 | No |
| 30 | CYP7B1 | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 7432 | -0.011 | 0.2188 | No |
| 31 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7856 | -0.020 | 0.1897 | No |
| 32 | FDXR | FDXR Entrez, Source | ferredoxin reductase | 7908 | -0.021 | 0.1888 | No |
| 33 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 8334 | -0.031 | 0.1610 | No |
| 34 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 9302 | -0.054 | 0.0957 | No |
| 35 | STUB1 | STUB1 Entrez, Source | STIP1 homology and U-box containing protein 1 | 9754 | -0.067 | 0.0709 | No |
| 36 | YWHAH | YWHAH Entrez, Source | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 9794 | -0.068 | 0.0772 | No |
| 37 | GBA2 | GBA2 Entrez, Source | glucosidase, beta (bile acid) 2 | 10142 | -0.079 | 0.0619 | No |
| 38 | MBTPS2 | MBTPS2 Entrez, Source | membrane-bound transcription factor peptidase, site 2 | 10788 | -0.102 | 0.0274 | No |
| 39 | CYP11A1 | CYP11A1 Entrez, Source | cytochrome P450, family 11, subfamily A, polypeptide 1 | 11705 | -0.150 | -0.0211 | No |
| 40 | ADM | ADM Entrez, Source | adrenomedullin | 12796 | -0.285 | -0.0643 | No |
| 41 | SOAT1 | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 12979 | -0.351 | -0.0302 | No |
| 42 | ABCG1 | ABCG1 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 1 | 13094 | -0.421 | 0.0186 | No |
