Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | double_gel_8d |
| GeneSet | SUBSTRATE_SPECIFIC_CHANNEL_ACTIVITY |
| Enrichment Score (ES) | 0.4053379 |
| Normalized Enrichment Score (NES) | 1.5560035 |
| Nominal p-value | 0.0022573364 |
| FDR q-value | 0.091525055 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 69 | 0.692 | 0.0517 | Yes |
| 2 | TRPM2 | TRPM2 Entrez, Source | transient receptor potential cation channel, subfamily M, member 2 | 161 | 0.520 | 0.0875 | Yes |
| 3 | AQP9 | AQP9 Entrez, Source | aquaporin 9 | 197 | 0.479 | 0.1241 | Yes |
| 4 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 331 | 0.377 | 0.1450 | Yes |
| 5 | AQP7 | AQP7 Entrez, Source | aquaporin 7 | 573 | 0.276 | 0.1495 | Yes |
| 6 | FXYD1 | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 789 | 0.221 | 0.1514 | Yes |
| 7 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 824 | 0.217 | 0.1667 | Yes |
| 8 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 874 | 0.211 | 0.1803 | Yes |
| 9 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 888 | 0.209 | 0.1964 | Yes |
| 10 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 912 | 0.206 | 0.2116 | Yes |
| 11 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 938 | 0.201 | 0.2263 | Yes |
| 12 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 1053 | 0.187 | 0.2330 | Yes |
| 13 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 1078 | 0.184 | 0.2463 | Yes |
| 14 | KCNK3 | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 1094 | 0.183 | 0.2602 | Yes |
| 15 | PDPN | PDPN Entrez, Source | podoplanin | 1169 | 0.174 | 0.2689 | Yes |
| 16 | AQP8 | AQP8 Entrez, Source | aquaporin 8 | 1275 | 0.166 | 0.2745 | Yes |
| 17 | KCNK15 | KCNK15 Entrez, Source | potassium channel, subfamily K, member 15 | 1313 | 0.163 | 0.2851 | Yes |
| 18 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 1332 | 0.162 | 0.2971 | Yes |
| 19 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 1475 | 0.151 | 0.2988 | Yes |
| 20 | NOX1 | NOX1 Entrez, Source | NADPH oxidase 1 | 1538 | 0.147 | 0.3061 | Yes |
| 21 | TRPV2 | TRPV2 Entrez, Source | transient receptor potential cation channel, subfamily V, member 2 | 1604 | 0.143 | 0.3129 | Yes |
| 22 | KCNK10 | KCNK10 Entrez, Source | potassium channel, subfamily K, member 10 | 1613 | 0.142 | 0.3240 | Yes |
| 23 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 1870 | 0.128 | 0.3151 | Yes |
| 24 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 1904 | 0.126 | 0.3230 | Yes |
| 25 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 1954 | 0.124 | 0.3294 | Yes |
| 26 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 1956 | 0.124 | 0.3395 | Yes |
| 27 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 2009 | 0.121 | 0.3455 | Yes |
| 28 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 2034 | 0.120 | 0.3536 | Yes |
| 29 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 2052 | 0.119 | 0.3621 | Yes |
| 30 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 2201 | 0.114 | 0.3603 | Yes |
| 31 | CLCNKB | CLCNKB Entrez, Source | chloride channel Kb | 2372 | 0.108 | 0.3563 | Yes |
| 32 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 2449 | 0.105 | 0.3592 | Yes |
| 33 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 2461 | 0.104 | 0.3669 | Yes |
| 34 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 2482 | 0.103 | 0.3739 | Yes |
| 35 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 2567 | 0.100 | 0.3758 | Yes |
| 36 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 2794 | 0.092 | 0.3662 | Yes |
| 37 | KCNN2 | KCNN2 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 2929 | 0.087 | 0.3633 | Yes |
| 38 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 2946 | 0.087 | 0.3692 | Yes |
| 39 | AQP2 | AQP2 Entrez, Source | aquaporin 2 (collecting duct) | 2986 | 0.085 | 0.3732 | Yes |
| 40 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 3015 | 0.084 | 0.3780 | Yes |
| 41 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 3083 | 0.082 | 0.3797 | Yes |
| 42 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 3089 | 0.082 | 0.3861 | Yes |
| 43 | CLCN1 | CLCN1 Entrez, Source | chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) | 3212 | 0.078 | 0.3833 | Yes |
| 44 | GLRA1 | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 3262 | 0.077 | 0.3859 | Yes |
| 45 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 3341 | 0.075 | 0.3861 | Yes |
| 46 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 3348 | 0.075 | 0.3918 | Yes |
| 47 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 3394 | 0.074 | 0.3945 | Yes |
| 48 | TRPV5 | TRPV5 Entrez, Source | transient receptor potential cation channel, subfamily V, member 5 | 3539 | 0.070 | 0.3893 | Yes |
| 49 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 3644 | 0.068 | 0.3870 | Yes |
| 50 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 3659 | 0.067 | 0.3915 | Yes |
| 51 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 3661 | 0.067 | 0.3969 | Yes |
| 52 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 3729 | 0.066 | 0.3973 | Yes |
| 53 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 3777 | 0.065 | 0.3990 | Yes |
| 54 | TRPV6 | TRPV6 Entrez, Source | transient receptor potential cation channel, subfamily V, member 6 | 3845 | 0.063 | 0.3991 | Yes |
| 55 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 3882 | 0.062 | 0.4015 | Yes |
| 56 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 3900 | 0.062 | 0.4053 | Yes |
| 57 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 4053 | 0.058 | 0.3986 | No |
| 58 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 4154 | 0.056 | 0.3957 | No |
| 59 | GLRB | GLRB Entrez, Source | glycine receptor, beta | 4280 | 0.053 | 0.3906 | No |
| 60 | AQP6 | AQP6 Entrez, Source | aquaporin 6, kidney specific | 4426 | 0.050 | 0.3837 | No |
| 61 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 4463 | 0.049 | 0.3850 | No |
| 62 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 4581 | 0.047 | 0.3800 | No |
| 63 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 4700 | 0.044 | 0.3747 | No |
| 64 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 4725 | 0.043 | 0.3764 | No |
| 65 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 4735 | 0.043 | 0.3793 | No |
| 66 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 4740 | 0.043 | 0.3825 | No |
| 67 | TRPV1 | TRPV1 Entrez, Source | transient receptor potential cation channel, subfamily V, member 1 | 4760 | 0.043 | 0.3846 | No |
| 68 | CNGB1 | CNGB1 Entrez, Source | cyclic nucleotide gated channel beta 1 | 4828 | 0.041 | 0.3829 | No |
| 69 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 4885 | 0.040 | 0.3820 | No |
| 70 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 4936 | 0.039 | 0.3814 | No |
| 71 | AQP5 | AQP5 Entrez, Source | aquaporin 5 | 4954 | 0.039 | 0.3833 | No |
| 72 | TRPM1 | TRPM1 Entrez, Source | transient receptor potential cation channel, subfamily M, member 1 | 5024 | 0.037 | 0.3812 | No |
| 73 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 5106 | 0.036 | 0.3780 | No |
| 74 | ACCN4 | ACCN4 Entrez, Source | amiloride-sensitive cation channel 4, pituitary | 5134 | 0.035 | 0.3788 | No |
| 75 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 5201 | 0.034 | 0.3766 | No |
| 76 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 5251 | 0.033 | 0.3756 | No |
| 77 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 5281 | 0.032 | 0.3761 | No |
| 78 | CLCA2 | CLCA2 Entrez, Source | chloride channel, calcium activated, family member 2 | 5467 | 0.029 | 0.3644 | No |
| 79 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 5571 | 0.026 | 0.3588 | No |
| 80 | GLRA2 | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 5658 | 0.024 | 0.3543 | No |
| 81 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 5737 | 0.023 | 0.3503 | No |
| 82 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 5740 | 0.023 | 0.3520 | No |
| 83 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 5759 | 0.023 | 0.3525 | No |
| 84 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 5774 | 0.022 | 0.3533 | No |
| 85 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 5907 | 0.020 | 0.3449 | No |
| 86 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 5930 | 0.020 | 0.3449 | No |
| 87 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 5958 | 0.019 | 0.3444 | No |
| 88 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 6183 | 0.015 | 0.3287 | No |
| 89 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 6322 | 0.011 | 0.3192 | No |
| 90 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 6344 | 0.011 | 0.3185 | No |
| 91 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 6533 | 0.007 | 0.3048 | No |
| 92 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 6736 | 0.004 | 0.2898 | No |
| 93 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 6807 | 0.002 | 0.2847 | No |
| 94 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 6910 | -0.000 | 0.2770 | No |
| 95 | CLCN2 | CLCN2 Entrez, Source | chloride channel 2 | 6939 | -0.001 | 0.2749 | No |
| 96 | BSND | BSND Entrez, Source | Bartter syndrome, infantile, with sensorineural deafness (Barttin) | 6986 | -0.002 | 0.2716 | No |
| 97 | NMUR2 | NMUR2 Entrez, Source | neuromedin U receptor 2 | 7018 | -0.003 | 0.2695 | No |
| 98 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 7037 | -0.003 | 0.2683 | No |
| 99 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 7121 | -0.004 | 0.2624 | No |
| 100 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 7175 | -0.006 | 0.2589 | No |
| 101 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 7210 | -0.006 | 0.2568 | No |
| 102 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 7275 | -0.008 | 0.2526 | No |
| 103 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 7491 | -0.012 | 0.2374 | No |
| 104 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 7663 | -0.016 | 0.2257 | No |
| 105 | CLCN3 | CLCN3 Entrez, Source | chloride channel 3 | 7723 | -0.017 | 0.2227 | No |
| 106 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 7874 | -0.020 | 0.2130 | No |
| 107 | CFTR | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 8112 | -0.026 | 0.1972 | No |
| 108 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 8234 | -0.028 | 0.1903 | No |
| 109 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 8268 | -0.029 | 0.1902 | No |
| 110 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 8615 | -0.037 | 0.1671 | No |
| 111 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 8788 | -0.041 | 0.1574 | No |
| 112 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 8895 | -0.043 | 0.1530 | No |
| 113 | CNGA3 | CNGA3 Entrez, Source | cyclic nucleotide gated channel alpha 3 | 8916 | -0.044 | 0.1551 | No |
| 114 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 8974 | -0.045 | 0.1545 | No |
| 115 | CUL5 | CUL5 Entrez, Source | cullin 5 | 9220 | -0.052 | 0.1402 | No |
| 116 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 9450 | -0.058 | 0.1276 | No |
| 117 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 9766 | -0.067 | 0.1093 | No |
| 118 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 10536 | -0.093 | 0.0587 | No |
| 119 | FXYD3 | FXYD3 Entrez, Source | FXYD domain containing ion transport regulator 3 | 10861 | -0.105 | 0.0429 | No |
| 120 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 11208 | -0.122 | 0.0267 | No |
| 121 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 11279 | -0.126 | 0.0317 | No |
| 122 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 11348 | -0.129 | 0.0371 | No |
| 123 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 12816 | -0.291 | -0.0499 | No |
| 124 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 12940 | -0.335 | -0.0317 | No |
| 125 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 12957 | -0.341 | -0.0048 | No |
| 126 | P2RX2 | P2RX2 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 2 | 13080 | -0.412 | 0.0198 | No |
