Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_single_gel_8d.class.cls
#double_gel_8d_versus_single_gel_8d_repos
Phenotypeclass.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in classdouble_gel_8d
GeneSetSUBSTRATE_SPECIFIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY
Enrichment Score (ES)0.38608664
Normalized Enrichment Score (NES)1.6296766
Nominal p-value0.0
FDR q-value0.056350846
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SUBSTRATE_SPECIFIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 141.2460.0376Yes
2ABCB11ABCB11
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 11460.7700.0579Yes
3P2RX5P2RX5
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 5690.6920.0773Yes
4SLC17A1SLC17A1
Entrez,  Source
solute carrier family 17 (sodium phosphate), member 11070.6060.0929Yes
5SLC25A15SLC25A15
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 151130.5970.1107Yes
6TRPM2TRPM2
Entrez,  Source
transient receptor potential cation channel, subfamily M, member 21610.5200.1229Yes
7AQP9AQP9
Entrez,  Source
aquaporin 91970.4790.1348Yes
8SLC7A2SLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 22230.4560.1467Yes
9SLC2A5SLC2A5
Entrez,  Source
solute carrier family 2 (facilitated glucose/fructose transporter), member 52760.4170.1554Yes
10SLC22A1SLC22A1
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 13130.3890.1645Yes
11SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 33190.3840.1758Yes
12SCN4BSCN4B
Entrez,  Source
sodium channel, voltage-gated, type IV, beta3310.3770.1864Yes
13SLC20A1SLC20A1
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 13720.3540.1941Yes
14SLC16A6SLC16A6
Entrez,  Source
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)3940.3400.2029Yes
15SLC6A9SLC6A9
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 93960.3400.2132Yes
16SLC22A7SLC22A7
Entrez,  Source
solute carrier family 22 (organic anion transporter), member 74370.3260.2200Yes
17SLC25A22SLC25A22
Entrez,  Source
solute carrier family 25 (mitochondrial carrier: glutamate), member 224880.3050.2255Yes
18SLC40A1SLC40A1
Entrez,  Source
solute carrier family 40 (iron-regulated transporter), member 15000.3000.2338Yes
19SLC11A2SLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 25380.2870.2397Yes
20SLC5A3SLC5A3
Entrez,  Source
solute carrier family 5 (inositol transporters), member 35650.2790.2462Yes
21AQP7AQP7
Entrez,  Source
aquaporin 75730.2760.2540Yes
22SLC25A10SLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 106420.2550.2566Yes
23SLC37A4SLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 46750.2460.2616Yes
24SLC17A3SLC17A3
Entrez,  Source
solute carrier family 17 (sodium phosphate), member 36870.2410.2681Yes
25SLC35A3SLC35A3
Entrez,  Source
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A36970.2390.2747Yes
26SLC13A2SLC13A2
Entrez,  Source
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 27810.2220.2751Yes
27FXYD1FXYD1
Entrez,  Source
FXYD domain containing ion transport regulator 1 (phospholemman)7890.2210.2813Yes
28COX4I2COX4I2
Entrez,  Source
cytochrome c oxidase subunit IV isoform 2 (lung)8110.2190.2864Yes
29P2RX7P2RX7
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 78240.2170.2921Yes
30KCNK1KCNK1
Entrez,  Source
potassium channel, subfamily K, member 18740.2110.2948Yes
31KCNC1KCNC1
Entrez,  Source
potassium voltage-gated channel, Shaw-related subfamily, member 18880.2090.3001Yes
32KCNA2KCNA2
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 29120.2060.3046Yes
33P2RX4P2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 49380.2010.3088Yes
34SLC25A1SLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 19460.2000.3144Yes
35KCNB2KCNB2
Entrez,  Source
potassium voltage-gated channel, Shab-related subfamily, member 210530.1870.3120Yes
36ITPR1ITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 110730.1850.3161Yes
37MS4A2MS4A2
Entrez,  Source
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)10780.1840.3214Yes
38KCNK3KCNK3
Entrez,  Source
potassium channel, subfamily K, member 310940.1830.3259Yes
39SLC6A2SLC6A2
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 210980.1820.3312Yes
40PDPNPDPN
Entrez,  Source
podoplanin11690.1740.3311Yes
41SLC23A1SLC23A1
Entrez,  Source
solute carrier family 23 (nucleobase transporters), member 111870.1720.3350Yes
42SLC22A4SLC22A4
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 411950.1710.3397Yes
43KCNK15KCNK15
Entrez,  Source
potassium channel, subfamily K, member 1513130.1630.3357Yes
44KCNJ10KCNJ10
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1013320.1620.3393Yes
45SLC28A2SLC28A2
Entrez,  Source
solute carrier family 28 (sodium-coupled nucleoside transporter), member 214590.1520.3343Yes
46TRPC3TRPC3
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 314750.1510.3377Yes
47NOX1NOX1
Entrez,  Source
NADPH oxidase 115380.1470.3374Yes
48ATP1A3ATP1A3
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 3 polypeptide15430.1460.3416Yes
49ATP2A3ATP2A3
Entrez,  Source
ATPase, Ca++ transporting, ubiquitous16000.1430.3416Yes
50TRPV2TRPV2
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 216040.1430.3458Yes
51KCNK10KCNK10
Entrez,  Source
potassium channel, subfamily K, member 1016130.1420.3495Yes
52ATP4AATP4A
Entrez,  Source
ATPase, H+/K+ exchanging, alpha polypeptide16540.1400.3507Yes
53SLC34A3SLC34A3
Entrez,  Source
solute carrier family 34 (sodium phosphate), member 316610.1390.3544Yes
54SLC5A1SLC5A1
Entrez,  Source
solute carrier family 5 (sodium/glucose cotransporter), member 116720.1390.3579Yes
55SLC9A3SLC9A3
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 318120.1300.3512Yes
56ATP1A4ATP1A4
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 4 polypeptide18230.1300.3544Yes
57SLC1A2SLC1A2
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 218330.1290.3577Yes
58COX7BCOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb18490.1290.3604Yes
59CHRNA3CHRNA3
Entrez,  Source
cholinergic receptor, nicotinic, alpha 318700.1280.3628Yes
60ATP2B3ATP2B3
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 318980.1260.3646Yes
61KCNIP2KCNIP2
Entrez,  Source
Kv channel interacting protein 219040.1260.3680Yes
62SLC12A3SLC12A3
Entrez,  Source
solute carrier family 12 (sodium/chloride transporters), member 319480.1240.3685Yes
63CHRNECHRNE
Entrez,  Source
cholinergic receptor, nicotinic, epsilon19540.1240.3719Yes
64CACNA1CCACNA1C
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1C subunit19560.1240.3756Yes
65CACNA1ECACNA1E
Entrez,  Source
calcium channel, voltage-dependent, alpha 1E subunit20090.1210.3753Yes
66SCN11ASCN11A
Entrez,  Source
sodium channel, voltage-gated, type XI, alpha20340.1200.3771Yes
67CHRNA2CHRNA2
Entrez,  Source
cholinergic receptor, nicotinic, alpha 2 (neuronal)20520.1190.3794Yes
68SLC22A2SLC22A2
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 221770.1150.3735Yes
69KCNC3KCNC3
Entrez,  Source
potassium voltage-gated channel, Shaw-related subfamily, member 322010.1140.3752Yes
70SLC31A1SLC31A1
Entrez,  Source
solute carrier family 31 (copper transporters), member 122370.1130.3760Yes
71SLC4A4SLC4A4
Entrez,  Source
solute carrier family 4, sodium bicarbonate cotransporter, member 422860.1110.3757Yes
72SLC16A8SLC16A8
Entrez,  Source
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)22970.1100.3782Yes
73SLC22A6SLC22A6
Entrez,  Source
solute carrier family 22 (organic anion transporter), member 623320.1090.3790Yes
74CLCNKBCLCNKB
Entrez,  Source
chloride channel Kb23720.1080.3793Yes
75KCNH4KCNH4
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 424490.1050.3766Yes
76RYR2RYR2
Entrez,  Source
ryanodine receptor 2 (cardiac)24610.1040.3790Yes
77P2RX3P2RX3
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 324820.1030.3806Yes
78COX8ACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)25010.1020.3823Yes
79CHRNA4CHRNA4
Entrez,  Source
cholinergic receptor, nicotinic, alpha 425670.1000.3804Yes
80ATP4BATP4B
Entrez,  Source
ATPase, H+/K+ exchanging, beta polypeptide25790.1000.3826Yes
81CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)26080.0990.3835Yes
82SLC9A5SLC9A5
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 526140.0990.3861Yes
83SLC25A5SLC25A5
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 527560.0940.3781No
84HTR3BHTR3B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 3B27940.0920.3781No
85ATP7BATP7B
Entrez,  Source
ATPase, Cu++ transporting, beta polypeptide29000.0880.3728No
86KCNN2KCNN2
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 229290.0870.3733No
87SLC16A1SLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)29350.0870.3755No
88CACNA1BCACNA1B
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1B subunit29460.0870.3774No
89SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 229690.0860.3783No
90ATP2A1ATP2A1
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, fast twitch 129700.0860.3809No
91KCNJ12KCNJ12
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1230150.0840.3801No
92KCNH3KCNH3
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 330830.0820.3775No
93KCNN3KCNN3
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 330890.0820.3796No
94SLC2A4SLC2A4
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 430910.0820.3820No
95SURF1SURF1
Entrez,  Source
surfeit 130980.0820.3841No
96CLCN1CLCN1
Entrez,  Source
chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant)32120.0780.3778No
97GLRA1GLRA1
Entrez,  Source
glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)32620.0770.3764No
98SLC17A5SLC17A5
Entrez,  Source
solute carrier family 17 (anion/sugar transporter), member 533070.0760.3753No
99KCNJ15KCNJ15
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1533410.0750.3751No
100KCNMB4KCNMB4
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 433480.0750.3769No
101CACNG2CACNG2
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 233940.0740.3757No
102SLC7A8SLC7A8
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 834360.0730.3748No
103TRPV5TRPV5
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 535390.0700.3691No
104SLC35B2SLC35B2
Entrez,  Source
solute carrier family 35, member B235590.0690.3698No
105SLC26A4SLC26A4
Entrez,  Source
solute carrier family 26, member 435760.0690.3706No
106CACNB2CACNB2
Entrez,  Source
calcium channel, voltage-dependent, beta 2 subunit36440.0680.3676No
107SCNN1GSCNN1G
Entrez,  Source
sodium channel, nonvoltage-gated 1, gamma36590.0670.3686No
108KCNA6KCNA6
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 636610.0670.3705No
109KCNE1KCNE1
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 137290.0660.3674No
110KCNN4KCNN4
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 437770.0650.3658No
111TRPV6TRPV6
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 638450.0630.3626No
112KCNS1KCNS1
Entrez,  Source
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 138820.0620.3617No
113KCNA4KCNA4
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 439000.0620.3623No
114SLC14A1SLC14A1
Entrez,  Source
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)40330.0590.3540No
115SLC35B1SLC35B1
Entrez,  Source
solute carrier family 35, member B140430.0580.3551No
116KCNE2KCNE2
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 240530.0580.3562No
117KCND3KCND3
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 341540.0560.3502No
118GLRBGLRB
Entrez,  Source
glycine receptor, beta42800.0530.3423No
119COX5BCOX5B
Entrez,  Source
cytochrome c oxidase subunit Vb43250.0520.3405No
120KCNH1KCNH1
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 144630.0490.3315No
121ATP1A2ATP1A2
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide45780.0470.3242No
122KCNQ1KCNQ1
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 145810.0470.3255No
123SLC34A1SLC34A1
Entrez,  Source
solute carrier family 34 (sodium phosphate), member 146900.0440.3186No
124SLC1A5SLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 546970.0440.3194No
125P2RX1P2RX1
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 147000.0440.3206No
126CHRNA7CHRNA7
Entrez,  Source
cholinergic receptor, nicotinic, alpha 747250.0430.3201No
127CACNA1HCACNA1H
Entrez,  Source
calcium channel, voltage-dependent, alpha 1H subunit47350.0430.3207No
128CACNA1ACACNA1A
Entrez,  Source
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit47400.0430.3217No
129TRPV1TRPV1
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 147600.0430.3216No
130SLC22A12SLC22A12
Entrez,  Source
solute carrier family 22 (organic anion/cation transporter), member 1248100.0420.3191No
131CNGB1CNGB1
Entrez,  Source
cyclic nucleotide gated channel beta 148280.0410.3190No
132UQCRC1UQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I48610.0410.3178No
133SLC6A6SLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 648740.0400.3181No
134KCNMB1KCNMB1
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 148850.0400.3186No
135KCNJ1KCNJ1
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 149360.0390.3160No
136UQCRHUQCRH
Entrez,  Source
ubiquinol-cytochrome c reductase hinge protein49660.0390.3149No
137RHCGRHCG
Entrez,  Source
Rh family, C glycoprotein50060.0380.3131No
138TRPM1TRPM1
Entrez,  Source
transient receptor potential cation channel, subfamily M, member 150240.0370.3129No
139CACNA1DCACNA1D
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1D subunit51060.0360.3078No
140ACCN4ACCN4
Entrez,  Source
amiloride-sensitive cation channel 4, pituitary51340.0350.3068No
141SLC6A5SLC6A5
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 551770.0340.3047No
142KCNJ4KCNJ4
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 452010.0340.3039No
143KCNA1KCNA1
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)52510.0330.3012No
144CACNA1GCACNA1G
Entrez,  Source
calcium channel, voltage-dependent, alpha 1G subunit52810.0320.2999No
145SLC1A3SLC1A3
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 353620.0310.2948No
146SLC17A7SLC17A7
Entrez,  Source
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 753730.0310.2949No
147COX4I1COX4I1
Entrez,  Source
cytochrome c oxidase subunit IV isoform 153800.0310.2954No
148CLCA2CLCA2
Entrez,  Source
chloride channel, calcium activated, family member 254670.0290.2897No
149SLC25A19SLC25A19
Entrez,  Source
solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 1954980.0280.2883No
150RYR1RYR1
Entrez,  Source
ryanodine receptor 1 (skeletal)55710.0260.2835No
151GLRA2GLRA2
Entrez,  Source
glycine receptor, alpha 256580.0240.2777No
152CACNB4CACNB4
Entrez,  Source
calcium channel, voltage-dependent, beta 4 subunit57370.0230.2724No
153CACNG4CACNG4
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 457400.0230.2730No
154KCNQ2KCNQ2
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 257590.0230.2723No
155KCNA5KCNA5
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 557740.0220.2719No
156COX5ACOX5A
Entrez,  Source
cytochrome c oxidase subunit Va58000.0220.2707No
157FXYD2FXYD2
Entrez,  Source
FXYD domain containing ion transport regulator 258620.0210.2666No
158RHAGRHAG
Entrez,  Source
Rh-associated glycoprotein58780.0210.2661No
159SCN7ASCN7A
Entrez,  Source
sodium channel, voltage-gated, type VII, alpha59070.0200.2646No
160SLC5A7SLC5A7
Entrez,  Source
solute carrier family 5 (choline transporter), member 759260.0200.2638No
161SCN4ASCN4A
Entrez,  Source
sodium channel, voltage-gated, type IV, alpha59300.0200.2642No
162SLC5A6SLC5A6
Entrez,  Source
solute carrier family 5 (sodium-dependent vitamin transporter), member 659440.0190.2638No
163CHRNB3CHRNB3
Entrez,  Source
cholinergic receptor, nicotinic, beta 359580.0190.2634No
164SLC22A8SLC22A8
Entrez,  Source
solute carrier family 22 (organic anion transporter), member 859840.0190.2620No
165ABCC8ABCC8
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 861130.0160.2527No
166SLC12A1SLC12A1
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 161290.0160.2520No
167CHRNB2CHRNB2
Entrez,  Source
cholinergic receptor, nicotinic, beta 2 (neuronal)61830.0150.2484No
168TRPC5TRPC5
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 563220.0110.2382No
169ATP1B2ATP1B2
Entrez,  Source
ATPase, Na+/K+ transporting, beta 2 polypeptide63250.0110.2384No
170ACCN1ACCN1
Entrez,  Source
amiloride-sensitive cation channel 1, neuronal (degenerin)63440.0110.2374No
171SLC4A1SLC4A1
Entrez,  Source
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)64790.0080.2274No
172SLC14A2SLC14A2
Entrez,  Source
solute carrier family 14 (urea transporter), member 265320.0070.2236No
173KCNJ5KCNJ5
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 565330.0070.2238No
174SLC1A6SLC1A6
Entrez,  Source
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 666740.0050.2132No
175SLC2A3SLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 366830.0040.2128No
176SLC1A4SLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 467040.0040.2114No
177KCNJ3KCNJ3
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 367360.0040.2091No
178ABCC5ABCC5
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 567900.0030.2051No
179CHRNA6CHRNA6
Entrez,  Source
cholinergic receptor, nicotinic, alpha 668070.0020.2040No
180SLC9A2SLC9A2
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 268620.0010.1999No
181CACNA2D1CACNA2D1
Entrez,  Source
calcium channel, voltage-dependent, alpha 2/delta subunit 16910-0.0000.1963No
182ATP2B1ATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 16925-0.0000.1952No
183CLCN2CLCN2
Entrez,  Source
chloride channel 26939-0.0010.1942No
184BSNDBSND
Entrez,  Source
Bartter syndrome, infantile, with sensorineural deafness (Barttin)6986-0.0020.1908No
185SLC7A9SLC7A9
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 97015-0.0020.1887No
186NMUR2NMUR2
Entrez,  Source
neuromedin U receptor 27018-0.0030.1886No
187CHRNDCHRND
Entrez,  Source
cholinergic receptor, nicotinic, delta7037-0.0030.1873No
188KCNQ3KCNQ3
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 37121-0.0040.1811No
189SCN9ASCN9A
Entrez,  Source
sodium channel, voltage-gated, type IX, alpha7175-0.0060.1772No
190TRPC4TRPC4
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 47210-0.0060.1748No
191SLC7A10SLC7A10
Entrez,  Source
solute carrier family 7, (neutral amino acid transporter, y+ system) member 107229-0.0070.1737No
192SLC5A2SLC5A2
Entrez,  Source
solute carrier family 5 (sodium/glucose cotransporter), member 27237-0.0070.1733No
193KCNA3KCNA3
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 37275-0.0080.1707No
194CCSCCS
Entrez,  Source
copper chaperone for superoxide dismutase7339-0.0090.1662No
195KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 27491-0.0120.1550No
196CHRNA1CHRNA1
Entrez,  Source
cholinergic receptor, nicotinic, alpha 1 (muscle)7663-0.0160.1424No
197CLCN3CLCN3
Entrez,  Source
chloride channel 37723-0.0170.1384No
198ATP2B4ATP2B4
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 47808-0.0190.1326No
199SCN2BSCN2B
Entrez,  Source
sodium channel, voltage-gated, type II, beta7874-0.0200.1282No
200ATP6V0E1ATP6V0E1
Entrez,  Source
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e17973-0.0230.1214No
201SLC4A3SLC4A3
Entrez,  Source
solute carrier family 4, anion exchanger, member 37978-0.0230.1218No
202SLC1A1SLC1A1
Entrez,  Source
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 18024-0.0240.1191No
203ATP6V0CATP6V0C
Entrez,  Source
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c8097-0.0250.1144No
204CFTRCFTR
Entrez,  Source
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)8112-0.0260.1141No
205CACNB1CACNB1
Entrez,  Source
calcium channel, voltage-dependent, beta 1 subunit8234-0.0280.1057No
206SCNN1BSCNN1B
Entrez,  Source
sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)8268-0.0290.1040No
207SLC22A3SLC22A3
Entrez,  Source
solute carrier family 22 (extraneuronal monoamine transporter), member 38310-0.0300.1018No
208ATP2C1ATP2C1
Entrez,  Source
ATPase, Ca++ transporting, type 2C, member 18499-0.0340.0885No
209SLC3A1SLC3A1
Entrez,  Source
18542-0.0360.0863No
210SLC7A5SLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 58548-0.0360.0870No
211KCNJ6KCNJ6
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 68615-0.0370.0831No
212ATP1B3ATP1B3
Entrez,  Source
ATPase, Na+/K+ transporting, beta 3 polypeptide8756-0.0400.0736No
213MCL1MCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)8765-0.0400.0742No
214KCNG2KCNG2
Entrez,  Source
potassium voltage-gated channel, subfamily G, member 28788-0.0410.0738No
215CHRNB4CHRNB4
Entrez,  Source
cholinergic receptor, nicotinic, beta 48895-0.0430.0670No
216CNGA3CNGA3
Entrez,  Source
cyclic nucleotide gated channel alpha 38916-0.0440.0668No
217SLC25A11SLC25A11
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 118929-0.0440.0672No
218SCN5ASCN5A
Entrez,  Source
sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)8974-0.0450.0652No
219ITPR2ITPR2
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 29021-0.0460.0631No
220ASNA1ASNA1
Entrez,  Source
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)9162-0.0500.0539No
221CUL5CUL5
Entrez,  Source
cullin 59220-0.0520.0512No
222ABCC3ABCC3
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 39289-0.0540.0476No
223SLC12A9SLC12A9
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 99300-0.0540.0485No
224ATP1A1ATP1A1
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 1 polypeptide9325-0.0550.0483No
225KCNJ14KCNJ14
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 149450-0.0580.0406No
226SLC30A3SLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 39566-0.0620.0337No
227SLC8A1SLC8A1
Entrez,  Source
solute carrier family 8 (sodium/calcium exchanger), member 19583-0.0620.0344No
228SLC29A1SLC29A1
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 19613-0.0630.0341No
229ATP2A2ATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 29620-0.0630.0355No
230PPBPPPBP
Entrez,  Source
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)9692-0.0650.0321No
231ATP7AATP7A
Entrez,  Source
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)9722-0.0660.0319No
232HTR3AHTR3A
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 3A9766-0.0670.0306No
233SERINC1SERINC1
Entrez,  Source
serine incorporator 19801-0.0680.0301No
234CLDN16CLDN16
Entrez,  Source
claudin 169988-0.0740.0181No
235SLC30A4SLC30A4
Entrez,  Source
solute carrier family 30 (zinc transporter), member 410051-0.0760.0157No
236SLC25A3SLC25A3
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 310075-0.0770.0163No
237SLC19A2SLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 210180-0.0810.0108No
238SLC9A1SLC9A1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)10314-0.0850.0032No
239SCN1BSCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta10536-0.093-0.0109No
240SLC12A4SLC12A4
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 410572-0.094-0.0107No
241SLC25A4SLC25A4
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 410578-0.094-0.0082No
242SLC20A2SLC20A2
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 210687-0.098-0.0135No
243FXYD3FXYD3
Entrez,  Source
FXYD domain containing ion transport regulator 310861-0.105-0.0236No
244SLC29A2SLC29A2
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 210955-0.109-0.0273No
245SLC2A1SLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 110998-0.112-0.0272No
246SLC15A2SLC15A2
Entrez,  Source
solute carrier family 15 (H+/peptide transporter), member 211088-0.116-0.0304No
247SLC12A2SLC12A2
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 211116-0.118-0.0289No
248ATP6V1C1ATP6V1C1
Entrez,  Source
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C111130-0.118-0.0263No
249CACNG1CACNG1
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 111208-0.122-0.0285No
250ATP6V1B2ATP6V1B2
Entrez,  Source
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B211244-0.124-0.0274No
251CACNG5CACNG5
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 511279-0.126-0.0262No
252CACNA1SCACNA1S
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1S subunit11348-0.129-0.0275No
253ITPR3ITPR3
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 311479-0.136-0.0333No
254ATP1B1ATP1B1
Entrez,  Source
ATPase, Na+/K+ transporting, beta 1 polypeptide11599-0.144-0.0380No
255SLC4A2SLC4A2
Entrez,  Source
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)11703-0.150-0.0413No
256SLC23A2SLC23A2
Entrez,  Source
solute carrier family 23 (nucleobase transporters), member 211798-0.156-0.0438No
257SLC5A5SLC5A5
Entrez,  Source
solute carrier family 5 (sodium iodide symporter), member 511882-0.163-0.0452No
258SLC34A2SLC34A2
Entrez,  Source
solute carrier family 34 (sodium phosphate), member 211932-0.167-0.0438No
259SLC2A8SLC2A8
Entrez,  Source
solute carrier family 2, (facilitated glucose transporter) member 812054-0.178-0.0477No
260SLC3A2SLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 212198-0.191-0.0528No
261SLC31A2SLC31A2
Entrez,  Source
solute carrier family 31 (copper transporters), member 212274-0.201-0.0524No
262LASP1LASP1
Entrez,  Source
LIM and SH3 protein 112412-0.216-0.0563No
263ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 212438-0.220-0.0515No
264SLC6A8SLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, creatine), member 812677-0.260-0.0618No
265COX15COX15
Entrez,  Source
COX15 homolog, cytochrome c oxidase assembly protein (yeast)12707-0.266-0.0560No
266SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 712774-0.279-0.0525No
267TRPC1TRPC1
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 112816-0.291-0.0468No
268KCNS3KCNS3
Entrez,  Source
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 312940-0.335-0.0460No
269CACNB3CACNB3
Entrez,  Source
calcium channel, voltage-dependent, beta 3 subunit12957-0.341-0.0368No
270SLC15A1SLC15A1
Entrez,  Source
solute carrier family 15 (oligopeptide transporter), member 112976-0.349-0.0276No
271GJA1GJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)13000-0.365-0.0182No
272P2RX2P2RX2
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 213080-0.412-0.0117No
273SLC10A2SLC10A2
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 213314-1.0410.0021No
Table: GSEA details [plain text format]



Fig 2: SUBSTRATE_SPECIFIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SUBSTRATE_SPECIFIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY: Random ES distribution   
Gene set null distribution of ES for SUBSTRATE_SPECIFIC_TRANSMEMBRANE_TRANSPORTER_ACTIVITY