Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_8d_versus_single_gel_8d.class.cls
#double_gel_8d_versus_single_gel_8d_repos
Phenotypeclass.cls#double_gel_8d_versus_single_gel_8d_repos
Upregulated in classdouble_gel_8d
GeneSetSUBSTRATE_SPECIFIC_TRANSPORTER_ACTIVITY
Enrichment Score (ES)0.394574
Normalized Enrichment Score (NES)1.6694955
Nominal p-value0.0
FDR q-value0.042350516
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SUBSTRATE_SPECIFIC_TRANSPORTER_ACTIVITY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 141.2460.0334Yes
2ABCB11ABCB11
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 11460.7700.0511Yes
3P2RX5P2RX5
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 5690.6920.0682Yes
4APOA4APOA4
Entrez,  Source
apolipoprotein A-IV960.6200.0830Yes
5SLC17A1SLC17A1
Entrez,  Source
solute carrier family 17 (sodium phosphate), member 11070.6060.0986Yes
6SLC25A15SLC25A15
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 151130.5970.1144Yes
7APOMAPOM
Entrez,  Source
apolipoprotein M1560.5270.1255Yes
8TRPM2TRPM2
Entrez,  Source
transient receptor potential cation channel, subfamily M, member 21610.5200.1392Yes
9SLCO2A1SLCO2A1
Entrez,  Source
solute carrier organic anion transporter family, member 2A11790.4950.1513Yes
10AQP9AQP9
Entrez,  Source
aquaporin 91970.4790.1630Yes
11SLC7A2SLC7A2
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 22230.4560.1734Yes
12SLC2A5SLC2A5
Entrez,  Source
solute carrier family 2 (facilitated glucose/fructose transporter), member 52760.4170.1807Yes
13SLC22A1SLC22A1
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 13130.3890.1885Yes
14SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 33190.3840.1985Yes
15SCN4BSCN4B
Entrez,  Source
sodium channel, voltage-gated, type IV, beta3310.3770.2079Yes
16SLC20A1SLC20A1
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 13720.3540.2144Yes
17SLC16A6SLC16A6
Entrez,  Source
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)3940.3400.2220Yes
18SLC6A9SLC6A9
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 93960.3400.2311Yes
19SLC22A7SLC22A7
Entrez,  Source
solute carrier family 22 (organic anion transporter), member 74370.3260.2369Yes
20SLC25A22SLC25A22
Entrez,  Source
solute carrier family 25 (mitochondrial carrier: glutamate), member 224880.3050.2413Yes
21SLC40A1SLC40A1
Entrez,  Source
solute carrier family 40 (iron-regulated transporter), member 15000.3000.2486Yes
22SLC11A2SLC11A2
Entrez,  Source
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 25380.2870.2535Yes
23SLC5A3SLC5A3
Entrez,  Source
solute carrier family 5 (inositol transporters), member 35650.2790.2591Yes
24AQP7AQP7
Entrez,  Source
aquaporin 75730.2760.2660Yes
25SLC25A10SLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 106420.2550.2677Yes
26SLC37A4SLC37A4
Entrez,  Source
solute carrier family 37 (glycerol-6-phosphate transporter), member 46750.2460.2719Yes
27SLC17A3SLC17A3
Entrez,  Source
solute carrier family 17 (sodium phosphate), member 36870.2410.2776Yes
28SLC35A3SLC35A3
Entrez,  Source
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A36970.2390.2834Yes
29SLC13A2SLC13A2
Entrez,  Source
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 27810.2220.2831Yes
30FXYD1FXYD1
Entrez,  Source
FXYD domain containing ion transport regulator 1 (phospholemman)7890.2210.2885Yes
31COX4I2COX4I2
Entrez,  Source
cytochrome c oxidase subunit IV isoform 2 (lung)8110.2190.2928Yes
32P2RX7P2RX7
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 78240.2170.2978Yes
33KCNK1KCNK1
Entrez,  Source
potassium channel, subfamily K, member 18740.2110.2997Yes
34PCTPPCTP
Entrez,  Source
phosphatidylcholine transfer protein8820.2100.3049Yes
35KCNC1KCNC1
Entrez,  Source
potassium voltage-gated channel, Shaw-related subfamily, member 18880.2090.3102Yes
36KCNA2KCNA2
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 29120.2060.3140Yes
37P2RX4P2RX4
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 49380.2010.3175Yes
38SLC25A1SLC25A1
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 19460.2000.3224Yes
39APOA1APOA1
Entrez,  Source
apolipoprotein A-I10520.1870.3194Yes
40KCNB2KCNB2
Entrez,  Source
potassium voltage-gated channel, Shab-related subfamily, member 210530.1870.3245Yes
41ITPR1ITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 110730.1850.3280Yes
42HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 410740.1850.3330Yes
43MS4A2MS4A2
Entrez,  Source
membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)10780.1840.3378Yes
44KCNK3KCNK3
Entrez,  Source
potassium channel, subfamily K, member 310940.1830.3416Yes
45SLC6A2SLC6A2
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 210980.1820.3463Yes
46PDPNPDPN
Entrez,  Source
podoplanin11690.1740.3456Yes
47SLC23A1SLC23A1
Entrez,  Source
solute carrier family 23 (nucleobase transporters), member 111870.1720.3490Yes
48SLC22A4SLC22A4
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 411950.1710.3531Yes
49PLSCR1PLSCR1
Entrez,  Source
phospholipid scramblase 112280.1680.3552Yes
50AQP8AQP8
Entrez,  Source
aquaporin 812750.1660.3561Yes
51KCNK15KCNK15
Entrez,  Source
potassium channel, subfamily K, member 1513130.1630.3577Yes
52KCNJ10KCNJ10
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1013320.1620.3607Yes
53SLC28A2SLC28A2
Entrez,  Source
solute carrier family 28 (sodium-coupled nucleoside transporter), member 214590.1520.3552Yes
54TRPC3TRPC3
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 314750.1510.3581Yes
55NOX1NOX1
Entrez,  Source
NADPH oxidase 115380.1470.3573Yes
56ATP1A3ATP1A3
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 3 polypeptide15430.1460.3610Yes
57ATP2A3ATP2A3
Entrez,  Source
ATPase, Ca++ transporting, ubiquitous16000.1430.3606Yes
58TRPV2TRPV2
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 216040.1430.3642Yes
59KCNK10KCNK10
Entrez,  Source
potassium channel, subfamily K, member 1016130.1420.3675Yes
60ATP4AATP4A
Entrez,  Source
ATPase, H+/K+ exchanging, alpha polypeptide16540.1400.3682Yes
61SLC34A3SLC34A3
Entrez,  Source
solute carrier family 34 (sodium phosphate), member 316610.1390.3715Yes
62SLC5A1SLC5A1
Entrez,  Source
solute carrier family 5 (sodium/glucose cotransporter), member 116720.1390.3745Yes
63SLC9A3SLC9A3
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 318120.1300.3673Yes
64ATP1A4ATP1A4
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 4 polypeptide18230.1300.3701Yes
65SLC1A2SLC1A2
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 218330.1290.3729Yes
66COX7BCOX7B
Entrez,  Source
cytochrome c oxidase subunit VIIb18490.1290.3752Yes
67CHRNA3CHRNA3
Entrez,  Source
cholinergic receptor, nicotinic, alpha 318700.1280.3772Yes
68ATP2B3ATP2B3
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 318980.1260.3785Yes
69KCNIP2KCNIP2
Entrez,  Source
Kv channel interacting protein 219040.1260.3815Yes
70SLC12A3SLC12A3
Entrez,  Source
solute carrier family 12 (sodium/chloride transporters), member 319480.1240.3816Yes
71CHRNECHRNE
Entrez,  Source
cholinergic receptor, nicotinic, epsilon19540.1240.3846Yes
72CACNA1CCACNA1C
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1C subunit19560.1240.3879Yes
73CACNA1ECACNA1E
Entrez,  Source
calcium channel, voltage-dependent, alpha 1E subunit20090.1210.3871Yes
74SCN11ASCN11A
Entrez,  Source
sodium channel, voltage-gated, type XI, alpha20340.1200.3886Yes
75CHRNA2CHRNA2
Entrez,  Source
cholinergic receptor, nicotinic, alpha 2 (neuronal)20520.1190.3905Yes
76SLC22A2SLC22A2
Entrez,  Source
solute carrier family 22 (organic cation transporter), member 221770.1150.3841Yes
77KCNC3KCNC3
Entrez,  Source
potassium voltage-gated channel, Shaw-related subfamily, member 322010.1140.3854Yes
78SLC31A1SLC31A1
Entrez,  Source
solute carrier family 31 (copper transporters), member 122370.1130.3858Yes
79SLC4A4SLC4A4
Entrez,  Source
solute carrier family 4, sodium bicarbonate cotransporter, member 422860.1110.3851Yes
80SLC16A8SLC16A8
Entrez,  Source
solute carrier family 16, member 8 (monocarboxylic acid transporter 3)22970.1100.3874Yes
81SLC22A6SLC22A6
Entrez,  Source
solute carrier family 22 (organic anion transporter), member 623320.1090.3877Yes
82CLCNKBCLCNKB
Entrez,  Source
chloride channel Kb23720.1080.3876Yes
83KCNH4KCNH4
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 424490.1050.3847Yes
84RYR2RYR2
Entrez,  Source
ryanodine receptor 2 (cardiac)24610.1040.3866Yes
85P2RX3P2RX3
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 324820.1030.3879Yes
86APODAPOD
Entrez,  Source
apolipoprotein D24910.1030.3901Yes
87COX8ACOX8A
Entrez,  Source
cytochrome c oxidase subunit 8A (ubiquitous)25010.1020.3922Yes
88CHRNA4CHRNA4
Entrez,  Source
cholinergic receptor, nicotinic, alpha 425670.1000.3899Yes
89ATP4BATP4B
Entrez,  Source
ATPase, H+/K+ exchanging, beta polypeptide25790.1000.3918Yes
90CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)26080.0990.3923Yes
91SLC9A5SLC9A5
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 526140.0990.3946Yes
92SLC25A5SLC25A5
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 527560.0940.3863No
93HTR3BHTR3B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 3B27940.0920.3859No
94ATP7BATP7B
Entrez,  Source
ATPase, Cu++ transporting, beta polypeptide29000.0880.3803No
95KCNN2KCNN2
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 229290.0870.3805No
96SLC16A1SLC16A1
Entrez,  Source
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)29350.0870.3825No
97CACNA1BCACNA1B
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1B subunit29460.0870.3840No
98SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 229690.0860.3847No
99ATP2A1ATP2A1
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, fast twitch 129700.0860.3870No
100AQP2AQP2
Entrez,  Source
aquaporin 2 (collecting duct)29860.0850.3882No
101KCNJ12KCNJ12
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1230150.0840.3883No
102KCNH3KCNH3
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 330830.0820.3854No
103KCNN3KCNN3
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 330890.0820.3872No
104SLC2A4SLC2A4
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 430910.0820.3894No
105SURF1SURF1
Entrez,  Source
surfeit 130980.0820.3911No
106CLCN1CLCN1
Entrez,  Source
chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant)32120.0780.3846No
107GLRA1GLRA1
Entrez,  Source
glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)32620.0770.3829No
108SLC17A5SLC17A5
Entrez,  Source
solute carrier family 17 (anion/sugar transporter), member 533070.0760.3816No
109KCNJ15KCNJ15
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 1533410.0750.3811No
110KCNMB4KCNMB4
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 433480.0750.3826No
111CACNG2CACNG2
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 233940.0740.3812No
112SLC7A8SLC7A8
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 834360.0730.3800No
113TRPV5TRPV5
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 535390.0700.3741No
114SLC35B2SLC35B2
Entrez,  Source
solute carrier family 35, member B235590.0690.3745No
115SLC26A4SLC26A4
Entrez,  Source
solute carrier family 26, member 435760.0690.3752No
116CACNB2CACNB2
Entrez,  Source
calcium channel, voltage-dependent, beta 2 subunit36440.0680.3719No
117SCNN1GSCNN1G
Entrez,  Source
sodium channel, nonvoltage-gated 1, gamma36590.0670.3726No
118KCNA6KCNA6
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 636610.0670.3744No
119KCNE1KCNE1
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 137290.0660.3710No
120KCNN4KCNN4
Entrez,  Source
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 437770.0650.3691No
121TRPV6TRPV6
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 638450.0630.3657No
122KCNS1KCNS1
Entrez,  Source
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 138820.0620.3646No
123KCNA4KCNA4
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 439000.0620.3650No
124SLC14A1SLC14A1
Entrez,  Source
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)40330.0590.3565No
125SLC35B1SLC35B1
Entrez,  Source
solute carrier family 35, member B140430.0580.3574No
126KCNE2KCNE2
Entrez,  Source
potassium voltage-gated channel, Isk-related family, member 240530.0580.3583No
127KCND3KCND3
Entrez,  Source
potassium voltage-gated channel, Shal-related subfamily, member 341540.0560.3521No
128GLRBGLRB
Entrez,  Source
glycine receptor, beta42800.0530.3440No
129COX5BCOX5B
Entrez,  Source
cytochrome c oxidase subunit Vb43250.0520.3420No
130AQP6AQP6
Entrez,  Source
aquaporin 6, kidney specific44260.0500.3357No
131KCNH1KCNH1
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 144630.0490.3343No
132ATP1A2ATP1A2
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide45780.0470.3268No
133KCNQ1KCNQ1
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 145810.0470.3279No
134RAMP1RAMP1
Entrez,  Source
receptor (calcitonin) activity modifying protein 146000.0460.3278No
135SLC34A1SLC34A1
Entrez,  Source
solute carrier family 34 (sodium phosphate), member 146900.0440.3222No
136SLC1A5SLC1A5
Entrez,  Source
solute carrier family 1 (neutral amino acid transporter), member 546970.0440.3229No
137P2RX1P2RX1
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 147000.0440.3239No
138CHRNA7CHRNA7
Entrez,  Source
cholinergic receptor, nicotinic, alpha 747250.0430.3233No
139CACNA1HCACNA1H
Entrez,  Source
calcium channel, voltage-dependent, alpha 1H subunit47350.0430.3237No
140CACNA1ACACNA1A
Entrez,  Source
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit47400.0430.3246No
141TRPV1TRPV1
Entrez,  Source
transient receptor potential cation channel, subfamily V, member 147600.0430.3243No
142SLC22A12SLC22A12
Entrez,  Source
solute carrier family 22 (organic anion/cation transporter), member 1248100.0420.3217No
143CNGB1CNGB1
Entrez,  Source
cyclic nucleotide gated channel beta 148280.0410.3215No
144UQCRC1UQCRC1
Entrez,  Source
ubiquinol-cytochrome c reductase core protein I48610.0410.3201No
145SLC6A6SLC6A6
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, taurine), member 648740.0400.3203No
146KCNMB1KCNMB1
Entrez,  Source
potassium large conductance calcium-activated channel, subfamily M, beta member 148850.0400.3206No
147KCNJ1KCNJ1
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 149360.0390.3179No
148NGBNGB
Entrez,  Source
neuroglobin49470.0390.3181No
149AQP5AQP5
Entrez,  Source
aquaporin 549540.0390.3187No
150UQCRHUQCRH
Entrez,  Source
ubiquinol-cytochrome c reductase hinge protein49660.0390.3189No
151RHCGRHCG
Entrez,  Source
Rh family, C glycoprotein50060.0380.3170No
152TRPM1TRPM1
Entrez,  Source
transient receptor potential cation channel, subfamily M, member 150240.0370.3167No
153CACNA1DCACNA1D
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1D subunit51060.0360.3114No
154ACCN4ACCN4
Entrez,  Source
amiloride-sensitive cation channel 4, pituitary51340.0350.3103No
155SLC6A5SLC6A5
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, glycine), member 551770.0340.3080No
156KCNJ4KCNJ4
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 452010.0340.3072No
157KCNA1KCNA1
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)52510.0330.3043No
158CACNA1GCACNA1G
Entrez,  Source
calcium channel, voltage-dependent, alpha 1G subunit52810.0320.3030No
159SLC1A3SLC1A3
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 353620.0310.2977No
160SLC17A7SLC17A7
Entrez,  Source
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 753730.0310.2977No
161COX4I1COX4I1
Entrez,  Source
cytochrome c oxidase subunit IV isoform 153800.0310.2981No
162CLCA2CLCA2
Entrez,  Source
chloride channel, calcium activated, family member 254670.0290.2923No
163SLC25A19SLC25A19
Entrez,  Source
solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 1954980.0280.2907No
164RYR1RYR1
Entrez,  Source
ryanodine receptor 1 (skeletal)55710.0260.2859No
165COG3COG3
Entrez,  Source
component of oligomeric golgi complex 356200.0250.2829No
166GLRA2GLRA2
Entrez,  Source
glycine receptor, alpha 256580.0240.2808No
167TSNAXTSNAX
Entrez,  Source
translin-associated factor X57030.0240.2780No
168CACNB4CACNB4
Entrez,  Source
calcium channel, voltage-dependent, beta 4 subunit57370.0230.2761No
169CACNG4CACNG4
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 457400.0230.2766No
170KCNQ2KCNQ2
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 257590.0230.2758No
171KCNA5KCNA5
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 557740.0220.2754No
172COX5ACOX5A
Entrez,  Source
cytochrome c oxidase subunit Va58000.0220.2740No
173FXYD2FXYD2
Entrez,  Source
FXYD domain containing ion transport regulator 258620.0210.2699No
174RHAGRHAG
Entrez,  Source
Rh-associated glycoprotein58780.0210.2693No
175SCN7ASCN7A
Entrez,  Source
sodium channel, voltage-gated, type VII, alpha59070.0200.2677No
176SLC5A7SLC5A7
Entrez,  Source
solute carrier family 5 (choline transporter), member 759260.0200.2669No
177SCN4ASCN4A
Entrez,  Source
sodium channel, voltage-gated, type IV, alpha59300.0200.2672No
178SLC5A6SLC5A6
Entrez,  Source
solute carrier family 5 (sodium-dependent vitamin transporter), member 659440.0190.2667No
179CHRNB3CHRNB3
Entrez,  Source
cholinergic receptor, nicotinic, beta 359580.0190.2662No
180SLC22A8SLC22A8
Entrez,  Source
solute carrier family 22 (organic anion transporter), member 859840.0190.2648No
181ABCC8ABCC8
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 861130.0160.2554No
182SLC12A1SLC12A1
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 161290.0160.2547No
183CHRNB2CHRNB2
Entrez,  Source
cholinergic receptor, nicotinic, beta 2 (neuronal)61830.0150.2511No
184TRPC5TRPC5
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 563220.0110.2408No
185ATP1B2ATP1B2
Entrez,  Source
ATPase, Na+/K+ transporting, beta 2 polypeptide63250.0110.2409No
186ACCN1ACCN1
Entrez,  Source
amiloride-sensitive cation channel 1, neuronal (degenerin)63440.0110.2398No
187SLC4A1SLC4A1
Entrez,  Source
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)64790.0080.2298No
188SLC14A2SLC14A2
Entrez,  Source
solute carrier family 14 (urea transporter), member 265320.0070.2260No
189KCNJ5KCNJ5
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 565330.0070.2262No
190SLC1A6SLC1A6
Entrez,  Source
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 666740.0050.2156No
191SLC2A3SLC2A3
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 366830.0040.2151No
192SLC1A4SLC1A4
Entrez,  Source
solute carrier family 1 (glutamate/neutral amino acid transporter), member 467040.0040.2137No
193KCNJ3KCNJ3
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 367360.0040.2114No
194ABCC5ABCC5
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 567900.0030.2074No
195CHRNA6CHRNA6
Entrez,  Source
cholinergic receptor, nicotinic, alpha 668070.0020.2062No
196SLC9A2SLC9A2
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 268620.0010.2021No
197CACNA2D1CACNA2D1
Entrez,  Source
calcium channel, voltage-dependent, alpha 2/delta subunit 16910-0.0000.1985No
198ATP2B1ATP2B1
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 16925-0.0000.1974No
199CLCN2CLCN2
Entrez,  Source
chloride channel 26939-0.0010.1965No
200BSNDBSND
Entrez,  Source
Bartter syndrome, infantile, with sensorineural deafness (Barttin)6986-0.0020.1930No
201SLC7A9SLC7A9
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 97015-0.0020.1909No
202NMUR2NMUR2
Entrez,  Source
neuromedin U receptor 27018-0.0030.1908No
203CHRNDCHRND
Entrez,  Source
cholinergic receptor, nicotinic, delta7037-0.0030.1895No
204KCNQ3KCNQ3
Entrez,  Source
potassium voltage-gated channel, KQT-like subfamily, member 37121-0.0040.1833No
205TAPBPTAPBP
Entrez,  Source
TAP binding protein (tapasin)7131-0.0050.1827No
206SCN9ASCN9A
Entrez,  Source
sodium channel, voltage-gated, type IX, alpha7175-0.0060.1796No
207TRPC4TRPC4
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 47210-0.0060.1771No
208SLC7A10SLC7A10
Entrez,  Source
solute carrier family 7, (neutral amino acid transporter, y+ system) member 107229-0.0070.1759No
209SLC5A2SLC5A2
Entrez,  Source
solute carrier family 5 (sodium/glucose cotransporter), member 27237-0.0070.1756No
210KCNA3KCNA3
Entrez,  Source
potassium voltage-gated channel, shaker-related subfamily, member 37275-0.0080.1730No
211AQP1AQP1
Entrez,  Source
aquaporin 1 (Colton blood group)7326-0.0090.1694No
212CCSCCS
Entrez,  Source
copper chaperone for superoxide dismutase7339-0.0090.1687No
213XPO6XPO6
Entrez,  Source
exportin 67390-0.0100.1651No
214KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 27491-0.0120.1578No
215CHRNA1CHRNA1
Entrez,  Source
cholinergic receptor, nicotinic, alpha 1 (muscle)7663-0.0160.1451No
216CLCN3CLCN3
Entrez,  Source
chloride channel 37723-0.0170.1411No
217ATP2B4ATP2B4
Entrez,  Source
ATPase, Ca++ transporting, plasma membrane 47808-0.0190.1351No
218SCN2BSCN2B
Entrez,  Source
sodium channel, voltage-gated, type II, beta7874-0.0200.1307No
219ATP6V0E1ATP6V0E1
Entrez,  Source
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e17973-0.0230.1238No
220SLC4A3SLC4A3
Entrez,  Source
solute carrier family 4, anion exchanger, member 37978-0.0230.1241No
221SLC1A1SLC1A1
Entrez,  Source
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 18024-0.0240.1213No
222ATP6V0CATP6V0C
Entrez,  Source
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c8097-0.0250.1165No
223CFTRCFTR
Entrez,  Source
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)8112-0.0260.1161No
224CACNB1CACNB1
Entrez,  Source
calcium channel, voltage-dependent, beta 1 subunit8234-0.0280.1076No
225SCNN1BSCNN1B
Entrez,  Source
sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)8268-0.0290.1058No
226SLC22A3SLC22A3
Entrez,  Source
solute carrier family 22 (extraneuronal monoamine transporter), member 38310-0.0300.1035No
227ATP2C1ATP2C1
Entrez,  Source
ATPase, Ca++ transporting, type 2C, member 18499-0.0340.0900No
228SLC3A1SLC3A1
Entrez,  Source
18542-0.0360.0878No
229SLC7A5SLC7A5
Entrez,  Source
solute carrier family 7 (cationic amino acid transporter, y+ system), member 58548-0.0360.0884No
230LRP1LRP1
Entrez,  Source
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)8598-0.0370.0856No
231KCNJ6KCNJ6
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 68615-0.0370.0854No
232ATP1B3ATP1B3
Entrez,  Source
ATPase, Na+/K+ transporting, beta 3 polypeptide8756-0.0400.0757No
233MCL1MCL1
Entrez,  Source
myeloid cell leukemia sequence 1 (BCL2-related)8765-0.0400.0762No
234KCNG2KCNG2
Entrez,  Source
potassium voltage-gated channel, subfamily G, member 28788-0.0410.0756No
235CHRNB4CHRNB4
Entrez,  Source
cholinergic receptor, nicotinic, beta 48895-0.0430.0687No
236CNGA3CNGA3
Entrez,  Source
cyclic nucleotide gated channel alpha 38916-0.0440.0683No
237SLC25A11SLC25A11
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 118929-0.0440.0686No
238SCN5ASCN5A
Entrez,  Source
sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)8974-0.0450.0665No
239ITPR2ITPR2
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 29021-0.0460.0642No
240ASNA1ASNA1
Entrez,  Source
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)9162-0.0500.0548No
241CUL5CUL5
Entrez,  Source
cullin 59220-0.0520.0518No
242ABCC3ABCC3
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 39289-0.0540.0481No
243HBZHBZ
Entrez,  Source
hemoglobin, zeta9299-0.0540.0489No
244SLC12A9SLC12A9
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 99300-0.0540.0504No
245ATP1A1ATP1A1
Entrez,  Source
ATPase, Na+/K+ transporting, alpha 1 polypeptide9325-0.0550.0500No
246KCNJ14KCNJ14
Entrez,  Source
potassium inwardly-rectifying channel, subfamily J, member 149450-0.0580.0421No
247SLC30A3SLC30A3
Entrez,  Source
solute carrier family 30 (zinc transporter), member 39566-0.0620.0349No
248SLC8A1SLC8A1
Entrez,  Source
solute carrier family 8 (sodium/calcium exchanger), member 19583-0.0620.0354No
249SLC29A1SLC29A1
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 19613-0.0630.0349No
250ATP2A2ATP2A2
Entrez,  Source
ATPase, Ca++ transporting, cardiac muscle, slow twitch 29620-0.0630.0361No
251PPBPPPBP
Entrez,  Source
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)9692-0.0650.0324No
252ATP7AATP7A
Entrez,  Source
ATPase, Cu++ transporting, alpha polypeptide (Menkes syndrome)9722-0.0660.0320No
253HTR3AHTR3A
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 3A9766-0.0670.0305No
254SERINC1SERINC1
Entrez,  Source
serine incorporator 19801-0.0680.0297No
255PITPNM1PITPNM1
Entrez,  Source
phosphatidylinositol transfer protein, membrane-associated 19942-0.0730.0210No
256CLDN16CLDN16
Entrez,  Source
claudin 169988-0.0740.0196No
257SLC30A4SLC30A4
Entrez,  Source
solute carrier family 30 (zinc transporter), member 410051-0.0760.0169No
258SLC25A3SLC25A3
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 310075-0.0770.0172No
259PITPNAPITPNA
Entrez,  Source
phosphatidylinositol transfer protein, alpha10116-0.0790.0162No
260SLC19A2SLC19A2
Entrez,  Source
solute carrier family 19 (thiamine transporter), member 210180-0.0810.0136No
261CDIPTCDIPT
Entrez,  Source
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)10202-0.0810.0142No
262SLC9A1SLC9A1
Entrez,  Source
solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)10314-0.0850.0080No
263SCN1BSCN1B
Entrez,  Source
sodium channel, voltage-gated, type I, beta10536-0.093-0.0064No
264SLC12A4SLC12A4
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 410572-0.094-0.0066No
265SLC25A4SLC25A4
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 410578-0.094-0.0044No
266SLC27A4SLC27A4
Entrez,  Source
solute carrier family 27 (fatty acid transporter), member 410628-0.096-0.0056No
267SLC20A2SLC20A2
Entrez,  Source
solute carrier family 20 (phosphate transporter), member 210687-0.098-0.0073No
268FXYD3FXYD3
Entrez,  Source
FXYD domain containing ion transport regulator 310861-0.105-0.0178No
269SLC29A2SLC29A2
Entrez,  Source
solute carrier family 29 (nucleoside transporters), member 210955-0.109-0.0219No
270SLC2A1SLC2A1
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 110998-0.112-0.0221No
271SLC15A2SLC15A2
Entrez,  Source
solute carrier family 15 (H+/peptide transporter), member 211088-0.116-0.0258No
272SLC12A2SLC12A2
Entrez,  Source
solute carrier family 12 (sodium/potassium/chloride transporters), member 211116-0.118-0.0247No
273ATP6V1C1ATP6V1C1
Entrez,  Source
ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C111130-0.118-0.0225No
274CACNG1CACNG1
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 111208-0.122-0.0251No
275ATP6V1B2ATP6V1B2
Entrez,  Source
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B211244-0.124-0.0244No
276CACNG5CACNG5
Entrez,  Source
calcium channel, voltage-dependent, gamma subunit 511279-0.126-0.0236No
277CACNA1SCACNA1S
Entrez,  Source
calcium channel, voltage-dependent, L type, alpha 1S subunit11348-0.129-0.0254No
278ITPR3ITPR3
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 311479-0.136-0.0316No
279ATP1B1ATP1B1
Entrez,  Source
ATPase, Na+/K+ transporting, beta 1 polypeptide11599-0.144-0.0369No
280SLC4A2SLC4A2
Entrez,  Source
solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)11703-0.150-0.0407No
281SLC23A2SLC23A2
Entrez,  Source
solute carrier family 23 (nucleobase transporters), member 211798-0.156-0.0437No
282SLC5A5SLC5A5
Entrez,  Source
solute carrier family 5 (sodium iodide symporter), member 511882-0.163-0.0456No
283SLC34A2SLC34A2
Entrez,  Source
solute carrier family 34 (sodium phosphate), member 211932-0.167-0.0449No
284SLC2A8SLC2A8
Entrez,  Source
solute carrier family 2, (facilitated glucose transporter) member 812054-0.178-0.0493No
285SLC3A2SLC3A2
Entrez,  Source
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 212198-0.191-0.0551No
286SLC31A2SLC31A2
Entrez,  Source
solute carrier family 31 (copper transporters), member 212274-0.201-0.0554No
287LASP1LASP1
Entrez,  Source
LIM and SH3 protein 112412-0.216-0.0600No
288ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 212438-0.220-0.0560No
289ABCA1ABCA1
Entrez,  Source
ATP-binding cassette, sub-family A (ABC1), member 112519-0.231-0.0559No
290SLC6A8SLC6A8
Entrez,  Source
solute carrier family 6 (neurotransmitter transporter, creatine), member 812677-0.260-0.0609No
291COX15COX15
Entrez,  Source
COX15 homolog, cytochrome c oxidase assembly protein (yeast)12707-0.266-0.0559No
292SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 712774-0.279-0.0534No
293TRPC1TRPC1
Entrez,  Source
transient receptor potential cation channel, subfamily C, member 112816-0.291-0.0487No
294KCNS3KCNS3
Entrez,  Source
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 312940-0.335-0.0490No
295CACNB3CACNB3
Entrez,  Source
calcium channel, voltage-dependent, beta 3 subunit12957-0.341-0.0410No
296SLC15A1SLC15A1
Entrez,  Source
solute carrier family 15 (oligopeptide transporter), member 112976-0.349-0.0329No
297GJA1GJA1
Entrez,  Source
gap junction protein, alpha 1, 43kDa (connexin 43)13000-0.365-0.0248No
298P2RX2P2RX2
Entrez,  Source
purinergic receptor P2X, ligand-gated ion channel, 213080-0.412-0.0197No
299ABCG1ABCG1
Entrez,  Source
ATP-binding cassette, sub-family G (WHITE), member 113094-0.421-0.0093No
300SLC10A2SLC10A2
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 213314-1.0410.0021No
Table: GSEA details [plain text format]



Fig 2: SUBSTRATE_SPECIFIC_TRANSPORTER_ACTIVITY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SUBSTRATE_SPECIFIC_TRANSPORTER_ACTIVITY: Random ES distribution   
Gene set null distribution of ES for SUBSTRATE_SPECIFIC_TRANSPORTER_ACTIVITY