Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | TGFBETA_ALL_UP |
| Enrichment Score (ES) | -0.61570895 |
| Normalized Enrichment Score (NES) | -1.9969581 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.008534258 |
| FWER p-Value | 0.12 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 378 | 0.352 | 0.0055 | No |
| 2 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 456 | 0.317 | 0.0302 | No |
| 3 | EFNA5 | EFNA5 Entrez, Source | ephrin-A5 | 1498 | 0.150 | -0.0336 | No |
| 4 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 1920 | 0.125 | -0.0532 | No |
| 5 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1938 | 0.125 | -0.0425 | No |
| 6 | IGFBP5 | IGFBP5 Entrez, Source | insulin-like growth factor binding protein 5 | 2222 | 0.114 | -0.0529 | No |
| 7 | MMP3 | MMP3 Entrez, Source | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 2981 | 0.085 | -0.1017 | No |
| 8 | WNT2B | WNT2B Entrez, Source | wingless-type MMTV integration site family, member 2B | 3037 | 0.084 | -0.0977 | No |
| 9 | RHOG | RHOG Entrez, Source | ras homolog gene family, member G (rho G) | 3472 | 0.072 | -0.1234 | No |
| 10 | RHOB | RHOB Entrez, Source | ras homolog gene family, member B | 3872 | 0.063 | -0.1474 | No |
| 11 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 3998 | 0.059 | -0.1511 | No |
| 12 | DVL1 | DVL1 Entrez, Source | dishevelled, dsh homolog 1 (Drosophila) | 4410 | 0.050 | -0.1772 | No |
| 13 | LRRC17 | LRRC17 Entrez, Source | leucine rich repeat containing 17 | 5108 | 0.036 | -0.2262 | No |
| 14 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 6077 | 0.017 | -0.2974 | No |
| 15 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 6247 | 0.013 | -0.3089 | No |
| 16 | ITGB2 | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 6482 | 0.008 | -0.3257 | No |
| 17 | NID1 | NID1 Entrez, Source | nidogen 1 | 6775 | 0.003 | -0.3474 | No |
| 18 | BSG | BSG Entrez, Source | basigin (Ok blood group) | 6969 | -0.001 | -0.3618 | No |
| 19 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 7115 | -0.004 | -0.3723 | No |
| 20 | ICAM1 | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 7160 | -0.005 | -0.3751 | No |
| 21 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 7444 | -0.011 | -0.3953 | No |
| 22 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 7664 | -0.016 | -0.4103 | No |
| 23 | LRP1 | LRP1 Entrez, Source | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | 8598 | -0.037 | -0.4769 | No |
| 24 | CDH6 | CDH6 Entrez, Source | cadherin 6, type 2, K-cadherin (fetal kidney) | 8608 | -0.037 | -0.4740 | No |
| 25 | MTA1 | MTA1 Entrez, Source | metastasis associated 1 | 9709 | -0.065 | -0.5505 | No |
| 26 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 9885 | -0.071 | -0.5568 | No |
| 27 | FN1 | FN1 Entrez, Source | fibronectin 1 | 9917 | -0.072 | -0.5522 | No |
| 28 | ARHGDIA | ARHGDIA Entrez, Source | Rho GDP dissociation inhibitor (GDI) alpha | 9931 | -0.073 | -0.5462 | No |
| 29 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 10376 | -0.087 | -0.5712 | No |
| 30 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 10444 | -0.090 | -0.5676 | No |
| 31 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 10846 | -0.105 | -0.5876 | No |
| 32 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 11190 | -0.121 | -0.6018 | Yes |
| 33 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 11315 | -0.127 | -0.5989 | Yes |
| 34 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 11420 | -0.132 | -0.5940 | Yes |
| 35 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 11683 | -0.149 | -0.5993 | Yes |
| 36 | PXN | PXN Entrez, Source | paxillin | 11831 | -0.159 | -0.5951 | Yes |
| 37 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 12106 | -0.182 | -0.5982 | Yes |
| 38 | MMP14 | MMP14 Entrez, Source | matrix metallopeptidase 14 (membrane-inserted) | 12177 | -0.189 | -0.5852 | Yes |
| 39 | NEO1 | NEO1 Entrez, Source | neogenin homolog 1 (chicken) | 12267 | -0.200 | -0.5726 | Yes |
| 40 | JUP | JUP Entrez, Source | junction plakoglobin | 12351 | -0.210 | -0.5586 | Yes |
| 41 | DSP | DSP Entrez, Source | desmoplakin | 12592 | -0.244 | -0.5532 | Yes |
| 42 | ZYX | ZYX Entrez, Source | zyxin | 12724 | -0.270 | -0.5371 | Yes |
| 43 | NOTCH2 | NOTCH2 Entrez, Source | Notch homolog 2 (Drosophila) | 12734 | -0.272 | -0.5115 | Yes |
| 44 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 12818 | -0.293 | -0.4895 | Yes |
| 45 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 12902 | -0.323 | -0.4646 | Yes |
| 46 | SMO | SMO Entrez, Source | smoothened homolog (Drosophila) | 12916 | -0.327 | -0.4341 | Yes |
| 47 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13010 | -0.371 | -0.4053 | Yes |
| 48 | RHOQ | RHOQ Entrez, Source | ras homolog gene family, member Q | 13078 | -0.412 | -0.3706 | Yes |
| 49 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 13213 | -0.582 | -0.3247 | Yes |
| 50 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 13233 | -0.633 | -0.2651 | Yes |
| 51 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13273 | -0.768 | -0.1941 | Yes |
| 52 | MARCKSL1 | MARCKSL1 Entrez, Source | MARCKS-like 1 | 13312 | -1.018 | -0.0988 | Yes |
| 53 | MMP2 | MMP2 Entrez, Source | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 13316 | -1.048 | 0.0020 | Yes |
