Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | TUMOR_SUPRESSOR |
| Enrichment Score (ES) | -0.5968851 |
| Normalized Enrichment Score (NES) | -1.609804 |
| Nominal p-value | 0.02226345 |
| FDR q-value | 0.113135114 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 2102 | 0.118 | -0.1178 | No |
| 2 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 2307 | 0.110 | -0.0957 | No |
| 3 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 4606 | 0.046 | -0.2525 | No |
| 4 | WT1 | WT1 Entrez, Source | Wilms tumor 1 | 5444 | 0.029 | -0.3054 | No |
| 5 | LCMT2 | LCMT2 Entrez, Source | leucine carboxyl methyltransferase 2 | 8973 | -0.045 | -0.5548 | No |
| 6 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 9345 | -0.056 | -0.5637 | No |
| 7 | CDKN2D | CDKN2D Entrez, Source | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | 9788 | -0.068 | -0.5739 | Yes |
| 8 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 10026 | -0.075 | -0.5661 | Yes |
| 9 | APC | APC Entrez, Source | adenomatosis polyposis coli | 10296 | -0.085 | -0.5575 | Yes |
| 10 | ACTB | ACTB Entrez, Source | actin, beta | 10590 | -0.095 | -0.5472 | Yes |
| 11 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 10720 | -0.099 | -0.5231 | Yes |
| 12 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 11382 | -0.130 | -0.5284 | Yes |
| 13 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 11501 | -0.137 | -0.4905 | Yes |
| 14 | BRCA1 | BRCA1 Entrez, Source | breast cancer 1, early onset | 11523 | -0.139 | -0.4449 | Yes |
| 15 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 11690 | -0.149 | -0.4066 | Yes |
| 16 | VHL | VHL Entrez, Source | von Hippel-Lindau tumor suppressor | 12112 | -0.183 | -0.3761 | Yes |
| 17 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 12251 | -0.199 | -0.3188 | Yes |
| 18 | MSH2 | MSH2 Entrez, Source | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | 12401 | -0.215 | -0.2569 | Yes |
| 19 | EP300 | EP300 Entrez, Source | E1A binding protein p300 | 12496 | -0.228 | -0.1862 | Yes |
| 20 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12500 | -0.229 | -0.1085 | Yes |
| 21 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12538 | -0.234 | -0.0317 | Yes |
| 22 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 12725 | -0.270 | 0.0463 | Yes |
