Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_8d_versus_single_gel_8d.class.cls #double_gel_8d_versus_single_gel_8d_repos |
| Phenotype | class.cls#double_gel_8d_versus_single_gel_8d_repos |
| Upregulated in class | single_gel_8d |
| GeneSet | VERHAAK_AML_NPM1_MUT_VS_WT_DN |
| Enrichment Score (ES) | -0.4422443 |
| Normalized Enrichment Score (NES) | -1.6404223 |
| Nominal p-value | 0.0019646366 |
| FDR q-value | 0.10057699 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 69 | 0.692 | 0.0290 | No |
| 2 | CYP2E1 | CYP2E1 Entrez, Source | cytochrome P450, family 2, subfamily E, polypeptide 1 | 87 | 0.637 | 0.0592 | No |
| 3 | AK3L1 | AK3L1 Entrez, Source | adenylate kinase 3-like 1 | 232 | 0.450 | 0.0706 | No |
| 4 | PDE4B | PDE4B Entrez, Source | phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) | 367 | 0.356 | 0.0780 | No |
| 5 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 510 | 0.296 | 0.0819 | No |
| 6 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 585 | 0.271 | 0.0897 | No |
| 7 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 596 | 0.268 | 0.1022 | No |
| 8 | ASS1 | ASS1 Entrez, Source | argininosuccinate synthetase 1 | 598 | 0.267 | 0.1154 | No |
| 9 | TRPM4 | TRPM4 Entrez, Source | transient receptor potential cation channel, subfamily M, member 4 | 633 | 0.257 | 0.1255 | No |
| 10 | OPTN | OPTN Entrez, Source | optineurin | 715 | 0.235 | 0.1310 | No |
| 11 | MST1 | MST1 Entrez, Source | macrophage stimulating 1 (hepatocyte growth factor-like) | 728 | 0.233 | 0.1416 | No |
| 12 | F2RL1 | F2RL1 Entrez, Source | coagulation factor II (thrombin) receptor-like 1 | 1102 | 0.181 | 0.1224 | No |
| 13 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 1217 | 0.169 | 0.1221 | No |
| 14 | SCCPDH | SCCPDH Entrez, Source | saccharopine dehydrogenase (putative) | 1284 | 0.165 | 0.1253 | No |
| 15 | EHD3 | EHD3 Entrez, Source | EH-domain containing 3 | 1350 | 0.160 | 0.1283 | No |
| 16 | FCER1A | FCER1A Entrez, Source | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | 1426 | 0.155 | 0.1303 | No |
| 17 | LRP3 | LRP3 Entrez, Source | low density lipoprotein receptor-related protein 3 | 1657 | 0.139 | 0.1198 | No |
| 18 | SERPINF1 | SERPINF1 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 1787 | 0.132 | 0.1166 | No |
| 19 | LCN2 | LCN2 Entrez, Source | lipocalin 2 (oncogene 24p3) | 1885 | 0.127 | 0.1155 | No |
| 20 | LMO4 | LMO4 Entrez, Source | LIM domain only 4 | 1984 | 0.122 | 0.1141 | No |
| 21 | ISG20 | ISG20 Entrez, Source | interferon stimulated exonuclease gene 20kDa | 2032 | 0.120 | 0.1165 | No |
| 22 | ALAS2 | ALAS2 Entrez, Source | aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) | 2203 | 0.114 | 0.1093 | No |
| 23 | BAALC | BAALC Entrez, Source | brain and acute leukemia, cytoplasmic | 2416 | 0.106 | 0.0985 | No |
| 24 | ST18 | ST18 Entrez, Source | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) | 2437 | 0.105 | 0.1022 | No |
| 25 | NRXN2 | NRXN2 Entrez, Source | neurexin 2 | 2553 | 0.101 | 0.0985 | No |
| 26 | RUNX3 | RUNX3 Entrez, Source | runt-related transcription factor 3 | 2707 | 0.095 | 0.0916 | No |
| 27 | RPS6KA2 | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 2807 | 0.091 | 0.0887 | No |
| 28 | HPGD | HPGD Entrez, Source | hydroxyprostaglandin dehydrogenase 15-(NAD) | 2832 | 0.090 | 0.0913 | No |
| 29 | GPM6B | GPM6B Entrez, Source | glycoprotein M6B | 2860 | 0.089 | 0.0937 | No |
| 30 | BZRAP1 | BZRAP1 Entrez, Source | benzodiazapine receptor (peripheral) associated protein 1 | 3235 | 0.078 | 0.0692 | No |
| 31 | ERG | ERG Entrez, Source | v-ets erythroblastosis virus E26 oncogene homolog (avian) | 3255 | 0.077 | 0.0716 | No |
| 32 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 3317 | 0.076 | 0.0707 | No |
| 33 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3378 | 0.074 | 0.0698 | No |
| 34 | SNCA | SNCA Entrez, Source | synuclein, alpha (non A4 component of amyloid precursor) | 3411 | 0.073 | 0.0711 | No |
| 35 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 3459 | 0.072 | 0.0711 | No |
| 36 | PTPRM | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 3619 | 0.068 | 0.0624 | No |
| 37 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 3691 | 0.067 | 0.0603 | No |
| 38 | PDE3B | PDE3B Entrez, Source | phosphodiesterase 3B, cGMP-inhibited | 3773 | 0.065 | 0.0574 | No |
| 39 | SYNGR1 | SYNGR1 Entrez, Source | synaptogyrin 1 | 3976 | 0.060 | 0.0451 | No |
| 40 | DPYSL2 | DPYSL2 Entrez, Source | dihydropyrimidinase-like 2 | 4035 | 0.059 | 0.0436 | No |
| 41 | DLK1 | DLK1 Entrez, Source | delta-like 1 homolog (Drosophila) | 4057 | 0.058 | 0.0449 | No |
| 42 | TRH | TRH Entrez, Source | thyrotropin-releasing hormone | 4155 | 0.056 | 0.0403 | No |
| 43 | GNG7 | GNG7 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 7 | 4540 | 0.047 | 0.0136 | No |
| 44 | RAMP1 | RAMP1 Entrez, Source | receptor (calcitonin) activity modifying protein 1 | 4600 | 0.046 | 0.0114 | No |
| 45 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 4745 | 0.043 | 0.0027 | No |
| 46 | CD2 | CD2 Entrez, Source | CD2 molecule | 4873 | 0.040 | -0.0049 | No |
| 47 | CHI3L1 | CHI3L1 Entrez, Source | chitinase 3-like 1 (cartilage glycoprotein-39) | 4937 | 0.039 | -0.0078 | No |
| 48 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 5315 | 0.032 | -0.0347 | No |
| 49 | PALM | PALM Entrez, Source | paralemmin | 5408 | 0.030 | -0.0402 | No |
| 50 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5460 | 0.029 | -0.0426 | No |
| 51 | PRODH | PRODH Entrez, Source | proline dehydrogenase (oxidase) 1 | 5569 | 0.026 | -0.0495 | No |
| 52 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 5843 | 0.021 | -0.0691 | No |
| 53 | CCR2 | CCR2 Entrez, Source | chemokine (C-C motif) receptor 2 | 5861 | 0.021 | -0.0694 | No |
| 54 | TPSAB1 | TPSAB1 Entrez, Source | tryptase alpha/beta 1 | 5872 | 0.021 | -0.0691 | No |
| 55 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 5893 | 0.020 | -0.0696 | No |
| 56 | ARHGEF12 | ARHGEF12 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 12 | 5936 | 0.020 | -0.0718 | No |
| 57 | FGFR1 | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 6165 | 0.015 | -0.0883 | No |
| 58 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 6279 | 0.012 | -0.0962 | No |
| 59 | ELA2 | ELA2 Entrez, Source | elastase 2, neutrophil | 6385 | 0.010 | -0.1037 | No |
| 60 | MX1 | MX1 Entrez, Source | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 6404 | 0.009 | -0.1046 | No |
| 61 | RAP2A | RAP2A Entrez, Source | RAP2A, member of RAS oncogene family | 6537 | 0.007 | -0.1142 | No |
| 62 | IL5RA | IL5RA Entrez, Source | interleukin 5 receptor, alpha | 6779 | 0.003 | -0.1323 | No |
| 63 | MSLN | MSLN Entrez, Source | mesothelin | 6896 | 0.000 | -0.1411 | No |
| 64 | CD200 | CD200 Entrez, Source | CD200 molecule | 6909 | 0.000 | -0.1420 | No |
| 65 | SLC38A1 | SLC38A1 Entrez, Source | solute carrier family 38, member 1 | 7296 | -0.008 | -0.1708 | No |
| 66 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 7340 | -0.009 | -0.1736 | No |
| 67 | ADIPOR1 | ADIPOR1 Entrez, Source | adiponectin receptor 1 | 7451 | -0.011 | -0.1813 | No |
| 68 | TMOD1 | TMOD1 Entrez, Source | tropomodulin 1 | 7618 | -0.015 | -0.1932 | No |
| 69 | ADCY3 | ADCY3 Entrez, Source | adenylate cyclase 3 | 7690 | -0.016 | -0.1977 | No |
| 70 | TMEM158 | TMEM158 Entrez, Source | transmembrane protein 158 | 7748 | -0.018 | -0.2012 | No |
| 71 | POU4F1 | POU4F1 Entrez, Source | POU domain, class 4, transcription factor 1 | 8602 | -0.037 | -0.2639 | No |
| 72 | NCAM1 | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 8637 | -0.038 | -0.2646 | No |
| 73 | NARFL | NARFL Entrez, Source | nuclear prelamin A recognition factor-like | 8666 | -0.038 | -0.2648 | No |
| 74 | CD3D | CD3D Entrez, Source | CD3d molecule, delta (CD3-TCR complex) | 9132 | -0.050 | -0.2975 | No |
| 75 | NT5E | NT5E Entrez, Source | 5'-nucleotidase, ecto (CD73) | 9276 | -0.054 | -0.3057 | No |
| 76 | BPGM | BPGM Entrez, Source | 2,3-bisphosphoglycerate mutase | 9399 | -0.057 | -0.3121 | No |
| 77 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 9441 | -0.058 | -0.3123 | No |
| 78 | CIITA | CIITA Entrez, Source | class II, major histocompatibility complex, transactivator | 9491 | -0.060 | -0.3131 | No |
| 79 | TACSTD2 | TACSTD2 Entrez, Source | tumor-associated calcium signal transducer 2 | 9527 | -0.061 | -0.3128 | No |
| 80 | EGFL7 | EGFL7 Entrez, Source | EGF-like-domain, multiple 7 | 9659 | -0.064 | -0.3195 | No |
| 81 | CD48 | CD48 Entrez, Source | CD48 molecule | 9919 | -0.072 | -0.3355 | No |
| 82 | MLLT3 | MLLT3 Entrez, Source | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 9964 | -0.074 | -0.3352 | No |
| 83 | ROBO1 | ROBO1 Entrez, Source | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 9979 | -0.074 | -0.3326 | No |
| 84 | NPR3 | NPR3 Entrez, Source | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | 10036 | -0.076 | -0.3331 | No |
| 85 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 10444 | -0.090 | -0.3594 | No |
| 86 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 10972 | -0.110 | -0.3939 | No |
| 87 | FGF13 | FGF13 Entrez, Source | fibroblast growth factor 13 | 10992 | -0.111 | -0.3898 | No |
| 88 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 11168 | -0.120 | -0.3971 | No |
| 89 | H1F0 | H1F0 Entrez, Source | H1 histone family, member 0 | 11275 | -0.125 | -0.3989 | No |
| 90 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 11404 | -0.131 | -0.4021 | No |
| 91 | BLNK | BLNK Entrez, Source | B-cell linker | 11704 | -0.150 | -0.4174 | No |
| 92 | VLDLR | VLDLR Entrez, Source | very low density lipoprotein receptor | 12034 | -0.176 | -0.4336 | Yes |
| 93 | MMP9 | MMP9 Entrez, Source | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | 12039 | -0.176 | -0.4251 | Yes |
| 94 | EMP1 | EMP1 Entrez, Source | epithelial membrane protein 1 | 12100 | -0.181 | -0.4207 | Yes |
| 95 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 12111 | -0.182 | -0.4124 | Yes |
| 96 | CD38 | CD38 Entrez, Source | CD38 molecule | 12249 | -0.199 | -0.4130 | Yes |
| 97 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 12291 | -0.203 | -0.4060 | Yes |
| 98 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12307 | -0.205 | -0.3970 | Yes |
| 99 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 12316 | -0.206 | -0.3874 | Yes |
| 100 | JUP | JUP Entrez, Source | junction plakoglobin | 12351 | -0.210 | -0.3796 | Yes |
| 101 | B4GALT6 | B4GALT6 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 12532 | -0.233 | -0.3817 | Yes |
| 102 | TGFB1I1 | TGFB1I1 Entrez, Source | transforming growth factor beta 1 induced transcript 1 | 12535 | -0.233 | -0.3703 | Yes |
| 103 | C1ORF24 | C1ORF24 Entrez, Source | chromosome 1 open reading frame 24 | 12549 | -0.235 | -0.3597 | Yes |
| 104 | SNRPN /// SNURF | 12625 | -0.249 | -0.3530 | Yes | ||
| 105 | FZD6 | FZD6 Entrez, Source | frizzled homolog 6 (Drosophila) | 12637 | -0.251 | -0.3414 | Yes |
| 106 | PTGER4 | PTGER4 Entrez, Source | prostaglandin E receptor 4 (subtype EP4) | 12657 | -0.255 | -0.3303 | Yes |
| 107 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12719 | -0.269 | -0.3216 | Yes |
| 108 | PROM1 | PROM1 Entrez, Source | prominin 1 | 12722 | -0.269 | -0.3084 | Yes |
| 109 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 12723 | -0.270 | -0.2951 | Yes |
| 110 | IFI44 | IFI44 Entrez, Source | interferon-induced protein 44 | 12827 | -0.295 | -0.2883 | Yes |
| 111 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 12835 | -0.298 | -0.2741 | Yes |
| 112 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 12892 | -0.318 | -0.2626 | Yes |
| 113 | FZD2 | FZD2 Entrez, Source | frizzled homolog 2 (Drosophila) | 12935 | -0.334 | -0.2493 | Yes |
| 114 | GMPR | GMPR Entrez, Source | guanosine monophosphate reductase | 12951 | -0.339 | -0.2337 | Yes |
| 115 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 13000 | -0.365 | -0.2193 | Yes |
| 116 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 13016 | -0.374 | -0.2019 | Yes |
| 117 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13055 | -0.401 | -0.1849 | Yes |
| 118 | CD69 | CD69 Entrez, Source | CD69 molecule | 13130 | -0.450 | -0.1682 | Yes |
| 119 | SCRN1 | SCRN1 Entrez, Source | secernin 1 | 13182 | -0.529 | -0.1459 | Yes |
| 120 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 13198 | -0.561 | -0.1193 | Yes |
| 121 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13208 | -0.576 | -0.0915 | Yes |
| 122 | SERINC5 | SERINC5 Entrez, Source | serine incorporator 5 | 13224 | -0.615 | -0.0623 | Yes |
| 123 | NBL1 | NBL1 Entrez, Source | neuroblastoma, suppression of tumorigenicity 1 | 13245 | -0.673 | -0.0305 | Yes |
| 124 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13271 | -0.763 | 0.0054 | Yes |
