| Gene Set | Leading Edge Genes |
|---|
| OXIDOREDUCTASE ACTIVITY | CYP1A2, CYP4F3, MGST3, GPX4, KMO, BLVRB, BDH1, BLVRA, NOX5, RDH5, MECR, SURF1, DECR1, COX5A, GPX2, L2HGDH, ALDH7A1, CYBA, AKR1C4, HSD17B6, MSRB2, BDH2, ADH6, EHHADH, NQO2, PRDX2, CYB5A, ETFB, HAO1, PYCR1, MTHFR, NOX1, GSTZ1, NDUFS4, HMOX1, HADH, AKR1A1, FDXR, EGLN2, SDHD |
| REACTOME ELECTRON TRANSPORT CHAIN | NDUFS5, NDUFA13, NDUFS7, NDUFA3, NDUFB8, COX5B, NDUFB5, NDUFA7, NDUFC2, NDUFB7, NDUFA6, ETFB, NDUFB3, NDUFS6, NDUFS4, COX4I1, UQCRQ, NDUFB6, NDUFA4, SDHD, NDUFB11 |
| KEGG DRUG METABOLISM CYTOCHROME P450 | CYP1A2, GSTA4, GSTO1, UGT2A1, GSTZ1, GSTK1, GSTA1, MGST3, MGST2, UGT2B15, ADH6, CYP2D6, GSTM4, UGT2B28, MAOA |
| KEGG GLUTATHIONE METABOLISM | GSTA4, GSTO1, GPX2, GSTK1, GSTZ1, GSTA1, MGST3, GPX4, MGST2, GSTM4 |
| KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450 | CYP1A2, GSTA4, GSTO1, UGT2A1, GSTZ1, GSTK1, GSTA1, MGST3, AKR1C4, MGST2, UGT2B15, EPHX1, ADH6, GSTM4, UGT2B28 |
| KEGG PEROXISOME | PXMP2, EPHX2, DECR2, PEX10, PEX7, PECR, PHYH, GNPAT, EHHADH, PEX16, MVK, HAO1, PEX11A, AMACR, BAAT, HMGCL, PXMP4, DHRS4, PEX12, IDH2, ECH1, HSD17B4, ABCD4 |
| OXIDOREDUCTASE ACTIVITY GO 0016616 | GRHPR, HADH, AKR1A1, UGDH, IDH1, AKR1C4, BDH1, EHHADH, ADH6, BDH2, HSD17B4, RDH5 |
| OXIDOREDUCTASE ACTIVITY ACTING ON CH OH GROUP OF DONORS | HAO1, GRHPR, HADH, AKR1A1, UGDH, L2HGDH, IDH1, AKR1C4, BDH1, EHHADH, ADH6, BDH2, HSD17B4, RDH5 |
| KEGG FATTY ACID METABOLISM | ALDH1B1, HADH, ALDH7A1, ALDH2, EHHADH, ADH6, ACAA2, DCI, ADH5 |
| KEGG BUTANOATE METABOLISM | ACSM3, ALDH1B1, ALDH7A1, HADH, HMGCS2, L2HGDH, ALDH2, HMGCL, BDH1, EHHADH, BDH2 |
| NCI EXOCYTOSIS OF ALPHA GRANULE | FGA, FGG, F5, F8, FGB, CFD |
| KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM | PPOX, HMOX1, UGT2A1, BLVRB, UGT2B15, UROD, UROS, BLVRA, UGT2B28, FTH1 |
| REACTOME GLUTATHIONE CONJUGATION | GSTA4, GSTO1, GSTM4, GSTA1, MGST3, MGST2 |
| KEGG ASCORBATE AND ALDARATE METABOLISM | UGT2A1, ALDH1B1, UGT2B28, ALDH7A1, UGDH, ALDH2, UGT2B15 |
| GLUTATHIONE TRANSFERASE ACTIVITY | GSTA4, GSTM4, GSTZ1, MGST3, MGST2 |
| KEGG RETINOL METABOLISM | PNPLA4, CYP1A2, UGT2A1, BCMO1, DHRS3, UGT2B15, DHRS4, ADH6, UGT2B28, ADH5, RDH5 |
| REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | F13B, FGA, FGG, F5, F8, FGB |
| KEGG PRIMARY BILE ACID BIOSYNTHESIS | AMACR, AKR1C4, BAAT |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS | AMACR, AKR1C4, BAAT |
| REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | SULT2B1, SULT1A1, SULT1A2, SULT1A3 |
| PHOSPHOLIPASE A2 ACTIVITY | PRDX6, PLA2G2A, PLA2G5, PLA2G6 |
| REACTOME STEROID HORMONES | LRP2, CYP24A1, LGMN, CYP2R1 |
| XENOBIOTIC METABOLIC PROCESS | UGT2B28, UGT2B15 |
| NCI SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | SLC27A2, SLC27A5, AMACR, AKR1C4 |
| NCI SYNTHESIS OF BILE ACIDS AND BILE SALTS | SLC27A2, SLC27A5, AMACR, AKR1C4 |
| REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | SLC27A2, SLC27A5, AMACR, AKR1C4 |
| REACTOME HORMONE LIGAND BINDING RECEPTORS | TSHB |
| DETECTION OF CHEMICAL STIMULUS | STIM1, UGT2A1, SYT1 |
| REACTOME PEPTIDE CHAIN ELONGATION | RPS15A, RPS18, RPS4Y1, RPL38, RPS17, RPS14, RPS21, RPS5, RPS16, RPS28, RPL26L1, RPL22, RPS9, RPL12, RPL13, RPS12, RPL30, UBA52, RPS13, RPL19, RPS29, RPL28, RPL31, RPL13A, RPL29, RPS27, RPS20, RPL10A, RPS27A |
| TRIACYLGLYCEROL METABOLIC PROCESS | PNLIPRP2 |
| KEGG SYSTEMIC LUPUS ERYTHEMATOSUS | HIST3H2A, HIST1H3D, HLA-DQB1, HIST1H2BD, HIST1H3H, C7, H2AFZ, HIST1H2BH, H2AFV, HLA-DMB, HIST1H2AG, HIST1H2AC |
| SENSORY PERCEPTION OF TASTE | TAS2R14 |
| NCI HORMONE LIGAND BINDING RECEPTORS | TSHB |
| KEGG AUTOIMMUNE THYROID DISEASE | HLA-DOA, HLA-F, HLA-DQB1, HLA-DMB, HLA-C, HLA-G |