| Gene Set | Leading Edge Genes |
|---|
| KEGG PATHWAYS IN CANCER | TRAF4, ITGA3, NRAS, NFKBIA, E2F3, PTK2, DVL1, TGFB1, ITGA2, EGLN1, MAP2K1, EGFR, PDGFA, MSH2, IGF1R, TRAF3, PPARG, GSK3B, MET, TRAF6, MAPK1, CCNE1, RALA, JUN, ITGA6, BIRC2, DVL3, SOS1, CASP3, TGFB2, RELA, E2F1, VEGFC, PIK3CA, GLI2, BRCA2, PIAS2, COL4A2, CUL2, RALGDS, NKX3-1, FGF2, ARNT2, LAMC1, BIRC3, CCNE2, TGFA, SMAD3, MITF, DAPK3, HDAC2, PTGS2, IL8, SMAD4, GRB2 |
| KEGG FOCAL ADHESION | ARHGAP5, DIAPH1, ACTN4, ITGA3, VASP, PAK2, PTK2, ITGA2, EGFR, ITGA5, MAP2K1, FLNA, PDGFA, IGF1R, CAV2, GSK3B, PDPK1, MET, ZYX, MAPK1, CAV1, JUN, ITGA6, SOS1, BIRC2, VEGFC, CAPN2, PIK3CA, COL4A2, CRK, LAMC1, CCND3, BIRC3, PXN, GRB2 |
| BIOCARTA MAPK PATHWAY | MAPK7, JUN, MAP3K12, RELA, TGFB2, MAP4K2, MEF2A, PAK2, MAP3K14, NFKBIA, MAP4K3, MAP3K2, TGFB1, MAP2K1, NFKB1, MAP2K4, MAP3K7, RPS6KA5, MAPKAPK2, DAXX, CREB1, MAP4K4, MAPK1, GRB2 |
| KEGG MAPK SIGNALING PATHWAY | MAPK7, BDNF, DUSP6, PAK2, RASA2, RRAS2, RELB, EGFR, MAP2K1, PDGFA, MAP3K7, TRAF6, DUSP4, DUSP10, JUN, SOS1, TGFB2, RELA, CASP3, DUSP14, MAP3K14, PPP3CC, MAP3K2, FGF2, DUSP5, DUSP3, PPP3CB, PPP3R1, RPS6KA5, CRKL, DAXX, MAPKAPK2, GRB2, DUSP1 |
| KEGG CHEMOKINE SIGNALING PATHWAY | CCL2, SOS1, RELA, CXCL3, NFKBIA, PIK3CA, PTK2, ADCY7, CXCL2, MAP2K1, NFKB1, CXCL1, CSK, GSK3B, CXCL5, CRKL, IL8, PXN, GRB2 |
| NCI LYSOPHOSPHOLIPID PATHWAY | NFKB1, JUN, HBEGF, GSK3B, CASP3, RELA, NFKBIA, PTK2, ADCY7, IL8, PXN, EGFR |
| REACTOME TOLL LIKE RECEPTOR 3 CASCADE | PPP2R5D, DUSP4, MAPK7, JUN, NFKB2, PPP2CB, DUSP6, MEF2A, RELA, NFKBIA, MAP2K1, NFKB1, DUSP3, MAP2K4, MAP3K7, RPS6KA5, PPP2R1B, MAPKAPK2, CREB1, MAPK1, TICAM1, TRAF6 |
| KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | NFKB1, CXCL1, JUN, CSK, HBEGF, CASP3, RELA, TJP1, ATP6V0A2, MAP3K14, NFKBIA, ADAM10, MET, IL8, EGFR |
| NETPATH TNF ALPHA PATHWAY | TXLNA, TRAF4, NFKBIA, PTK2, BTRC, RELB, CFLAR, NFKB1, FLNA, TNIP1, TRAF3, MAP3K7IP2, CSNK2A2, GSK3B, SMARCA4, TNFAIP3, RASAL2, TRAF6, CAV1, KTN1, NFKB2, NFKBIE, BIRC2, RELA, CASP3, CASP7, MAP3K14, MARK2, MAP3K2, REL, BIRC3, PSMD12, DPF2, PPP6C, NSMAF, KPNA3, DDX3X, HDAC2, RPS6KA5 |
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | TNFRSF10B, CCL2, TGFB2, CLCF1, CXCL3, VEGFC, OSMR, TGFB1, CXCL2, IL10RB, EGFR, TNFRSF21, PDGFA, CXCL1, TNFRSF12A, CXCL5, TNFSF9, MET, ACVR1, IL8 |
| KEGG CHRONIC MYELOID LEUKEMIA | SOS1, RELA, TGFB2, E2F1, NFKBIA, E2F3, PIK3CA, CBLB, TGFB1, MAP2K1, NFKB1, SMAD3, HDAC2, CRKL, SMAD4, MAPK1, GRB2 |
| REACTOME MAP KINASES ACTIVATION IN TLR CASCADE | DUSP4, MAPK7, JUN, PPP2CB, DUSP6, MEF2A, MAP2K1, DUSP3, MAP2K4, MAP3K7, RPS6KA5, PPP2R1B, MAPKAPK2, TRAF6, TICAM1, MAPK1 |
| NETPATH EGFR1 PATHWAY UP | EMP1, EREG, ITGA3, DUSP6, PHLDA2, SLC20A1, GPRC5A, TAGLN, EHD1, TNFAIP3, MET, TFPI2, SFN, BUB1B, CAV1, DUSP4, PPP1R10, TGFB2, PLAU, PTHLH, AKAP12, SDC4, IER3, ROR1, NAV3, PHLDA1, PLK2, SPRY2, PPAT, PTGS2, DUSP1, PLAUR |
| NCI MET PATHWAY | JUN, SOS1, PDPK1, PIK3CA, PTK2, MET, PXN, GRB2, MAP2K1 |
| BIOCARTA MET PATHWAY | JUN, SOS1, PIK3CA, CRKL, MET, PTK2, PXN, GRB2, MAP2K1 |
| REACTOME TRAF6 MEDIATED INDUCTION OF THE ANTIVIRAL CYTOKINE IFN ALPHA BETA CASCADE | NFKB1, DUSP4, MAPK7, JUN, PPP2CB, DUSP3, DUSP6, MAP3K7, MEF2A, RELA, NFKBIA, RPS6KA5, TRAF6, TICAM1, MAP2K1 |
| LOCOMOTORY BEHAVIOR | CXCL1, CCL2, TGFB2, PLAU, FOSL1, IL8, PLAUR, FGF2 |
| KEGG T CELL RECEPTOR SIGNALING PATHWAY | JUN, NFKBIE, SOS1, PAK2, RELA, MAP3K14, NFKBIA, PIK3CA, CBLB, PPP3CC, MAP2K1, PPP3CB, GSK3B, MALT1, MAP3K7, PPP3R1, GRB2 |
| BIOCARTA FAS PATHWAY | LMNB1, JUN, PARP1, MAP2K4, LMNA, MAP3K7, CASP3, CASP7, PAK2, FAS, DAXX, LMNB2, CFLAR |
| KEGG B CELL RECEPTOR SIGNALING PATHWAY | JUN, NFKBIE, PPP3CB, MALT1, GSK3B, SOS1, RELA, NFKBIA, PPP3R1, PIK3CA, PPP3CC, MAP2K1 |
| NCI NFAT TFPATHWAY | FOSL1, GATA3, PTGS2, JUN, JUNB, IL8, PPARG |
| BIOCARTA HIVNEF PATHWAY | LMNB1, BIRC2, LMNA, CASP3, CASP7, PAK2, RELA, MAP3K14, NFKBIA, PTK2, CFLAR, BIRC3, PARP1, PSEN2, FAS, PSEN1, DAXX, LMNB2 |
| BIOCARTA AGR PATHWAY | JUN, PAK2, GIT2, PTK2, DVL1, PXN, MAPK1, EGFR |
| ST B CELL ANTIGEN RECEPTOR | NFKBIA, PIK3CA, CSK, NFKBIE, SOS1, MAP2K1, GRB2 |
| KEGG SMALL CELL LUNG CANCER | CCNE1, TRAF4, ITGA6, ITGA3, BIRC2, RELA, NFKBIA, E2F3, PIK3CA, PTK2, ITGA2, LAMC1, BIRC3, TRAF3, CCNE2, PTGS2, TRAF6 |
| NCI DISSOLUTION OF FIBRIN CLOT | PLAU, SERPINE1, PLAUR |
| BIOCARTA FCER1 PATHWAY | JUN, PPP3CB, SOS1, PAK2, PIK3CA, PPP3CC, GRB2, MAP2K1 |
| BIOCARTA NGF PATHWAY | PIK3CA, JUN, SOS1, GRB2, MAP2K1 |
| ST T CELL SIGNAL TRANSDUCTION | NFKBIA, CSK, NFKBIE, MAPK1, SOS1, GRB2, PAK2 |
| BIOCARTA TCR PATHWAY | JUN, PPP3CB, SOS1, RELA, NFKBIA, PIK3CA, PPP3CC, MAP2K1, GRB2 |
| BIOCARTA TNFR1 PATHWAY | JUN, PARP1, MAP2K4, LMNA, CASP3, MAP3K7, PAK2, LMNB2 |
| BIOCARTA GLEEVEC PATHWAY | PIK3CA, CRKL, JUN, SOS1, MAP2K1, GRB2 |
| NCI PDGFRAPATHWAY | CAV1, PIK3CA, PDGFA, CRKL, JUN, SHB, SOS1, GRB2 |
| VIRAL INFECTIOUS CYCLE | TNIP1, CCL2, IL8 |
| BIOCARTA CDMAC PATHWAY | NFKBIA, JUN, MAP2K1, RELA |
| NETPATH IL 7 PATHWAY UP | CXCL1, JUN, MCL1, TRAF3, CXCL3, CXCL5, CXCL2, IL8 |
| CHEMOKINE ACTIVITY | CXCL3, CXCL1, CCL2, IL8 |
| VIRAL GENOME REPLICATION | TNIP1, CCL2, IL8 |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | BIRC3, CXCL1, CCL2, BIRC2, RELA, NFKBIA, TNFAIP3, CXCL2, IL8, TRAF6 |
| CHEMOKINE RECEPTOR BINDING | CXCL3, CXCL1, CCL2, IL8 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL3, CXCL1, CCL2, IL8 |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | NFKB1, TRAF3, DDX3Y, MAP3K7, RELA, DDX3X, NFKBIA, IL8, TRAF6, DDX58 |
| BIOCARTA INFLAM PATHWAY | PDGFA, TGFB1, IL8, TGFB2 |
| POSITIVE REGULATION OF CELL PROLIFERATION | LAMC1, PDGFA, EREG, CDC7, TGFB2, TBX3, TGFA, PTHLH, FOSL1, TBRG4, HOXC10, EGFR |
| NCI AVB3 OPN PATHWAY | PLAU, MAP3K14, NFKBIA, PIK3CA, JUN, PIP5K1A, RELA |
| ST TUMOR NECROSIS FACTOR PATHWAY | BIRC3, JUN, NFKBIE, BIRC2, CASP3, MAP3K7, NFKBIA, TNFAIP3, CFLAR |
| POSITIVE REGULATION OF PHOSPHATE METABOLIC PROCESS | CCND3, EREG, TGFB1, CLCF1, EGFR |
| ECTODERM DEVELOPMENT | PTHLH, ATP2C1, EMP1, FST, SMURF1, TGFB2 |
| BIOCARTA STEM PATHWAY | IL8 |
| NCI PLK1 PATHWAY | FBXO5, BUB1B, ECT2, KIF2A, CDC20, BUB1, CDC25C, PLK1, AURKA, PRC1, CENPE, BTRC, GORASP1 |
| NCI TNFPATHWAY | NFKB1, CAV1, BIRC3, MAP3K7IP2, BIRC2, MAP3K7, MAP4K2, PRKCI, RELA, NSMAF, SQSTM1, MAP4K3, TNFAIP3, MAP4K4 |
| ADAPTIVE IMMUNE RESPONSE | SOCS5, TGFB1, MALT1, TRAF6, MAP3K7 |
| POSITIVE REGULATION OF PHOSPHORYLATION | CCND3, EREG, CLCF1, EGFR |
| CORUM CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 COMPLEX | NFKB1, NFKBIA, SPAG9, REL, TNIP1, NFKBIE, RELA |
| BIOCARTA CYTOKINE PATHWAY | IL8 |
| POSITIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | SOCS5, FST, EREG, TGFB1, TRAF6, MALT1, TGFB2 |
| POSITIVE REGULATION OF RESPONSE TO STIMULUS | EREG, IL8, MALT1, TRAF6, MAP3K7, TGFB2 |
| ADAPTIVE IMMUNE RESPONSE GO 0002460 | SOCS5, TGFB1, MALT1, TRAF6, MAP3K7 |
| PEPTIDYL TYROSINE PHOSPHORYLATION | NF2, LYN, EGFR, CLCF1 |
| BIOCARTA ERYTH PATHWAY | TGFB1, TGFB2 |
| REGULATION OF IMMUNE SYSTEM PROCESS | SOCS5, EREG, TGFB1, TRAF6, MALT1, TGFB2 |
| REGULATION OF PEPTIDYL TYROSINE PHOSPHORYLATION | CLCF1, EGFR |
| NCI CD40 PATHWAY | BIRC3, JUN, TRAF3, BIRC2, RELA, MAP3K14, NFKBIA, TNFAIP3, TRAF6 |
| POSITIVE REGULATION OF IMMUNE SYSTEM PROCESS | SOCS5, EREG, TGFB1, TRAF6, MALT1, MAP3K7, TGFB2 |
| REGULATION OF RESPONSE TO STIMULUS | EREG, IL8, MALT1, TRAF6, MAP3K7, TGFB2 |
| BIOCARTA IL17 PATHWAY | IL8 |
| PEPTIDYL TYROSINE MODIFICATION | NF2, TPST2, LYN, EGFR, CLCF1 |
| NCI EPHRINA EPHAPATHWAY | EPHA2 |
| VIRAL REPRODUCTIVE PROCESS | |
| BIOCARTA NFKB PATHWAY | MAP3K14, NFKBIA, IRAK1, TNFAIP3, TRAF6, MAP3K7, RELA |
| NETPATH IL 1 PATHWAY | |
| KEGG HYPERTROPHIC CARDIOMYOPATHY HCM | |
| NCI CXCR4 PATHWAY | |
| TISSUE MORPHOGENESIS | TBX3, TGFB2 |
| BIOCARTA LYM PATHWAY | |
| REGULATION OF CYTOKINE PRODUCTION | SMAD3, EREG, SMAD4, MALT1, TRAF6, MAP3K7, TGFB2 |
| BIOCARTA CD40 PATHWAY | MAP3K14, NFKBIA, TNFAIP3, TRAF3, TRAF6, DUSP1, RELA |
| NETPATH ANDROGEN RECEPTOR PATHWAY | |
| POSITIVE REGULATION OF IMMUNE RESPONSE | EREG, MALT1, TRAF6, MAP3K7, TGFB2 |
| EPIDERMIS DEVELOPMENT | EMP1, FST, TGFB2 |
| NEGATIVE REGULATION OF IMMUNE SYSTEM PROCESS | |
| SIG CD40PATHWAYMAP | NFKBIA, PIK3CA, NFKBIE, TRAF3, TRAF6, DUSP1 |
| CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX CHUK KPNA3 NFKB2 NFKBIB REL IKBKG NFKB1 NFKBIE RELB NFKBIA RELA TNIP2 | |
| LEUKOCYTE CHEMOTAXIS | |
| REGULATION OF IMMUNE RESPONSE | EREG, MALT1, TRAF6, MAP3K7, TGFB2 |
| KEGG HEMATOPOIETIC CELL LINEAGE | |
| CORUM TNF-ALPHA/NF-KAPPA B SIGNALING COMPLEX RPL6 RPL30 RPS13 CHUK DDX3X NFKB2 NFKBIB REL IKBKG NFKB1 MAP3K8 RELB GLG1 NFKBIA RELA TNIP2 GTF2I | |
| BIOCARTA TNFR2 PATHWAY | MAP3K14, NFKBIA, TNFAIP3, TRAF3, DUSP1, RELA |
| POSITIVE REGULATION OF JNK ACTIVITY | |
| PRODUCTION OF MOLECULAR MEDIATOR OF IMMUNE RESPONSE | |
| NEGATIVE REGULATION OF MULTICELLULAR ORGANISMAL PROCESS | |