| Gene Set | Leading Edge Genes |
|---|
| NETPATH IL 2 PATHWAY UP | DUSP4, ZNF267, PFKFB3, IL1RAP, RELA, SLC2A3, PMAIP1, ASNS, PIM1, FOS, CREM, BHLHB2, IER3, CFLAR, IFIT1, KLF6, DUSP5, LIF, GARS, TOP1, ETS2, VEGF, NFIL3, SERPINE1, ICAM1, IL8, IRF1, SLC7A5, CHSY1, PLAUR |
| NETPATH IL 5 PATHWAY UP | BIRC3, DUSP5, PPIF, CCL2, NFKBIE, RELA, NFIL3, EGR1, ICAM1, IL8, CD55, PIM1, RELB, IER3, IER2 |
| RESPONSE TO EXTERNAL STIMULUS | IL1RAP, CXCL1, EREG, CCL2, CEBPB, TFPI, RELA, PLAU, FOSL1, CXCL5, SERPINE1, IL8, RIPK2, FOS, CXCL2, PLAUR |
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | PDGFB, LIF, IL1RAP, CXCL1, CCL2, IL15, CXCL5, IL6, MET, CXCL2, IL8 |
| LOCOMOTORY BEHAVIOR | FOSL1, PLAU, CXCL5, CXCL1, CCL2, IL8, CXCL2, PLAUR |
| NETPATH EGFR1 PATHWAY UP | EMP1, EREG, ITGA3, PLAU, EGR1, AKAP12, SDC4, IER3, GPRC5A, LIF, VEGF, CXCL5, MET, TNFAIP3, TFPI2, MYC, PLAUR |
| BEHAVIOR | CXCL1, CCL2, FOSB, PLAU, FOSL1, CXCL5, CXCL2, IL8, PLAUR |
| NETPATH IL 1 PATHWAY UP | PDE4D, NFKBIE, CCL2, RELA, FOSL1, NFKBIA, CXCL2, SOD2, BIRC3, CXCL1, LIF, CXCL5, SERPINE1, ZFP36, IL8, MYC |
| NETPATH IL 3 PATHWAY UP | NFIL3, MCL1, CCL2, PIM1, IL8, FOS |
| IMMUNE SYSTEM PROCESS | NFIL3, SEMA4D, IL6, EREG, CCL2, CEBPB, IL8, IL15, BNIP3 |
| RESPONSE TO WOUNDING | CXCL1, EREG, IL1RAP, CEBPB, TFPI, RELA, SERPINE1, IL8, RIPK2, FOS, CXCL2 |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | CXCL5, CXCL1, CCL2, CXCL2, IL8 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | CXCL5, CXCL1, CCL2, CXCL2, IL8 |
| CYTOKINE ACTIVITY | CXCL5, CXCL1, CCL2, IL8, CXCL2 |
| NETPATH IL 4 PATHWAY DOWN | NFKBIA, CCL2, CXCL2, IL8, IRF1, DDIT4 |
| CHEMOKINE ACTIVITY | CXCL5, CXCL1, CCL2, CXCL2, IL8 |
| RECEPTOR BINDING | CXCL1, EREG, CCL2, HMGA1, TGFA, EFNA1, CXCL5, IL8, CXCL2 |
| NCI DISSOLUTION OF FIBRIN CLOT | SERPINE1, PLAUR |
| KEGG JAK STAT SIGNALING PATHWAY | IL6, LIF, PIM1, MYC, SPRY1, IL15 |
| NETPATH KIT RECEPTOR PATHWAY UP | DUSP4, MCL1, JUNB, CCL2, RELA, VEGF, EGR1, PIM1, FOS, IER3 |
| G PROTEIN COUPLED RECEPTOR BINDING | CXCL5, CXCL1, CCL2, CXCL2, IL8 |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | BIRC3, CXCL1, CCL2, BIRC2, RELA, NFKBIA, TNFAIP3, RIPK2, CXCL2, IL8 |
| REACTOME GPCR LIGAND BINDING | CXCL5, CXCL1, CCL2, IL8, CXCL2 |
| EXTRACELLULAR SPACE | TNFAIP2, CXCL1, EREG, CCL2, CXCL2, IL8 |
| CHEMOKINE RECEPTOR BINDING | CXCL5, CXCL1, CCL2, CXCL2, IL8 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL5, CXCL1, CCL2, CXCL2, IL8 |
| KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY | NFKBIA, DDX3X, IL8, RELA |
| NCI NFAT TFPATHWAY | FOSL1, EGR1, JUNB, IL8, FOS |
| BIOCARTA STEM PATHWAY | IL8 |
| NETPATH IL 6 PATHWAY UP | CXCL1, MCL1, JUNB, CEBPB, SLC2A3, MAFF, ZFP36, IRF1, PIM1, BHLHB2 |
| IMMUNE RESPONSE | NFIL3, EREG, CEBPB, CCL2, BNIP3, IL15 |
| CALCIUM MEDIATED SIGNALING | IL8 |
| NCI IL23PATHWAY | NFKBIA, CXCL1, CCL2, RELA |
| BIOCARTA INFLAM PATHWAY | IL8, IL15 |
| NETPATH IL 7 PATHWAY UP | CXCL5, CXCL1, MCL1, IL8, CXCL2 |
| POSITIVE REGULATION OF CELL PROLIFERATION | TGFA, FOSL1, CXCL5, IL6, LIF, EREG, MYC, IL15 |
| REACTOME G ALPHA I SIGNALLING EVENTS | CXCL5, CXCL1, IL8, CXCL2 |
| BIOCARTA CYTOKINE PATHWAY | IL8, IL15 |
| DEFENSE RESPONSE | TNIP1, CXCL1, EREG, IL1RAP, CEBPB, RELA, FOSL1, VEZF1, IL8, RIPK2, FOS, CXCL2, BNIP3 |
| INFLAMMATORY RESPONSE | CXCL1, CEBPB, IL8, CXCL2, RIPK2, RELA |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | NFKBIA, IL8, FOS, MAP3K8, TICAM1, RELA |
| POSITIVE REGULATION OF RESPONSE TO STIMULUS | EREG, IL8 |
| NETPATH TNF ALPHA PATHWAY DOWN | IFIT5, MAP3K14, NFKBIA, EGR1, SDC4, CXCL2, BHLHB2, IER3, KLF6, CXCL1, NR4A1, KLF10, PPP1R15A, JUNB, FOSB, VEGF, DDX3X, TNFAIP2, MAFF, TNFAIP3, ZFP36, IRF1 |
| NCI CHEMOKINE RECEPTORS BIND CHEMOKINES | |
| KEGG LEISHMANIA INFECTION | NFKBIA, FOS, RELA |
| CELL CELL SIGNALING | |
| DEVELOPMENTAL GROWTH | |
| NETPATH HEDGEHOG PATHWAY UP | VEGF, NR4A1 |
| NCI CD40 PATHWAY | MAP3K14, NFKBIA, BIRC3, TNFAIP3, MYC, BIRC2, RELA |
| BIOCARTA DEATH PATHWAY | |
| EXTRACELLULAR REGION PART | |
| BIOCARTA LAIR PATHWAY | |
| ST TUMOR NECROSIS FACTOR PATHWAY | NFKBIA, BIRC3, TNFAIP3, NFKBIE, BIRC2, CFLAR |
| NCI IL12 2PATHWAY | RELB, FOS, RIPK2, RELA |