| Gene Set | Leading Edge Genes |
|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | IL1RAP, CCL2, CD40, OSMR, CXCL16, CCL5, CXCL2, IL17RA, CXCL11, CXCL10, CXCL1, CCL28, IFNGR1, TNFRSF11A, CXCL5, FAS, IL6, TNFRSF14, IL1B |
| RESPONSE TO EXTERNAL STIMULUS | HDAC9, ELF3, CXCL1, CCL2, CD40, MDK, PLAU, CXCL5, C3AR1, CCL5, FOS, CXCL2, CXCL11, CXCL10, PLAUR |
| REACTOME SIGNALING IN IMMUNE SYSTEM | CD200, CD40, MAP3K8, IKBKE, TLR4, SLC7A11, NFKBIA, FOS, PDCD1LG2, CFB, IFITM1, C1S, ICOSLG, SLC16A3, CSK, CD274, TBK1, TNFRSF14, CD14, TICAM1 |
| NETPATH IL 5 PATHWAY UP | BIRC3, PPIF, TRAF3, CCL2, MAX, NFKBIE, TLR4, NFIL3, EGR1, IL1B, RELB, PIM1, CD55, ABP1, CASP4, MYD88 |
| NETPATH IL 2 PATHWAY UP | ADAM19, SLC2A3, TLR4, TRAFD1, PLAU, PMAIP1, PRKCD, IFI44, CTSH, PIM1, FOS, CREM, BHLHB2, B4GALT5, KLF6, IRF5, NFIL3, TNFRSF11A, KCNAB1, FAS, IL1B, CASP1, PBEF1, PTGER2, MYC, PLAUR, MX1 |
| IMMUNE SYSTEM PROCESS | ICOSLG, HDAC9, IL27RA, CCL2, TRAF2, CD274, TLR4, NFIL3, CTSS, SEMA4D, IL6, HCLS1, CCL5, LAT2, MAFB |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | CXCL1, CCL2, CXCL5, CXCL16, C3AR1, CCL5, PTGER2, CXCL2, ADORA2B, CXCL10 |
| KEGG COMPLEMENT AND COAGULATION CASCADES | PLAU, C1S, F3, CFB, PLAUR |
| BEHAVIOR | PLAU, CXCL5, CXCL1, CCL5, CCL2, CXCL2, CXCL10, PLAUR |
| DEFENSE RESPONSE | TCIRG1, HDAC9, ELF3, TNIP1, CXCL1, LGALS3BP, KCNN4, C3AR1, CCL5, ADORA2B, FOS, CXCL2, CXCL10, MX1 |
| LOCOMOTORY BEHAVIOR | PLAU, CXCL5, CXCL1, CCL5, CCL2, CXCL2, CXCL11, CXCL10, PLAUR |
| KEGG CHEMOKINE SIGNALING PATHWAY | JAK2, CXCL1, CCL2, CXCL5, NFKBIA, PRKCD, STAT2, ADCY7, CXCL16, RAC2, CCL5, CXCL2, CXCL11, CXCL10 |
| REACTOME GPCR LIGAND BINDING | CXCL1, CCL2, CXCL5, CXCL16, CCL5, CXCL2, ADORA2B, PTGER2, CXCL10 |
| KEGG JAK STAT SIGNALING PATHWAY | OSMR, IL6, JAK2, IFNGR1, STAT2, PIM1, MYC |
| KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY | BIRC3, CXCL1, CCL2, BIRC2, NFKBIA, TNFAIP3, IL1B, CASP1, CCL5, CXCL2 |
| RESPONSE TO WOUNDING | HDAC9, ELF3, CXCL1, CD40, MDK, C3AR1, CCL5, FOS, CXCL2, CXCL11, CXCL10 |
| EXTRACELLULAR SPACE | CXCL1, TGFBI, CCL2, MMP2, TNFAIP2, LGALS3BP, IL1B, PSAP, CXCL2 |
| KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY | CD40, MAP3K8, IKBKE, TLR4, CTSK, NFKBIA, CCL5, FOS, CXCL11, CXCL10, IRF5, TRAF3, TBK1, IL1B, CD14, TICAM1 |
| NETPATH IL 1 PATHWAY UP | MMP14, NFKBIE, CCL2, NFKBIA, PRKCD, PTGES, MT2A, CXCL2, SOD2, CFB, BMP1, BIRC3, CXCL1, NP, ST3GAL4, CXCL5, IL1B, PBEF1, ZFP36, MYC |
| KEGG PRIMARY IMMUNODEFICIENCY | ADA, TAP2, CD40, TAP1 |
| REACTOME PEPTIDE LIGAND BINDING RECEPTORS | CXCL5, CXCL1, C3AR1, CXCL16, CCL5, CCL2, CXCL2, CXCL10 |
| CYTOKINE ACTIVITY | GDF15, CXCL1, CCL2, CXCL5, CXCL16, CCL5, CXCL2, CXCL10, CXCL11 |
| CHEMOKINE ACTIVITY | CXCL1, CCL2, CXCL5, CXCL16, CCL5, CXCL2, CXCL10, CXCL11 |
| CHEMOKINE RECEPTOR BINDING | CXCL1, CCL2, CXCL5, CXCL16, CCL5, CXCL2, CXCL10, CXCL11 |
| KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION | ICOSLG, IL6, CCL28, TGFB1, CD40, ITGB7 |
| REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL5, CXCL1, CCL5, CCL2, CXCL2, CXCL10 |
| NETPATH IL 3 PATHWAY UP | NFIL3, IL1B, CCL2, PIM1, FOS, MYC |
| IMMUNE RESPONSE | NFIL3, CTSS, CCL5, CCL2, TRAF2, CD274 |
| REACTOME G ALPHA I SIGNALLING EVENTS | CXCL5, CXCL1, C3AR1, ADCY7, CXCL16, CCL5, CXCL2, CXCL10 |
| G PROTEIN COUPLED RECEPTOR BINDING | CXCL1, CCL2, CXCL5, CXCL16, CCL5, CXCL2, CXCL10, CXCL11 |
| INFLAMMATORY RESPONSE | HDAC9, ELF3, CXCL1, CCL5, CXCL2, CXCL11, CXCL10 |
| KEGG ANTIGEN PROCESSING AND PRESENTATION | CTSB, CTSS, PSME2, TAP2, LGMN, IFI30, TAP1, PSME1 |
| KEGG GRAFT VERSUS HOST DISEASE | FAS, IL6, IL1B |
| REACTOME COMPLEMENT CASCADE | C1S, CFB |
| CATION HOMEOSTASIS | C3AR1, HFE, CCL5, GNA15, MT2A, CCL2, MYC |
| REACTOME INNATE IMMUNITY SIGNALING | C1S, IKBKE, TLR4, NFKBIA, CD14, FOS, TICAM1, CFB |
| CHEMICAL HOMEOSTASIS | HFE, C3AR1, CCL5, GNA15, MT2A, CCL2, MYC |
| CELLULAR CATION HOMEOSTASIS | C3AR1, HFE, CCL5, GNA15, MT2A, CCL2, MYC |
| KEGG LEISHMANIA INFECTION | NFKBIA, IL1B, JAK2, FOS, TLR4 |
| BIOCARTA COMP PATHWAY | C1S, CFB |
| CELLULAR DEFENSE RESPONSE | TCIRG1, LGALS3BP, CCL5, ADORA2B |
| ION HOMEOSTASIS | HFE, C3AR1, CCL5, GNA15, MT2A, CCL2, MYC |
| NCI IL12 2PATHWAY | IL1B, JAK2, RELB, FOS |
| CELLULAR HOMEOSTASIS | HFE, C3AR1, CCL5, GNA15, MT2A, CCL2, MYC |
| REACTOME INITIAL TRIGGERING OF COMPLEMENT | C1S, CFB |
| HUMORAL IMMUNE RESPONSE | CCL2 |
| BIOCARTA NO2IL12 PATHWAY | JAK2 |
| NETPATH IL 7 PATHWAY UP | CXCL5, CXCL1, LITAF, CCL5, TRAF3, CXCL2, MYC |
| RESPONSE TO VIRUS | IFI44, CCL5, BCL3 |
| BIOCARTA CLASSIC PATHWAY | C1S |
| NCI IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | CD200, IFITM1, CD40 |
| BIOCARTA IL22BP PATHWAY | JAK2, STAT2 |
| NETPATH IL 6 PATHWAY UP | CXCL1, CEBPD, JUNB, BCL3, SLC2A3, MAFF, ZFP36, PIM1, BHLHB2, MX1, SBNO2 |
| RESPONSE TO OTHER ORGANISM | IFI44, CCL5, BCL3 |
| NCI CD40 PATHWAY | BIRC3, TRAF2, TRAF3, CD40, BIRC2, NFKBIA, TNFAIP3, MYC |
| MULTI ORGANISM PROCESS | MAFF, TNIP1, IFI44, CCL5, BCL3 |
| RESPONSE TO BIOTIC STIMULUS | DNAJA1, IFI44, CCL5, BCL3 |
| REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | CD200, IFITM1, CD40 |
| BIOCARTA CASPASE PATHWAY | BIRC3, CASP1, BIRC2, CASP4 |
| REACTOME CLASSICAL ANTIBODY MEDIATED COMPLEMENT ACTIVATION | C1S |
| NICOTINIC ACETYLCHOLINE ACTIVATED CATION SELECTIVE CHANNEL ACTIVITY | |
| NICOTINIC ACETYLCHOLINE GATED RECEPTOR CHANNEL COMPLEX | |
| CYTOKINE PRODUCTION | TRAF2, BCL3, TLR4 |
| RESPONSE TO BACTERIUM | |
| BIOCARTA LAIR PATHWAY | |
| POSITIVE REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | TLR4 |
| CYTOKINE METABOLIC PROCESS | BCL3, TLR4 |
| NCI NFAT TFPATHWAY | EGR1, JUNB, FOS |
| REGULATION OF INTERFERON GAMMA BIOSYNTHETIC PROCESS | |
| NCI CHEMOKINE RECEPTORS BIND CHEMOKINES | CXCL16 |
| POSITIVE REGULATION OF TRANSLATION | BCL3, TLR4 |
| REGULATION OF CYTOKINE BIOSYNTHETIC PROCESS | BCL3, TLR4 |
| REACTOME TOLL LIKE RECEPTOR 4 CASCADE | CD14, TICAM1, TBK1, TLR4 |
| CYTOKINE BIOSYNTHETIC PROCESS | BCL3, TLR4 |